Feline Immunodeficiency Virus in South America by Bruno M. Teixeira, Mitika K. Hagiwara, Margaret J. Hosie, Juliano C. M. Cruz

“…Lentiviruses, comprising a genus of the Retroviridae family, cause persistent infection that can lead to varying degrees of morbidity and mortality depending on the virus and the host species involved. …”
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Centrosomal latency of incoming foamy viruses in resting cells. by Jacqueline Lehmann-Che, Noémie Renault, Marie Lou Giron, Philippe Roingeard, Emmanuel Clave, Joelle Tobaly-Tapiero, Patricia Bittoun, Antoine Toubert, Hugues de Thé, Ali Saïb

“…While gammaretroviruses require mitosis for proviral integration, lentiviruses are able to replicate in post-mitotic non-dividing cells. …”
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Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr? by Maudet Claire, Ayinde Diana, Transy Catherine, Margottin-Goguet Florence

“…This review focuses on two HIV accessory proteins whose functions might be more specifically related to macrophage infection: Vpr, which is conserved across primate lentiviruses including HIV-1 and HIV-2, and Vpx, a protein genetically related to Vpr, which is unique to HIV-2 and a subset of simian lentiviruses. …”
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Mechanisms underlying HIV-1 Vpu-mediated viral egress by Nicolas eRoy, Grégory ePacini, Clarisse eBerlioz-Torrent, Katy eJanvier

“…Viruses such as lentiviruses that are responsible for long lasting infections, have to evade several level of cellular immune mechanisms to persist and efficiently disseminate in the host. …”
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Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma. by Laura P Brandt, Joachim Albers, Tomas Hejhal, Antonella Catalano, Peter J Wild, Ian J Frew

“…We discovered that MuLE lentiviruses efficiently infect uterine stromal cells but not endometrial epithelial cells when injected into the uterus of cycling, pseudopregnant or ovarectomized mice. …”
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Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines by Klasse Per, Moore John P

“…<p>Abstract</p> <p>Correlates of protection (CoPs) against infection by primate lentiviruses remain undefined. Modest protection against HIV-1 was observed in one human vaccine trial, whereas previous trials and vaccine-challenge experiments in non-human primates have yielded inconsistent but intriguing results. …”
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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. by Natalia Sharova, Yuanfei Wu, Xiaonan Zhu, Ruzena Stranska, Rajnish Kaushik, Mark Sharkey, Mario Stevenson

“…Primate lentiviruses encode four "accessory proteins" including Vif, Vpu, Nef, and Vpr/Vpx. …”
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Extending the Coding Potential of Viral Genomes with Overlapping Antisense ORFs: A Case for the De Novo Creation of the Gene Encoding the Antisense Protein ASP of HIV-1 by Angelo Pavesi, Fabio Romerio

“…On one hand, asp may have originally been present in the ancestor of contemporary lentiviruses, and subsequently lost in all descendants except for most HIV-1 strains of group M due to selective advantage. …”
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HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. by Ajit Janardhan, Tomek Swigut, Brian Hill, Michael P Myers, Jacek Skowronski

“…The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. …”
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Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV. by Jordan Wilkins, Yi-Min Zheng, Jingyou Yu, Chen Liang, Shan-Lu Liu

“…Overall, our study reveals some new and unexpected features of IFITMs in restricting primate lentiviruses, which enhances our understanding of virus-host interaction and AIDS pathogenesis.…”
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Os vírus da imunodeficiência. by W F Ferreira, A S Pinto, E P Alvarez, R A Sousa

“…The presence of a gene that deactivates the activated lymphocytes only present in the lentiviruses of the primates, as well as the known tropism of those viruses to CD4 lymphocytes, and not found in the other groups, are biological aspects that are pointed out. …”
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HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65 by Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers, Rebecca P. Sumner

“…Conclusions We have discovered a novel mechanism by which lentiviruses antagonise NF-κB activation by targeting p65. …”
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Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. by Oliver I Fregoso, Jinwoo Ahn, Chuanping Wang, Jennifer Mehrens, Jacek Skowronski, Michael Emerman

“…SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. …”
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Isolation and Identification of Caprine Arthritis Encephalitis Virus from Animals in the Republic of Mordovia by Olga Kolbasova, Timofey Sevskikh, Ilya Titov, Denis Kolbasov

“…The isolate was found during monitoring studies of goat blood samples for the viral genome, and the presence of antibodies to lentiviruses was detected. According to the recommendation of the OIE, the positive result of PCR was confirmed with nucleotide sequencing. …”
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Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. by Barbara Felice, Claudia Cattoglio, Davide Cittaro, Anna Testa, Annarita Miccio, Giuliana Ferrari, Lucilla Luzi, Alessandra Recchia, Fulvio Mavilio

“…Gamma-retroviruses and lentiviruses integrate non-randomly in mammalian genomes, with specific preferences for active chromatin, promoters and regulatory regions. …”
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Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells by Liang Zhang, Di Zhao, Mingxing Jin, Mengzhao Song, Shanchuan Liu, Kangkang Guo, Yanming Zhang

“…In this study, we showed that knockdown of Rab18 by lentiviruses inhibited CSFV production, while overexpression of Rab18 by lentiviruses enhanced CSFV production. …”
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Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. by Bin Jia, Ruth Serra-Moreno, William Neidermyer, Andrew Rahmberg, John Mackey, Ismael Ben Fofana, Welkin E Johnson, Susan Westmoreland, David T Evans

“…HIV-1 overcomes this restriction by expressing an accessory protein, Vpu, which counteracts tetherin. Since lentiviruses of the SIV(smm/mac)/HIV-2 lineage do not have a vpu gene, this activity has likely been assumed by other viral gene products. …”
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Multivariate statistical analyses demonstrate unique host immune responses to single and dual lentiviral infection. by Sunando Roy, Jennie Lavine, Francesca Chiaromonte, Julie Terwee, Sue VandeWoude, Ottar Bjornstad, Mary Poss

“…Feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV) are recently identified lentiviruses that cause progressive immune decline and ultimately death in infected cats and humans. …”
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APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host. by Annabel Krupp, Kevin R McCarthy, Marcel Ooms, Michael Letko, Jennifer S Morgan, Viviana Simon, Welkin E Johnson

“…To overcome APOBEC3G-mediated restriction, many lentiviruses encode Vif, a protein that targets APOBEC3G for degradation. …”
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Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion by Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Anke Heigele, Gregory K. Tharp, Prachi Mehrotra Gupta, Sydney Nelson, Steven Bosinger, Laura Parodi, Luis Giavedoni, Guido Silvestri, Daniel Sauter, Christiane Stahl-Hennig, Frank Kirchhoff

“…Summary: The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. …”
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