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441
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis
Published 2024-03-01“…This study is the first to perform extrachromosomal circular DNA (eccDNA) sequencing for MM, and it revealed that eccDNA induced PI resistance by amplifying kinesin family member 3 C (KIF3C) to reduce MUC20 expression in MM. …”
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442
DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway
Published 2023-02-01“…This study aimed to explore the effect of DEP domain 1 protein (DEPDC1) and kinesin super-family protein 4A (KIF4A) in OS and understand its mechanism. …”
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443
Microtubule acetylation dyshomeostasis in Parkinson’s disease
Published 2023-05-01“…Motor proteins like kinesins and dynein mechanistically regulate polarized anterograde (from the soma to the synapse) and retrograde (from the synapse to the soma) commute of the cargos, respectively. …”
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444
Prospects for single-molecule electrostatic detection in molecular motor gliding motility assays
Published 2021-01-01“…Molecular motor gliding motility assays based on myosin/actin or kinesin/microtubules are of interest for nanotechnology applications ranging from cargo-trafficking in lab-on-a-chip devices to novel biocomputation strategies. …”
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445
Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing
Published 2022-07-01“…Small-molecule activatable caged siRNAs were developed with the 5′-vitamin E-benzonobonadiene-modified antisense strand targeting the green fluorescent protein (GFP) gene and the mitotic kinesin-5 (Eg5) gene. The addition of tetrazine triggered the reaction with benzonobonadiene linker and induced the linker cleavage to release the active siRNA. …”
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446
Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk
Published 2023-10-01“…Multiple C2 And Transmembrane Domain Containing-1 (<i>MCTP1</i>)_rs4290997, Kinesin Family Member-7 (<i>KIF7</i>)_rs2350480, Coagulation Factor-II (<i>F2</i>)_rs2070850, Peroxisomal Biogenesis Factor-3 (<i>PEX3</i>)_rs223231, TBC1 Domain Family Member-22A (<i>TBC1D22A</i>)_rs910543, and Phospholipase A2 Group-IV-C (<i>PLA2G4C</i>)_rs7252136 interact with each other to have a threefold influence on PC. …”
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447
Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1
Published 2007-05-01“…<it>KIF21A </it>encodes a kinesin motor involved in anterograde axonal transport, and the familial and <it>de novo </it>mutations reported to date predictably alter one of only a few KIF21A amino acids – three within the third coiled-coil region of the stalk and one in the distal motor domain, suggesting they result in altered KIF21A function. …”
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448
Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis
Published 2024-04-01“…Additionally, we analyzed the infiltration levels of 28 immune cells in the expression profile and their relationship with the hub genes using single-sample gene set enrichment analysis.ResultsThree hub genes, namely, ribonucleotide reductase regulatory subunit M2 (RRM2), DLG-associated protein 5 (DLGAP5), and kinesin family member 11 (KIF11), were identified through WGCNA, LASSO, SVM-RFE, and RF algorithms. …”
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449
An Analysis Regarding the Association Between the Nuclear Pore Complex (NPC) and Hepatocellular Carcinoma (HCC)
Published 2023-06-01“…A series of experiments performed to explore the function of the Targeting protein for Xenopus kinesin-like protein 2 (TPX2) in HCC.Results: Patients with HCC can be divided into two NPC clusters. …”
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450
SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis
Published 2022-02-01“…Thereafter, bioinformatics analysis, RNA immunoprecipitation assay, luciferase reporter assay, and RNA pull-down assay were applied for determining the binding sites and binding capacities between SLCO4A1-AS1 and miR-4673 or kinesin family member 21B (KIF21B) and miR-4673. The results depicted that SLCO4A1-AS1 was upregulated in PC, and SLCO4A1-AS1 knockdown suppressed PC cell growth, migration, invasion, and induced cell apoptosis. …”
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451
miR-218-5p Targeting TPX2 Regulates p53 Pathway and Inhibits Malignant Progression of Lung Adenocarcinoma
Published 2023-10-01“…Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is highly expressed in a variety of cancer cells and may be associated with the progression of LUAD. …”
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452
Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum
Published 2022-04-01“…Puzzlingly, two distinct, non-overlapping functions for calsyntenins were proposed: As postsynaptic neurexin ligands in synapse formation, or as presynaptic kinesin adaptors in vesicular transport. Here, we show that, surprisingly, acute CRISPR-mediated deletion of calsyntenin-3 in mouse cerebellum in vivo causes a large decrease in inhibitory synapse, but a robust increase in excitatory parallel-fiber synapses in Purkinje cells. …”
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453
The regulation of KIF3A motor subunit by phosphorylation
Published 2018“…The Kinesin-2 family member KIF3 forms a heterotrimeric complex comprising the motor subunits KIF3A, KIF3B and the cargo carrying subunit KAP3. …”
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454
Intracellular trafficking of the invasion-promoting cell surface proteinase MT1-MMP
Published 2020“…Itoh’s research group and others have found that MT1-MMP cell surface exposure is achieved by intracellular trafficking of MT1-MMP-containing vesicles along microtubules and that kinesin superfamily motor proteins (KIFs) play a role. …”
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455
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
Published 2024-02-01“…Knockdown of components of other microtubule-associated motor protein complexes, including dynein and kinesin, also increased the formation of TDP-43 inclusions, indicating that intracellular transport along microtubules plays a key role in TDP-43 pathology. …”
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456
Death receptor 6 promotes ovarian cancer cell migration through KIF11
Published 2018-09-01“…Notably, mass spectrometric analysis indicated that DR6 co‐purified with kinesin family member 11 (KIF11), and we verified the interaction between KIF11 and DR6 by co‐immunoprecipitation and glutathione S‐transferase pull‐down. …”
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457
Improving Localized Radiotherapy for Glioblastoma via Small Molecule Inhibition of KIF11
Published 2023-06-01“…To achieve cell cycle arrest in mitosis we used ispinesib, a small molecule inhibitor to the mitotic kinesin, KIF11. Cell culture studies validated that ispinesib radiosensitized patient-derived GBM cells. …”
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458
Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
Published 2023-06-01“…In this study, we found that tetraploid cells are significantly more susceptible to inhibitors of a mitotic kinesin (CENP‐E) than are diploids. Treatment with a CENP‐E inhibitor preferentially diminished the tetraploid cell population in a diploid–tetraploid co‐culture at optimum conditions. …”
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459
RNA localization mechanisms transcend cell morphology
Published 2023-03-01“…In both cell types, the regulatory activity of this motif was dependent on it being in the 5′ UTR of the transcript, was abolished upon perturbation of the RNA-binding protein LARP1, and was reduced upon inhibition of kinesin-1. To extend these findings, we compared subcellular RNAseq data from neuronal and epithelial cells. …”
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460
Expanding the Knowledge of KIF1A-Dependent Disorders to a Group of Polish Patients
Published 2023-04-01“…Background: <i>KIF1A</i> (kinesin family member 1A)-related disorders encompass a variety of diseases. …”
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