Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket by Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra

“…The screening of the human structural kinome revealed at least 12 other oncogenic kinases which carry at least one activating mutant in this disorder-prone region and hence would be amenable to allosteric inhibition by molecules such as EAI045. …”
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Darkness in the human gene and protein function space : widely modest or absent illumination by the life science literature and the trend for fewer protein function discoveries sin... by Sinha, Swati, Eisenhaber, Birgit, Jensen, Lars Juhl, Kalbuaji, Bharata, Eisenhaber, Frank

“…It has been found that less than 5000 human genes have each at least 100 FPEs in the available literature corpus. …”
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PMU-based state estimator for micro-grids by Soh, Wee Cheng.

“…This project aims to formulate Weighted Least Square (WLS) state estimation using Phasor Measurement Units (PMU). …”
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Coffee over the internet by Zhu, Yatao.

“…I hope this project provides part of the answer at least.…”
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Global supply chain : the impact of location variables on competitiveness. by Lim, Lian Kheng.

“…However, this is also one of the least studied element in supply chain management. …”
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Banking prospects in China by Ong Lay Peng, Chia Jui Lee

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Intelligent Portable Traffic Light by Monica, Josephine

“…This manual approach has at least two draw backs: Waste of human resources. Limited communication between the two faraway workers (especially in a big construction area). …”
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Scientific theory and possibility by Baron, S, Le Bihan, J, Read, J

“…We argue that it is the models of effective theories that we should believe correspond, at least in part, to possibilities. It is thus effective theories that should guide modal reasoning in science. …”

'The darker angels of our nature': a butchered Early Bronze Age human bone assemblage from Charterhouse Warren, Somerset, UK by Schulting, R, Fernández-Crespo, T, Ordoño, J, Brock, F, Kellow, A, Snoeck, C, Cartwright, IR, Walker, D, Loe, L, Audsley, T

“…An Early Bronze Age assemblage of human remains from Charterhouse Warren, southwest England, exhibits evidence of extreme violence. At least 37 men, women and children were killed and butchered and their disarticulated remains were thrown down a 15m deep natural shaft in what is most plausibly interpreted as a single event. …”

Design of digital filters by optimization techniques by Zhang, Dongye

“…To design better complex coefficient FIR filters, a weighed least-squares (WLS) constraint in magnitude is imposed and combined with minimax constraints in magnitude. …”
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Performance of microwave formed angle ply composites by Bhudolia Somen Kumar.

“…The traditional method of Autoclave curing (Thermal curing), although being expensive, is still the most accepted because it gives least standard deviation during all mechanical tests as compared to other available methods like the use of Ultraviolet and gamma rays heating. …”
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Implementation of a radar prototype on an unmanned arial vehicle by Liu, Jiaqing

“…In the part of system integration, it further covers aspects like RF testing and measurement for different parts of the system, verification of choice of components, power budget and payload distribution for UAV. Last but not the least; the conclusion part illustrates the executive summary and recommendation for the future development.…”
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Three essays on family firms by Lim, So-Yeon

“…The evidence suggests that having at least two unrelated cofounders involved in management reduces agency problems through mutual monitoring, reducing the number of shareholder proposals and serving as a substitute for other governance mechanisms. …”
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Book review : Facts, values and the policy world by Phil Ryan by Ginsburg, Norman

“…The distinction between facts and values is a methodological conundrum which faces all social scientists, not least critical social policy analysts. It concerns the need for evidence and rational argument to support a critical perspective on a social issue. …”
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Interferometric scattering microscopy by Young, G, Kukura, P

“…Interferometric scattering microscopy (iSCAT) is an extremely sensitive imaging method based on the efficient detection of light scattered by nanoscopic objects. The ability to, at least in principle, maintain high imaging contrast independent of the exposure time or the scattering cross section of the object allows for unique applications in single-particle tracking, label-free imaging of nanoscopic (dis)assembly, and quantitative single-molecule characterization. …”

Low energy levels of harmonic spheres into analytic manifolds by Rupflin, M

“…While a well known conjecture asserts that ΞE(N) is discrete whenever N is analytic, for most analytic targets it is only known that any potential accumulation point of the energy spectrum must be given by the sum of the energies of at least two harmonic spheres. The lowest energy level that could hence potentially be an accumulation point of ΞE is thus 2Emin. …”

A counterexample to the coarse Menger conjecture by Nguyen, T, Scott, A, Seymour, P

“…Recently, Georgakopoulos and Papasoglu and, independently, Albrechtsen, Huynh, Jacobs, Knappe and Wollan conjectured a coarse analogue of Menger’s theorem, when the k paths are required to be pairwise at some distance at least d. The result is known for k ≤ 2, but we will show that it is false for all k ≥ 3, even if G is constrained to have maximum degree at most three. …”

Crossing and intersecting families of geometric graphs on point sets by Álvarez-Rebollar, J. L., Cravioto-Lagos, J., Marín, N., Solé-Pi, O., Urrutia, J.

“…For points in convex position we prove that any set of 3n points in convex position contains a family with at least $$n^2$$ n 2 intersecting triangles.…”
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Interventions for smoking cessation in hospitalised patients by Rigotti, NA, Munafo, MR, Murphy, MRG, Stead, LF, Munafo', MR

“…Intensive intervention (inpatient contact plus follow‐up for at least one month) was associated with a significantly higher quit rate compared to control (Peto Odds Ratio 1.82, 95% CI 1.49‐2.22, six trials). …”

Dose escalation pre-clinical trial of novel DOK7-AAV in mouse model of DOK7 congenital myasthenia by Cossins, J, Kozma, I, Canzonetta, C, Hawkins, A, Beeson, D, Sepulveda, P, Dong, YY

“…However, male models treated with 1 × 1014 vg/kg showed the least decrement that was not statistically different from wild-type littermates. …”