KIF5A upregulation in hepatocellular carcinoma: A novel prognostic biomarker associated with unique tumor microenvironment status by Qi Liu, Qi Liu, Yu-yang Liu, Xue-min Chen, Xue-min Chen, Bing-yan Tao, Kuang Chen, Wei-min Li, Wei-min Li, Chang-tao Xu, Chang-tao Xu, Ying Shi, Hao Li, Hao-run Liu, Hao-run Liu

“…Thus, it is crucial to identify potential biomarker that is capable of accurately predicting the prognosis and therapeutic response of LIHC. Kinesin family member 5A (KIF5A) is a microtubule-based motor protein involved in the transport of macromolecules such as organelle proteins in cells. …”
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KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer by Shanshan Liu, Ziwei Ye, Vivian Weiwen Xue, Qi Sun, Huan Li, Desheng Lu

“…Abstract Background The kinesin-13 family member 2C (KIF2C) is a versatile protein participating in many biological processes. …”
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Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant by Kelly A. Rich, Megan G. Pino, Mehmet E. Yalvac, Ashley Fox, Hallie Harris, Maria H.H. Balch, W. David Arnold, Stephen J. Kolb

“…Kinesin family member 5A (KIF5A) is an essential, neuron-specific microtubule-associated motor protein responsible for the anterograde axonal transport of various cellular cargos. …”
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Forkhead box O6 (FoxO6) promotes cardiac pathological remodeling and dysfunction by activating Kif15–TGF‐β1 under aggravated afterload by Bing Zhang, Lei Shi, Yanzhen Tan, Yenong Zhou, Jun Cui, Yujie Song, Yingying Liu, Miao Zhang, Weixun Duan, Zhenxiao Jin, Jincheng Liu, Dinghua Yi, Yang Sun, Wei Yi

“…Further studies identified kinesin family member 15 (Kif15) as downstream molecule of FoxO6. …”
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Regulation of <i>KIF2A</i> by Antitumor <i>miR-451a</i> Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma by Akifumi Uchida, Naohiko Seki, Keiko Mizuno, Yasutaka Yamada, Shunsuke Misono, Hiroki Sanada, Naoko Kikkawa, Tomohiro Kumamoto, Takayuki Suetsugu, Hiromasa Inoue

“…Among these targets, high kinesin family member 2A (<i>KIF2A</i>) expression was significantly associated with poor prognosis (overall survival: <i>p</i> = 0.043, disease-free survival: <i>p</i> = 0.028). …”
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Molecular Mapping of Biofortification Traits in Bread Wheat (<i>Triticum aestivum</i> L.) Using a High-Density SNP Based Linkage Map by Vasudha Jadon, Shashi Sharma, Hari Krishna, Gopalareddy Krishnappa, Rahul Gajghate, Narayana Bhat Devate, Kusuma Kumari Panda, Neelu Jain, Pradeep Kumar Singh, Gyanendra Pratap Singh

“…In silico analysis revealed that the key putative candidate genes such as P-loop containing nucleoside triphosphatehydrolase, Nodulin-like protein, NAC domain, Purine permease, Zinc-binding ribosomal protein, Cytochrome P450, Protein phosphatase 2A, Zinc finger CCCH-type, and Kinesin motor domain were located within the identified QTL regions and these putative genes are involved in the regulation of iron homeostasis, zinc transportation, Fe, Zn, and protein remobilization to the developing grain, regulation of grain size and shape, and increased nitrogen use efficiency. …”
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Whole-Genome Sequencing Identifies a Rice Grain Shape Mutant, gs9–1 by Liangrong Jiang, Guotian Li, Mawsheng Chern, Rashmi Jain, Nhan T. Pham, Joel A. Martin, Wendy S. Schackwitz, Juan Zhao, Deling Ruan, Rongyu Huang, Jingsheng Zheng, Pamela C. Ronald

“…This locus is a new allele of the BC12/GDD1/MTD1 gene that encodes a kinesin-like protein involved in cell-cycle progression, cellulose microfibril deposition and gibberellic acid (GA) biosynthesis. …”
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Identification of Alternative Splicing Events Associated with Paratuberculosis in Dairy Cattle Using Multi-Tissue RNA Sequencing Data by Houcheng Li, Jinfeng Huang, Junnan Zhang, Yahui Gao, Bo Han, Dongxiao Sun

“…Of note, six DAS events were highly and significantly correlated with the DESFs (<i>R</i>² > 0.9; <i>p</i> < 0.01), and their corresponding genes (<i>COPI coat complex subunit gamma 2</i><i>gene</i> (<i>COPG2</i>), <i>kinesin family member 2C gene</i> (<i>KIF2C</i>), <i>exocyst complex component 7</i> (<i>EXOC7</i>), <i>Rab9 effector protein with kelch motifs gene</i> (<i>RABEPK</i>), <i>deoxyribonuclease 1 gene</i> (<i>DNASE1</i>) and <i>early endosome antigen 1</i><i>gene</i> (<i>EEA1</i>)) were significantly enriched in immune response such as vesicle-mediated transport, regulation of acute inflammatory response and tuberculosis through gene ontology (GO) and KEGG analysis. …”
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Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth by Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals

“…We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. …”
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A bioinformatics analysis of the clinicopathological and prognostic significance of FAM64A mRNA expression in gynecological cancers by Hua-Chuan Zheng, Dong-Hui Ren, Cong-Yu Zhang, Ying Chen, Li Zhang

“…Top hub genes primarily included cell cycle-related proteins in breast cancer, mucins and acetylgalactosaminyl transferases in cervical cancer, kinesin family members in endometrial cancer, and synovial sarcoma X and the cancer/testis antigen in ovarian cancer. …”
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Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex by Yue Qu, Ines Hahn, Meredith Lees, Jill Parkin, André Voelzmann, Karel Dorey, Alex Rathbone, Claire T Friel, Victoria J Allan, Pilar Okenve-Ramos, Natalia Sanchez-Soriano, Andreas Prokop

“…They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmental disorders linked to the mammalian kinesin Kif21A. How cortical collapse factors influence axon growth is little understood. …”
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KIFC1 Is Associated with Basal Type, Cisplatin Resistance, PD-L1 Expression and Poor Prognosis in Bladder Cancer by Yohei Sekino, Quoc Thang Pham, Kohei Kobatake, Hiroyuki Kitano, Kenichiro Ikeda, Keisuke Goto, Tetsutaro Hayashi, Hikaru Nakahara, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Jun Teishima, Nobuyuki Hinata

“…Kinesin family member C1 (<i>KIFC1</i>), a minus end-directed motor protein, is reported to play an essential role in cancer. …”
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Multi-omics analysis reveals the association between elevated KIF18B expression and unfavorable prognosis, immune evasion, and regulatory T cell activation in nasopharyngeal carcin... by Siqi Tang, Zhenyu Wu, Lusi Chen, Longjiang She, Weihan Zuo, Weijun Luo, Yang Zhang, Shaoqiang Liang, Guichao Liu, Biyi He, Jinfeng He, Ning Zhang

“…The expression profile and functions of kinesin family member 18B (KIF18B) remain unclear in NPC.MethodsBulk and single-cell transcriptome data for NPC were downloaded. …”
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Biallelic Variants in <i>KIF17</i> Associated with Microphthalmia and Coloboma Spectrum by Antonella Riva, Antonella Gambadauro, Valeria Dipasquale, Celeste Casto, Maria Domenica Ceravolo, Andrea Accogli, Marcello Scala, Giorgia Ceravolo, Michele Iacomino, Federico Zara, Pasquale Striano, Caterina Cuppari, Gabriella Di Rosa, Maria Concetta Cutrupi, Vincenzo Salpietro, Roberto Chimenz

“…The <i>KIF17</i> gene encodes the kinesin-like protein Kif17, a microtubule-based, ATP-dependent, motor protein that is pivotal for outer segment development and disc morphogenesis in different animal models, including mice and zebrafish. …”
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Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes by Jian Huang, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Linsheng Zhong, Xiaohu Zhou, Qiong Shi, Gang Lv, Jiadai Chenyu, Yidan Xia Abuliezi, Duo Yu, Xuejiao Jiang, Mallu Chenna Reddy, Namrta Choudhry, Naganna Nimishetti, Dun Yang

“…Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease. …”
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Identification of prognostic and therapeutic biomarkers in type 2 papillary renal cell carcinoma by Yue Wang, Xi Tian, Shu-Xuan Zhu, Wen-Hao Xu, Aihetaimujiang Anwaier, Jia-Qi Su, Hua-Lei Gan, Yuan-Yuan Qu, Jian-Yuan Zhao, Hai-Liang Zhang, Ding-Wei Ye

“…Higher expression level of TPX2 was significantly associated with worse overall survival in PRCC2 and kinesin family genes expression were found significantly elevated in high risk PRCC2. …”
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Targeting the Id1-Kif11 Axis in Triple-Negative Breast Cancer Using Combination Therapy by Archana P. Thankamony, Reshma Murali, Nitheesh Karthikeyan, Binitha Anu Varghese, Wee S. Teo, Andrea McFarland, Daniel L. Roden, Holly Holliday, Christina Valbirk Konrad, Aurelie Cazet, Eoin Dodson, Jessica Yang, Laura A. Baker, Jason T. George, Herbert Levine, Mohit Kumar Jolly, Alexander Swarbrick, Radhika Nair

“…In order to understand the molecular underpinning of Id proteins on the cell cycle phenotype, we carried out a large-scale small interfering RNA (siRNA) screen of 61 putative targets identified by using genomic analysis of two Id TNBC tumor models. Kinesin Family Member 11 (<i>Kif11</i>) and Aurora Kinase A (<i>Aurka</i>), which are critical cell cycle regulators, were further validated as Id targets. …”
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Genome-wide association study of feed conversion ratio in turbot (Scophthalmus maximus) based on genome resequencing by Zhifeng Liu, Haowen Chang, Fei Xu, Haichi Zhao, Liguang Zhu, Zhibin Sun, Mingchao Yang, Xinan Wang, Aijun Ma

“…According to their localization in genome, four candidate genes were identified on Chr6, including uncharacterized protein KIAA1755, Kinesin Family Member 21B (KIF21B), Discs large homolog-associated protein 4B (DLGAP4B), and Copine 5B (CPNE5B), all of which are closely located in the genome and exhibit significant functional similarities. …”
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Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1 by Lin Gao, Wenbin Zhou, Ni Xie, Junying Qiu, Jingyi Huang, Zhe Zhang, Malin Hong, Jinquan Xia, Jing Xu, Pan Zhao, Li Fu, Yuwei Luo, Jing Jiang, Hui Gong, Jigang Wang, Yong Dai, Dixian Luo, Chang Zou

“…Recently, we reported that kinectin 1 (KTN1), a member of the kinesin‐binding protein family, promotes cell invasion of triple‐negative breast cancer and high‐grade breast cancer cells by augmenting the NF‐κB signaling pathway. …”
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Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging by Martin Neukam, Pia Sala, Andreas-David Brunner, Katharina Ganß, Alessandra Palladini, Michal Grzybek, Oleksandra Topcheva, Jovana Vasiljević, Johannes Broichhagen, Kai Johnsson, Thomas Kurth, Matthias Mann, Ünal Coskun, Michele Solimena

“…We find that the lipid composition changes over time, along with the physical properties of the membrane, and that kinesin-1 heavy chain (KIF5b) as well as Ras-related protein 3a (RAB3a) associate preferentially with younger granules. …”
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