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321
Mutation Characteristics and Phylogenetic Analysis of Five <i>Leishmania</i> Clinical Isolates
Published 2022-01-01“…Among the genes associated with virulence, L_HCZ had the most mutations in cysteine peptidase A, cysteine peptidase B, cysteine peptidase C, heat-shock protein 70, gp63, acid phosphatase, kinesin k39, kinesin, phosphoglycan beta 1, amastin-like surface protein and amastin-like proteins. …”
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322
Emerging roles of centrosome cohesion
Published 2022-10-01“…Alternatively, centrosomes can be kept together by the action of the minus end directed kinesin motor protein KIFC3 that works on interdigitating microtubules organized by both centrosomes and probably by the actin network. …”
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323
Emerging role and function of SPDL1 in human health and diseases
Published 2024-04-01“…SPDL1 encodes a protein, hSpindly, which plays a critical role in the maintenance of spindle checkpoint silencing during mitosis. hSpindly coordinates microtubule attachment by promoting kinesin recruitment and mitotic checkpoint signaling. …”
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324
Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.
Published 2013-01-01“…We further demonstrate that the activity of Kermit in PCP differentially relies on the motor proteins: the microtubule-based dynein and kinesin motors and the actin-based myosin VI. Our results place Kermit as a potential transducer of Go, linking Vang with motor proteins for its delivery to dedicated cellular compartments during PCP establishment.…”
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325
Biogenetic Relationships of Bioactive Sponge Merotriterpenoids
Published 2017-09-01“…In this review, an in depth structural analysis of sponge merotriterpenoids, including the adociasulfate family of kinesin motor protein inhibitors, provides insight into their biosynthesis. …”
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326
The rate of microtubule breaking increases exponentially with curvature
Published 2022-12-01“…We observed breaking of taxol-stabilized microtubules in a gliding motility assay where microtubules are propelled by surface-adhered kinesin-1 motor proteins. We find that over 95% of all breaking events are associated with the strong bending following pinning events (where the leading tip of the microtubule becomes stuck). …”
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327
Microtubule Retrograde Motors and Their Role in Retroviral Transport
Published 2020-04-01“…Within a eukaryotic cell, microtubules act as the roads, while the microtubule-associated proteins dynein and kinesin are the vehicles that viruses exploit to achieve retrograde and anterograde trafficking. …”
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328
Mitotic spindle scaling during Xenopus development by kif2a and importin α
Published 2013-02-01“…To identify mechanisms that scale the spindle during Xenopus laevis embryogenesis, we established an in vitro system using cytoplasmic extracts prepared from embryos that recapitulates in vivo spindle size differences between stage 3 (4 cells, 37 µm) and stage 8 (∼4000 cells, 18 µm). We identified the kinesin-13 kif2a as a driver of developmental spindle scaling whose microtubule-destabilizing activity is inhibited in stage 3 spindles by the transport receptor importin α, and activated in stage 8 when importin α partitions to a membrane pool. …”
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329
Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila.
Published 2023-08-01“…Miro GTPases control mitochondrial morphology, calcium homeostasis, and regulate mitochondrial distribution by mediating their attachment to the kinesin and dynein motor complex. It is not clear, however, how Miro proteins spatially and temporally integrate their function as acute disruption of protein function has not been performed. …”
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330
Genetic Factors Associated with Toe Walking in Children
Published 2020-06-01“…Association of gait abnormality with variants in genes listed below is shown: PMP22 (peripheral myelin protein 22), EGR2 (early growth response protein 2), AIFM1 (apoptosis inducing factor mitochondria associated 1), MORC2 (member of the Microrchidia family CW-type zinc finger 2), DHTKD1 (dehydrogenase E1 and transketolase domain containing 1), GDAP1 (ganglioside induced differentiation associated protein 1), KIF1B (kinesin family member 1B), FGD4 (FYVE, RhoGEF and PH domain containing 4), SBF2 (SET binding factor 2), SH3TC2 (SH3 domain and tetratricopeptide repeats 2), NAGLU (N-acetyl-alpha-glucosaminidase), NEFL (neurofilament light) и PRX (periaxin). …”
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331
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle
Published 2020“…Here, we analyze the requirements for core CPC subunits, survivin and INCENP, and the mitotic kinesin-like protein 2 (MKLP2) in targeting to these distinct localizations. …”
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332
Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A
Published 2019“…We show that one such factor is the kinesin KIF4A, which is present along the chromosome axes throughout mitosis and the central spindle in anaphase. …”
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333
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.
Published 2013“…Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. …”
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334
Germ Plasm Anchoring Is a Dynamic State that Requires Persistent Trafficking
Published 2013-12-01“…This motility relies on cortical microtubules, is mediated by kinesin and dynein motors, and requires coordination between the microtubule and actin cytoskeletons. …”
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335
Recent Advances in the Applications of Small Molecules in the Treatment of Multiple Myeloma
Published 2023-01-01“…Highlighted in the discussion are recent developments in the applications of alkylating agents, immunomodulators, proteasome inhibitors, apoptosis inducers, kinesin spindle protein inhibitors, blockers of nuclear transport, and drugs that affect various kinases involved in intracellular signaling pathways. …”
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336
Lipid Droplet Motility and Organelle Contacts
Published 2019-12-01“…LDs can be transported directly by motor proteins along either actin filaments or microtubules, via Kinesin-1, Cytoplasmic Dynein, and type V Myosins. …”
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337
MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology
Published 2015-12-01“…Recent findings have revealed a myriad of molecules that are associated with MIRO, particularly the kinesin adaptor Milton/TRAK, mitofusin, PINK1 and Parkin, as well as the endoplasmic reticulum-mitochondria encounter structure (ERMES) complex. …”
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338
Recent advances in primary cilia in bone metabolism
Published 2023-10-01“…The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. …”
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339
Taxol acts differently on different tubulin isotypes
Published 2023-09-01“…Using in vitro reconstitution, we demonstrate that single-isotype α1β4 GDP-tubulin lattices are stabilised and expanded by 10 µM taxol, as reported by accelerated microtubule gliding in kinesin motility assays, whereas single-isotype α1β3 GDP-tubulin lattices are stabilised but not expanded. …”
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340
Cellular cartography: Towards an atlas of the neuronal microtubule cytoskeleton
Published 2023-03-01“…The polar nature of microtubules is quintessential for their function, allowing them to serve as tracks for long-distance, directed intracellular transport by kinesin and dynein motors. Most of these motors move exclusively towards either the plus- or minus-end of a microtubule and some have been shown to have a preference for either dynamic or stable microtubules, those bearing a particular post-translational modification or those decorated by a specific microtubule-associated protein. …”
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