Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…</p> <p>We found that across a range of clinical prodromal features, RBD patients were at least as impaired as those with established Parkinson’s and that neuropsychiatric disorders were particularly prominent in RBD patients. …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…Moreover, we predict that at least 67% of known habitats fall outside protected areas, exacerbating their vulnerability. …”

Adaptation of the WHO AWaRe (Access, Watch, Reserve) antibiotic classification to support national antimicrobial stewardship priorities in the UK: findings from a modified Delphi a... by Bou-Antoun, S, Oettle, RC, Leanord, A, Seaton, RA, Cooper, BS, Muller-Pebody, B, Conlon-Bingham, G, Kerr, F, Hand, KS, Sandoe, JAT, Llewelyn, MJ, Fleming, N, Brown, NM, Reid, N, Howard, P, Mckinstry, S, Malcolm, W, Demirjian, A, Ashiru-Oredope, D

“…Consensus was most easily reached, with least between-expert variation, for Access antibiotics. …”

15th-century printed Italian editions of Aesopian texts by Malaspina, M

“…</p> <p>It highlights how the introduction of the new medium did not correspond, at least within the first decades, to a standardisation in the written circulation of the rich Aesopian corpus; on the contrary, it fostered the composition of new versions, translations and rewritings, contributing to enhance its varied and multiform nature. …”

On the weak convergence of stochastic integrals on Skorokhod space: From general theory to applications within the realm of continuous-time random walks by Wunderlich, F

“…For stochastic integrals driven by strictly M1 convergent CTRWs and moving averages, where weak convergence may fail markedly, we determine natural classes of integrand processes that restore weak continuity. Not least, restricting to these classes yields functional limit theorems for certain stochastic delay differential equations driven by moving averages.…”

Emergency care knowledge, utilization, and barriers in Northern Tanzania: A community-based survey by Shayo, F, Zaccheus, GG, Sakita, F, Hernandes, TR, Vissoci, JRN, Gordee, A, Kuchibhatla, M, Kiremeji, M, Minja, L, Mmbaga, BT, Staton, CA, Keating, EM, Joiner, AP

“…The mean monthly household income was 226,107.6 Tanzanian Shillings. 76 (14.1%) households reported experiencing an emergency condition in the past year and 225 (41.7%) of respondents had an inappropriate response to at least one hypothetical emergency condition. A higher proportion of those with delayed access to healthcare paid with personal cash and a lower proportion had national health insurance. …”

Genotype-phenotype maps for gene networks: from evolution to computation by Camargo, FQ

“…<p>One of the most fundamental and least understood elements of evolution is the mapping between genotype and phenotype. …”

Networks of care for the modern adolescent by White, SR, Soneson, E, OxWell Study Team, Fazel, M

“…Informal sources had high acceptability, with around 80–90% reporting them as helpful, whereas child and adolescent mental health services (CAMHS), helplines, and online supports were perceived to be the least helpful. The networks also identified groups who might not be optimally served by current systems, including gender diverse adolescents and adolescents who found mental health support from their parents unhelpful.…”

A simple approach to improve recording of concerns about child maltreatment in primary care records: developing a quality improvement intervention by Woodman, J, Allister, J, Rafi, I, de Lusignan, S, Belsey, J, Petersen, I, Gilbert, R

“…<p><b>Results</b> The rate of children with at least one maltreatment-related code was 8.4/1000 child years (11 study practices, 2009–2010), and 8.0/1000 child years (THIN, 2009–2010). …”

Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth by Cetin, I, Carlson, SE, Burden, C, da Fonseca, EB, di Renzo, GC, Hadjipanayis, A, Harris, WS, Kumar, KR, Olsen, SF, Mader, MS, McAuliffe, FM, Muhlhausler, B, Oken, E, Poon, LC, Poston, L, Ramakrishnan, U, Roehr, CC, Savona-Ventura, C, Smuts, CM, Sotiriadis, A, Su, K-P, Tribe, RM, Vannice, G, Koletzko, B, Clinical Practice Guideline

“…Women of childbearing age should obtain a supply of at least 250 mg/d of docosahexaenoic+eicosapentaenoic acid from diet or supplements, and in pregnancy an additional intake of ≥100 to 200 mg/d of docosahexaenoic acid. …”

Galaxy bias in the era of LSST: perturbative bias expansions by Nicola, A, Hadzhiyska, B, Findlay, N, García-García, C, Alonso, D, Slosar, A, Guo, Z, Kokron, N, Angulo, R, Aviles, A, Blazek, J, Dunkley, J, Jain, B, Pellejero, M, Sullivan, J, Walter, CW, Zennaro, M

“…We find both HEFT methods as well as LPT and EPT combined with non-perturbative predictions for the matter power spectrum to yield unbiased constraints on cosmological parameters up to at least a maximal scale of&nbsp;<em>k</em>_max&nbsp;=&nbsp;0.4&nbsp;Mpc^-1&nbsp;for all samples considered, even in the presence of assembly bias. …”

Soft law, hard stakes? State commitment to non-binding international instruments and the case of the UN Declaration on the Rights of Indigenous Peoples by Villeneuve, L

“…It is often assumed that its non-binding status upon adoption makes commitment to soft law a relatively inconsequential endeavor, at least in comparison to hard law. In this thesis, incorporating insights from public international law into rationalist IR approaches, I argue that soft law instruments can have important effects over time and bring substantial costs for states to bear. …”

Participation and cooperation in global climate governance by Rowan, SS

“…<p>International climate politics have seemed stalled throughout much of the past three decades. At least until the 2015 Paris Agreement on Climate Change, states largely failed to adopt new substantive treaties through the United Nations-led climate governance process. …”

Foreign language learning in the age of the internet: A comparison of informal acquirers and traditional classroom learners in central Brazil by Cole, J

“…</p> <p>The key research question asked whether there existed, in more than rare circumstances, FASILs who attained levels of proficiency at least as high as highly-motivated, well-trained CTLs? …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…There is considerable evidence that at least some of this peripheral activity is regulated by the transport and local translation of mRNA molecules at the distant cytoplasm of neurons. …”

Building fabric improvement and heat pump deployment: a set of policy conundrums by Killip, G, Topouzi, M, Fawcett, T

“…For example, the mandate to replace all fossil-fired heating systems presents a new opportunity for policy intervention: transitioning to a new heating system can act as a trigger for at least minimal fabric improvements. The paper explores various tests associated with the 'understanding first' approach, discussing how to strike a balance between simplicity and complexity in policy. …”

Identification and characterization of Botrytis cinerea causing gray mold on tomatoes in Cameron Highlands, Malaysia by Siti Fairuz Yusoff, Siti Izera Ismail, Farah Farhanah Haron, Zahir Shah Safari, Rohasmizah Hashim, Paiman

“…The pathogenicity experiments showed P6 isolates of B. cinerea were highly pathogenic and caused gray mold development on tomato fruits that led to severe symptoms in five days. Meanwhile, the least pathogenic isolate was P9. In terms of temperature, B. cinerea grew faster on PDA at 20ºC, slower grew below 20ºC and did not grow at 25ºC. …”
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Low diversity of major histocompatibility complex (MHC) genes in endangered Malayan Tapir (Tapirus indicus) by Ismail, Nurul Adilah, Christina, Seok Yien Yong, Simon, Yung Wa Sin, Annavi, Geetha

“…This study characterises the MHC class I and II genes from seven individuals, investigates evidence of balancing selection and their relationships with homologous genes of other species. We identified at least one class I gene and four class II genes. Five sequences of alpha1 (α1) and four of alpha2 (α2) domains of class I alleles, two DRA, two DQA, three DRB and three DQB of class II alleles were isolated. α1 and α2 domains of class I and DRB domain of class II displayed evidence of selection with a higher rate of non-synonymous over synonymous substitutions. …”

Prevalence and associated factors of lipohypertrophy in insulin-injected patients with diabetes in selected primary care clinics in Peninsular Malaysian: a cross-sectional study by Alias, Siti Hawa, Teng, Cheong Lieng, Devaraj, Navin Kumar, Amirrudin, Saadatunnoor, Abd Latib, Noor Rawaida, Chong, Fui Yee, Yussof, Syamimi, Mohamad Din, Mohamad Danial, Lim, Poon Wah

“…Methods: This cross-sectional study was conducted among adults aged ≥18 years with type 1 or 2 diabetes treated with insulin for at least 6 months at six selected public primary care clinics in Malaysia. …”
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Unbiased metabolomics of volatile secondary metabolites in essential oils originated from Myrtaceae species by Manickavasagam, Ganapaty, San, Priscilla Wong Chie, Gorji, Sara Ghorbani, Sungthong, Bunleu, Yong, Yoke Keong, Fitzgerald, Melissa, Dewi, Firli Rahmah Primula, Lim, Vuanghao

“…Both principal component analysis and partial least squares discriminant analysis generated using the identified metabolites revealed a clear discrimination into five clusters of oils. …”
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