Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization by Tina Rauchenwald, Florian Handle, Catherine E. Connolly, Antonia Degen, Christof Seifarth, Martin Hermann, Christoph H. Tripp, Doris Wilflingseder, Susanne Lobenwein, Dragana Savic, Leo Pölzl, Evi M. Morandi, Dolores Wolfram, Ira-Ida Skvortsova, Patrizia Stoitzner, Johannes Haybaeck, Marko Konschake, Gerhard Pierer, Christian Ploner

“…In vitro, ASCs exposed to M1, but not to M2 macrophage secretome showed a pro-fibrotic response characterized by stress fiber formation, elevated alpha smooth muscle actin (SMA), and increased expression of integrins ITGA5 and ITGAV. Macrophage-secreted IL1B and TGFB1 mediated this response via the PI3K/AKT and p38-MAPK pathways. …”
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Aspectos y consideraciones generales en la enfermedad inflamatoria intestinal durante la pandemia por COVID-19 by J.L. de León-Rendón, C. Hurtado-Salazar, J.K. Yamamoto-Furusho

“…Finally, biologic treatment with anti-TNF-alpha agents or any other mechanism of action, such as anti-integrins or anti-interleukins, should be suspended if patients become infected with SARS-CoV-2. …”
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Potential diagnostic of lymph node metastasis and prognostic values of TM4SFs in papillary thyroid carcinoma patients by Kun Wang, Kun Wang, Haomin Li, Junyu Zhao, Jinming Yao, Yiran Lu, Jianjun Dong, Jie Bai, Lin Liao, Lin Liao

“…Finally, we explored the correlation between TM4SFs and TMB/MSI.Results: We identified 21 DEGs from the 41 TM4SFs between N0 (without LNM) and N1 (with LNM) patients, with TM4SF1, TM4SF4, UPK1B, and CD151 being highly expressed in the N1 group; several DEGs were observed in the TNM, T, and N cancer stages. The “integrins and other cell-surface receptors” pathway was the most significantly enriched functional category related to LNM and TM4SFs. …”
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Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes. by Tan, L, Mowat, A, Fazou, C, Rostron, T, Roskell, H, Dunbar, P, Tournay, C, Romagné, F, Peyrat, M, Houssaint, E, Bonneville, M, Rickinson, AB, Mcmichael, A, Callan, M

“…The enrichment might reflect preferential recruitment of subpopulations of virus-specific T cells, perhaps based on expression of selectins, chemokine receptors or integrins. Alternatively, T cells specific for certain viral epitopes may be stimulated to proliferate within the joint, by viral antigens themselves or by cross-reactive self-antigens. …”