Evaluating the Extent of Ultrasound-Guided Cervical Selective Nerve Root Block in the Lower Cervical Spine: Evidence Based on Computed Tomography Images by Ma L, Wang Y, Yao M, Huang B, Deng J, Wen H

“…Following placement of the puncture needle tip between the target nerve root and posterior tubercle, 3 mL of the drug was administered per root (0.33% lidocaine 0.5 mL + Compound betamethasone injection 0.5mL + methylcobalamin injection 1mL + iohexol 1mL). …”
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Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation by Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean

“…Surprisingly, the compound is also a highly effective sodium channel inhibitor when applied extracellularly, producing more potent inhibition than lidocaine or bupivacaine. The charged inhibitor produced potent and long-lasting analgesia in mouse models of incisional wound and inflammatory pain, inhibited release of the neuropeptide calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and reduced inflammation in a mouse model of allergic asthma, which has a strong neurogenic component. …”
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A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation by Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen

“…However, based on the prior study, although lidocaine, the most used painkiller in zebrafish, has been shown to ameliorate amputated zebrafish behaviors, it still causes some prolonged effects. …”
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<i>Epilobium angustifolium</i> L. Essential Oil—Biological Activity and Enhancement of the Skin Penetration of Drugs—In Vitro Study by Anna Nowak, Wiktoria Duchnik, Edyta Makuch, Łukasz Kucharski, Paula Ossowicz-Rupniewska, Krystyna Cybulska, Tadeusz Sulikowski, Michał Moritz, Adam Klimowicz

“…The EOEa enhanced the percutaneous penetration of ibuprofen and lidocaine. After a 24 h test, the content of terpene in the skin and the acceptor fluid was examined. …”
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β-Glucan and Fatty Acid Based Mucoadhesive Carrier for Gastrointestinal Tract Specific Local and Sustained Drug Delivery by Stephanie Vargas Esquivel, Himanshu N. Bhatt, Rimpy Diwan, Ahsan Habib, Wen-Yee Lee, Zehedina Khatun, Md Nurunnabi

“…We observed a comparatively higher drug release of lidocaine in gastric juice than that in intestinal fluids, demonstrating the influence of the pH values of the media on drug-release kinetics. …”
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Enhancing diagnosis and treatment of superior cluneal nerve entrapment: cadaveric, clinical, and ultrasonographic insights by Wei-Ting Wu, Kamal Mezian, Ondřej Naňka, Lan-Rong Chen, Vincenzo Ricci, Chih-Peng Lin, Ke-Vin Chang, Levent Özçakar

“…The CSA of the SCN, pressure-pain threshold, and pain measurements were obtained from asymptomatic controls and patients with SCN entrapment at various time points after hydrodissection (with 1 mL of 50% dextrose, 4 mL of 1% lidocaine, and 5 mL of 1% normal saline) in the short-axis view. …”
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Opioid-free anesthesia with ultrasound-guided quadratus lumborum block in the supine position for lower abdominal or pelvic surgery: a randomized controlled trial by Jingwei Dai, Shanliang Li, Qijun Weng, Jinxiong Long, Duozhi Wu

“…In group Q, 20 ml of 0.50% lidocaine and 0.20% ropivacaine diluted in normal saline (NS) were injected into each side. …”
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Ultrasound-guided erector spinae plane block for perioperative analgesia in patients undergoing laparoscopic nephrectomy surgery: A randomized controlled trial by Ming Yang, Lei Cao, Tong Lu, Cheng Xiao, Zhuoxi Wu, Xuetao Jiang, Wei Wang, Hong Li

“…In the ESPB group, a mixture of 10 mL of 1% lidocaine, 10 mL of 0.7% ropivacaine, 0.5 μg/kg dexmedetomidine, and 5 mg of dexamethasone was administered. …”
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Therapeutic Approach for Trigeminal Neuralgia: A Systematic Review by Muhammad Haseeb Rana, Abdul Ahad Ghaffar Khan, Imran Khalid, Muhammad Ishfaq, Mukhatar Ahmed Javali, Fawaz Abdul Hamid Baig, Mohammad Zahir Kota, Mohasin Abdul Khader, Mohammad Shahul Hameed, Sharaz Shaik, Gotam Das

“…Drug combinations using carbamazepine, baclofen, gabapentin, ropivacaine, tizanidine, and pimozide can yield satisfactory results and improve the tolerance to the treatment. Intravenous lidocaine can be used to treat acute exaggerations and botulinum toxin-A can be used in refractory cases. …”
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Pencegahan dan Pengobatan Disfungsi Kognitif setelah Cedera Otak Traumatik by Dewi Yulianti Bisri, Tatang Bisri

“…In general, the ABCDE of neuroanesthesia/neuroresuscitation is still commonly used, and in specific case, the need to administration of lidocaine infusion, sodium lactate hyperosmolar, cholinergic, catecholaminergic, and tricyclic antidepressants.…”
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A Retrospective Analysis of Safety in Participants Treated with a Hybrid Hyaluronic Acid and Calcium Hydroxyapatite Filler by André Braz, MD, Ligia Colucci, MD, Luciana Macedo de Oliveira, MD, Grasiela Monteiro, MD, Patricia Ormiga, MD, MSc, Fabiana Wanick, PhD, Camila Cazerta, MD, Graeme Kerson, BSc, Maria Musumeci, PhD, Michael Silberberg, MD

“…Limited long-term safety data are published on HA/CaHA/L, a hybrid dermal filler combining hyaluronic acid (HA), calcium hydroxyapatite (CaHA), and lidocaine (L). Methods:. This retrospective multicenter study assessed treatment-emergent adverse events (TEAEs) in adults treated with HA/CaHA/L. …”
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Ionic complexation improves wound healing in deep second-degree burns and reduces in-vitro ciprofloxacin cytotoxicity in fibroblasts by María Florencia Sanchez, María Laura Guzman, Jesica Flores-Martín, Mariano Cruz Del Puerto, Carlos Laino, Elio Andrés Soria, Ana Carolina Donadio, Susana Genti-Raimondi, María Eugenia Olivera

“…In this study, antibiotic-anesthetic (AA) smart systems obtained by ionic complexation of polyelectrolytes with ciprofloxacin and lidocaine were obtained as films and hydrogels. Ionic complexation with sodium alginate and hyaluronate decreased cytotoxicity of ciprofloxacin above 70% in a primary culture of isolated fibroblasts (p < 0.05). …”
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Effectiveness of ultrasound guided interfascial hydrodissection with the use of saline anesthetic solution for myofascial pain syndrome of the upper trapezius: a single blind rando... by Charidy Suarez-Ramos, Consuelo Gonzalez-Suarez, Consuelo Gonzalez-Suarez, Ivan Neil Gomez, Ivan Neil Gomez, Maria Katherine Gonzalez, Philippe Hubert Co, Jose Alfonso Llamas

“…It is theorized that this technique blocks the nerve branches and improve gliding in between the muscle and fascia.ObjectiveTo determine the short and long-term effects of interfascial hydrodissection using 2% Lidocaine and saline solution compared to dry needling with MPS of the upper trapezius on pain and quality of life using.MethodsThis study is a single-blind randomized controlled trial where ultrasound guided IH with ASS was compared to dry needling (DN) of the MTrPs. …”
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Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain—Narrative Review by Magdalena Kocot-Kępska, Renata Zajączkowska, Joanna Mika, David J. Kopsky, Jerzy Wordliczek, Jan Dobrogowski, Anna Przeklasa-Muszyńska

“…The evidence from RCTs and reviews supports 5% lidocaine patches, 8% capsaicin patches, and botulinum toxin A injections as effective treatments in patients with peripheral neuropathic pain. …”
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The Clinical Efficacy of Platelet-Rich Plasma Injection Therapy versus Different Control Groups for Chronic Low Back Pain: A Network Meta-Analysis of Randomized Controlled Trials by Zhang X, Zhang A, Guan H, Zhou L, Zhang J, Yin W

“…After 3 months, radiofrequency (RF) emerged as the best therapy in pain (SUCRA=100%) and disability index (SUCRA=98.5%), followed by PRP (SUCRA=62.3%, SUCRA=64.3%, respectively), CS (SUCRA=24.6%, SUCRA=25.9%, respectively) and lidocaine (SUCRA=13.1%, SUCRA=11.3%, respectively). …”
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The size of the Hill Sachs defect increases during reduction of a first time shoulder dislocation in older adults: a pilot study in 20 cases by Miguel Angel Ruiz Ibán, Roque Pérez Expósito, Agustina Vicente Bártulos, Rosa Vega Rodriguez, Raquel Ruiz Díaz, Jorge Diaz Heredia

“…The shoulder was reduced in the emergency room with intraarticular lidocaine; if two attempts failed, the shoulder was reduced under anaesthesia. …”
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Analgesia postoperatoria con morfina base en cirugía abdominal Post-operative analgesia with morphine basis for abdominal surgery by Maribel Correa Torres, Verónica Castillo Pérez, Ariadna García Rodríguez, Ariel Gonzáles Martínez, Pedro Bazart Padrón

“…In group I, spinal anesthesia with hyperbaric lidocaine 0.5 % (150 mg) (control group). Group II, spinal anesthesia with hyperbaric plus morphine 0.2 mg. …”
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Wide Awake Local Anesthesia No Tourniquet Surgery of Carpal Tunnel Syndrome: Patients’ Experience and Recall Bias in a Day-Care Setting by Saulius Knystautas, Kęstutis Braziulis, Ernest Zacharevskij, Karolis Varkalys, Violeta Šimatonienė, Loreta Pilipaitytė

“…For WALANT, a hand surgeon used a combination of 1:200,000 epinephrine, 1% lidocaine, and 1 mL 8.4% sodium bicarbonate solution without tourniquet application and sedating the patient. …”
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A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors by Yueshan Sun, Hong Li, Lei Liu, Xiaoqin Bai, Liping Wu, Jing Shan, Xiaobin Sun, Qiong Wang, Yuanbiao Guo

“…Mast cell (MC) plays a central role in intestinal permeability; however, few MC-targeting drugs are currently available for protection of the intestinal barrier in clinical practice. A nonfluorinated Lidocaine analog 2-diethylamino-N-2,5-dimethylphenyl acetamide (JM25-1) displays anti-allergic effect, but its impact on MC remains elusive. …”
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Deep electroacupuncture of neurogenic spots attenuates immobilization stress-induced acute hypertension in rats by Cong Zhan, Han Byeol Jang, DanBi Ahn, Suchan Chang, Yeonhee Ryu, Hyung Kyu Kim, Bong Hyo Lee, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Kim

“…Results: Electrical stimulation of the neurogenic spot at a 3-mm depth most effectively lowered blood pressure compared with controls and stimulation at 1- and 2-mm depths, which was inhibited by pretreatment with a local anesthetic lidocaine. Electrical stimulation of the neurogenic spot or injection of substance P (SP) at a 3-mm depth significantly excited the rostral ventrolateral medulla (rVLM) compared with superficial stimulation. …”
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