MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis by Xiaobin Wang, Yingqing Shi, Hua Shi, Xiaoyu Liu, Aijun Liao, Zhuogang Liu, Robert Z. Orlowski, Rui Zhang, Huihan Wang

“…This study is the first to perform extrachromosomal circular DNA (eccDNA) sequencing for MM, and it revealed that eccDNA induced PI resistance by amplifying kinesin family member 3 C (KIF3C) to reduce MUC20 expression in MM. …”
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DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway by Mingming Yang, Hang Zhang, Shichang Gao, Wei Huang

“…This study aimed to explore the effect of DEP domain 1 protein (DEPDC1) and kinesin super-family protein 4A (KIF4A) in OS and understand its mechanism. …”
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Microtubule acetylation dyshomeostasis in Parkinson’s disease by Padmashri Naren, Khan Sabiya Samim, Kamatham Pushpa Tryphena, Lalitkumar K. Vora, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri

“…Motor proteins like kinesins and dynein mechanistically regulate polarized anterograde (from the soma to the synapse) and retrograde (from the synapse to the soma) commute of the cargos, respectively. …”
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Prospects for single-molecule electrostatic detection in molecular motor gliding motility assays by M Sanchez Miranda, R Lyttleton, P H Siu, S Diez, H Linke, A P Micolich

“…Molecular motor gliding motility assays based on myosin/actin or kinesin/microtubules are of interest for nanotechnology applications ranging from cargo-trafficking in lab-on-a-chip devices to novel biocomputation strategies. …”
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Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing by Xueli Zhang, Amu Gubu, Jianfei Xu, Ning Yan, Wenbo Su, Di Feng, Qian Wang, Xinjing Tang

“…Small-molecule activatable caged siRNAs were developed with the 5′-vitamin E-benzonobonadiene-modified antisense strand targeting the green fluorescent protein (GFP) gene and the mitotic kinesin-5 (Eg5) gene. The addition of tetrazine triggered the reaction with benzonobonadiene linker and induced the linker cleavage to release the active siRNA. …”
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Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk by Yong-Hwa Lee, Sunmin Park

“…Multiple C2 And Transmembrane Domain Containing-1 (<i>MCTP1</i>)_rs4290997, Kinesin Family Member-7 (<i>KIF7</i>)_rs2350480, Coagulation Factor-II (<i>F2</i>)_rs2070850, Peroxisomal Biogenesis Factor-3 (<i>PEX3</i>)_rs223231, TBC1 Domain Family Member-22A (<i>TBC1D22A</i>)_rs910543, and Phospholipase A2 Group-IV-C (<i>PLA2G4C</i>)_rs7252136 interact with each other to have a threefold influence on PC. …”
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Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1 by Gutowski Nicholas J, Pott Jan WR, Traboulsi Elias I, Yazdani Ahmad, Hunter David G, Geraghty Michael T, Lyons Christopher, Armstrong Linlea, Fredrick Douglas, Dragan Laryssa, Andrews Caroline, Chan Wai-Man, Ellard Sian, Young Elizabeth, Hanisch Frank, Koc Feray, Schnall Bruce, Engle Elizabeth C

“…<it>KIF21A </it>encodes a kinesin motor involved in anterograde axonal transport, and the familial and <it>de novo </it>mutations reported to date predictably alter one of only a few KIF21A amino acids – three within the third coiled-coil region of the stalk and one in the distal motor domain, suggesting they result in altered KIF21A function. …”
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Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis by Ying-Kai Wu, Ying-Kai Wu, Cai-De Liu, Chao Liu, Jun Wu, Zong-Gang Xie

“…Additionally, we analyzed the infiltration levels of 28 immune cells in the expression profile and their relationship with the hub genes using single-sample gene set enrichment analysis.ResultsThree hub genes, namely, ribonucleotide reductase regulatory subunit M2 (RRM2), DLG-associated protein 5 (DLGAP5), and kinesin family member 11 (KIF11), were identified through WGCNA, LASSO, SVM-RFE, and RF algorithms. …”
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An Analysis Regarding the Association Between the Nuclear Pore Complex (NPC) and Hepatocellular Carcinoma (HCC) by Huang P, Hu YD, Liu YJ, Li JP, Zhang YH

“…A series of experiments performed to explore the function of the Targeting protein for Xenopus kinesin-like protein 2 (TPX2) in HCC.Results: Patients with HCC can be divided into two NPC clusters. …”
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SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis by Zhang Jianxin, Shen Yanbing, Ma Dandan, Li Zhonghu, Zhang Zhiyong, Jin Weidong

“…Thereafter, bioinformatics analysis, RNA immunoprecipitation assay, luciferase reporter assay, and RNA pull-down assay were applied for determining the binding sites and binding capacities between SLCO4A1-AS1 and miR-4673 or kinesin family member 21B (KIF21B) and miR-4673. The results depicted that SLCO4A1-AS1 was upregulated in PC, and SLCO4A1-AS1 knockdown suppressed PC cell growth, migration, invasion, and induced cell apoptosis. …”
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miR-218-5p Targeting TPX2 Regulates p53 Pathway and Inhibits Malignant Progression of Lung Adenocarcinoma by Jiangong XU

“…Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is highly expressed in a variety of cancer cells and may be associated with the progression of LUAD. …”
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Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum by Zhihui Liu, Man Jiang, Kif Liakath-Ali, Alessandra Sclip, Jaewon Ko, Roger Shen Zhang, Thomas C Südhof

“…Puzzlingly, two distinct, non-overlapping functions for calsyntenins were proposed: As postsynaptic neurexin ligands in synapse formation, or as presynaptic kinesin adaptors in vesicular transport. Here, we show that, surprisingly, acute CRISPR-mediated deletion of calsyntenin-3 in mouse cerebellum in vivo causes a large decrease in inhibitory synapse, but a robust increase in excitatory parallel-fiber synapses in Purkinje cells. …”
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The regulation of KIF3A motor subunit by phosphorylation by Chen, Kunning

“…The Kinesin-2 family member KIF3 forms a heterotrimeric complex comprising the motor subunits KIF3A, KIF3B and the cargo carrying subunit KAP3. …”
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Intracellular trafficking of the invasion-promoting cell surface proteinase MT1-MMP by Gifford, V

“…Itoh’s research group and others have found that MT1-MMP cell surface exposure is achieved by intracellular trafficking of MT1-MMP-containing vesicles along microtubules and that kinesin superfamily motor proteins (KIFs) play a role. …”

Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD by Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, Osamu Onodera, Hideki Mochizuki, Toshiki Mizuno, Keiji Wada, Yoshitaka Nagai

“…Knockdown of components of other microtubule-associated motor protein complexes, including dynein and kinesin, also increased the formation of TDP-43 inclusions, indicating that intracellular transport along microtubules plays a key role in TDP-43 pathology. …”
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Death receptor 6 promotes ovarian cancer cell migration through KIF11 by Bianhua Shi, Jiayu Bao, Yongbin Liu, Juan Shi

“…Notably, mass spectrometric analysis indicated that DR6 co‐purified with kinesin family member 11 (KIF11), and we verified the interaction between KIF11 and DR6 by co‐immunoprecipitation and glutathione S‐transferase pull‐down. …”
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Improving Localized Radiotherapy for Glioblastoma via Small Molecule Inhibition of KIF11 by Miranda M. Tallman, Abigail A. Zalenski, Ian Stabl, Morgan S. Schrock, Luke Kollin, Eliane de Jong, Kuntal De, Treg M. Grubb, Matthew K. Summers, Monica Venere

“…To achieve cell cycle arrest in mitosis we used ispinesib, a small molecule inhibitor to the mitotic kinesin, KIF11. Cell culture studies validated that ispinesib radiosensitized patient-derived GBM cells. …”
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Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells by Koya Yoshizawa, Akira Matsura, Masaya Shimada, Sumire Ishida‐Ishihara, Fuyu Sato, Takahiro Yamamoto, Kan Yaguchi, Eiji Kawamoto, Taruho Kuroda, Kazuya Matsuo, Nobuyuki Tamaoki, Ryuichi Sakai, Yasuhito Shimada, Mithilesh Mishra, Ryota Uehara

“…In this study, we found that tetraploid cells are significantly more susceptible to inhibitors of a mitotic kinesin (CENP‐E) than are diploids. Treatment with a CENP‐E inhibitor preferentially diminished the tetraploid cell population in a diploid–tetraploid co‐culture at optimum conditions. …”
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RNA localization mechanisms transcend cell morphology by Raeann Goering, Ankita Arora, Megan C Pockalny, J Matthew Taliaferro

“…In both cell types, the regulatory activity of this motif was dependent on it being in the 5′ UTR of the transcript, was abolished upon perturbation of the RNA-binding protein LARP1, and was reduced upon inhibition of kinesin-1. To extend these findings, we compared subcellular RNAseq data from neuronal and epithelial cells. …”
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Expanding the Knowledge of KIF1A-Dependent Disorders to a Group of Polish Patients by Justyna Paprocka, Aleksandra Jezela-Stanek, Robert Śmigiel, Anna Walczak, Hanna Mierzewska, Anna Kutkowska-Kaźmierczak, Rafał Płoski, Ewa Emich-Widera, Barbara Steinborn

“…Background: <i>KIF1A</i> (kinesin family member 1A)-related disorders encompass a variety of diseases. …”
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