Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses by Yvette den Hartog, S. Reshwan K. Malahe, Wim J. R. Rietdijk, Marjolein Dieterich, Lennert Gommers, Daryl Geers, Susanne Bogers, Debbie van Baarle, Dimitri A. Diavatopoulos, A. Lianne Messchendorp, Renate G. van der Molen, Ester B. M. Remmerswaal, Frederike J. Bemelman, Ron T. Gansevoort, Luuk B. Hilbrands, Jan-Stephan Sanders, Corine H. GeurtsvanKessel, Marcia M. L. Kho, Marlies E. J. Reinders, Rory D. de Vries, Carla C. Baan, on behalf of RECOVAC Consortium

“…Here, we profiled 12 cytokines after stimulation of whole blood obtained 28 days post second 100 μg mRNA-1273 vaccination with peptides covering the SARS-CoV-2 spike (S)-protein from patients with chronic kidney disease (CKD) stage 4/5, on dialysis, kidney transplant recipients (KTR), and healthy controls. …”
Get full text

Ferric Carboxymatose in Non-Hemodialysis CKD Patients: A Longitudinal Cohort Study by Roberto Minutolo, Patrizia Berto, Maria Elena Liberti, Nicola Peruzzu, Silvio Borrelli, Antonella Netti, Carlo Garofalo, Giuseppe Conte, Luca De Nicola, Lucia Del Vecchio, Francesco Locatelli

“…These changes were independent from ESA use and clinical setting (non-dialysis CKD, peritoneal dialysis and kidney transplant). Among ESA-treated patients (<i>n</i> = 24), ESA doses significantly decreased by 26% with treatment and stopped either temporarily or persistently in nine patients. …”
Get full text

Circulating Omentin-1, Sustained Inflammation and Hyperphosphatemia at the Interface of Subclinical Atherosclerosis in Chronic Kidney Disease Patients on Chronic Renal Replacement... by Davide Bolignano, Marta Greco, Valentina Arcidiacono, Pierangela Presta, Alfredo Caglioti, Michele Andreucci, Francesco Dragone, Daniela Patrizia Foti, Giuseppe Coppolino

“…<i>Materials and Methods</i>: In this pilot study, we measured circulating levels of Omentin-1, a recently discovered adipokine with strong anti-atherogenic properties, in a heterogeneous cohort of 77 asymptomatic RRT individuals (40 chronic kidney transplant recipients, Ktx; and 37 chronic hemodialysis patients, HD) and in 30 age-matched controls. …”
Get full text

An Initial Analysis of the Baseline Levels of Dd-cfDNA After Pancreas Transplantation: A Prospective Study From High-volume Centers in the United States by Ashley Yoo, BS, Alexandria Riedel, BS, Ian Qian, BS, Amanda Bartosic, MBA, Rudi Soltani, BS, Gulam Kibria, MBBS, MSPH, Abdolreza Haririan, MD, MPH, Cinthia B. Drachenberg, MD, Peter L. Abrams, MD, Jon S. Odorico, MD, Matthew Cooper, MD, Jonathan S. Bromberg, MD, PhD, Joseph R. Scalea, MD

“…The mean dd-cfDNA level for all pancreas transplant recipients is <1.0%, consistent with the published kidney transplant rejection threshold (>1.0%), regardless of SPK or PTA. …”
Get full text

Value of Renal Histology in Predicting Cardiorenal Outcomes in Heart Transplant–listed Patients by Sumita Barua, FRACP, Tao Yang, MBBS, MSc, PhD, FRCPA, Sean Conte, BA, MBBS, Christopher Bragg, BSc, Jacob Sevastos, BSc (Med), PhD, FRACP, Peter S. Macdonald, MBBS, FRACP, PhD, MD, FCSANZ, Kavitha Muthiah, MBChB, PhD, FRACP, FCSANZ, Christopher S. Hayward, BMedSc, MD, FRACP, FCSANZ

“…There are no validated markers to predict major adverse kidney events (MAKEs), for which simultaneous heart-kidney transplant (SHKT) could offer improved survival. …”
Get full text

Evolving outcomes of peritoneal dialysis: secular trends at a single large center over three decades by Minjung Kang, Yae Lim Kim, Eunjeong Kang, Hyunjin Ryu, Yong Chul Kim, Dong Ki Kim, Hajeong Lee, Seung Seok Han, Kwon-Wook Joo, Yon Su Kim, Curie Ahn, Kook-Hwan Oh

“…The median PD treatment duration was 45 months (interquartile range, 19–77 months); 362 patients (30.1%) transferred to hemodialysis, 289 (24.0%) received kidney transplants, and 224 (18.6%) died. Overall, the 5- and 8-year adjust patient survival rates were 64% and 49%, respectively. …”
Get full text

Optimization of osteoporosis and osteopenia management among renal transplant recipients by Mohammed K. Afifi, Ahmed S. Kenawy, Heba H. El Demellawy, Amany A. Azouz, Torki Al-Otaibi, Osama Gheith, Mohamed Abd ElMonem, Mohamed S. AbdElhalim, Raghda R. S. Hussein

“…Results The study was conducted Iin Hamed Al-Essa Kidney transplant center, Kuwait, in 2020. The data of 52 denosumab and 48 ibandronate patients were collected at the baseline and after one year of treatment. …”
Get full text

Patient activation and its association with symptom burden and quality of life across the spectrum of chronic kidney disease stages in England by Winnie Magadi, Courtney J. Lightfoot, Katherine E. Memory, Shalini Santhakumaran, Sabine N. van der Veer, Nicola Thomas, Rachel Gair, Alice C. Smith

“…Methods Non-dialysis, dialysis, and kidney transplant patients from 14 renal units across England completed a survey comprising questionnaires assessing patient activation, symptom burden, and HRQoL. …”
Get full text

Heart Transplantation, Either Alone or Combined With Liver and Kidney, a Viable Treatment Option for Selected Patients With Severe Cardiac Amyloidosis by Soulef Guendouz, MD, Philippe Grimbert, MD, PhD, Costin Radu, MD, PhD, Daniel Cherqui, MD, PhD, Chady Salloum, MD, Nicolas Mongardon, MD, PhD, Sami Maghrebi, MD, Karim Belhadj, MD, Fabien Le Bras, MD, Emmanuel Teiger, MD, PhD, Jean-Paul Couetil, MD, PhD, Adriana Balan, MD, Mounira Kharoubi, MSc, Mélanie Bézard, MSc, Silvia Oghina, MD, Diane Bodez, MD, PhD, Luc Hittinger, MD, PhD, Vincent Audard, MD, PhD, Violaine Planté-Bordeneuve, MD, PhD, Alexandre De la Taille, MD, PhD, Eric Bergoend, MD, Valerie Frenkel, MD, PhD, Pascale Fanen, MD, PhD, Vincent Leroy, MD, PhD, Christophe Duvoux, MD, PhD, Maryvonnick Carmagnat, PharmD, Thierry Folliguet, MD, PhD, Thibaud Damy, MD, PhD

“…Among AL patients, 13 had heart-only and 5 had heart-kidney transplantations. Among ATTRv patients, 1 had heart-only and 5 had heart-liver transplantations. …”
Get full text

Identifying Patterns of Adverse Events of Solid Organ Transplantation Through Departmental Case Reviews by Amit K. Mathur, MD, MS, Cynthia Stemper-Bartkus, MSN, RN, Kevin Engholdt, MS, MBA, Andrea Thorp, MSN, RN, Melissa Dosmann, RN, Hasan Khamash, MD, Kunam S. Reddy, MD, Bashar Aqel, MD, Adyr Moss, MD, Harini Chakkera, MD, D. Eric Steidley, MD, Octavio Pajaro, MD, PhD, Sadia Shah, MD, Elizabeth J. Oakley, MS, David Douglas, MD

“…Results: Over 30 months, we performed 1449 transplant and living donor procedures with a total of 45 deaths and 31 graft losses; 91 DCRs were performed (kidney transplant n=43; liver transplant n=24; pancreas transplant n=10; heart transplant n=6; lung transplant n=3; living donor n=5). …”
Get full text

A systematic review on the correlation between COVID-19 and lower urinary tract symptoms by Ashkan Shafigh, Amir Mohammadi-Garebagh, Kavous Shahsavarinia, Sona Tayebi, Ali Mostafaei, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi

“…The qualitative publications were systematically reviewed separately under the titles of LUTS, benign prostatic hyperplasia (BPH), and kidney failures or kidney transplant recipients. The analysis of eligible studies showed a 3.3 % prevalence of LUTS in infected patients (95 % CI: 2.0 % - 5.3 %; Q-value: 1021.397, I2: 97.45 %). …”
Get full text

Cost-effectiveness of Interventions to Increase Utilization of Kidneys From Deceased Donors With Primary Brain Malignancy in an Australian Setting by James A. Hedley, MBiostats, Patrick J. Kelly, PhD, Melanie Wyld, PhD, Karan Shah, MS, Rachael L. Morton, PhD, Juliet Byrnes, PhD, Brenda M. Rosales, PhD, Nicole L. De La Mata, PhD, Kate Wyburn, PhD, Angela C. Webster, PhD

“…We assessed the cost-effectiveness of increasing utilization of potential deceased donors with brain cancer using a Markov model simulation of 1500 patients waitlisted for a kidney transplant, based on linked transplant registry data and with a payer perspective (Australian government). …”
Get full text

B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients by Ana-Luisa Stefanski, Ana-Luisa Stefanski, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Eva Schrezenmeier, Eva Schrezenmeier, Eva Schrezenmeier, Kirsten Karberg, Franziska Szelinski, Franziska Szelinski, Jacob Ritter, Jacob Ritter, Yidan Chen, Yidan Chen, Bernd Jahrsdörfer, Bernd Jahrsdörfer, Carolin Ludwig, Carolin Ludwig, Hubert Schrezenmeier, Hubert Schrezenmeier, Andreia C. Lino, Thomas Dörner, Thomas Dörner

“…Eleven patients with rheumatoid arthritis (RA) on other therapies, 11 kidney transplant recipients (KTR) on regular immunosuppression and 15 healthy controls (HC) served as controls. …”
Get full text

The Potential Protective Effect and Underlying Mechanisms of Physiological Unconjugated Hyperbilirubinemia Mediated by UGT1A1 Antisense Oligonucleotide Therapy in a Mouse Model of... by Basma H. Marghani, Mohamed El-Adl, Ahmed I. Ateya, Basma H. Othman, Heba I. Ghamry, Mustafa Shukry, Mohamed Mohamed Soliman, Mohamed Abdo Rizk

“…However, its use is often limited because it is thought to be linked to the development of chronic kidney disease after kidney transplants. This study aimed to investigate the protective effects and underlying mechanisms of physiological unconjugated (UC) hyperbilirubinemia mediated by UGT1A1 antisense oligonucleotide in a mouse model of CsA-induced chronic kidney disease, and match these with that of chitosan (CH) as a natural chelator against kidney injury. …”
Get full text

Electrolytes Play a Role in Detecting Cisplatin-Induced Kidney Complications and May Even Prevent Them—Retrospective Analysis by Bahauddeen M. Alrfaei, Abdulaziz O. Almutairi, Alaa A. Aljohani, Hajar Alammar, Abdulaziz Asiri, Yahya Bokhari, Feda S. Aljaser, Manal Abudawood, Majed Halwani

“…This study will help reduce the risk of dialysis or the need for kidney transplant. It is also important to manage any underlying conditions and control patients’ intake of electrolytes.…”
Get full text

Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function by Amber O. Molnar, Anan Bader Eddeen, Robin Ducharme, Amit X. Garg, Ziv Harel, Megan K. McCallum, Jeffrey Perl, Ron Wald, Deborah Zimmerman, Manish M. Sood

“…Cox proportional models were used to determine the hazard ratio for AF censored for death, dialysis, kidney transplant, or end of follow‐up. Fine and Grey models were used to determine the subdistribution hazard ratio for AF, with death as a competing event. …”
Get full text

Immunogenicity and Safety of the Three-Dose COVID-19 Vaccine Regimen in Patients Receiving Renal Replacement Therapy: A Systematic Review and Meta-Analysis by Becky Mingyao Ma, Anthony Raymond Tam, Kam Wa Chan, Ivan Fan Ngai Hung, Sydney Chi Wai Tang, Tak Mao Chan, Desmond Yat-Hin Yap

“…The seropositivity rate of anti-SARS-CoV-2 in kidney transplant recipients (KTRs) was 64.6% (95% CI: 58.7–70.5%), and 43.5% (95% CI: 38.5–48.6%) of non-responders after second dose became seropositive after third dose. …”
Get full text

The Inhibition of Complement System in Formal and Emerging Indications: Results from Parallel One-Stage Pairwise and Network Meta-Analyses of Clinical Trials and Real-Life Data Stu... by Coralina Bernuy-Guevara, Hassib Chehade, Yannick D. Muller, Julien Vionnet, François Cachat, Gabriella Guzzo, Carlos Ochoa-Sangrador, F. Javier Álvarez, Daniel Teta, Débora Martín-García, Marcel Adler, Félix J. de Paz, Frank Lizaraso-Soto, Manuel Pascual, Francisco Herrera-Gómez

“…In addition, meta-analysis on clinical trials shows that eculizumab mitigates a refractory generalized myasthenia gravis (rgMG) crisis (0.29/0.13 to 0.61) and prevents new acute antibody-mediated rejection (AMR) episodes in kidney transplant recipients (0.25/0.13 to 0.49). The update of findings from this meta-analysis will be useful to promote a better use of complement inhibitors, and to achieve personalization of treatments with this class of drugs.…”
Get full text

A Study on the Correlations of Anxiety and Depression With Self-Management Ability and Endogenous Creatinine Clearance Rate in Renal Transplant Recipients by ShiMin Hu, Yu Li, MingTao Quan, ShuJuan Yang, ZhaoMei Wan, XiaoYong Yan, ZhouKe Tan, GuoBiao Liang

“…The self-made general data sheet, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and Self-Management Scale for Kidney Transplant Recipients were used. Correlation analysis was used to find factors related to endogenous creatinine clearance, while multiple linear regression was used to identify factors influencing endogenous creatinine clearance. …”
Get full text

Humoral Response in Hemodialysis Patients Post-SARS-CoV-2 mRNA Vaccination: A Systematic Review of Literature by Kin Israel Notarte, Jesus Alfonso Catahay, Princess Juneire Peligro, Jacqueline Veronica Velasco, Abbygail Therese Ver, Jonathan Jaime Guerrero, Jin Liu, Giuseppe Lippi, Stefanie W. Benoit, Brandon Michael Henry, César Fernández-de-las-Peñas

“…Patients with chronic kidney disease elicited the highest antibody immune response, followed by HDP and, lastly, kidney transplant recipients. Overall, post-vaccination antibody titers were comparatively lower than in the healthy population. …”
Get full text