The functional organization of mitochondrial genomes in human cells. by Iborra, F, Kimura, H, Cook, P

“…These foci (nucleoids) are tethered directly or indirectly through mitochondrial membranes to kinesin, marked by KIF5B, and microtubules in the surrounding cytoplasm. …”

A structural and dynamic visualization of the interaction between MAP7 and microtubules by Agnes Adler, Mamata Bangera, J. Wouter Beugelink, Salima Bahri, Hugo van Ingen, Carolyn A. Moores, Marc Baldus

“…MT-associated protein 7 (MAP7) has the unusual ability of both MT binding and activating kinesin-1-mediated cargo transport along MTs. Additionally, the protein is reported to stabilize MTs with its 112 amino-acid long MT-binding domain (MTBD). …”
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Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation by Amy M Winans, Sean R Collins, Tobias Meyer

“…Our data argue for a mechanical control system whereby actin waves transiently widen the neurite shaft to allow increased microtubule polymerization to direct Kinesin-based transport and create bursts of neurite extension. …”
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Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro by Cecilia D. Velasco, Rachel Santarella-Mellwig, Martin Schorb, Li Gao, Oliver Thorn-Seshold, Artur Llobet

“…An analogous effect was obtained by dialyzing the cytosol with Kif18A, a plus-end-directed kinesin with microtubule depolymerizing activity. …”
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Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations. by Karine Normandin, Jasmin Coulombe-Huntington, Corinne St-Denis, Alexandre Bernard, Mohammed Bourouh, Thierry Bertomeu, Mike Tyers, Vincent Archambault

“…Genes identified encode proteins that are functionally linked to PLK1 in multiple ways, most notably factors that promote centromere and kinetochore function. Loss of the kinesin KIF18A or the outer kinetochore protein SKA1 in PLK1-compromised cells resulted in mitotic defects, activation of the spindle assembly checkpoint and nuclear reassembly defects. …”
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Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia by Alison Leaf, Mark Von Zastrow

“…In this study, we show that D1-type dopaminergic receptors are delivered to cilia from the extra-ciliary plasma membrane by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23, a small guanine nucleotide binding protein that has important effects on physiological signaling from cilia but was not known previously to be essential for ciliary delivery of any cargo. …”
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KIF2C is a Biomarker Correlated With Prognosis and Immunosuppressive Microenvironment in Human Tumors by Xiuyuan Zhang, Yiming Li, Pengbo Hu, Liang Xu, Hong Qiu

“…Kinesin superfamily member 2C (KIF2C) is an essential regulator of the cell cycle and its aberrant expression can promote tumor progression. …”
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Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons by Nuria Ruiz-Reig, Dario García-Sánchez, Olivier Schakman, Philippe Gailly, Fadel Tissir, Fadel Tissir

“…KIF2A is an atypical kinesin that depolymerizes MT in ATP-dependent manner and regulates MT dynamics. …”
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Extreme-value analysis of intracellular cargo transport by motor proteins by Takuma Naoi, Yuki Kagawa, Kimiko Nagino, Shinsuke Niwa, Kumiko Hayashi

“…Here, we rely on EVA to investigate the motility functions of nanoscale motor proteins in neurons of the living worm Caenorhabditis elegans (C. elegans), namely the motion of kinesin and dynein along microtubules. While the essential difference between the two motors cannot be inferred from the mean velocities, such becomes evident in the EVA plots. …”
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Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis. by Alcina, A, Ramagopalan, S, Fernández, O, Catalá-Rabasa, A, Fedetz, M, Ndagire, D, Leyva, L, Arnal, C, Delgado, C, Lucas, M, Izquierdo, G, Ebers, G, Matesanz, F

“…This marker is located on chromosome 1p36.22, which is 1 Mb away from the MS-associated kinesin motor protein KIF1B, although linkage disequilibrium was not observed between these two markers. …”

Therapeutic challenges in quadruple negative breast cancer by Galina Yaneva, Tsonka Dimitrova, Stoyan Stoyanov, Nikoleta Ivanova, Galina Nenkova, Dobri Ivanov, Ivayla Kuleva

“…Some subtypes and related pathway proteins are preferentially expressed in QNBC and may act as effective therapeutic targets such as acyl-CoA synthetase4, S-phase kinase associated protein 2, immune checkpoint inhibitors, kinesin family member C1,and epidermal growth factor receptor. …”
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Functional analysis and signaling pathway enrichment analysis of genes associated with Alzheimer’s disease and Parkinson’s disease by N. Yu. Chasovskikh, A. Yu. Grechishnikova, D. V. Smirnov

“…We have defined 14 shared functions: collagen catabolic process, cellular response to retinoic acid, regulation of calcium-mediated signaling, negative regulation of cell projection organization, negative regulation of neuron projection development, glial cell activation, microglial cell activation, macrophage activation, regulation of cholesterol metabolism, clathrin-mediated endocytosis, regulation of protein oligomerization, regulation of dendritic spine development, kinesin binding and clathrin binding. Also, we have defined 3 shared signaling pathways: trans-Golgi Network Vesicle Budding, Clathrin derived vesicle budding, Intestinal immune network for IgA production. …”
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CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons by Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky

“…CRMP2 is attached to neuronal mitochondria and binds to dynamin-related protein 1 (Drp1), Miro 2, and Kinesin 1 light chain (KLC1). Treating neurons with okadaic acid (OA), an inhibitor of phosphatases PP1 and PP2A, resulted in increased CRMP2 phosphorylation at Thr509/514, Ser522, and Thr555, and augmented Drp1 phosphorylation at Ser616. …”
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Reconstitution of an active human CENP-E motor by Benjamin Craske, Thibault Legal, Julie P. I. Welburn

“…CENP-E is a large kinesin motor protein which plays pivotal roles in mitosis by facilitating chromosome capture and alignment, and promoting microtubule flux in the spindle. …”
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A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary by Wen Lu, Margot Lakonishok, Anna S Serpinskaya, Vladimir I Gelfand

“…Furthermore, replacing dynein with a minus-end directed plant kinesin linked to the actin cortex is sufficient for transporting organelles and cytoplasm to the oocyte and driving its growth. …”
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SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23 by Yongkang Wu, Weijie Chen, Huilai Miao, Tuo Xu

“…Abstract Objective This study was designed to investigate the regulatory effects of kinesin family member (KIF) 23 on anaplastic thyroid cancer (ATC) cell viability and migration and the underlying mechanism. …”
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Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner by Anand N. Rao, Ankita Patil, Mark M. Black, Erin M. Craig, Kenneth A. Myers, Howard T. Yeung, Peter W. Baas

“…Computational modeling revealed that dynein-mediated transport of microtubules can establish and preserve a predominantly plus-end-out microtubule pattern as per the details of the experimental findings, but only if a kinesin motor and a static cross-linker protein are also at play. …”
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Photoreceptor Compartment-Specific TULP1 Interactomes by Lindsey A. Ebke, Satyabrata Sinha, Gayle J. T. Pauer, Stephanie A. Hagstrom

“…We report the identification of: (1) an IS-specific interaction between Tulp1 and the motor protein Kinesin family member 3a (Kif3a), (2) a synaptic-specific interaction between Tulp1 and the scaffold protein Ribeye, and (3) an interaction between Tulp1 and the cytoskeletal protein microtubule-associated protein 1B (MAP1B) in both compartments. …”
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Localization of oskar mRNA by agglomeration in ribonucleoprotein granules. by Catherine E Eichler, Hui Li, Michelle E Grunberg, Elizabeth R Gavis

“…In contrast to the earlier kinesin-dependent oskar transport, late-phase localization depends on the sequence as well as on the structure of the spliced oskar localization element (SOLE), but not on the adjacent exon junction complex deposition. …”
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Kif21a deficiency leads to impaired glomerular filtration barrier function by Hanna Riedmann, Séverine Kayser, Martin Helmstädter, Daniel Epting, Carsten Bergmann

“…By using zebrafish as a vertebrate in vivo model, we report a novel role of the Kinesin-like motor protein Kif21a in glomerular filtration. …”
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