Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection by Daniel Kummer, Klaus Ebnet

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Mechanism of integrin activation by talin and its cooperation with kindlin by Fan Lu, Liang Zhu, Thomas Bromberger, Jun Yang, Qiannan Yang, Jianmin Liu, Edward F. Plow, Markus Moser, Jun Qin

“…The authors report here that talin and kindlin, the two key integrin binders and activators, are bridged by paxillin to induce microclustering of integrins to potently bind to multivalent extracellular ligand and trigger rapid cell attachment.…”
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Kindlin-1 regulates integrin dynamics and adhesion turnover. by Coert Margadant, Maaike Kreft, Giovanna Zambruno, Arnoud Sonnenberg

“…Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Kindler syndrome. …”
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Molecular Delivery of Cytotoxic Agents via Integrin Activation by Martina Cirillo, Daria Giacomini

Subjects: “…integrins…”
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A prognostic model based on the integrin genes for osteosarcoma by Jian Zhang, Zhiqiang Cheng, Xiaohu Chang, Siyi Wang

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Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities by Siyi Li, Chibuzo Sampson, Changhao Liu, Hai-long Piao, Hong-Xu Liu

Subjects: “…Integrin…”
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Integrins are double-edged swords in pulmonary infectious diseases by Ye Yao, Huijun Liu, Lin Yuan, Xizi Du, Yu Yang, Kai Zhou, Xinyu Wu, Ling Qin, Ming Yang, Yang Xiang, Xiangping Qu, Xiaoqun Qin, Chi Liu

Subjects: “…Integrins…”
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Are Integrins Still Practicable Targets for Anti-Cancer Therapy? by Begoña Alday-Parejo, Roger Stupp, Curzio Rüegg

“…In spite of compelling preclinical results demonstrating that the inhibition of integrin αVβ3/αVβ5 and α5β1 has therapeutic potential, clinical trials with integrin inhibitors targeting those integrins have repeatedly failed to demonstrate therapeutic benefits in cancer patients. …”
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The Actin Network Interfacing Diverse Integrin-Mediated Adhesions by Benjamin Geiger, Rajaa Boujemaa-Paterski, Sabina E. Winograd-Katz, Jubina Balan Venghateri, Wen-Lu Chung, Ohad Medalia

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Inside the Cell: Integrins as New Governors of Nuclear Alterations? by Elena Madrazo, Andrea Cordero Conde, Javier Redondo-Muñoz

Subjects: “…integrins…”
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Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment by Pier Giorgio Amendola, Raphael Reuten, Janine Terra Erler

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Regulation of integrin-mediated linkages during cell migration by Palecek, Sean Paul

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Structures and interactions of the leukocyte-specific integrins cytoplasmic tails by Chua, Geok Lin

“…Integrins are devoid of enzymatic activity but yet are involved in almost all aspects of mammalian physiology. …”
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Structural and biochemical study of kindlin-3 in integrin activation by Bu, Wenting

“…Interestingly, Talin and Kindlin-3 independently interact with different regions of integrin β tail. However, it is still unknown how do they cooperate with each other in order to activate integrin. …”
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Integrin linked kinase is important in platelet signalling and function by Tucker, K, Stevens, J, Jordan, P, Sage, T, Jones, S, Barrett, N, St-Arnaud, R, Frampton, J, Dedhar, S, Gibbins, J

The molecular basis of filamin binding to integrins and competition with talin. by Kiema, T, Lad, Y, Jiang, P, Oxley, C, Baldassarre, M, Wegener, K, Campbell, I, Ylänne, J, Calderwood, D

“…Notably, the structurally defined filamin binding site overlaps with that of the integrin-regulator talin, and these proteins compete for binding to integrin tails, allowing integrin-filamin interactions to impact talin-dependent integrin activation. …”

Multiple roles of integrin-α3 at the neuromuscular junction. by Ross, J, Webster, R, Lechertier, T, Reynolds, L, Turmaine, M, Bencze, M, Jamshidi, Y, Cetin, H, Muntoni, F, Beeson, D, Hodilvala-Dilke, K, Conti, F

“…These results demonstrate multiple roles of integrin-α3 at the NMJ, and suggest that alterations in its function could underlie defects that occur in neurodegeneration or ageing.…”

Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway by Maria Raffaella Greco, Loredana Moro, Stefania Forciniti, Khalid Alfarouk, Stefania Cannone, Rosa Angela Cardone, Stephan Joel Reshkin

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Angiogenesis in the Outer Membrane of Chronic Subdural Hematomas through Thrombin-Cleaved Osteopontin and the Integrin α9 and Integrin β1 Signaling Pathways by Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Satoru Honma, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi

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Collagen Assembly at the Cell Surface: Dogmas Revisited by Moses Musiime, Joan Chang, Uwe Hansen, Karl E. Kadler, Cédric Zeltz, Donald Gullberg

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