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501
KIF5A upregulation in hepatocellular carcinoma: A novel prognostic biomarker associated with unique tumor microenvironment status
Published 2023-01-01“…Thus, it is crucial to identify potential biomarker that is capable of accurately predicting the prognosis and therapeutic response of LIHC. Kinesin family member 5A (KIF5A) is a microtubule-based motor protein involved in the transport of macromolecules such as organelle proteins in cells. …”
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502
KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer
Published 2023-04-01“…Abstract Background The kinesin-13 family member 2C (KIF2C) is a versatile protein participating in many biological processes. …”
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503
Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant
Published 2023-06-01“…Kinesin family member 5A (KIF5A) is an essential, neuron-specific microtubule-associated motor protein responsible for the anterograde axonal transport of various cellular cargos. …”
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504
Forkhead box O6 (FoxO6) promotes cardiac pathological remodeling and dysfunction by activating Kif15–TGF‐β1 under aggravated afterload
Published 2023-10-01“…Further studies identified kinesin family member 15 (Kif15) as downstream molecule of FoxO6. …”
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505
Regulation of <i>KIF2A</i> by Antitumor <i>miR-451a</i> Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma
Published 2019-02-01“…Among these targets, high kinesin family member 2A (<i>KIF2A</i>) expression was significantly associated with poor prognosis (overall survival: <i>p</i> = 0.043, disease-free survival: <i>p</i> = 0.028). …”
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506
Molecular Mapping of Biofortification Traits in Bread Wheat (<i>Triticum aestivum</i> L.) Using a High-Density SNP Based Linkage Map
Published 2023-01-01“…In silico analysis revealed that the key putative candidate genes such as P-loop containing nucleoside triphosphatehydrolase, Nodulin-like protein, NAC domain, Purine permease, Zinc-binding ribosomal protein, Cytochrome P450, Protein phosphatase 2A, Zinc finger CCCH-type, and Kinesin motor domain were located within the identified QTL regions and these putative genes are involved in the regulation of iron homeostasis, zinc transportation, Fe, Zn, and protein remobilization to the developing grain, regulation of grain size and shape, and increased nitrogen use efficiency. …”
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507
Whole-Genome Sequencing Identifies a Rice Grain Shape Mutant, gs9–1
Published 2019-07-01“…This locus is a new allele of the BC12/GDD1/MTD1 gene that encodes a kinesin-like protein involved in cell-cycle progression, cellulose microfibril deposition and gibberellic acid (GA) biosynthesis. …”
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508
Identification of Alternative Splicing Events Associated with Paratuberculosis in Dairy Cattle Using Multi-Tissue RNA Sequencing Data
Published 2022-03-01“…Of note, six DAS events were highly and significantly correlated with the DESFs (<i>R</i><sup>2</sup> > 0.9; <i>p</i> < 0.01), and their corresponding genes (<i>COPI coat complex subunit gamma 2</i><i>gene</i> (<i>COPG2</i>), <i>kinesin family member 2C gene</i> (<i>KIF2C</i>), <i>exocyst complex component 7</i> (<i>EXOC7</i>), <i>Rab9 effector protein with kelch motifs gene</i> (<i>RABEPK</i>), <i>deoxyribonuclease 1 gene</i> (<i>DNASE1</i>) and <i>early endosome antigen 1</i><i>gene</i> (<i>EEA1</i>)) were significantly enriched in immune response such as vesicle-mediated transport, regulation of acute inflammatory response and tuberculosis through gene ontology (GO) and KEGG analysis. …”
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509
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Published 2019-12-01“…We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. …”
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510
A bioinformatics analysis of the clinicopathological and prognostic significance of FAM64A mRNA expression in gynecological cancers
Published 2023-12-01“…Top hub genes primarily included cell cycle-related proteins in breast cancer, mucins and acetylgalactosaminyl transferases in cervical cancer, kinesin family members in endometrial cancer, and synovial sarcoma X and the cancer/testis antigen in ovarian cancer. …”
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511
Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex
Published 2019-11-01“…They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmental disorders linked to the mammalian kinesin Kif21A. How cortical collapse factors influence axon growth is little understood. …”
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512
KIFC1 Is Associated with Basal Type, Cisplatin Resistance, PD-L1 Expression and Poor Prognosis in Bladder Cancer
Published 2021-10-01“…Kinesin family member C1 (<i>KIFC1</i>), a minus end-directed motor protein, is reported to play an essential role in cancer. …”
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513
Multi-omics analysis reveals the association between elevated KIF18B expression and unfavorable prognosis, immune evasion, and regulatory T cell activation in nasopharyngeal carcin...
Published 2023-09-01“…The expression profile and functions of kinesin family member 18B (KIF18B) remain unclear in NPC.MethodsBulk and single-cell transcriptome data for NPC were downloaded. …”
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514
Biallelic Variants in <i>KIF17</i> Associated with Microphthalmia and Coloboma Spectrum
Published 2021-04-01“…The <i>KIF17</i> gene encodes the kinesin-like protein Kif17, a microtubule-based, ATP-dependent, motor protein that is pivotal for outer segment development and disc morphogenesis in different animal models, including mice and zebrafish. …”
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515
Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes
Published 2024-08-01“…Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease. …”
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516
Identification of prognostic and therapeutic biomarkers in type 2 papillary renal cell carcinoma
Published 2023-03-01“…Higher expression level of TPX2 was significantly associated with worse overall survival in PRCC2 and kinesin family genes expression were found significantly elevated in high risk PRCC2. …”
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517
Targeting the Id1-Kif11 Axis in Triple-Negative Breast Cancer Using Combination Therapy
Published 2020-09-01“…In order to understand the molecular underpinning of Id proteins on the cell cycle phenotype, we carried out a large-scale small interfering RNA (siRNA) screen of 61 putative targets identified by using genomic analysis of two Id TNBC tumor models. Kinesin Family Member 11 (<i>Kif11</i>) and Aurora Kinase A (<i>Aurka</i>), which are critical cell cycle regulators, were further validated as Id targets. …”
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518
Genome-wide association study of feed conversion ratio in turbot (Scophthalmus maximus) based on genome resequencing
Published 2023-12-01“…According to their localization in genome, four candidate genes were identified on Chr6, including uncharacterized protein KIAA1755, Kinesin Family Member 21B (KIF21B), Discs large homolog-associated protein 4B (DLGAP4B), and Copine 5B (CPNE5B), all of which are closely located in the genome and exhibit significant functional similarities. …”
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519
Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1
Published 2022-09-01“…Recently, we reported that kinectin 1 (KTN1), a member of the kinesin‐binding protein family, promotes cell invasion of triple‐negative breast cancer and high‐grade breast cancer cells by augmenting the NF‐κB signaling pathway. …”
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520
Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging
Published 2024-03-01“…We find that the lipid composition changes over time, along with the physical properties of the membrane, and that kinesin-1 heavy chain (KIF5b) as well as Ras-related protein 3a (RAB3a) associate preferentially with younger granules. …”
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