Gene Expression and Photophysiological Changes in <i>Pocillopora acuta</i> Coral Holobiont Following Heat Stress and Recovery by Rosa Celia Poquita-Du, Yi Le Goh, Danwei Huang, Loke Ming Chou, Peter A. Todd

“…Significant changes in gene expression levels of selected genes of interest (GOI) were observed following heat exposure and stress removal among sites and colonies, including <i>Actin</i>, calcium/calmodulin-dependent protein kinase type IV (<i>Camk4</i>), kinesin-like protein (<i>KIF9</i>), and small heat shock protein 16.1 (<i>Hsp16.1</i>). …”
Get full text

Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes by Blaker-Lee, Alicia, Gupta, Sunny, McCammon, Jasmine M., De Rienzo, Gianluca, Sive, Hazel L.

“…In a screen for 16p11.2 genes whose function is sensitive to hemizygosity, the aldolase a (aldoaa) and kinesin family member 22 (kif22) genes were identified as giving clear phenotypes when RNA levels were reduced by ~50%, suggesting that these genes are deletion dosage sensors. …”
Get full text
Get full text

Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling by Morthorst, Stine Kjær, Nielsen, Camilla, Farinelli, Pietro, Anvarian, Zeinab, Rasmussen, Christina Birgitte R., Serra-Marques, Andrea, Grigoriev, Ilya, Altelaar, Maarten, Fürstenberg, Nicoline, Ludwig, Alexander, Akhmanova, Anna, Christensen, Søren Tvorup, Pedersen, Lotte Bang

“…The kinesin-3 motor KIF13B functions in endocytosis, vesicle transport and regulation of ciliary length and signaling. …”
Get full text

Physiological and molecular effects of gibberellic acid and paclobutrazol on young clonal palm growth and development by Chai, Sook Keat

“…Higher expression of the growth suppressor RCC and two- to eight-fold lower expression of cytoskeletal motor genes actin 3 and kinesin 3, cellulose synthase CESA2, pectin activator WAK3 and pectin lyase-like suggested that PBZ may suppressed cell expansion in leaves by enhancing secondary cell wall rigidity in oil palm. …”
Get full text

Transcriptome and metabolome analyses reveal the key genes related to grain size of big grain mutant in Tartary Buckwheat (Fagopyrum tartaricum) by Xiaomei Fang, Xiaomei Fang, Yingqian Wang, Jingbin Cui, Linqing Yue, Aohua Jiang, Jiaqi Liu, Yichao Wu, Xingxing He, Chunhua Li, Jian Zhang, Jian Zhang, Mengqi Ding, Mengqi Ding, Zelin Yi, Zelin Yi

“…Using a combined comprehensive analysis, we identified 24 potential candidate genes that encode E3 ubiquitin-protein ligase HIP1, EMBRYO-DEFECTIVE (EMB) protein, receptor-like protein kinase FERONIA (FER), kinesin-4 protein SRG1, and so on, which may be associated with the big-grain mutant bg1. …”
Get full text

Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A by Yanan Zhu, Chunling Ma, Aiai Lv, Changwei Kou

“…Here, we intended to investigate role and mechanism of circ_0010235 in NSCLC proliferation, migration and invasion.Methods and results Expression of circ_0010235, microRNA (miR)-338-3p and kinesin family member 2A (KIF2A) was detected by quantitative real-time PCR, western blotting and immunohistochemistry (IHC). …”
Get full text

Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis by Yun-Hua Ji, Lin-Meng Wang, Fu-Xun Zhang, Hao-Zhong Hou, Zhi-Rong Luo, Qi Xue, Man-Man Shi, Yong Jiao, Dong Cui, Da-Li He, Wei Xue, Yu-qi Wen, Qi-Sheng Tang, Bo Zhang

“…Hypobaric hypoxia downregulates the genes controlling granule secretion and organic matter biosynthesis, upregulates tektin 1 (TEKT1) and kinesin family member 2C (KIF2C), and downregulates 60S ribosomal protein 11 (RPL11) and cilia- and flagella-associated protein 206 (CFAP206). …”
Get full text

EGFR‐mediated hyperacetylation of tubulin induced docetaxel resistance by downregulation of HDAC6 and upregulation of MCAK and PLK1 in prostate cancer cells by Yeong‐Shiau Pu, Chao‐Yuan Huang, Hung‐Lin Wu, Jyun‐Hong Wu, Ying‐Fang Su, Chang‐Tze Ricky Yu, Chi‐Yu Lu, Wen‐Jeng Wu, Shu‐Pin Huang, Ying‐Tang Huang, Tzyh‐Chyuan Hour

“…PC/DX25 with greater resistance to docetaxel had higher levels of acetyl‐tubulin and mitotic centromere‐associated kinesin (MCAK) than PC3 cells. This study found that docetaxel induced the expression of acetyl‐tubulin and MCAK in PC3 cells at a dose‐ and time‐dependent manner. …”
Get full text

KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo by Albert Hiu Ka Fok, Yuhua Huang, Beth Wing Lam So, Qiyu Zheng, Chun Sing Carlos Tse, Xiaoyang Li, Kenneth Kin-Yip Wong, Jiandong Huang, Kwok-On Lai, Cora Sau Wan Lai

“…Summary: Kinesin 1 (KIF5) is one major type of motor protein in neurons, but its members’ function in the intact brain remains less studied. …”
Get full text

Mechanism of miR‐424‐5p promoter methylation in promoting epithelial–mesenchymal transition of hepatocellular carcinoma cells by Hong‐Cheng Lv, Yan‐Yan Lv, Gang Wang, Xie‐Hua Zhang, Sheng‐Nan Li, Xiao‐Fen Yue, Wei Lu

“…Dual‐luciferase reporter assay further validated that miR‐424‐5p bound to the kinesin family member 2A (KIF2A), and miR‐424‐5p overexpression downregulated KIF2A. …”
Get full text

TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5 by Miaomiao Hao, Miaomiao Hao, Jie Zhang, Mingfang Sun, Kexin Diao, Jian Wang, Shiping Li, Qixue Cao, Shundong Dai, Xiaoyi Mi

“…By studying the relationship between TRAF4 and Eg5, a member of the kinesin family that plays a critical role in spindle assembly, we demonstrated that TRAF4 regulated Eg5 ubiquitination and contributed to Eg5-mediated breast cancer proliferation and inhibited breast cancer apoptosis. …”
Get full text

Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor by Linghao Cai, Bo Shi, Kun Zhu, Xiaohui Zhong, Dengming Lai, Jinhu Wang, Jinfa Tou

“…Top 12 genes were identified for further study after constructing a PPI network and screening hub gene modules. Kinesin family member 2C (KIF2C) was identified as the most significant gene predicting the overall survival of WT patients. …”
Get full text

Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains by Elaine L. Bearer, Elaine L. Bearer, Christopher S. Medina, Taylor W. Uselman, Russell E. Jacobs

“…Mn(II), a contrast agent for MRI, enters neurons through voltage-activated calcium channels and relies on kinesin-1 and amyloid-precursor protein to transport out axons to distal destinations. …”
Get full text

Association of variants in the KIF1A gene with amyotrophic lateral sclerosis by Panlin Liao, Yanchun Yuan, Zhen Liu, Xiaorong Hou, Wanzhen Li, Jin Wen, Kexuan Zhang, Bin Jiao, Lu Shen, Hong Jiang, Jifeng Guo, Beisha Tang, Zhuohua Zhang, Zhonghua Hu, Junling Wang

“…Notably, sensory and motor neuron diseases such as hereditary sensory and autonomic neuropathy type 2 (HSAN2) and spastic paraplegia 30 (SPG30) share several causative genes with ALS, as well as having common clinical phenotypes. KIF1A encodes a kinesin 3 motor that transports presynaptic vesicle precursors (SVPs) and dense core vesicles and has been reported as a causative gene for HSAN2 and SPG30. …”
Get full text

Genome-wide analyses identify KIF5A as a novel ALS gene by Nicolas, A, Kenna, KP, Renton, AE, Ticozzi, N, Faghri, F, Chia, R, Dominov, JA, Kenna, BJ, Nalls, MA, Keagle, P, Rivera, AM, Van Rheenen, W, Murphy, NA, Van Vugt, JJFA, Geiger, JT, Van Der Spek, RA, Pliner, HA, Shankaracharya, Smith, BN, Marangi, G, Topp, SD, Abramzon, Y, Gkazi, AS, Eicher, JD, Kenna, A, Italsgen Consortium, Mora, G, Calvo, A, Mazzini, L, Riva, N, Mandrioli, J, Caponnetto, C, Battistini, S, Volanti, P, La Bella, V, Conforti, FL, Borghero, G, Messina, S, Simone, IL, Trojsi, F, Salvi, F, Logullo, FO, D'Alfonso, S, Corrado, L, Capasso, M, Ferrucci, L, Genomic Translation For ALS Care (GTAC) Consortium, Moreno, CDAM, Kamalakaran, S, Goldstein, DB, ALS Sequencing Consortium, Gitler, AD, Harris, T, Myers, RM, NYGC ALS Consortium, Phatnani, H, Musunuri, RL, Evani, US, Abhyankar, A, Zody, MC, Answer ALS Foundation, Kaye, J, Finkbeiner, S, Wyman, SK, Lenail, A, Lima, L, Fraenkel, E, Svendsen, CN, Thompson, LM, Van Eyk, JE, Berry, JD, Miller, TM, Kolb, SJ, Cudkowicz, M, Baxi, E, Clinical Research In ALS And Related Disorders For Therapeutic Development (CREATE) Consortium, Benatar, M, Taylor, JP, Rampersaud, E, Wu, G, Wuu, J, Slagen Consortium, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, GP, Sorarù, G, Cereda, C, French ALS Consortium, Corcia, P, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, RW, Sidle, KC, Malaspina, A, Hardy, J, Singleton, AB, Johnson, JO, Arepalli, S, Sapp, PC, McKenna-yasek, D, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, De Belleroche, J, Baas, F, Asbroek, ALMA, Muñoz-Blanco, JL, Hernandez, DG, Ding, J, Gibbs, JR, Scholz, SW, Floeter, MK, Campbell, RH, Landi, F, Bowser, R, Pulst, SM, Ravits, JM, Macgowan, DJL, Kirby, J, Pioro, EP, Pamphlett, R, Broach, J, Gerhard, G, Dunckley, TL, Brady, CB, Kowall, NW, Troncoso, JC, Le Ber, I, Mouzat, K, Lumbroso, S, Heiman-Patterson, TD, Kamel, F, Van Den Bosch, L, Baloh, RH, Strom, TM, Meitinger, T, Shatunov, A, Van Eijk, KR, De Carvalho, M, Kooyman, M, Middelkoop, B, Moisse, M, McLaughlin, RL, Van Es, MA, Weber, M, Boylan, KB, Van Blitterswijk, M, Rademakers, R, Morrison, KE, Basak, AN, Mora, JS, Drory, VE, Shaw, PJ, Turner, MR, Talbot, K, Hardiman, O, Williams, KL, Fifita, JA, Nicholson, GA, Blair, IP, Rouleau, GA, Esteban-Pérez, J, García-Redondo, A, Al-Chalabi, A, Project Mine ALS Sequencing Consortium, Rogaeva, E, Zinman, L, Ostrow, LW, Maragakis, NJ, Rothstein, JD, Simmons, Z, Cooper-Knock, J, Brice, A, Goutman, SA, Feldman, EL, Gibson, SB, Taroni, F, Ratti, A, Gellera, C, Van Damme, P, Robberecht, W, Fratta, P, Sabatelli, M, Lunetta, C, Ludolph, AC, Andersen, PM, Weishaupt, JH, Camu, W, Trojanowski, JQ, Van Deerlin, VM, Brown, RH, Van Den Berg, LH, Veldink, JH, Harms, MB, Glass, JD, Stone, DJ, Tienari, P, Silani, V, Chiò, A, Shaw, CE, Traynor, BJ, Landers, JE

“…Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. …”

Single-cell transcriptomics reveals the role of Macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma by Zhuomao Mo, Daiyuan Liu, Yihan Chen, Jin Luo, Wenjing Li, Jiahui Liu, Ling Yu, Bijun Huang, Shijun Zhang

“…Based on the MNT score, five relevant drugs (inhibitor of polo-like kinase 1, inhibitor of kinesin family member 11, dabrafenib, ispinesib, and epothilone-b) were predicted. …”
Get full text

KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway by Hao Deng, Xiaobo Gong, Guanghai Ji, Chenglong Li, Shaoping Cheng

“…Recently, more attention was paid to the functions of Kinesin family member 2C (KIF2C) in cancer progression, while the specific function of KIF2C in ccRCC has not been sufficiently elucidated. …”
Get full text

Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma by Xiaofeng Zuo, Peixin Meng, Yuxin Bao, Chuntao Tao, Yitao Wang, Xianjun Liu, Youquan Bu, Jiang Zhu

“…Protein–protein interaction (PPI) network analysis identified a 15 hub-gene core network with overexpressed kinesin family member 2C (KIF2C) as a central regulator. …”
Get full text

Comprehensive Pan-Cancer Analysis of KIF18A as a Marker for Prognosis and Immunity by Ting Liu, Kun Yang, Jiamin Chen, Liming Qi, Xingang Zhou, Peng Wang

“…KIF18A belongs to the Kinesin family, which participates in the occurrence and progression of tumors. …”
Get full text

TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs by Hongbo Wang, Fang Chu, Xiao-feng Zhang, Peng Zhang, Li-xin Li, Yun-long Zhuang, Xiao-feng Niu, Xi He, Zhi-jie Li, Ying Bai, Da Mao, Zhen-wen Liu, Da-li Zhang, Bo-an Li

“…The target protein for the Xenopus plus end-directed kinesin-like protein (Xklp2) known as TPX2 that was previously considered as a tubulin regulator, also functions as the regulator of some transcription factors and pro-oncogenes in human malignances. …”
Get full text