Effect of lanosterol on human cataract nucleus by P Mahesh Shanmugam, Aditya Barigali, Jayant Kadaskar, Sandip Borgohain, Divaynsh Kailash Chandra Mishra, Rajesh Ramanjulu, C K Minija

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Comment to: Effect of lanosterol on human nuclei by Ramesh Venkatesh, Prachi Gurav, Shailja Tibrewal

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Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. by SF Tuck, H Patel, E Safi, CH Robinson

“…Lanosterol 14 alpha-demethylase (P45014DM) is the cytochrome P450 enzyme complex responsible for an early step in cholesterol biosynthesis, namely the 14 alpha-demethylation of lanosterol. …”
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Inhibition of cholesterol biogenesis by arsenite: preparation of labeled lanosterol* by Mary L. Moller, T.T. Tchen

“…When mevalonic acid-2-C14 was incubated with rat liver homogenate with the usual cofactors plus 10−3 M arsenite, the formation of labeled cholesterol was inhibited and labeled lanosterol accumulated. This inhibitory effect of arsenite provides a convenient method of preparing labeled lanosterol in high yield (>10%) from commercially available C14-labeled mevalonic acid.…”
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Using genetics to investigate the association between lanosterol and cataract by Munisa Hashimi, Hasnat A. Amin, Loukas Zagkos, Alexander C. Day, Alexander C. Day, Fotios Drenos

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Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase by H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway

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Protective Effects of Lanosterol Synthase Up-Regulation in UV-B-Induced Oxidative Stress by Hui Hua, Tianyao Yang, Liting Huang, Rentong Chen, Menglin Li, Zhenzhen Zou, Nan Wang, Dan Yang, Yang Liu

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Lanosterol regulates abnormal amyloid accumulation in LECs through the mediation of cholesterol pathway metabolism by Yingxue Su, Danyuan Sun, Chen Cao, Yandong Wang

Subjects: “…Lanosterol…”
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The Oxidosqualene Cyclase from the Oomycete Saprolegnia Parasitica Synthesizes Lanosterol as a Single Product by Paul Dahlin, Vaibhav Srivastava, Vincent Bulone, Vincent Bulone, Lauren Sara McKee, Lauren Sara McKee

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Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats by Saori Deguchi, Reita Kadowaki, Hiroko Otake, Atsushi Taga, Yosuke Nakazawa, Manju Misra, Naoki Yamamoto, Hiroshi Sasaki, Noriaki Nagai

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Probes for protein adduction in cholesterol biosynthesis disorders: Alkynyl lanosterol as a viable sterol precursor by Keri A. Tallman, Hye-Young H. Kim, Zeljka Korade, Thiago C. Genaro-Mattos, Phillip A. Wages, Wei Liu, Ned A. Porter

“…The identities of adducted proteins and the effects of adduction on protein function are mostly unknown and an increased understanding of these factors may help to define the pathogenesis of various human disorders involving oxidative stress. 7-Dehydrocholesterol (7-DHC), the immediate biosynthetic precursor to cholesterol, is highly oxidizable and gives electrophilic oxysterols that adduct proteins readily, a sequence of events proposed to occur in Smith-Lemli-Opitz syndrome (SLOS), a human disorder resulting from an error in cholesterol biosynthesis. Alkynyl lanosterol (a-Lan) was synthesized and studied in Neuro2a cells, Dhcr7-deficient Neuro2a cells and human fibroblasts. …”
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An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence. by Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels

“…We identified several conserved amino acids within the ScArv1 homology domain (ScAhd) required for maintaining normal azole susceptibility. Erg11 lanosterol 14-α-demethylase is the rate-limiting enzyme in sterol biosynthesis and is the direct target of azole antifungals, so we used our ScArv1 mutants in order to explore the relationship between ScArv1 and ScErg11. …”
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Lanosterol synthase deficiency promotes tumor progression by orchestrating PDL1‐dependent tumor immunosuppressive microenvironment by Yuan Gao, Kun Zhao, Yulan Huang, Dapeng Zhang, Na Luo, Xiaoqing Peng, Feng Yang, Weidong Xiao, Meng Wang, Rongchen Shi, Hongming Miao

Subjects: “…lanosterol synthase…”
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Development of Procathepsin L (pCTS-L)-Inhibiting Lanosterol-Carrying Liposome Nanoparticles to Treat Lethal Sepsis by Weiqiang Chen, Cassie Shu Zhu, Xiaoling Qiang, Shujin Chen, Jianhua Li, Ping Wang, Kevin J. Tracey, Haichao Wang

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Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats by Noriaki Nagai, Kazuki Umachi, Hiroko Otake, Mikako Oka, Noriko Hiramatsu, Hiroshi Sasaki, Naoki Yamamoto

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IDENTIFICACIÓN DE UN DERIVADO DE LANOSTEROL PROCEDENTE DEL HONGO CULTIVADO Pisolithus arhizus (Scop.) Rauschert by Olivia Márquez-Fernández, Eloy Herrera, Olaya Castellanos-Onorio, Arturo Estrada-Torres, Ángel Trigos

“…Algunos derivados triterpénicos de lanosterol se han aislado tanto del micelio como de los cuerpos fructíferos del hongo ectomicorrizógeno Pisolithus arhizus. …”
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Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. by Suryadevara, P, Olepu, S, Lockman, J, Ohkanda, J, Karimi, M, Verlinde, C, Kraus, J, Schoepe, J, Van Voorhis, W, Hamilton, A, Buckner, F, Gelb, M

“…We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14alpha-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. …”

RNAi-mediated gene silencing of lanosterol 14α- demethylase (ERG11)-encoding gene in ganoderma boninense by Lim, Fook Hwa

“…The objectives of this study are to isolate the full-length cDNA encoding Lanosterol 14α-demethylase (GbERG11) from G. boninense, to optimize a polyethylene glycol (PEG)-mediated protoplast transformation protocol for G. boninense, to perform the GbERG11 gene functional study via RNAi-mediated gene silencing approach and to transform the hpRNA-GbERG11 vectors into oil palm. …”
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Induced expression of Ganoderma boninense lanosterol 14α-demethylase (ERG11) during interaction with oil palm by Lim, Fook-Hwa, Abd Rasid, Omar, Abu Seman, Idris, Abdul Wahab, Mohd As’wad, Vadamalai, Ganesan, Ahmad Parveez, Ghulam Kadir, Wong, Mui-Yun

“…Background: The basidiomycete fungus, Ganoderma boninense is the main contributor to oil palm Basal Stem Rot (BSR) in Malaysia and Indonesia. Lanosterol 14α-Demethylase (ERG11) is a key enzyme involved in biosynthesis of ergosterol, which is an important component in the fungal cell membrane. …”

Data on molecular docking of tautomers and enantiomers of ATTAF-1 and ATTAF-2 selectivty to the human/fungal lanosterol-14α-demethylase by Hamid Irannejad, Saeed Emami, Hassan Mirzaei, Seyedeh Mahdieh Hashemi

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