Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer by Ritu Pandey, Muhan Zhou, Yuliang Chen, Dalila Darmoul, Conner C. Kisiel, Valentine N. Nfonsam, Natalia A. Ignatenko

“…The top KLK6-interaction partners were found to be the members of kallikrein family (KLK7, KLK8, KLK10), extracellular matrix associated proteins (keratins, integrins, small proline rich repeat, S100A families) and TGF-β, FOS, and Ser/Thr protein kinase signaling pathways. …”
Get full text

Candida albicans Sap6 Initiates Oral Mucosal Inflammation via the Protease Activated Receptor PAR2 by Rohitashw Kumar, Isolde Gina Rojas, Mira Edgerton

“…Beside its protease activity, Sap6 contains RGD (RGDRGD) motif required for its binding to host integrins. Sap6 activates immune cells to induce proinflammatory cytokines, although its ability to interact and activate human oral epithelial cells (OECs) remain unknown. …”
Get full text

Trends in research of exosomes associated with breast cancer over the past decade: a scientometric analysis by Jiaxin Wu, Daitian Zheng, Haiting Wang, Zhongming Zhou, Qiuping Yang, Jinyao Wu, Huiting Tian, Zeqi Ji, Lingzhi Chen, Jiehui Cai, Yexi Chen, Zhiyang Li

“…The most cited document was “Tumor exosome integrins determine organotropic metastasis”, with 2730 citations. …”
Get full text

Micropattern Silk Fibroin Film Facilitates Tendon Repair In Vivo and Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells through the α2β1/FAK/PI3K/AKT Signaling Path... by Kang Lu, Hong Tang, Yang Wang, Liyuan Wang, Mei Zhou, Gang He, Hao Lu, Chuyue Tang, Wan Chen, Xiaoqing Ma, Kanglai Tang, Zhongliang Deng

“…Western blot analysis showed that the expression of integrins α2β1, tenascin-C (TNC), and tenomodulin (TNMD) and the phosphorylation of AKT were significantly increased in the micropattern SF film group, which could be abrogated by applying PI3K/AKT inhibitors. …”
Get full text

VDAC1 Silencing in Cancer Cells Leads to Metabolic Reprogramming That Modulates Tumor Microenvironment by Erez Zerbib, Tasleem Arif, Anna Shteinfer-Kuzmine, Vered Chalifa-Caspi, Varda Shoshan-Barmatz

“…This was reflected in the altered expression of a battery of genes associated with TME, including those involved in extracellular matrix organization and structure, matrix-related peptidases, angiogenesis, intercellular interacting proteins, integrins, and growth factors associated with stromal activities. …”
Get full text

Investigations of tetraspanin functions using large extracellular loops by Liu, Christopher C

Get full text
Get full text

The structural and cellular biology of endogenous TLR4 activators in inflammatory disease by Coker, J

“…Next, using an unbiased proteomics workflow to probe the cell-surface FReP interactome, I provide evidence to suggest that integrins and lipoprotein receptors, not TLR4, may be the direct FReP receptors. …”

Why some tumours trigger neovascularisation and others don’t: the story thus far by Adighibe, O, Leek, R, Fernandez-Mercado, M, Hu, J, Snell, C, Gatter, K, Harris, A, Pezzella, F

“…Results The non-angiogenic tumours were distinguished from the angiogenic ones by having higher levels of proteins associated with ephrin pathways, mitochondria, cell biogenesis, and hypoxia-inducible factor 1 (HIF1) regulation by oxygen and transcription of HIF-controlled genes but lower levels of proteins involved in the stroma, cell–cell signaling and adhesion, integrins, and Delta-Notch and epidermal growth factor (EGF)-related signaling. …”

Identification of putative drug targets for human sperm-egg interaction defect using protein network approach by Sabetian, Soudabeh, Shamsir, Mohd. Shahir

“…The potential drug targets are from integrins, fibronectins, epidermal growth factor receptors, collagens and tetraspanins protein families. …”

The Human Tissue-Engineered Cornea (hTEC): Recent Progress by Louis-Philippe Guérin, Gaëtan Le-Bel, Pascale Desjardins, Camille Couture, Elodie Gillard, Élodie Boisselier, Richard Bazin, Lucie Germain, Sylvain L. Guérin

“…However, studies have emerged that describe the production of tridimensional (3D) tissue-engineered corneas using untransformed human corneal epithelial cells grown on a totally natural stroma synthesized by living corneal fibroblasts, that also show appropriate histology and expression of both extracellular matrix (ECM) components and integrins. This review highlights contributions from laboratories working on the production of human tissue-engineered corneas (hTECs) as future substitutes for grafting purposes. …”
Get full text

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance by Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad

“…Generally, these three TM4SF members interact with different integrins and receptors to significantly induce intracellular signaling and regulate the proliferation, migration, and invasion of cancer cells. …”
Get full text

Dynamic Interplay in Tumor Ecosystems: Communication between Hepatoma Cells and Fibroblasts by Gábor Petővári, Gábor Tóth, Lilla Turiák, Anna L. Kiss, Krisztina Pálóczi, Anna Sebestyén, Adrián Pesti, András Kiss, Kornélia Baghy, Katalin Dezső, Tibor Füle, Péter Tátrai, Ilona Kovalszky, Andrea Reszegi

“…Conversely, in HuH7/LX2 co-culture, fibronectin, thrombospondin-1, type IV collagen, and cell surface syndecan-1 were dominant matrix components. Integrins α6β4 and α6β1 were upregulated in HLE, while α5β1 and αVβ1 were increased in HuH7. …”
Get full text

The Effect of Gene Editing by CRISPR-Cas9 of miR-21 and the Indirect Target MMP9 in Metastatic Prostate Cancer by Juliana A. Camargo, Nayara I. Viana, Ruan Pimenta, Vanessa R. Guimarães, Gabriel A. dos Santos, Patrícia Candido, Vitória Ghazarian, Poliana Romão, Iran A. Silva, Alexander Birbrair, Miguel Srougi, William C. Nahas, Kátia R. Leite, Ericka B. Trarbach, Sabrina T. Reis

“…The miR-21 targets, integrins, BAX and mTOR, were evaluated by qPCR. Flow cytometry was performed with Annexin5, 7-AAD and Ki67 markers. …”
Get full text

Integrative analysis implicates the significance of m6A in the liver fibrosis of biliary atresia by regulating THY1 by Junfeng Wang, Min Du, Lingdu Meng, Yifan Yang, Shiwei He, Ye Zhu, Xue Ren, Meng Wei, Rui Dong, Shan Zheng, Gong Chen

“…Bulk array (GSE46960, GSE15235), single-cell RNA sequencing (GSE136103), primary HSC interventions, and co-immunoprecipitation revealed that THY1 was correlated with extracellular matrix organization, promoted HSC activation, showed higher interactions with integrins on myeloid cells in cholestatic fibrosis, and was correlated with native liver survival in BA. …”
Get full text

Dupuytren’s Disease Is Mediated by Insufficient TGF-β1 Release and Degradation by Lisa Oezel, Marie Wohltmann, Nele Gondorf, Julia Wille, Irmak Güven, Joachim Windolf, Simon Thelen, Carina Jaekel, Vera Grotheer

“…Therefore, the complex in which TGF-β1 is secreted in the extracellular matrix to elicit its biological activity, and proteins such as plasmin, integrins, and matrix metalloproteinases (MMPs), which are involved in the TGF-β1 activation, were herein analyzed in DD-fibroblasts (DD-FBs). …”
Get full text

Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program by Carlos Jiménez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Solé, Marc Masanas, Adrià Molero-Valenzuela, Aroa Soriano, Josep Sánchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulàlia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura

“…Genome-wide chromatin remodelling and transcriptomic analyses revealed that BAF disruption results in the epigenetic repression of an extensive invasiveness-related expression program involving integrins, cadherins, and key mesenchymal regulators, thereby reducing adhesion to the extracellular matrix and the subsequent invasion in vitro and drastically inhibiting the initiation and growth of neuroblastoma metastasis in vivo. …”
Get full text

A selective CB2R agonist (JWH133) protects against pulmonary fibrosis through inhibiting FAK/ERK/S100A4 signaling pathways by Xiao Wu, Lina Chen, Yiju Cheng, Yuquan Zhang, Wenting Yang, Lin Pan, Chenkun Fu, Honglan Zhu, Menglin Zhang

“…Focal adhesion kinase (FAK) plays a crucial role in regulating signals from growth factor receptors and Integrins. It is also involved in the transformation of fibroblasts into myofibroblasts. …”
Get full text

Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation by Yannas, Ioannis V, Tzeranis, Dimitrios, So, Peter T. C.

“…These observations were explained by the evidence of a surface-biological interaction of MFB with the scaffold, specifically involving binding of MFB integrins α[subscript 1]β[subscript 1] and α[subscript 2]β[subscript 1] to ligands GFOGER and GLOGER naturally present on the surface of the collagen scaffold. …”
Get full text
Get full text
Get full text

iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer by Lo, Justin H., Hao, Liangliang, Muzumdar, Mandar, Raghavan, Srivatsan, Kwon, Ester, Pulver, Emilia M, Hsu, Felicia, Aguirre, Andrew J., Wolpin, Brian M., Fuchs, Charles S., Hahn, William C., Jacks, Tyler E, Bhatia, Sangeeta N

“…Noting that the cyclic peptide iRGD mediates tumor targeting and penetration through interactions with a v b 3/5 integrins and neuropilin-1, we hypothesized that "tandem" peptides combining a cell-penetrating peptide and iRGD can encapsulate siRNA to form tumor-penetrating nanocomplexes (TPN) capable of delivering siRNA to PDAC. …”
Get full text

Three members of transmembrane-4-superfamily, tm4sf1, Tm4sf4, and tm4sf5, as emerging anticancer molecular Targets against cancer phenotypes and chemoresistance by Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad

“…Generally, these three TM4SF members interact with different integrins andreceptors to significantly induce intracellular signaling and regulate the proliferation, migration, and invasion of cancer cells. …”
Get full text
Get full text