Report to the President for year ended June 30, 2022, Koch Institute for Integrative Cancer Research at MIT by Vander Heiden, Matthew

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Expanding the landscape of antibody discovery by Johnson, Shelbe, DeKosky, Brandon J

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Dendritic cell nediated inhibition of lentiviral infection by Drake, Adam, Browne, Edward P., Phennicie, Ryan T., Chen, Jianzhu

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing by Li, Bowen, Manan, Rajith Singh, Liang, Shun-Qing, Gordon, Akiva, Jiang, Allen, Varley, Andrew, Gao, Guangping, Langer, Robert, Xue, Wen, Anderson, Daniel

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Activated Metals to Generate Heat for Biomedical Applications by Remlova, Eva, Feig, Vivian Rachel, Kang, Ziliang, Patel, Ashka, Ballinger, Ian, Ginzburg, Anna, Kuosmanen, Johannes, Fabian, Niora, Ishida, Keiko, Jenkins, Joshua, Hayward, Alison, Traverso, Giovanni

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An organometallic swap strategy for bottlebrush polymer-protein conjugate synthesis by Liu, Bin, Rodriguez, Jacob, Kilgallon, Landon J., Wang, Wencong, Wang, Yuyan, Wang, Aiden, Dai, Yutong, Nguyen, Hung V.-T., Pentelute, Bradley L., Johnson, Jeremiah A.

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In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

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Circular RNA migration in agarose gel electrophoresis by Abe, Brian T, Wesselhoeft, R Alexander, Chen, Robert, Anderson, Daniel G, Chang, Howard Y

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Wearable bio-adhesive metal detector array (BioMDA) for spinal implants

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First-in-human trial of an ingestible vitals-monitoring pill by Traverso, Giovanni, Finomore, Victor, Mahoney, James, Kupec, Justin, Stansbury, Robert, Bacher, Daniel, Pless, Benjamin, Schuetz, Shannon, Hayward, Alison, Langer, Robert, Rezai, Ali

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Sororin actively maintains sister chromatid cohesion by Ladurner, Rene, Kreidl, Emanuel, Ivanov, Miroslav P., Ekker, Heinz, Idarraga‐Amado, Maria H., Busslinger, Georg A., Wutz, Gordana, Cisneros, David A., Peters, Jan‐Michael

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Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery by Li, Ying, Lee, Jung Seung, Kirtane, Ameya R., Li, Mengyuan, Coffey, Charles William, Hess, Kaitlyn, Lopes, Aaron, Collins, Joy, Tamang, Siddartha, Ishida, Keiko, Hayward, Alison, Wainer, Jacob, Wentworth, Adam J., Traverso, Giovanni

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Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery by Chen, Wei, Wainer, Jacob, Ryoo, Si Won, Qi, Xiaoyue, Chang, Rong, Li, Jason, Lee, Seung Ho, Min, Seokkee, Wentworth, Adam, Collins, Joy E., Tamang, Siddartha, Ishida, Keiko, Hayward, Alison, Langer, Robert, Traverso, Giovanni

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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

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Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib by Miettinen, Teemu P., Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M., Trost, Matthias, Björklund, Mikael

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A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability by Moretton, Amandine, Kourtis, Savvas, Gañez Zapater, Antoni, Calabrò, Chiara, Espinar Calvo, Maria L., Fontaine, Frédéric, Darai, Evangelia, Abad Cortel, Etna, Block, Samuel, Pascual‐Reguant, Laura, Pardo‐Lorente, Natalia, Ghose, Ritobrata, Vander Heiden, Matthew G.

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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B by Santaguida, Stefano, De Antoni, Anna, Maffini, Stefano, Knapp, Stefan, Musacchio, Andrea

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Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD by Kanai, Ryan, Norton, Emily, Stern, Patrick, Hynes, Richard O., Lamar, John M.

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