Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface by Yi-Wen Chang, T. Tony Yang, Min-Chun Chen, Y-geh Liaw, Chieh-Fan Yin, Xiu-Qi Lin-Yan, Ting-Yu Huang, Jen-Tzu Hou, Yi-Hsuan Hung, Chia-Lang Hsu, Hsuan-Cheng Huang, Hsueh-Fen Juan

“…Using a combination of spatial proteomics, interaction proteomics, and transcriptomics analyses, we find ATP synthase complex is first assembled in the mitochondria and subsequently delivered to the cell surface along the microtubule via the interplay of dynamin-related protein 1 (DRP1) and kinesin family member 5B (KIF5B). We further demonstrate that the mitochondrial membrane fuses to the plasma membrane in turn to anchor ATP syntheses on the cell surface using super-resolution imaging and real-time fusion assay in live cells. …”
Get full text

Generation of a human induced pluripotent stem cell line (SDUBMSi001-A) from a hereditary spastic paraplegia patient carrying kif1a c.773C>T missense mutation by Wang Xiaojing, Ma Yanyan, Duan Ruonan, Liu Xiaolin, Zhang Haiyan, Ma Jian, Liu Yi, Sun Wenjie, Liu Qiji

“…KIF1A gene encodes the kinesin 1a protein, an axonal motor protein participating in axonal transport. …”
Get full text

Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling by Gongsheng Yuan, Shu-ting Yang, Shuying Yang

“…Mechanistically, RGS12 overexpression in synovial fibroblasts increased the length and number of cilia but decreased the protein level of kinesin family member 2A (KIF2A). The results of LC-MS analyses showed that RGS12 interacted with MYC binding protein 2 to enhance its ubiquitination activity, through which the KIF2A protein was degraded in synovial fibroblasts. …”
Get full text

Generation of an iPSC line from a patient with spastic paraplegia type 10 carrying a novel mutation in KIF5A gene by Serena Santangelo, Patrizia Bossolasco, Stefania Magri, Claudia Colombrita, Sabrina Invernizzi, Cinzia Gellera, Lorenzo Nanetti, Daniela Di Bella, Vincenzo Silani, Franco Taroni, Antonia Ratti

“…We generated an iPSC line from a patient with spastic paraplegia type 10 (SPG10) carrying the novel missense variant c.50G > A (p.R17Q) in the N-terminal motor domain of the kinesin family member 5A (KIF5A) gene.This patient-derived in vitro cell model will help to investigate the role of different KIF5A mutations in inducing neurodegeneration in spastic paraplegia and in other KIF5A-related disorders, including Charcot-Marie-Tooth type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).…”
Get full text

Testing the ion-current model for flagellar length sensing and IFT regulation by Hiroaki Ishikawa, Jeremy Moore, Dennis R Diener, Markus Delling, Wallace F Marshall

“…The recent discovery that IFT entry into flagella is regulated by the phosphorylation of kinesin through a calcium-dependent protein kinase has provided further impetus for the ion-current model. …”
Get full text

The role of microtubules and the dynein/dynactin motor complex of host cells in the biogenesis of the Coxiella burnetii-containing vacuole. by Rodolfo M Ortiz Flores, Jesús S Distel, Milton O Aguilera, Walter Berón

“…The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex. The Rab7 adapter protein FYCO1 controls the anterograde transport of the endocytic compartments through the interaction with the kinesin KIF5. …”
Get full text

Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle by Jonathan S. Bogan, Jonathan S. Bogan, Jonathan S. Bogan

“…In adipocytes, TUGUL modifies a single protein, the KIF5B kinesin motor, which carries GLUT4 and other vesicle cargoes to the cell surface. …”
Get full text

Aspirin Exerts Its Antitumor Effect in Esophageal Squamous Cell Carcinoma by Downregulating the Expression of ATAD2 and KIF4A by Man Zhang, Zhenzhen Ren, Xianzeng Wang, Cong Liu, Zhaoyang Zheng, Junwei Zhao, Hongchun Liu

“…To investigate the expression of ATPase family AAA domain-containing protein 2 (ATAD2) and kinesin family member 4A (KIF4A) in esophageal squamous cell carcinoma (ESCC) tissues and their association with clinicopathological features and to explore the role of ATAD2 in regulating KIF4A expression and biological functions in ESCC cells and the effect of aspirin on their expression. …”
Get full text

Development and validation of a personalized classifier to predict the prognosis and response to immunotherapy in glioma based on glycolysis and the tumor microenvironment by Pengfei Fan, Jinjin Xia, Meifeng Zhou, Chao Zhuo, Hui He

“…Lastly, the effect of kinesin family member 20A (KIF20A) on the proliferation and migration of glioma cells was evaluated in vitro. …”
Get full text

Targeting cell cycle proteins in breast cancer cells with siRNA by using lipid-substituted polyethylenimines by Manoj eParmar, Hamid M. Aliabadi, Parvin eMahdipoor, Cezary eKucharski, Robert eMaranchuk, Judith C Hugh, Hasan eUludag

“…Using a library of siRNAs against cell cycle proteins, we identified cell division cycle protein 20 (CDC20), a recombinase RAD51, and serine-threonine protein kinase CHEK1 as effective targets for breast cancer therapy, and demonstrated their therapeutic potential in breast cancer MDA-MB-435, MDA-MB-231 and MCF7 cells with respect to another well-studied cell cycle protein, kinesin spindle protein. We also explored the efficacy of dicer-substrate siRNA (DsiRNA) against CDC20, RAD51 and CHEK1, where a particular DsiRNA against CDC20 showed an exceptionally high inhibition of cell growth in vitro. …”
Get full text

294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models by John Smith, Stefan Husted, Jay Pilrose, Disha Kuchangi, Stephanie C. Ems-McClung, Richard L. Carpenter, Claire E. Walczak

“…One potential target is the Kinesin 13 MCAK, which limits aneuploidy. METHODS/STUDY POPULATION: TCGA and GSE47561 databases were probed for MCAK expression, and data was stratified by subtype and survival statistics. …”
Get full text

KIF15 promotes the development and progression of chordoma via activating PI3K-AKT signalling pathway by Jinxing Yang, Lijun Liu, Xu Xu, Hui Zeng

“…Aims: Despite its implication in various human cancers, the expression and functional significance of Kinesin family member 15 (KIF15) in chordomas remain unexplored. …”
Get full text

iMotor-CNN : identifying molecular functions of cytoskeleton motor proteins using 2D convolutional neural network via Chou's 5-step rule by Le, Nguyen Quoc Khanh, Yapp, Edward Kien Yee, Ou, Yu-Yen, Yeh, Hui-Yuan

“…There are three superfamilies of cytoskeletal motor proteins with various molecular functions and structures: dynein, kinesin, and myosin. The functional loss of a specific motor protein molecular function has linked to a variety of human diseases, e.g., Charcot-Marie-Tooth disease, kidney disease. …”
Get full text

POPX2 phosphatase regulates cell polarity and centrosome placement by Hoon, Jing Ling

“…We observed that high POPX2 expression results in a reduced peripheral N-cadherin localization using immunofluorescence staining, and this is due to the inhibition of Kinesin-2 motor motility by POPX2. Consequently, this perturbs the localization of focal adhesions as well as Cdc42-Par6/PKCζ signaling, thus impairing proper centrosome orientation. …”
Get full text

The study of Drosophila melanogaster blue cheese (bchs) function in the involvement of autophagy in neurodegenerative disorders by Sim, Joan Poh Ling

“…Bchs is unlikely to be a motor protein adaptor mediating cargo assembly due to the absence of interaction with dynein or kinesin compared to APP-Iike interacting protein 1 (Aplipl). …”
Get full text

A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol: Two meta-analyses and a meta-regression analysis by Ference, B, Yoo, W, Flack, J, Clarke, M

“…Methods: We conducted a meta-analysis of the association between a common Trp719Arg polymorphism in the kinesin-like protein 6 (KIF6) gene and the risk of cardiovascular disease (CVD), and a meta-regression analysis to measure the effect modification of this polymorphism on the association between LDL cholesterol and the risk of CVD. …”

A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. by Lee, M, Daniels, M, Garnett, M, Venkitaraman, A

“…Moreover, its interaction with HMG20b, a protein of uncertain function containing a promiscuous DNA-binding domain and kinesin-like coiled coils, has been implicated in the G2-M transition. …”

KIF14 and citron kinase act together to promote efficient cytokinesis. by Gruneberg, U, Neef, R, Li, X, Chan, E, Chalamalasetty, R, Nigg, E, Barr, F

“…Multiple mitotic kinesins and microtubule-associated proteins (MAPs) act in concert to direct cytokinesis (Glotzer, M. 2005. …”

A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor by Lee, M, Daniels, M, Garnett, M, Venkitaraman, A

“…Moreover, its interaction with HMG20b, a protein of uncertain function containing a promiscuous DNA-binding domain and kinesin-like coiled coils, has been implicated in the G2-M transition. …”

Genes expression profiles in vascular cambium of Eucalyptus urophylla × Eucalyptus grandis at different ages by Guo Liu, Zhihua Wu, Jianzhong Luo, Chubiao Wang, Xiuhua Shang, Guowu Zhang

“…The DEGs encoding expansin, kinesin, cycline, PAL, GRP9, KNOX, C2C2-dof, REV, etc., were highly expressed in E. urograndis at three years old, leading to positive effects on growth and development. …”
Get full text