Modeling complement activation on human glomerular microvascular endothelial cells by Kes H. Stevens, Laura M. Baas, Thea J. A. M. van der Velden, Romy N. Bouwmeester, Niels van Dillen, Eiske M. Dorresteijn, Arjan D. van Zuilen, Jack F. M. Wetzels, Marloes A. H. M. Michels, Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel

“…This patient had already chronic kidney failure and an ongoing deterioration of kidney function despite absence of markers indicating an aHUS flare. …”
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Aspirin Therapy on Prophylactic Anticoagulation for Patients Hospitalized With COVID‐19: A Propensity Score‐Matched Cohort Analysis of the HOPE‐COVID‐19 Registry by Francesco Santoro, Ivan J. Núñez‐Gil, Enrica Vitale, María C. Viana‐Llamas, Rodolfo Romero, Charbel Maroun Eid, Gisela Feltes Guzman, Victor Manuel Becerra‐Muñoz, Inmaculada Fernández Rozas, Aitor Uribarri, Emilio Alfonso‐Rodriguez, Marcos García Aguado, Jia Huang, Alex Fernando Castro Mejía, Juan Fortunato Garcia Prieto, Javier Elola, Fabrizio Ugo, Enrico Cerrato, Jaime Signes‐Costa, Sergio Raposeiras Roubin, Jorge Luis Jativa Mendez, Carolina Espejo Paeres, Alvaro López Masjuan, Francisco Marin, Federico Guerra, Ibrahim El‐Battrawy, Bernardo Cortese, Harish Ramakrishna, Julian Perez‐Villacastín, Antonio Fernandez‐Ortiz, Natale Daniele Brunetti

“…At multivariable analysis in propensity matched population of patients with COVID‐19, including age, sex, hypertension, diabetes, kidney failure, and invasive ventilation, aspirin treatment was associated with lower risk of in‐hospital mortality (hazard ratio [HR], 0.62; [95% CI 0.42–0.92], P=0.018). …”
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Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease by Wilkinson, K, Brunskill, S, Trivella, M, al., E

“…Long-term mortality was similar between randomised groups in one trial each comparing restrictive and liberal transfusion or standard and non-standard CPB prime.Four trials explored a range of adverse effects following red cell transfusion. Kidney failure was the only adverse event that was significantly different: patients receiving cell salvaged red blood cells during CPB were less likely to have renal failure than patients not exposed to cell salvage (risk ratio (RR) 0.26, 95% confidence interval (CI) 0.09 to 0.79, 1 study, 309 participants). …”

Oral Chinese Herbal Medicine plus usual care for diabetic kidney disease: study protocol for a randomized, double-blind, placebo-controlled pilot trial by Meifang Liu, Meifang Liu, Meifang Liu, Yuan Ming Di, Lei Zhang, Lei Zhang, Lihong Yang, La Zhang, Junhui Chen, Ruobing Wang, Xiaoning Xie, Fang Lan, Liping Xie, Juan Huang, Anthony Lin Zhang, Charlie Changli Xue, Xusheng Liu, Xusheng Liu

“…BackgroundDiabetic kidney disease (DKD) has become the leading cause of kidney failure, causing a significant socioeconomic burden worldwide. …”
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A 12-Connected [Y₄((<i>μ</i>₃-OH)₄]⁸⁺ Cluster-Based Luminescent Metal-Organic Framework for Selective Turn-on Detection of F⁻... by Juan Li, Airong Wang, Shiming Qiu, Xiaoli Wang, Jiaming Li

“…Over intake of F⁻ can give rise to dental fluorosis, kidney failure, or DNA damage. As a result, developing affordable, equipment-free and credible approaches for F⁻ detection is an important task. …”
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Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary by Win Hlaing Than, Gordon Chun-Kau Chan, Bonnie Ching-Ha Kwan, Ka-Bik Lai, Ronald Cheong-Kin Chan, Jeromy Yuen Chun Teoh, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Kai-Ming Chow, Phyllis Mei-Shan Cheng, Man-Ching Law, Philip Kam-Tao Li, Cheuk-Chun Szeto

“…However, neither plasma adiponectin level nor its adipose tissue mRNA expression was an independent prognostic indicator in kidney failure patients newly started on PD.…”
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Combining robust urine biomarkers to assess chronic kidney disease progressionResearch in context by Frank Bienaimé, Mordi Muorah, Marie Metzger, Melanie Broeuilh, Pascal Houiller, Martin Flamant, Jean-Philippe Haymann, Jacky Vonderscher, Jacques Mizrahi, Gérard Friedlander, Bénédicte Stengel, Fabiola Terzi, François Vrtovsnik, Eric Daugas, Martin Flamant, Emmanuelle Vidal-Petiot, Christian Jacquot, Alexandre Karras, Stéphane Roueff, Eric Thervet, Pascal Houillier, Marie Courbebaisse, Dominique Eladari et Gérard Maruani, Pablo Urena-Torres, Jean-Jacques Boffa, Pierre Ronco, H. Fessi, Eric Rondeau, Emmanuel Letavernier, Nahid Tabibzadeh, Jean-Philippe Haymann

“…LASSO logistic regressions identified a combination of five biomarkers including CCL2, EGF, KIM1, NGAL, and TGF-α that improved the prediction of fast mGFR decline compared to the kidney failure risk equation variables alone: age, gender, mGFR, and albuminuria. …”
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Calcium dobesilate efficiency in the treatment of diabetic kidney disease through suppressing MAPK and chemokine signaling pathways based on clinical evaluation and network pharmac... by Bingyu Du, Bingyu Du, Bingyu Du, Bingyu Du, Yanyan Yin, Yanyan Yin, Yanyan Yin, Yuqing Wang, Hui Fu, Helin Sun, Zhaodi Yue, Zhaodi Yue, Shaohong Yu, Shaohong Yu, Shaohong Yu, Zhongwen Zhang, Zhongwen Zhang, Zhongwen Zhang

“…Compared with routine therapy, the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) significantly decreased in the CaD treatment (early stage of DKD, Scr: p &lt; 0.00001; BUN: p &lt; 0.0001; clinical stage of DKD, Scr: p &lt; 0.00001; BUN: p &lt; 0.00001; kidney failure stage, Scr: p = 0.001; BUN: p = 0.004). …”
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Early treatment improves urodynamic prognosis in neurogenic voiding dysfunction: 20 years of experience by Lucia M. Costa Monteiro, Glaura O. Cruz, Juliana M. Fontes, Eliane T.R.C. Vieira, Eloá N. Santos, Grace F. Araújo, Eloane G. Ramos

“…Keywords: Urinary incontinence, Neurogenic bladder, Urodynamics, Treatment, Kidney failure, Follow-up, Palavras-chave: Incontinência urinária, Bexiga neurogênica, Urodinâmica, Tratamento, Insuficiência renal, Seguimento…”
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Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor by Robin Schürfeld, Benjamin Sandner, Annett Hoffmann, Annett Hoffmann, Nora Klöting, Ekaterine Baratashvili, Ekaterine Baratashvili, Marcin Nowicki, Sabine Paeschke, Joanna Kosacka, Susan Kralisch, Anette Bachmann, Armin Frille, Anja Dietel, Jens-Uwe Stolzenburg, Matthias Blüher, Matthias Blüher, Ming-Zhi Zhang, Ming-Zhi Zhang, Raymond C. Harris, Raymond C. Harris, Berend Isermann, Michael Stumvoll, Anke Tönjes, Thomas Ebert

“…However, regulation of ACBP has not been investigated in conditions with impaired kidney function, so far.Design/methodsSerum ACBP concentrations were investigated by enzyme-linked immunosorbent assay i) in a cohort of 60 individuals with kidney failure (KF) on chronic haemodialysis and compared to 60 individuals with a preserved kidney function; and ii) in a human model of acute kidney dysfunction (AKD). …”
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Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012) by Fen Liu, Guo-Li Du, Ning Song, Yi-Tong Ma, Xiao-Mei Li, Xiao-Ming Gao, Yi-Ning Yang

“…Abstract Background Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been recognized as a key risk factor contributing to development of hyperuricemia. …”
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Pengaruh Ketepatan Terapi dan Kepatuhan terhadap Hasil Terapi Hipertensi Di Poliklinik Penyakit dalam RSUP Dr. Sardjito Yogyakarta by Adam M. Ramadhan

“…Complication in blood tissue that is caused by hypertension and that is becoming the leading cause of death might include several diseases such as coronary artery disease (CAD), hearth attack, and stroke and kidney failure. The therapy of antihypertensive drug either in monotherapy or in combination therapy plays a very essential role for patients in which the therapy in this case must be given in consideration of the blood pressure and possibility of complication. …”
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Implementation of a One-Day Living Kidney Donor Assessment Clinic to Improve the Efficiency of the Living Kidney Donor Evaluation: Program Report by Seychelle Yohanna, Kyla L. Naylor, Jessica M. Sontrop, Christine M. Ribic, Catherine M. Clase, Matthew C. Miller, Sunchit Madan, Richard Hae, Jasper Ho, Jian Roushani, Sarah Parfeniuk, Melodie Jansen, Sharon Shavel, Michelle Richter, Kimberly Young, Brooke Cowell, Shahid Lambe, Peter Margetts, Kevin Piercey, Vikas Tandon, Colm Boylan, Carol Wang, Susan McKenzie, Barb Longo, Amit X. Garg

“…A shorter, more efficient donor evaluation process may help more patients with kidney failure receive a transplant, including a pre-emptive kidney transplant (ie, avoiding the need for dialysis). …”
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COVID-19 in solid organ transplant recipients: initial report from national multicenter observational study «ROKKOR-recipient» by S. V. Gautier, A. O. Shevchenko, O. M. Tsirulnikova, S. M. Khomyakov, O. N. Kotenko, V. E. Vinogradov, I. N. Abyzov, G. D. Avetisyan, A. Yu. Anisimov, L. Yu. Artyukhina, M. T. Bekov, V. A. Berdinsky, V. S. Bogdanov, A. Yu. Bykov, A. Yu. Vinokurov, A. Yu. Goncharova, D. P. Evdokimov, D. V. Ezersky, V. E. Zagainov, V. M. Zakharevich, K. N. Zelenin, E. S. Ivanova, A. A. Kartashev, N. G. Kvadratova, I. G. Kim, N. N. Koloskova, V. L. Korobka, I. R. Kurbanuglov, M. A. Lysenko, I. A. Miloserdov, Ya. G. Moisyuk, G. V. Nikolaev, I. V. Ostrovskaya, N. Yu. Petrova, A. V. Petryaev, A. V. Pinchuk, V. S. Platonov, V. N. Poptsov, Z. A. Porchkhidze, D. A. Saydulaev, A. D. Sapozhnikov, S. B. Semchenko, M. M. Skorobogatov, V. Yu. Tereshchenko, N. F. Frolova, D. V. Khalikova, T. A. Khalilulin

“…Predictors of adverse events include associated cardiovascular diseases, pulmonary diseases, diabetes, and kidney failure. Symptoms of the disease include dyspnea, rash and catarrhal signs, as well as initial low blood oxygen saturation (SpO2 &lt;92%), leukocytosis (white blood cell count &gt;10 × 109/L), elevated creatinine levels (&gt;130 μmol/L) and a marked decrease in glomerular filtration rate, requiring hemodialysis. …”
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In vivo Anti-lithiasis activity and antibacterial effect of hydroalcoholic extract and infusion of Punica granatum L. peel. by Rabie Kachkoul, Ghita Benjelloun Touimi, Bahia Bennani, Ghita El Mouhri, Radouane El Habbani, Mohamed Mohim, Tarik Sqalli Houssaini, Sara Boukansa, Layla Tahiri, Hinde El Fatemi, Imane Gouzi, Fatima Elagy, Mohammed Sekal, Anissa Lahrichi

“…Objective: Urolithiasis disease is a severe pathology causing painful bleeding in patients and can lead to kidney failure. Current treatments are limited, expensive, invasive with side effects and requires new alternatives, especially those based on natural products. …”
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Niveles de quinasa ligada a la integrina endotelial y calcificación valvular: estudio molecular de la calcificación en la estenosis valvular aórtica by Mercedes Castro-Pinto, José López-Menéndez, Sandra Sánchez-Esteban, Ignacio Hernández, Paula Reventún, Jorge Rodríguez-Roda, Carlos Zaragoza, Marta Saura

“…Stepwise multiple logistic regression was used to control for confounding factors, introducing clinical parameters related to atherosclerosis and valve calcification (age, DM, HBP, kidney failure). Results: Samples from 75 patients whit aortic stenosis, and 28 controls were obtained. …”
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MAIT cells altered phenotype and cytotoxicity in lupus patients are linked to renal disease severity and outcome by Elena Litvinova, Carine Bounaix, Guillaume Hanouna, Jennifer Da Silva, Laura Noailles, Lucie Beaudoin, Michael Padden, Nessrine Bellamri, Agnès Lehuen, Eric Daugas, Eric Daugas, Renato C. Monteiro, Renato C. Monteiro, Héloïse Flament, Héloïse Flament

“…Proliferative lesions represent the most severe form of lupus nephritis (LN) and often lead to kidney failure and death. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T cells that recognize microbial-derived ligands from the riboflavin synthesis pathway. …”
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Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney... by Michael G. Collins, PhD, Magid A. Fahim, PhD, Elaine M. Pascoe, MBiostats, Carmel M. Hawley, MMedSc, David W. Johnson, PhD, Julie Varghese, BHMS, Laura E. Hickey, BSc, Philip A. Clayton, PhD, John S. Gill, MD, Kathryn B. Dansie, MBiostats, Rachael C. McConnochie, MN, Liza A Vergara, PhD, Charani Kiriwandeniya, BSc, Donna Reidlinger, MPH, Peter F. Mount, PhD, Laurence Weinberg, PhD, Colin J. McArthur, MBChB, P. Toby Coates, PhD, Zoltan H. Endre, PhD, David Goodman, PhD, Kirsten Howard, PhD, Martin Howell, PhD, Jagadish S. Jamboti, DM, John Kanellis, PhD, Jerome M. Laurence, PhD, Wai H. Lim, PhD, Steven J. McTaggart, PhD, Philip J. O’Connell, PhD, Helen L. Pilmore, MD, Germaine Wong, PhD, Steven J. Chadban, PhD, on behalf of the BEST-Fluids Investigators and the Australasian Kidney Trials Network

“…Most key characteristics were similar between trial participants and US recipients, with moderate differences (|d| ≥ 0.2; all P < 0.001) in kidney failure cause, diabetes, dialysis duration, ischemic time, and several donor risk predictors, likely reflecting underlying population differences. …”
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Efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection for the treatment of renal anemia in Chinese hemodialysis patients: A randomized, open‐label, par... by Bicheng Liu, Nan Chen, Jinghong Zhao, Aiping Yin, Xiongfei Wu, Changying Xing, Gengru Jiang, Junzhou Fu, Mei Wang, Rong Wang, Jianying Niu, Ping Fu, Zhaohui Ni, Fanfan Hou, Jiuyang Zhao, Jing Chen, Yuqing Chen, Wei Shi, Jianghua Chen, Wenge Li, Gang Xu, Ling Zhong, Wenhu Liu, Guohua Ding, Yuichiro Kondo, Changhe Yue, Changlin Mei

“…Abstract Background This study was to explore the clinical efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection (recombinant human erythropoietin injection, rHuEPO) for the treatment of anemia associated with chronic kidney failure in Chinese patients undergoing hemodialysis. …”
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Nephrotic Syndrome in Children with This Condition by Masoud Rezagholizamenjany, Parsa Yousefichaijan

“…Children with non-MCNS manifestations (clear hematuria, high blood pressure, kidney failure, serum deficiency, aged under-1 or over 8 years of age) should be treated with a renal biopsy candidate before treatment (16). …”
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