-
521
Low grain weight, a new allele of BRITTLE CULM12, affects grain size through regulating GW7 expression in rice
Published 2022-09-01“…Map-based cloning revealed that all mutant phenotypes resulted from a nine-base pair (bp) deletion in LGW, which encodes the kinesin-like protein BRITTLE CULM12 (BC12). Protein sequence alignment analysis revealed that the mutation site was located at the nuclear localization signal (NLS) of LGW/BC12, resulting in the lgw protein not being located in the nucleus. …”
Get full text
Article -
522
rMELEISH: A Novel Recombinant Multiepitope-Based Protein Applied to the Serodiagnosis of Both Canine and Human Visceral Leishmaniasis
Published 2023-02-01“…Methods: a chimeric protein (rMELEISH) was constructed based on amino acid sequences from kinesin 39 (k39), alpha-tubulin, and heat-shock proteins HSP70 and HSP 83.1, and tested in enzyme-linked immunosorbent (ELISA) for the detection of <i>L. infantum</i> infection using canine (<i>n</i> = 140) and human (<i>n</i> = 145) sera samples. …”
Get full text
Article -
523
Comparative cytological and transcriptome analyses of ny2 mutant delayed degeneration of tapetal cells and promotes abnormal microspore development in neo-tetraploid rice
Published 2023-07-01“…Moreover, 9 genes related to tapetum or pollen fertility showed down-regulation, such as OsABCG26 (ATP Binding Cassette G26), TMS9-1 (Thermosensitive Male Sterility), EAT1 (Programmed cell death regulatory), KIN14M (Kinesin Motor), OsMT1a (Metallothionein), and OsSTRL2 (Atypical strictosidine synthase), which were validated by qRT-PCR. …”
Get full text
Article -
524
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
Published 2024-04-01“…Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. …”
Get full text
Article -
525
Quantitative proteomic dataset of whole protein in three melanoma samples of 92.1, 92.1-A and 92.1-B
Published 2022-12-01“…However, it is difficult to determine whether the relevant proteins in peripheral blood are the same kinesins as those in primary lesions and metastases. …”
Get full text
Article -
526
Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes
Published 2021-12-01“…In eukaryotic cells, intracellular components are organized by the microtubule motors cytoplasmic dynein-1 (dynein) and kinesins, which are linked to cargos via adaptor proteins. …”
Get full text
Article -
527
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.
Published 2006“…The EC 'Structural Proteomics In Europe' contract is aimed specifically at the atomic resolution structure determination of human protein targets closely linked to health, with a focus on cancer (kinesins, kinases, proteins from the ubiquitin pathway), neurological development and neurodegenerative diseases and immune recognition. …”
Journal article -
528
Identification and characterization of host proteins interacting with NSm, the Tomato spotted wilt virus movement protein
Published 2002-06-01“…J-domain chaperones from different host species and a protein denominated At-4/1 from Arabidopsis thaliana showing homologies to myosins and kinesins were identified as NSm-interacting partners. …”
Get full text
Article -
529
Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers
Published 2016-01-01“…Concentration matrices show that BH3-mimetic-mediated inhibition of Bcl-xL synergises with perturbations that induce an SAC-mediated mitotic block, including drugs that dampen microtubule dynamics, and inhibitors targeting kinesins and kinases required for spindle assembly. …”
Get full text
Article -
530
Regulatory mechanisms of the dynein-2 motility by post-translational modification revealed by MD simulation
Published 2023-01-01“…Abstract Intraflagellar transport for ciliary assembly and maintenance is driven by dynein and kinesins specific to the cilia. It has been shown that anterograde and retrograde transports run on different regions of the doublet microtubule, i.e., separate train tracks. …”
Get full text
Article -
531
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.
Published 2004“…Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. …”
Journal article -
532
Axon-Targeting Motifs: Mechanisms and Applications of Enhancing Axonal Localisation of Transmembrane Proteins
Published 2022-03-01“…These motifs target proteins to the axonal compartment by a variety of mechanisms including: promoting segregation into axon-targeted secretory vesicles, increasing interaction with axonal kinesins and enhancing somatodendritic endocytosis. …”
Get full text
Article -
533
Ubiquitination associated proteolysis inhibition impairs plus ended motor proteins dynamics during mitosis.
Published 2011“…Kinesins (Kif4A and Eg5) are microtubule-based motor proteins known to play imperative roles in cellular activities like cell division, intracellular transport of organelles and signal transduction. …”
Get full text
Final Year Project (FYP) -
534
Characterisation of mitotic phosphorylation on chromokinesin KIF4A
Published 2015“…Chromokinesins are a group of kinesins characterized by their association to the arms of chromosomes during mitosis. …”
Get full text
Thesis -
535
Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A.
Published 2008-01-01“…Intact transport depends on both kinesins and dyneins and is inhibited upon colcemide treatments. …”
Get full text
Article -
536
Mitotic Poisons in Research and Medicine
Published 2020-10-01“…In this review article, the main approaches on how to target cancer cell mitosis are described, involving microtubule inhibition, targeting aurora and polo-like kinases and kinesins inhibition. The main representatives of all groups of compounds are discussed and attention has also been paid to the presence and future of the clinical use of these compounds as well as their novel derivatives, reviewing the finished and ongoing clinical trials.…”
Get full text
Article -
537
Differential Expression of Mitosis and Cell Cycle Regulatory Genes during Recovery from an Acute Respiratory Virus Infection
Published 2021-12-01“…Our findings revealed prominent differential expression of inflammation-associated genes as well as numerous genes and gene families implicated in mitosis and cell-cycle regulation, including cyclins, cyclin-dependent kinases, cell division cycle genes, E2F transcription factors, kinesins, centromere proteins, and aurora kinases, among others. …”
Get full text
Article -
538
Host Cytoskeleton Gene Expression Is Correlated with the Formation of Ascovirus Reproductive Viral Vesicles
Published 2022-06-01“…In <i>T. ni</i>, many cytoskeleton genes were upregulated at 48 hours post-infection (hpi), including 29 tubulins, 21 actins, 21 dyneins, and 13 kinesins. Mitochondrial genes were upregulated as much as two-fold at 48 hpi and were expressed at levels comparable to controls in both <i>T. ni</i> and <i>S. frugiperda</i>, even after 21 dpi, when several cytoskeleton genes remained upregulated. …”
Get full text
Article -
539
Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus.
Published 2013-01-01“…These changes suggest that anterograde axonal transport mediated by these kinesins may be impaired in hippocampal neurons, which may lead to changes in synaptic proteins, thus contributing to changes in hippocampal neurotransmission and to cognitive and memory impairments.…”
Get full text
Article -
540
Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination.
Published 2018-08-01“…Amongst the identified genetic causes, mutations in genes encoding motor proteins such as kinesins have been involved in various HSP clinical isoforms. …”
Get full text
Article