Characteristics of COVID-19 Disease in Renal Transplant Recipients by Emilija Zimnickaitė, Ieva Kucinaitė, Birutė Zablockienė, Aistė Lisinskaitė, Rolandas Zablockis, Laurynas Rimševičius, Marius Miglinas, Ligita Jančorienė

“…In the study group, there were more cases of mild (26.4% vs. 11.3%, <i>p</i> = 0.023) and critically severe forms of COVID-19 infection (26.4% vs. 3.1%, <i>p</i> < 0.001), kidney failure was more prevalent (34.0% vs. 1.0%, <i>p</i> < 0.001), and a greater number of patients were transferred to the intensive care unit (22.6% vs. 3.1%, <i>p</i> < 0.001) and died (18.9% vs. 1.0%, <i>p</i> < 0.001). …”
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Prevalence of anemia and associated factors among adult hypertensive patients in Referral Hospitals, Amhara Regional State by Yibeltal Yismaw Gela, Daniel Gashaneh Belay, Dagmawi Chilot, Amare Agmas Andualem, Desalegn Anmut Bitew, Deresse Sinamaw, Habitu Birhan Eshetu, Abdulwase Mohammed Seid, Wudneh Simegn, Anteneh Ayelign Kibret, Mohammed Abdu Seid, Mengistie Diress

“…Low hemoglobin and hematocrit levels might be strongly indicate hypertensive end-organ damage, specifically kidney failure. Therefore, this study determined the prevalence of anemia and associated factors among hypertensive patients in Referral Hospitals, Amhara Regional State, Ethiopia, in 2020. …”
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Ethnic differences in kidney function in childhood: the Born in Bradford Cohort Renal Study [version 1; peer review: 1 approved, 2 approved with reservations] by Simon D.S. Fraser, Dan Mason, Dagmar Waiblinger, Ho M. Yuen, John Wright, Nisreen A. Alwan, Paul J. Roderick, Richard J.M. Coward, Rafaq Azad, Robin F. Jeffrey, Nida Ziauddeen

“…Background: Endstage kidney failure rates are higher in South Asians than in White Europeans. …”
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Autologous adipose-derived mesenchymal stem cell therapy reverses detrusor underactivity: open clinical trial by Henrique Rodrigues Scherer Coelho, Silvia Cordeiro das Neves, Jovino Nogueira da Silva Menezes, Andréia Conceição Milan Brochado Antoniolli-Silva, Rodrigo Juliano Oliveira

“…Abstract Background Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infection, urinary retention and kidney failure and has no effective treatment in traditional medicine. …”
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Renal Safety of [¹⁷⁷Lu]Lu-PSMA-617 Radioligand Therapy in Patients with Compromised Baseline Kidney Function by Florian Rosar, Niklas Kochems, Mark Bartholomä, Stephan Maus, Tobias Stemler, Johannes Linxweiler, Fadi Khreish, Samer Ezziddin

“…<i>Conclusions:</i> As pre-treatment chronic kidney failure did not lead to detectable RLT-induced deterioration of renal function in our study, the nephrotoxic potential of [¹⁷⁷Lu]Lu-PSMA-617 RLT may be overestimated and not of clinical priority in the setting of palliative treatment in mCRPC. …”
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Severe Pulmonary Bleeding after Assist Device Implantation: Incidence, Risk Factors and Prognostic Impact by Bernd Panholzer, Kevin Pilarczyk, Katharina Huenges, Charlotte Aldinger, Christine Friedrich, Ulrike Nowak-Göttl, Jochen Cremer, Assad Haneya

“…SPB was associated with a complicated postoperative course with a higher incidence of acute kidney failure (100% versus 36.7%, <i>p</i> = 0.001) and delirium (44.4% versus 14.8%, <i>p</i> = 0.045); a higher need for red blood cell (26 packs versus 7, <i>p</i> < 0.001), fresh frozen plasma (18 units versus 6, <i>p</i> = 0.002), and platelet transfusion (8 pools versus 1, <i>p</i> = 0.001); longer ventilation time (1206 versus 171 h, <i>p</i> = 0.001); longer ICU-stay (58 versus 13 days, <i>p</i> = 0.002); and higher hospital mortality (66.7% vs. 29%, <i>p</i> = 0.029). …”
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Epidemiological investigation of lower respiratory tract infections during influenza A (H1N1) pdm09 virus pandemic based on targeted next-generation sequencing by Xiaodan Li, Yang Liu, Minzhe Li, Jing Bian, Demei Song, Chaoying Liu

“…However, they exhibited lower proportions of respiratory failure, acute kidney failure, septic shock, and hospital stays lasting more than 10 days. …”
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The role of genetic testing in the diagnostic workflow of pediatric patients with kidney diseases: the experience of a single institution by Tiziana Vaisitti, Valeria Bracciamà, Angelo Corso Faini, Giulia Margherita Brach Del Prever, Martina Callegari, Silvia Kalantari, Fiorenza Mioli, Carmelo Maria Romeo, Maria Luca, Roberta Camilla, Francesca Mattozzi, Bruno Gianoglio, Licia Peruzzi, Antonio Amoroso, Silvia Deaglio

“…Abstract Purpose Inherited kidney diseases are among the leading causes of kidney failure in children, resulting in increased mortality, high healthcare costs and need for organ transplantation. …”
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Kidney Function Worsening Is Linked to Parenteral-Nutrition-Dependent Survival in Palliative Care Patients by Lea Kum, Alexander Friedrich, Markus Kieler, Elias Meyer, Petar Popov, Paul Kössler, Anna Kitta, Feroniki Adamidis, Raimund Oberle, Eva Katharina Masel, Matthias Unseld

“…Routine laboratory parameters might help to decide whether to start or forgo PN, which could decrease overtreatment at the end of life. Kidney failure was frequently associated with survival. …”
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Biocompatible, adsorptive and antibacterial polysulfone hollow fibre membrane incorporated with silica alpha mangostin for uremic toxins removal by Mansur, Sumarni

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Biocompatible, adsorptive and antibacterial polysulfone hollow fibre membrane incorporated with silica alpha mangostin for uremic toxins removal by Mansur, Sumarni

“…Kidney failure patients rely on haemodialysis treatment to survive. …”
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Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence by Noureddine Bencheikh, Amine Elbouzidi, Loubna Kharchoufa, Hayat Ouassou, Ilyass Alami Merrouni, Hamza Mechchate, Imane Es-safi, Christophe Hano, Mohamed Addi, Mohamed Bouhrim, Bruno Eto, Mostafa Elachouri

“…Kidney disease is one of the most common health problems and kidney failure can be fatal. It is one of the health disorders associated with extreme pain and discomfort in patients. …”
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Sodium glucose co-transporter 2 inhibition with empagliflozin on metabolic, cardiac and renal outcomes in recent cardiac transplant recipients (EMPA-HTx): protocol for a randomised... by Kavitha Muthiah, Jerry R Greenfield, Nicole K Bart, Peter MacDonald, Eugene Kotlyar, Christopher S Hayward, Andrew Jabbour, Lisa Mary Raven, Christopher A Muir, Cassia Kessler Iglesias

“…This study will potentially provide a novel therapy to improve or prevent complications (diabetes, kidney failure and heart fibrosis) that occur with immunosuppressive medications.Methods The EMPA-HTx study is a randomised, placebo-controlled trial of the SGLT2 inhibitor empagliflozin 10 mg daily versus placebo in recent CTx recipients. …”
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Profile and characteristics of the adequacy of blood transfusions in Trauma Intensive Care. A cross sectional multicenter study by Raúl Juárez-Vela, Raúl Juárez-Vela, Raúl Juárez-Vela, Manuel Quintana-Diaz, Manuel Quintana-Diaz, Antonio Rodríguez-Calvo, Antonio Rodríguez-Calvo, José Ángel Santos-Sánchez, José Ángel Santos-Sánchez, María Gero-Escapa, Elena Gallego-Curto, Pedro José Satústegui-Dordá, Juan Luis Sánchez-González, Carlos Jericó, Regina Ruiz de Viñaspre-Hernández, Regina Ruiz de Viñaspre-Hernández, Guadalupe Gil-Fernández, José Antonio García-Erce

“…As we can see, the incidence of kidney failure was also different between the groups analyzed, reaching 44.00% in transfused patients and 13.64% in the group of patients without blood transfusion, p = 0.005. …”
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Associations of Estradiol With Mortality and Health Outcomes in Patients Undergoing Hemodialysis: A Prospective Cohort Study by Lina Lau, Natasha Wiebe, Sharanya Ramesh, Sofia Ahmed, Scott Klarenbach, Juan-Jesus Carrero, Peter Stenvinkel, Barbara Thorand, Peter Senior, Marcello Tonelli, Aminu K. Bello

“…Background: Both lower and higher estradiol (E2) levels have been associated with increased mortality among women with kidney failure. However, robust data are still lacking. …”
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Diabetes Mellitus and Its Association with Adverse In-Hospital Outcomes in Patients with COVID-19—A Nationwide Study by Volker H. Schmitt, Lukas Hobohm, Ingo Sagoschen, Visvakanth Sivanathan, Omar Hahad, Christine Espinola-Klein, Thomas Münzel, Karsten Keller

“…DM was an independent risk factor for acute kidney failure (OR 1.49 (95% CI: 1.44–1.53), <i>p</i> < 0.001), dialysis (OR 1.56 (95% CI: 1.47–1.66), <i>p</i> < 0.001), mechanical ventilation (OR: 1.49 (95% CI: 1.43–1.56), <i>p</i> < 0.001), extracorporeal membrane oxygenation (OR 1.44 (95% CI: 1.27–1.62), <i>p</i> < 0.001), major adverse cardiac and cerebrovascular events (OR: 1.24 (95% CI: 1.20–1.27), <i>p</i> < 0.001), and in-hospital mortality (OR: 1.26 (95% CI: 1.22–1.30), <i>p</i> < 0.001). …”
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Patterns of Renal Dysfunction and Profile of Kidney Biopsies in Hematopoietic Stem Cell Transplant Recipients by Elenjickal Elias John, Sanjeet Roy, Anup J. Devasia, Reka Karuppusami, Nisha Jose, Selvin Sundar Raj Mani, Jeethu Joseph Eapen, Sabina Yusuf, Athul Thomas, Anna T. Valson, Vinoi George David, Vikram Mathews, Biju George, Santosh Varughese, Suceena Alexander

“…Allogenic recipients who did not receive immunosuppression (IS) for renal disease had a lower eGFR at biopsy, a longer latency between withdrawal of GvHD prophylaxis and biopsy, and were significantly at a higher risk of kidney failure (IS: 2/11, 18.1% vs. no IS: 2/6, 33.3%, p = 0.04). …”
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Finerenone cardiovascular and kidney outcomes by age and sex: FIDELITY post hoc analysis of two phase 3, multicentre, double-blind trials by George L Bakris, Peter Rossing, Stefan D Anker, Gerasimos Filippatos, Bertram Pitt, Shweta Bansal, Maria E F Canziani, Rita Birne, Luis M Ruilope, Alfredo E Farjat, Peter Kolkhof, Andrea Lage, Meike Brinker

“…Objectives This study aimed to evaluate the efficacy and safety of finerenone, a selective, non-steroidal mineralocorticoid receptor antagonist, on cardiovascular and kidney outcomes by age and/or sex.Design FIDELITY post hoc analysis; median follow-up of 3 years.Setting FIDELITY: a prespecified analysis of the FIDELIO-DKD and FIGARO-DKD trials.Participants Adults with type 2 diabetes and chronic kidney disease receiving optimised renin–angiotensin system inhibitors (N=13 026).Interventions Randomised 1:1; finerenone or placebo.Primary and secondary outcome measures Cardiovascular (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalisation for heart failure (HHF)) and kidney (kidney failure, sustained ≥57% estimated glomerular filtration rate (eGFR) decline or renal death) composite outcomes.Results Mean age was 64.8 years; 45.2%, 40.1% and 14.7% were aged &lt;65, 65–74 and ≥75 years, respectively; 69.8% were male. …”
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Construction of a Novel circRNA/miRNA/mRNA Regulatory Network to Explore the Potential Pathogenesis of Wilson’s Disease by Taohua Wei, Taohua Wei, Nannan Qian, Nannan Qian, Wenming Yang, Wenming Yang, Wenming Yang, Yue Yang, Yue Yang, Jie Liu, Wenjie Hao, Wenjie Hao, Ting Cheng, Ran Yang, Wei Dong, Wei Dong, Wei Dong, Yulong Yang, Yulong Yang

“…Taken together, this study identified the circRNA/miRNA/mRNA network involved in kidney failure in WD, which may serve as a potential biomarker for the pathogenesis of WD.…”
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An Integrated Care Platform System (C3-Cloud) for Care Planning, Decision Support, and Empowerment of Patients With Multimorbidity: Protocol for a Technology Trial by Malte von Tottleben, Katie Grinyer, Ali Arfa, Lamine Traore, Dolores Verdoy, Sarah N Lim Choi Keung, Igor Larranaga, Marie-Christine Jaulent, Esteban De Manuel Keenoy, Mikael Lilja, Marie Beach, Christopher Marguerie, Mustafa Yuksel, Gokce Banu Laleci Erturkmen, Gunnar O Klein, Pontus Lindman, Javier Mar, Dipak Kalra, Theodoros N Arvanitis

“…The objective of this study is to pilot test the platforms and evaluate their impact on patients with 2 or more chronic conditions (diabetes mellitus type 2, heart failure, kidney failure, depression), their informal caregivers, health care professionals, and, to some extent, health care systems. …”
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