An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex by Lukas Simon Enz, Anne Winkler, Claudia Wrzos, Boris Dasen, Stefan Nessler, Christine Stadelmann, Nicole Schaeren-Wiemers

“…To induce long-lasting cortical demyelination and chronic meningeal inflammation, we immunized female Lewis rats against myelin oligodendrocyte glycoprotein (MOG) and injected lentiviruses for continuing overexpression of the cytokines TNFα and IFNγ in the cortical brain parenchyma. …”
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PIMT regulates hepatic gluconeogenesis in mice by Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V.L. Parsa, Parimal Misra

“…Here, we observed that the expression of PIMT was upregulated in the livers of short-term fasted and obese mice. Lentiviruses expressing Tgs1-specific shRNA or cDNA were injected into wild-type mice. …”
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Induced Pluripotent Stem (iPS) Cell Research Overview by Shih-Ping Liu, Ru-Huei Fu, Yu-Chuen Huang, Shih-Yin Chen, Ying-Jiun Chien, Chien Yu Hsu, Chang-Hai Tsai, Woei-Cherng Shyu M.D., Ph.D., Shinn-Zong Lin MD., Ph.D.

“…For this reason, iPS cells are considered an increasingly important cell therapy technology. iPS cell production entails the use of retroviruses, lentiviruses, adenoviruses, plasmid transfections, transposons, or recombinant proteins. …”
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Transgenesis and web resources in quail by Olivier Serralbo, David Salgado, Nadège Véron, Caitlin Cooper, Marie-Julie Dejardin, Timothy Doran, Jérome Gros, Christophe Marcelle

“…Most of them were generated using replication-deficient lentiviruses, a technique that presents diverse limitations. …”
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C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells by Lei Yang, Lanjie Lei, Qihan Zhao, Ying Gong, Gaopeng Guan, Shaoxin Huang

“…Leydig cells isolated from mouse testis were cultured and treated with shNPR2 lentiviruses or CNP. And then the cyclic guanosine mono-phosphate production, testosterone secretion, cell proliferation, cell cycle and cell apoptosis in mouse Leydig cells were ana-lyzed by ELISA, RT-qPCR, Cell Counting Kit-8, and flow cytometry. …”

A neuron-based screening platform for optimizing genetically-encoded calcium indicators. by Trevor J Wardill, Tsai-Wen Chen, Eric R Schreiter, Jeremy P Hasseman, Getahun Tsegaye, Benjamin F Fosque, Reza Behnam, Brenda C Shields, Melissa Ramirez, Bruce E Kimmel, Rex A Kerr, Vivek Jayaraman, Loren L Looger, Karel Svoboda, Douglas S Kim

“…Efficient neuronal GECI expression was achieved using lentiviruses containing a neuronal-selective gene promoter. …”
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Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway. by Lu Zhang, Yu Fang, Yuming Xu, Yajun Lian, Nanchang Xie, Tianwen Wu, Haifeng Zhang, Limin Sun, Ruifang Zhang, Zhenhua Wang

“…Furthermore, the cognition enhancement effect of curcumin could be mimicked by the overexpression of BDNF in the hippocampus and blocked by either bilateral hippocampal injections with lentiviruses that express BDNF shRNA or a microinjection of ERK inhibitor. …”
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Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2 by Roberto Patarca, William A. Haseltine

“…The multifunctional Tat proteins of lentiviruses (HIV-1, HIV-2, and SIV) transactivate gene expression by recruiting host proteins and binding to transacting responsive regions (TARs) in viral and host RNAs. …”
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Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses. by Melvyn W Yap, George R Young, Renata Varnaite, Serge Morand, Jonathan P Stoye

“…These genes exhibited a range of restriction phenotypes, with activities directed against gamma-, spuma-, and lentiviruses. It seems likely, at least in the case of M. caroli, that the observed gene duplication may expand the breadth of restriction beyond the capacity of Fv1 alone and that one or more such viruses have recently driven or continue to drive the evolution of the Fv1 and Fv7 genes.…”
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Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives by Wendy Dong, Boris Kantor

“…In this review, we will devote attention to (<i>i</i>) the basic biology of lentiviruses, and (<i>ii</i>) recent advances in the development of safer and more efficient CRISPR/Cas vector systems towards their use in preclinical and clinical applications. …”
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Fluorescent image analysis of HIV-1 and HIV-2 uncoating kinetics in the presence of old world monkey TRIM5α. by Eri Takeda, Ken Kono, Amy E Hulme, Thomas J Hope, Emi E Nakayama, Tatsuo Shioda

“…These results confirmed and further extended the previous notion that accelerated uncoating is associated with restriction activity of TRIM5α against lentiviruses.…”
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Structural Insights into APOBEC3-Mediated Lentiviral Restriction by Krista A. Delviks-Frankenberry, Belete A. Desimmie, Vinay K. Pathak

“…In this review, we summarize our current understanding of the role of human A3 proteins as barriers against HIV-1 infection, how Vif overcomes their antiviral activity, and highlight recent structural and functional insights into A3-mediated restriction of lentiviruses.…”
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Lentiviral vector mediated thymidine kinase expression in pluripotent stem cells enables removal of tumorigenic cells. by Tiong-Ti Lim, Caroline Geisen, Michael Hesse, Bernd K Fleischmann, Katrin Zimmermann, Alexander Pfeifer

“…Our aim was to study the conditions required for a safe mechanism to clear residual undifferentiated cells but using low MOIs of lentiviruses to reduce the risk of insertional mutagenesis. …”
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Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI by Hahn Beatrice H, Dejucq-Rainsford Nathalie, Burgener Adam, Forssmann Wolf-Georg, Staendker Ludger, Roan Nadia R, Zirafi Onofrio, Yolamanova Maral, Kim Kyeong-Ae, Shaw George M, Greene Warner C, Kirchhoff Frank, Münch Jan

“…</p> <p>Conclusions</p> <p>Our results show that semen strongly enhances the infectivity of HIV-1 and other primate lentiviruses and that SEVI contributes to this effect. …”
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BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells by Fei Xiao, Chuandong Wang, Chenglong Wang, Yuan Gao, Xiaoling Zhang, Xiaodong Chen

“…After overexpressing or silencing BMPER with lentiviruses or siRNA, hBMSCs were stimulated by BMP-2, and osteogenic differentiation activity was detected by alkaline phosphatase and alizarin red staining. …”
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Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1 by Plemenitas Ana, Tanuri Amilcar, Aguiar Renato S, Lopes Adriana, Chen Nan, Costa Luciana J, Peterlin B Matija

“…<p>Abstract</p> <p>Background</p> <p>Nef is an accessory protein of primate lentiviruses, HIV-1, HIV-2 and SIV. Besides removing CD4 and MHC class I from the surface and activating cellular signaling cascades, Nef also binds GagPol during late stages of the viral replicative cycle. …”
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Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteins. by David Perez-Caballero, Steven J Soll, Paul D Bieniasz

“…TRIM5 and APOBEC restriction factors are most often studied in the context of modern primate lentiviruses, but it is likely that ancient retroviruses imposed the selective pressure that is evident in primate TRIM5 and APOBEC3 genes. …”
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Human Immunodeficiency Virus Type 2 (HIV-2) Gag Is Trafficked in an AP-3 and AP-5 Dependent Manner. by Justine E Alford, Michela Marongiu, Gemma L Watkins, Emma C Anderson

“…Although human immunodeficiency virus (HIV) types 1 and 2 are closely related lentiviruses with similar replication cycles, HIV-2 infection is associated with slower progression to AIDS, a higher proportion of long term non-progressors, and lower rates of transmission than HIV-1, likely as a consequence of a lower viral load during HIV-2 infection. …”
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A DNA sequence recognition loop on APOBEC3A controls substrate specificity. by Eric C Logue, Nicolin Bloch, Erica Dhuey, Ruonan Zhang, Ping Cao, Cecile Herate, Lise Chauveau, Stevan R Hubbard, Nathaniel R Landau

“…APOBEC3A (A3A), one of the seven-member APOBEC3 family of cytidine deaminases, lacks strong antiviral activity against lentiviruses but is a potent inhibitor of adeno-associated virus and endogenous retroelements. …”
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Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity. by Vyacheslav Furtak, Alok Mulky, Stephen A Rawlings, Lina Kozhaya, KyeongEun Lee, Vineet N Kewalramani, Derya Unutmaz

“…The actions of Mov10 are not limited to HIV, however, as ectopic expression of Mov10 restricts the production of other lentiviruses as well as the gammaretrovirus, murine leukemia virus. …”
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