Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins by Jiang Xu, Shuai Guo, Xianmei Yin, Mingqian Li, He Su, Xuejiao Liao, Qiushi Li, Liang Le, Shiyu Chen, Baosheng Liao, Haoyu Hu, Juan Lei, Yingjie Zhu, Xiaohui Qiu, Lu Luo, Jun Chen, Ruiyang Cheng, Zhenzhan Chang, Han Zhang, Nicholas Chieh Wu, Yiming Guo, Dianyun Hou, Jin Pei, Jihai Gao, Yan Hua, Zhihai Huang, Shilin Chen

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A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis by Dan Wang, Bochuan Deng, Lu Cheng, Jieru Li, Jiao Zhang, Xiang Zhang, Xiaomin Guo, Tiantian Yan, Xin Yue, Yingying An, Bangzhi Zhang, Wenle Yang, Junqiu Xie, Rui Wang

“…DR3penA (DHα-(4-pentenyl)-ANPQIR-NH2) was verified to have a longer half-life in serum and to significantly inhibit oxidative damage, epithelial–mesenchymal transition (EMT) and fibrogenesis in vitro and in vivo. …”
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The efficacy and safety of short-course radiotherapy followed by sequential chemotherapy and Cadonilimab for locally advanced rectal cancer: a protocol of a phase II study by Tongzhen Xu, Lingling Feng, Wenjue Zhang, Haoyue Li, Huiying Ma, Muyasha Abulimiti, Yutong Tan, Feiyan Deng, Wenting Huang, Shuangmei Zou, Wenyan Kang, Liming Jiang, Ying Wang, Chen Hu, Yinggang Chen, Haitao Zhou, Yuan Tang, Jing Jin

“…The secondary endpoints included local–regional control, distant metastasis, disease-free survival, overall survival, toxicity profile, quality of life and functional outcome of the rectum. To detect an increase in the complete remission rate from 21.8% to 40% with 80% power, 50 patients were needed. …”
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Comparison of Organic and Mineral Selenium on Performance, Microbial Population, Intestinal Histopathologhy and Cecum Acidity of Laying Hens by Zahra Tahami, Behrouz Dastar, Ehsan Oskoueian, Seyed reza Hashemi

“…Increasing the population of beneficial bacteria due to the provision of sufficient selenium for their synthesis is also an antioxidant property of selenium in preserving the life of these bacteria. It appears that beneficial bacteria, such as Lactobacillus, can competitively eliminate harmful bacteria such as Escherichia coli in the gut (Lukaszewicz et al., 2011). …”
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Mitochondrial transplantation ameliorates doxorubicin-induced cardiac dysfunction via activating glutamine metabolism by Xiaolei Sun, Hang Chen, Rifeng Gao, Ya Huang, Yanan Qu, Heng Yang, Xiang Wei, Shiyu Hu, Jian Zhang, Peng Wang, Yunzeng Zou, Kai Hu, Junbo Ge, Aijun Sun

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Optimising the care for older persons with complex chronic conditions in home care and nursing homes: design and protocol of I-CARE4OLD, an observational study using real-world dat... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Hein PJ van Hout, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska

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Efficacy of very low-calorie ketogenic diet with the Pronokal® method in obese women with polycystic ovary syndrome: a 16-week randomized controlled trial by Srdjan Pandurevic, Ilaria Mancini, Dimitri Mitselman, Matteo Magagnoli, Rita Teglia, Roberta Fazzeri, Paola Dionese, Carolina Cecchetti, Massimiliamo Caprio, Costanzo Moretti, Justyna Sicinska, Alessandro Agostini, Domenica Gazineo, Lea Godino, Ignacio Sajoux, Flaminia Fanelli, Cristina M Meriggiola, Uberto Pagotto, Alessandra Gambineri

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A Histological Study of the Skin of the Dorsal and Ventral Areas of the Flounder Boleophthalmus dussumieri (Teleostei: Oxudercidae) in Khor Musa (Northwest of the Persian Gulf) by Fahime Saberi, Ahmad Gharzi, Ashraf Jazayeri, Vahid Akmali, Khosro Chehri

“…Based on the amphibian way of life of slugs, in species that are more hydrophilic, the upper and middle parts of the body, which are often exposed to air, have smaller amounts of diffusion distance. …”
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An Analysis of the Process of Sanctification of Tree in the Cultural Sphere of Halil Rood by Mohsen Akbarizadeh, Fatemeh Taheri

“…Linked to the phenomenon of human life, death, and immortality, this gives the tree a symbolic aspect.  …”
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MODIFIED SEIRD MODEL: A NOVEL SYSTEM DYNAMICS APPROACH IN MODELLING THE SPREAD OF COVID-19 IN MALAYSIA DURING THE PRE-VACCINATION PERIOD by Norsyahidah Zulkarnain, Nurul Farahain Mohammad, Ibrahim Shogar

“… Mathematical modelling is an effective tool for understanding the complex structures and behaviors of natural phenomena, such as coronavirus disease 2019 (COVID-19), which is an infectious disease caused by a life-threatening virus called SARS-CoV-2. It has rapidly spread across the world in the last three years, including Malaysia. …”
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Penanganan Edema Serebri Berat dan Herniasi Serebri pada Cedera Kepala Traumatik by Agus Baratha Suyasa, Sri Rahardjo

“…Management of Severe Cerebral Edema and Cerebral Herniation in Traumatic Brain Injury Traumatic brain injury is one of life-threatening condition to victims of serious accidents, and is the leading cause of disability and death in adults and children. …”
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Analytical Comparison of Espionage Methods in Seven Historical Literary Stories by elham arabshahi kashi, Reza Shajari

“…The method of hard penetration and espionage is one of the old tactics in war, when a person volunteered to defend the ideals of their country, nation, group or tribe by risking their life, this is somewhat reminiscent of the same jurisprudential ruling of "Tatarros" is also in Islam. …”
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B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma by Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N. Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J. Harris, Silvia Mele, Giulia Pellizzari, Anna B. M. Black, Heather J. Bax, Anthony Cheung, Mano Nakamura, Ricarda M. Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K. Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K. Dunn-Walters, Eleftherios P. Diamandis, Sophia Tsoka, James Spicer, Katie E. Lacy, Franca Fraternali, Sophia N. Karagiannis

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Proposing a Model for Commercialization of Entrepreneurial Ideas in University Incubators by Seyed Foad Zarifi, Morteza Mousa Khani, Adel Azar, Mehdi Alvani

“…This requires researches and developments at all stages of commercialization by taking into account the life span of the idea, and also considering the time, make fundamental changes to current ideas should be done in order to benefit from mutual benefits for the market as well as entrepreneurs. …”
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Evidence and gap map report: Social and Behavior Change Communication (SBCC) interventions for strengthening HIV prevention and research among adolescent girls and young women (AGY... by Devi Leena Bose, Anhad Hundal, Sabina Singh, Shweta Singh, Kuhika Seth, Saif ul Hadi, Ashrita Saran, Jessy Joseph, Kriti Goyal, Solomon Salve

“…Similarly, evidence on extrinsic factors—such as strengthening social and community norms, relationships, and household dynamics—that determine individual thought and action such as negotiation and life skills were also found to be less populated. …”
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Introduction by Xin Li

“…For instance, various forms of neighbourhood decline, such as crime, social disorder or physical environmental deterioration, often have a negative influence on residents’ perceived quality of life, which can trigger some residents to move out as shown for the United States, United Kingdom and the Netherlands (Feijten and van Ham, 2009; Livingston et al., 2010; Vale,1997). …”
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Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum by Flore Nardella, Irina Dobrescu, Haitham Hassan, Fabien Rodrigues, Sabine Thiberge, Liliana Mancio-Silva, Ambre Tafit, Corinne Jallet, Véronique Cadet-Daniel, Stéphane Goussin, Audrey Lorthiois, Yoann Menon, Nicolas Molinier, Dany Pechalrieu, Christophe Long, François Sautel, Mariette Matondo, Magalie Duchateau, Guillaume Médard, Benoit Witkowski, Artur Scherf, Ludovic Halby, Paola B. Arimondo

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Hyperkalemia as a limiting factor of neurohormonal blockade/modulation in everyday clinical practice by Henrique Vasconcelos, Joana Cabral, Emília Moreira, Manuel Campelo, Sandra Amorim, Brenda Moura, Alexandra Sousa, Roberto Pinto, Paulo Maia-Araújo, Cláudia Dias, José Silva-Cardoso

“…We assessed the relevance of hyperkalemia as a limiting factor of neurohormonal blockade/modulation in real life clinical conditions. Methods: We reviewed the medical records of HFrEF patients attending a HF clinic at a tertiary Portuguese hospital during 2018 (n=240). …”
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RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillanceResearch in context by Stephen R. Stockdale, Adam A. Blanchard, Amit Nayak, Aliabbas Husain, Rupam Nashine, Hemanshi Dudani, C. Patrick McClure, Alexander W. Tarr, Aditi Nag, Ekta Meena, Vikky Sinha, Sandeep K. Shrivastava, Colin Hill, Andrew C. Singer, Rachel L. Gomes, Edward Acheampong, Saravana B. Chidambaram, Tarun Bhatnagar, Umashankar Vetrivel, Sudipti Arora, Rajpal Singh Kashyap, Tanya M. Monaghan

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A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles by Lei Cao, Ruohui Han, Yingying Zhao, Xiaoyang Qin, Qian Li, Hui Xiong, Yu Kong, Ziyi Liu, Zexing Li, Feng Dong, Ting Li, Xiujuan Zhao, Lei Lei, Qian Zhao, Dayong Liu, Baofeng Wang, Xudong Wu

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