SIRT1/Nrf2/NF-κB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage by Manea A. I. Alqrad, Dina S. El-Agamy, Sabrin R. M. Ibrahim, Alaa Sirwi, Hossam M. Abdallah, Essam Abdel-Sattar, Ali M. El-Halawany, Wael M. Elsaed, Gamal A. Mohamed

“…TAA-induced injury was associated with oxidative and inflammatory responses in both organs as there was an elevation of oxidative stress parameters (4-HNE (4-hydroxy-nonenal), MDA (malondialdehyde), NOx (nitric oxide)), decline of antioxidants (reduced glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (TAC)), and an increase in the gene expression/level of inflammatory mediators (interleukins (1β&6)). The inflammatory response was linked to a significant activation of NF-κB (nuclear-factor kappa-B)/TNF-α (tumor-necrosis factor-alpha) signaling. …”
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Effects of 14-weeks betaine supplementation on pro-inflammatory cytokines and hematology status in professional youth soccer players during a competition season: a double blind, ra... by Hadi Nobari, Jason M. Cholewa, Jorge Pérez-Gómez, Alfonso Castillo-Rodríguez

“…The aim of this study was to investigate the effects of betaine supplementation on tumor necrosis factor alpha (TNF-α), interleukins-1 beta (IL-1β), − 6 (IL-6) and the complete blood cell (CBC) count in professional youth soccer players during a competitive season. …”
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Protective Effect of Galantamine against Doxorubicin-Induced Neurotoxicity by Rawan S. Alsikhan, Maha A. Aldubayan, Ibtesam S. Almami, Ahmad H. Alhowail

“…The animals were subjected to behavioral tests to assess the memory function followed by the biochemical estimation of inflammatory markers, including tumor necrosis factor-α (TNF-<i>α</i>), interleukine-1β (IL-1<i>β</i>), and interleukine-6 (IL-6) in rat brain tissue and RT-qPCR. …”
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¹⁸F-FDG and ¹⁸F-NaF PET/CT Global Assessment of Large Joint Inflammation and Bone Turnover in Rheumatoid Arthritis by Natasha Reddy, William Y. Raynor, Thomas J. Werner, Joshua F. Baker, Abass Alavi, Mona-Elisabeth Revheim

“…No significant correlation was observed between either PET parameter and age, height, erythrocyte sedimentation rate (ESR), and interleukins 1 and 6 (IL-1 and IL-6); however, FDG was correlated with inflammatory markers such as C-reactive protein (CRP) and patient global visual analogue scale (VAS-PtGlobal) in some joints. …”
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Identification of Bacterial Profiles and Their Interactions with Selected Quality, Oxidative, and Immunological Parameters of Turkey Semen by Michal Lenický, Tomáš Slanina, Miroslava Kačániová, Lucia Galovičová, Michaela Petrovičová, Michal Ďuračka, Filip Benko, Ján Kováč, Eva Tvrdá

“…Furthermore, levels of interleukins 1 and 6 (IL-1, IL-6), C-reactive protein, cathelicidin, and β-defensin were quantified in the seminal plasma using the ELISA method. …”
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Relation between Inflammation, Oxidative Stress, and Macronutrient Intakes in Normal and Excessive Body Weight Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome by Małgorzata Mizgier, Grażyna Jarząbek-Bielecka, Natalia Wendland, Elżbieta Jodłowska-Siewert, Marcin Nowicki, Alicja Brożek, Witold Kędzia, Dorota Formanowicz, Justyna Opydo-Szymaczek

“…The studied markers were total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukins 1 and 6 (IL-1 and IL-6). We found plant protein intake inversely correlated with IL-6 (<i>p</i> = 0.007; <i>r</i> = −0.557), TNF-α (<i>p</i> = 0.006; <i>r</i> = −0.564), MDA (<i>p</i> = 0.01; <i>r</i> = −0.539) in the Ov/Ob group and with TAC (<i>p</i> = 0.021; <i>r</i> = −0.38) in the N group. …”
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Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177^® (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomy... by Joseph Aliaga, Aldo Bonaventura, Eleonora Mezzaroma, Yogesh Dhakal, Adolfo Gabriele Mauro, Antonio Abbate, Stefano Toldo

“…Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility and diastolic function. …”
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Gamma-aminobutyric acid type A receptor alpha 4 coordinates autophagy, inflammation, and immunometabolism to promote innate immune activation by Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Sang Min Jeon, In Soo Kim, June-Young Lee, Jun Young Heo, Sang-Hee Lee, Jin-Woo Bae, Jin-Man Kim, Jin Bong Park, Eun-Kyeong Jo

“…Abbreviation AM: Alveolar macrophage; AMPK: AMP-activated protein kinase; ASC: Apoptosis-associated speck-like protein containing a CARD; ATP: Adenosine 5’-triphosphate; BAL: Bronchoalveolar lavage; BCG: Mycobacterium bovis Bacillus Calmette–Guérin; BMDM: Bone marrow-derived macrophage; CCL: CC motif chemokine ligand; CFU: Colony forming unit; CKO: Conditional knock out; CXCL: C-X-C motif ligand; Dpi: Days post-infection; ECAR: Extracellular acidification rate; EGFP: Enhanced green fluorescent protein; FOXO3: Forkhead box O3; GABA: Gamma-aminobutyric acid; GABAAR: GABA type A receptor; Gabarap: GABA type A receptor-associated protein; Gabarapl1: GABA type A receptor-associated protein like 1; GABRA4: Gamma-aminobutyric acid type A receptor subunit alpha4; HIF-1α: Hypoxia-inducible factor-1 alpha; IL: Interleukin; i.n.: Intranasal; i.p.: Intraperitoneal; LDHA: Lactate dehydrogenase A; LPS: Lipopolysaccharide; Mabc: Mycobacteroides abscessus subsp. abscessus; MOI: Multiplicities of infection; Mtb: Mycobacterium tuberculosis; mtROS: Mitochondrial reactive oxygen species; OCR: Oxygen consumption rate; OXPHOS: Oxidative phosphorylation; PM: Peritoneal macrophage; TNF: Tumor necrosis factor; WT: Wild type…”
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Evaluation of dietary supplementation of frankincense oil on broiler chicken growth performance, hepatic histomorphology, antioxidant activity, blood biochemical parameters, and in... by Shimaa A. Amer, Amany Behairy, Ghada I. Abd El-Rahman, Ahmed Gouda, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Amr A. Moustafa, Hebatallah Abdel Moniem, Simon J. Davies, Asmaa EL-Sayed Kamel

“…Dietary FKO linearly lowered serum malondialdehyde levels and enhanced blood total antioxidant capacity, catalase, superoxide dismutase, and pro-inflammatory cytokines (interleukine-1 β and interferon γ) compared to the control group. …”
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Evaluation of Spray-Dried Bovine Hemoglobin Powder as a Dietary Animal Protein Source in Nile Tilapia, <i>Oreochromis niloticus</i> by Shimaa A. Amer, Mahmoud Farahat, Tarek Khamis, Samar A. Abdo, Elsayed M. Younis, Abdel-Wahab A. Abdel-Warith, Rehab Reda, Sozan A. Ali, Simon J. Davies, Rowida E. Ibrahim

“…The expressions of immune-related genes (transforming growth factor-beta (<i>TGF-β</i>), Toll-like receptor 2 (<i>TLR2</i>), and interleukin <i>10</i> (<i>IL10</i>)) were up-regulated by SDBH inclusion with the highest expression in the SDBH5 group. …”
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Delay of Feed Post-Hatch Causes Changes in Expression of Immune-Related Genes and Their Correlation with Components of Gut Microbiota, but Does Not Affect Protein Expression by Katarzyna B. Miska, Stanislaw Kahl, Lori L. Schreier, Beverly Russell, Kouassi R. Kpodo, Monika Proszkowiec-Weglarz

“…Quantitative PCR (qPCR) was carried out to measure the expression of avian interleukin (<i>IL)-1β, IL-4</i>, <i>IL-6</i>, <i>IL-8</i>, <i>IL-18</i>, transforming growth factor (<i>TGF-β</i>), toll-like receptor (TLR)2, TLR4, interferon (<i>IFN</i>)<i>-β</i>, <i>IFN-γ</i>, and avian β-defensins (<i>AvBD</i>) I, <i>2</i>, <i>3</i>, <i>5</i>, <i>6</i>, <i>7</i>, <i>8</i>, <i>9</i>, and <i>10</i>. …”
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Impact of Dietary Lavender Essential Oil on the Growth and Fatty Acid Profile of Breast Muscles, Antioxidant Activity, and Inflammatory Responses in Broiler Chickens by Shimaa A. Amer, Ahmed A. A. Abdel-Wareth, Ahmed Gouda, Gehan K. Saleh, Arwa H. Nassar, Wafaa R. I. A. Sherief, Sarah Albogami, Shimaa I. Shalaby, Aaser M. Abdelazim, Mosleh Mohammad Abomughaid

“…Still, they significantly increased the serum enzyme activities of total antioxidant capacity, catalase, superoxide dismutase, and the pro-inflammatory cytokine (interleukine-1 beta and interferon γ) compared with the unsupplemented group. …”
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Cytokines, GM-CSF and IFNγ administered by priming and post-chemotherapy cycling in recurrent ovarian cancer patients receiving carboplatin by Patenia Rebecca S, Gallardo Stacie T, Ramirez Pedro T, Levenback Charles F, Gordon Ilyssa O, Bassett Roland L, Cohen Lorenzo, Vadhan-Raj Saroj, Apte Sachin M, Garcia Michael E, Iyer Revathy B, Freedman Ralph S

“…Relative to pretreatment baseline values, white blood cell, neutrophil, MO, and eosinophil counts increased (<it>P </it>≤ .001 for each); the proportion of platelets increased 9 days after the second (<it>P </it>≤ .002) and third (<it>P </it>≤ .04) carboplatin treatments; and the number of cells in the activated MO subsets CD14+HLA-DR+, CD14+CD64+, and CD14⁺CXCR3⁺increased (<it>P </it>≤ .04 for each); plasma levels of the proangiogenic interleukins 1α, 6, and 8 were lower (<it>P </it>≤ .03 for each); M-CSF, a product of activated MO/MA, was increased on day 9 (<it>P </it>= .007); and GM-CSF was increased in plasma after GM-CSF administration (<it>P </it>≤ .04). …”
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Association of Interleukin Genes <i>IL10</i> and <i>IL10RB</i> with Parameters of Overweight in Military Students by Ewelina Maculewicz, Magdalena Dzitkowska-Zabielska, Bożena Antkowiak, Oktawiusz Antkowiak, Andrzej Mastalerz, Aleksandra Garbacz, Myosotis Massidda, Aleksandra Bojarczuk, Łukasz Dziuda, Paweł Cięszczyk

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Understanding the sub-lethal effects of ZNO nanoparticles and its implications to skin repair by Wu, Zhuoran

“…Transcriptome analysis revealed that the cross-talk between these two sub-population of cells were mediated primarily via interleukins (1α, 1β, 6, 8, 15, 18, 23, 33). Further mechanistic studies revealed that it is the Nrf-2 mediated enhancement in proteolytic activity of the Nano-ZnO conditioned cells, but not the anti-oxidant effects that accounts for the cyto-protective adaption process. …”
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Association and risk of circulating inflammatory markers with hyperglycemia in coal-burning arsenicosis by Yonglian Liu, Wenjuan Wang, Zhonglan Zou, Baofei Sun, Bing Liang, Aihua Zhang

“…Participant’s hyperglycemia-related parameters, including fasting blood glucose (FBG), fasting serum insulin (FINS), homeostasis model assessment for both insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-β), as well as circulating inflammatory biomarkers i.e., Interleukins-1β (IL-1β), IL- 2, IL − 6, IL-10, IL- 17, IL-18 and TNF-α), were determined and analyzed after completing questionnaire investigation and physical examination. …”
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Interdependence between Chromogranin-A, Alternatively Activated Macrophages, Tight Junction Proteins and the Epithelial Functions. A Human and In-Vivo/In-Vitro Descriptive Study by Nour Eissa, Hayam Hussein, Diane M. Tshikudi, Geoffrey N. Hendy, Charles N. Bernstein, Jean-Eric Ghia

“…<b>Methods:</b> Correlations between <i>CHGA</i> mRNA expression of and TJ proteins mRNA expressions of (Occludin [<i>OCLN</i>], zonula occludens-1 [<i>ZO1</i>], Claudin-1 [<i>CLDN1</i>]), epithelial associated cytokines (interleukin <i>[IL]-8</i>, <i>IL-18</i>), and collagen (<i>COL1A2</i>) were determined in human colonic mucosal biopsies isolated from active UC and healthy patients. …”
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Effects of Vitamin A on Immune Responses and Vitamin A Metabolism in Broiler Chickens Challenged with Necrotic Enteritis by Shuangshuang Guo, Lai He, Yuanke Zhang, Junlong Niu, Changwu Li, Zhengfan Zhang, Peng Li, Binying Ding

“…NE challenge up-regulated mRNA expression of interleukin (<i>IL</i>)-13, transforming growth factor-β4, aldehyde dehydrogenase (<i>RALDH</i>)-2 and <i>RALDH-3</i> in the jejunum, while VitA supplementation increased jejunal <i>IL-13</i> mRNA expression and hepatic VitA content, but down-regulated splenic <i>IL-13</i> mRNA expression (<i>p</i> < 0.05). …”
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