MCAK Inhibitors Induce Aneuploidy in Triple-Negative Breast Cancer Models by John C. Smith, Stefan Husted, Jay Pilrose, Stephanie C. Ems-McClung, Jane R. Stout, Richard L. Carpenter, Claire E. Walczak

“…One potential target is the microtubule depolymerizing kinesin, MCAK, which limits aneuploidy by regulating microtubule dynamics during mitosis. …”
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Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model by Jing Liu, Pingyang Ke, Haokun Guo, Juan Gu, Yan Liu, Xin Tian, Xuefeng Wang, Fei Xiao

“…Furthermore, activation of TLR7 induced autophagy and decreased the expression of kinesin family member 5 A (KIF5A), which influenced interactions with γ-aminobutyric acid type A receptor (GABAAR)-associated protein and GABAARβ2/3, thus producing abnormal GABAAR-mediated postsynaptic transmission. …”
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What to Learn from a Few Visible Transitions’ Statistics? by Pedro E. Harunari, Annwesha Dutta, Matteo Polettini, Édgar Roldán

“…We illustrate the developed framework in experimentally validated biophysical models of kinesin and dynein molecular motors, and in a minimal model for template-directed polymerization. …”
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Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly by Lora Winters, Ivana Ban, Marcel Prelogović, Iana Kalinina, Nenad Pavin, Iva M. Tolić

“…We introduce the contour length of microtubules as a measure of activity of motors that drive microtubule sliding, which we used together with observation of Cut7/kinesin-5 motors and our theory to reveal the minus-end-directed motility of this motor in vivo. …”
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Muscleblind-1 interacts with tubulin mRNAs to regulate the microtubule cytoskeleton in C. elegans mechanosensory neurons. by Dharmendra Puri, Sunanda Sharma, Sarbani Samaddar, Sruthy Ravivarma, Sourav Banerjee, Anindya Ghosh-Roy

“…In a genetic screen conducted using mechanosensory neurons of C. elegans, we identified a mutation in muscleblind-1/mbl-1 as a suppressor of loss of kinesin-13 family microtubule destabilizing factor klp-7. …”
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Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor by Zhengcheng He, Lin Mei, Marisa Connell, Christopher A. Maxwell

“…But, HMMR is an intracellular, microtubule-associated, spindle assembly factor that localizes protein complexes to augment the activities of mitotic kinases, like polo-like kinase 1 and Aurora kinase A, and control dynein and kinesin motor activities. Expression of HMMR is elevated in cells prior to and during mitosis and tissues with detectable HMMR expression tend to be highly proliferative, including neoplastic tissues. …”
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Axons Degenerate in the Absence of Mitochondria in C. elegans by Rawson, Randi L., Yam, Lung, Weimer, Robby M., Bend, Eric G., Clark, Scott G., Jorgensen, Erik M., Hartwieg, Erika A., Horvitz, Howard Robert

“…Here, we identify a C. elegans mutant, ric-7, in which mitochondria are unable to exit the neuron cell bodies, similar to the kinesin-1/unc-116 mutant. When axons lacking mitochondria are cut with a laser, they rapidly degenerate. …”
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Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes by Neal, AT

“…The findings of this thesis suggest that kinesins and microtubules may play previously unconsidered roles in the regulation, production, or trafficking of PfEMP1.…”

CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease. by Reed, A, Loh, N, Terryn, S, Lippiat, J, Partridge, C, Galvanovskis, J, Williams, SE, Jouret, F, Wu, F, Courtoy, P, Nesbit, M, Rorsman, P, Devuyst, O, Ashcroft, F, Thakker, R

“…Here, we report that CLC-5 interacts with kinesin family member 3B (KIF3B), a heterotrimeric motor protein that facilitates fast anterograde translocation of membranous organelles. …”

Towards elimination of visceral leishmaniasis in the Indian subcontinent—Translating research to practice to public health by Hirve, S, Kroeger, A, Matlashewski, G, Mondal, D, Banjara, MR, Das, P, Be-Nazir, A, Arana, B, Olliaro, P

“…TDR has played a critical role in the evaluation and subsequent use of the 39-aminoacid–recombinant kinesin antigen (rK39) rapid diagnostic test (RDT) as a confirmatory test for VL in the national program. …”

The chromosomal passenger complex: regulation of chromosome segregation in kinetoplastids by Ballmer, D

“…In the first part of my thesis, I identify two kinetoplastid-specific kinesins, KIN-A and KIN-B, as bona fide CPC proteins in <em>T. brucei</em>. …”

Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model by Karen Linnemannstöns, Pradhipa Karuna M, Leonie Witte, Dolma Choezom, Mona Honemann‐Capito, Alex Simon Lagurin, Chantal Vanessa Schmidt, Shreya Shrikhande, Lara‐Kristin Steinmetz, Möbius Wiebke, Christof Lenz, Julia Christina Gross

“…We furthermore discovered a so far unknown function of Rab14 along with the kinesin Klp98A in EV biogenesis and secretion.…”
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Diagnostic biomarker KIF23 is associated with immune infiltration and immunotherapy response in gastric cancer by Maoshu Bai, Xin Liu

“…Kinesin family member 23 (KIF23), an index of tumor proliferation, can serve as a prognostic marker in numerous tumors. …”
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Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel by Hu J, He Q, Tian T, Chang N, Qian L

“…However, the role and mechanism of Targeting protein for Xenopus kinesin-like protein 2 (TPX2), which is highly expressed in NSCLC, is still unclear.Methods: Bioinformatics analysis was used to analyze the relationship between TPX2 and the clinicopathological features of NSCLC. …”
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Combinations of deletion and missense variations of the dynein-2 DYNC2LI1 subunit found in skeletal ciliopathies cause ciliary defects by Hantian Qiu, Yuta Tsurumi, Yohei Katoh, Kazuhisa Nakayama

“…Bidirectional protein trafficking within cilia is mediated by the intraflagellar transport (IFT) machinery containing IFT-A and IFT-B complexes, with the aid of kinesin-2 and dynein-2 motors. The dynein-2 complex drives retrograde trafficking of the IFT machinery after its transportation to the ciliary tip as an IFT cargo. …”
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Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking by Andre Voelzmann, Pilar Okenve-Ramos, Yue Qu, Monika Chojnowska-Monga, Manuela del Caño-Espinel, Andreas Prokop, Natalia Sanchez-Soriano

“…This cascade involves microtubule stability as the initial trigger, JNK signalling as the central mediator, and kinesin-3 mediated axonal transport as the key effector. …”
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KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring by Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G Chaudhary, Mohammed H Al-Qahtani, Nobutaka Hirokawa

“…Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. …”
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The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma by Yuanyuan Shi, Xiaowen Cui, Tianyi Jiang, Yufei Pan, Yunkai Lin, Xiaofan Feng, Zhiwen Ding, Chun Yang, Yexiong Tan, Hongyang Wang, Liwei Dong

“…Here, we identified several compound candidates against CCA using a high-throughput drug screen with approved or emerging oncology drugs, among which kinesin spindle protein (KSP) inhibitors showed potent cytotoxic effects on CCA cells. …”
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Identification of KIFC1 as an independent prognostic marker in renal clear cell carcinoma correlates with tumor proliferation and immune infiltration by Bin Du, Jia Wang, Jinping Zheng, Jing Huo, Pu Wang

“…Practical prognostic markers remain to be discovered. Kinesin-like protein (KIFC1), a critical factor in maintaining the stability of the microtubule system, has significant prognostic value in some tumors. …”
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Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites by Xing Liang, Marcela Kokes, Richard D Fetter, Maria Danielle Sallee, Adrian W Moore, Jessica L Feldman, Kang Shen

“…The MTOC tracks the extending growth cone by kinesin-1/UNC-116-mediated endosome movements on distal plus-end-out microtubules and dynein clusters this advancing MTOC. …”
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