Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells by Andreas Schmid, Ann-Kathrin Vlacil, Jutta Schuett, Thomas Karrasch, Bernhard Schieffer, Andreas Schäffler, Karsten Grote

“…In MyEND cells, CTRP3 inhibited the LPS-induced expression of interleukin <i>(Il)-6</i> and the tumor necrosis factor <i>(Tnf)-α</i>, and suppressed the LPS-dependent expression of the major endothelial adhesion molecules <i>Vcam-1</i> and <i>Icam-1</i>. …”
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Extracellular Ribosomal RNA Acts Synergistically with Toll-like Receptor 2 Agonists to Promote Inflammation by Karsten Grote, Marina Nicolai, Uwe Schubert, Bernhard Schieffer, Christian Troidl, Klaus T. Preissner, Stefan Bauer, Silvia Fischer

“…Gene and protein expression of tumor necrosis factor <i>(Tnf)-α</i>; interleukin <i>(Il)-1β, Il-6</i>; or monocyte chemoattractant protein <i>(Mcp)-1</i> were analyzed and furthermore <i>in vitro</i> binding studies to TLR2 were performed. …”
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Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers. by Tousoulis, D, Antoniades, C, Tentolouris, C, Tsioufis, C, Toutouza, M, Toutouzas, P, Stefanadis, C

“…Purpose of this study was to investigate the effect of combined administration of antioxidant vitamins C and E on endothelial function and serum levels of inflammatory markers such as tumor necrosis factor alpha (TNF-alpha), interleukines 1b (IL-1b) and 6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in chronic smokers. …”

The Interleukins Orchestrate Mucosal Immune Responses to <i>Salmonella</i> Infection in the Intestine by Fu-Chen Huang

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A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining Virucidal Activity and Maintenance of the Skin Barrier and Microbiome by Ana Carolina Henriques Ribeiro Machado, Laís Júlio Marinheiro, Heather Ann Elizabeth Benson, Jeffrey Ernest Grice, Tereza da Silva Martins, Alexandra Lan, Patricia Santos Lopes, Newton Andreo-Filho, Vania Rodrigues Leite-Silva

“…In vitro analysis, using monolayer cells and human equivalent skin, was performed by rRTq-PCR to determine the expression of interleukins 1, 6, 8, and 17, aquaporin-3, involucrin, filaggrin, FoxO3, and SIRT-1. …”
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Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil by Soukaina Essadek, Habiba Bouchab, Riad El Kebbaj, Catherine Gondcaille, Soufiane El Kamouni, Stéphane Savary, Joseph Vamecq, Abdelkhalid Essamadi, Mustapha Cherkaoui-Malki, Boubker Nasser, Pierre Andreoletti

“…In a short-term LPS treatment, lipid peroxidation (malonaldehyde assay) increased in the brain and liver with upregulations of proinflammatory <i>tumor necrosis factor</i> (<i>Tnf</i>)-<i>α</i> and anti-inflammatory <i>interleukin</i> (<i>Il</i>)-<i>10</i> genes, especially in the liver. …”
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Diabetes-induced renal failure is associated with tissue inflammation and neutrophil gelatinase-associated lipocalin: Effects of resveratrol by Koca Halit B., Pektas Mehmet B., Koca Selcen, Pektas Gökhan, Sadi Gökhan

“…In addition to renal glucose, lipid, angiopoietin-1 (ANG-1), asymmetric dimethylarginine (ADMA), erythropoietin (EPO), malondialdehyde (MDA) and neutrophil gelatinase-associated lipocalin (NGAL) content, the gene expressions of pro-inflammatory markers, including inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NF-κB), nuclear factor (erythroid-derived 2) like-2 (Nrf2), and the protein contents of interleukins-1β,6,8 (IL-1β,6,8) and tumor necrosis factor-α (TNF-α) were analyzed using qRT-PCR and ELISA, respectively. …”
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Investigation of the cytokine status in patients during the acute period of intracranial arterial aneurysm rupture by Marina Globa, Nikolay Lisianyi, Orest Tsimeyko, Lyudmila Belska

“…There was a reliable increase of its level in patients with cerebral vasospasm (VS) compared to those without VS (p<0,05). The interleukins-1β and -4 indices were moderately (2–5 times) increased in comparison with those in the control group, they did not differ significantly in patients with VS and without it. …”
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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets by Meng Zhang, Qian Liu, Hui Meng, Hongxia Duan, Xin Liu, Jian Wu, Fei Gao, Shijun Wang, Rubin Tan, Jinxiang Yuan

“…This review article elucidates the underlying mechanisms involved in Wnt signaling, as well as the complex interplay between Wnt and other pathways, including Notch, phosphatidylinositol 3-kinase/protein kinase B, transforming growth factor-β, nuclear factor kappa, bone morphogenetic protein, N-methyl-D-aspartic acid receptor-Ca2+-Activin A, Hippo-Yes-associated protein, toll-like receptor 4/toll-interleukine-1 receptor domain-containing adapter-inducing interferon-β, and hepatocyte growth factor/mesenchymal-epithelial transition factor. …”
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Effect of Puncture Vine on Growth Performance, Carcass and Meat Traits, Metabolic and Immunological Blood Indicators, and Selected Cecal Microbiota in Broiler Chickens by Hani H. Al-Baadani, Abdulrahman S. Alharthi, Saleh Al-Ghamdi, Ibrahim A. Alhidary

“…Total protein and globulin were higher in T2 and T3 (14 days old), and the glucose level was lower in T2 (35 days old) than at T1. Interleukins (<i>IL-4</i>, <i>IL-6</i>, and <i>IL-10</i>) and tumor necrosis factor-α (<i>TNF-α</i>) were higher in T2 than T1 and T3 (35 days old). …”
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Aspirin and Cancer Survival: An Analysis of Molecular Mechanisms by Manoj Pandey, Monika Rajput, Pooja Singh, Mridula Shukla, Bin Zhu, Jill Koshiol

“…Crosstalk of <i>PTGS2</i> with <i>EGFR</i>, <i>JAK/AKT</i>, <i>TP53</i>, interleukin/<i>TNFα</i>/<i>NFκB</i>, <i>GSK3B/BRCA/PARP</i>, <i>CXCR/MUC1</i>, and <i>WNT/CTNNB</i> pathways was identified. …”
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The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis by Cristina Rosell-Cardona, Concepció Amat, Christian Griñán-Ferré, Javier Polo, Mercè Pallàs, Anna Pérez-Bosque, Miquel Moretó, Lluïsa Miró

“…Senescence impaired short- and long-term memory, reduced cortical brain-derived neurotrophic factor (BDNF) abundance, increased interleukin (<i>Il)-1</i><i>β</i>, <i>Il-6</i>, and Toll-like receptor 2 <i>(Tlr2)</i> expression, and reduced transforming growth factor <i>β</i> (<i>Tgf-</i><i>β)</i> expression and IL-10 concentration (all <i>p</i> < 0.05) and these effects were mitigated by SDP (all <i>p</i> < 0.05). …”
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Functional differentiation and spatial-temporal co-expression networks of the NBS-encoding gene family in Jilin ginseng, Panax ginseng C.A. Meyer. by Rui Yin, Mingzhu Zhao, Kangyu Wang, Yanping Lin, Yanfang Wang, Chunyu Sun, Yi Wang, Meiping Zhang

“…Seven conserved motifs were identified in both the Toll/interleukine-1 receptor (TIR) and coiled-coil (CC) typed genes whereas six were identified in the RPW8 typed genes. …”
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Th17/Treg-Related Intracellular Signaling in Patients with Chronic Obstructive Pulmonary Disease: Comparison between Local and Systemic Responses by Juliana D. Lourenço, Walcy R. Teodoro, Denise F. Barbeiro, Ana Paula P. Velosa, Larissa E. F. Silva, Júlia B. Kohler, Alyne R. Moreira, Marcelo V. Aun, Isadora C. da Silva, Frederico L. A. Fernandes, Elnara M. Negri, Jefferson L. Gross, Iolanda F. L. C. Tibério, Juliana T. Ito, Fernanda D. T. Q. S. Lopes

“…Gene expression of <i>STAT3</i> and <i>-5</i>, <i>RORγt</i>, <i>Foxp3</i>, interleukin <i>(IL)-6</i>, <i>-17</i>, <i>-10</i>, and <i>TGF-β</i> was assessed by RT-qPCR. …”
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Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta. by Brili, S, Tousoulis, D, Antoniades, C, Aggeli, C, Roubelakis, A, Papathanasiu, S, Stefanadis, C

“…Serum levels of soluble vascular adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), E-selectin, and interleukines 1b (IL-1b) and 6 (IL-6) were determined by ELISA. …”

Seminal Bacterioflora of Two Rooster Lines: Characterization, Antibiotic Resistance Patterns and Possible Impact on Semen Quality by Eva Tvrdá, Michaela Petrovičová, Filip Benko, Michal Ďuračka, Ján Kováč, Tomáš Slanina, Lucia Galovičová, Jana Žiarovská, Miroslava Kačániová

“…Moreover, the levels of pro-inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interleukins 1 and 6 (IL-1, IL-6) and C-reactive protein, as well as the concentrations of selected antibacterial proteins (cathelicidin, β-defensin and lysozyme) in the seminal plasma were evaluated with the enzyme-linked immunosorbent assay. …”
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Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis by Petra Borilova Linhartova, Zdenek Danek, Tereza Deissova, Filip Hromcik, Bretislav Lipovy, David Szaraz, Julius Janos, Antonin Fassmann, Jirina Bartova, Ivo Drizhal, Lydie Izakovicova Holla

“…This case-control study aimed to perform a multilocus analysis of functional variants in selected interleukin (<i>IL</i>) genes in patients with the generalized form of AgP in a homogenous population. …”
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Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses by Dmitry V. Chistyakov, Arina I. Nikolskaya, Sergei V. Goriainov, Alina A. Astakhova, Marina G. Sergeeva

“…Rat primary astrocytes were treated with LPS with and without 4-MU and gene expression levels of inflammatory (interleukins 1β, (IL-1β), 6, (IL-6), tumor necrosis factor alpha TNFα,) and resolution interleukin 10 (IL-10) markers were evaluated via real-time PCR and western blot. …”
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A clinical case of successful treatment with an interleukin 6 receptor blocker of a systemic variant of juvenile arthritis associated with spinal injury by G. V. Santalova, S. V. Plakhotnikova

“…It stressed the importance of early initiation of therapy from the standpoint of modern understanding of the pathogenesis of this disease: the use of new biological agents, which action is directed at interleukins 1 and 6. This approach is associated with inefficiency of such drugs as corticosteroids, methotrexate, tumour necrosis factor inhibitors. …”
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PINK1/Parkin-Mediated Mitophagy Partially Protects against Inorganic Arsenic-Induced Hepatic Macrophage Polarization in Acute Arsenic-Exposed Mice by Gaoyang Qu, Zi Liu, Jiaxin Zhang, Yaning Guo, Hui Li, Ruijie Qu, Wei Su, Huan Zhang, Lin Zhang, Hong Xu, Fuhai Shen, Shoufang Jiang, Heliang Liu, Jinlong Li

“…Our results indicate that acute arsenic exposure induced macrophage polarization with up-regulated gene expression of inducible nitric oxide synthase (<i>Inos</i>) and arginase-1 (<i>Arg1</i>), monocyte chemotactic protein-1 (<i>Mcp-1</i>) and macrophage inflammatory protein-2 (<i>Mip-2</i>), tumor necrosis factor (<i>Tnf</i>)-α, interleukin (<i>Il</i>)-1β and <i>Il-6</i>, as well as anti-inflammatory factors <i>Il-4</i> and <i>Il-10</i>. …”
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