An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis by Daniel J. Leite, Anna Schönauer, Grace Blakeley, Amber Harper, Helena Garcia-Castro, Luis Baudouin-Gonzalez, Ruixun Wang, Naïra Sarkis, Alexander Günther Nikola, Venkata Sai Poojitha Koka, Nathan J. Kenny, Natascha Turetzek, Matthias Pechmann, Jordi Solana, Alistair P. McGregor

“…This revealed new insights into the cellular basis and genetic regulation of head patterning, hematopoiesis, limb development, gut development, and posterior segmentation. …”
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Blood transcriptome comparison between sexes and their function in 4-week Rhode Island red chickens by Hana Kim, Hyojun Choo, Jihye Cha, Myoungjin Jang, Juhwan Son, Taejoon Jeong, Bong-Hwan Choi, Youngjo Lim, Han-Ha Chai, Jungjae Lee, Dajeong Lim, Donghyun Shin, Woncheoul Park, Jong-Eun Park

“…The gene ontology (GO) terms are significantly (p < 0.05) enriched, which were limb development, inner ear development, positive regulation of dendrite development, the KEGG pathway the TGF-beta signaling pathway, and melanogenesis (p < 0.05). …”
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Phylogeny of Paleozoic limbed vertebrates reassessed through revision and expansion of the largest published relevant data matrix by David Marjanović, Michel Laurin

“…We discuss phylogeny, approaches to coding, methods of phylogenetics (Bayesian inference vs. equally weighted vs. reweighted parsimony), some character complexes (e.g. preaxial/postaxial polarity in limb development), and prospects for further improvement of this matrix. …”
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Screening and identification of miRNAs regulating Tbx4/5 genes of Pampus argenteus by Cheng Zhang, Shun Zhang, Mengdi Liu, Yajun Wang, Danli Wang, Shanliang Xu

“…Tbx4/5 genes are highly conserved regulatory factors that regulate limb development in vertebrates and are in turn regulated by microRNAs (miRNAs). …”
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IHH enhancer variant within neighboring NHEJ1 intron causes microphthalmia anophthalmia and coloboma by Ohad Wormser, Yonatan Perez, Vadim Dolgin, Bahman Kamali, Jared A. Tangeman, Libe Gradstein, Yuval Yogev, Noam Hadar, Ofek Freund, Max Drabkin, Daniel Halperin, Inbar Irron, Erika Grajales-Esquivel, Katia Del Rio-Tsonis, Ramon Y. Birnbaum, Gidon Akler, Ohad S. Birk

“…The human NHEJ1 intronic variant lies within a known specifically limb-development enhancer of a neighboring gene, Indian hedgehog (Ihh), known to be involved in eye development in mice and chickens. …”
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The role of PRX1-expressing cells in periodontal regeneration and wound healing by Zhen Huang, Xu Su, Miliya Julaiti, Xiaotao Chen, Qingxian Luan

“…Post-natal cells expressing the paired-related homeobox protein 1 (PRX1 or PRRX1), a transcription factor expressed in the mesenchyme during craniofacial and limb development, have been shown to have characteristics of skeletal stem cells. …”
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Establishment of a control induced pluripotent stem cell line SMBCi018-A from a patient with congenital talipes equinovarus by Zhenzhong Han, Jing Wang, Jing Luan, Yazhou Cui, Jinxiang Han

“…According to recent studies, the PITX1-TBX4 transcriptional pathway regulatory for early limb development has identified a key developmental pathway in clubfoot etiology by the common disease-rare hypothesis. …”
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Aberrant Ras/MAPK signaling in skeletal development by Nedelcu, Simona

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A complex structural variant near SOX3 causes X-linked split-hand/foot malformation by Elke de Boer, Carlo Marcelis, Kornelia Neveling, Ellen van Beusekom, Alexander Hoischen, Willemijn M. Klein, Nicole de Leeuw, Tuomo Mantere, Uirá S. Melo, Jeroen van Reeuwijk, Dominique Smeets, Malte Spielmann, Tjitske Kleefstra, Hans van Bokhoven, Lisenka E.L.M. Vissers

“…SHFM is caused by failure to maintain normal apical ectodermal ridge function during limb development. Although several genes and contiguous gene syndromes are implicated in the monogenic etiology of isolated SHFM, the disorder remains genetically unexplained for many families and associated genetic loci. …”
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Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway by Jeonghyeon Moon, Keun-Hyung Cho, JooYeon Jhun, JeongWon Choi, Hyun-Sik Na, Jeong Su Lee, Seung Yoon Lee, Jun-Ki Min, Anan Shetty, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho

“…Joint injury, being overweight, differences in leg length, high levels of joint stress, abnormal joint or limb development, and inherited factors have been implicated in the etiology of OA. …”
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Genome Sequencing of the Japanese Eel (<i>Anguilla japonica</i>) for Comparative Genomic Studies on <i>tbx4</i> and a <i>tbx4</i> Gene Cluster in Teleost Fishes by Weiwei Chen, Chao Bian, Xinxin You, Jia Li, Lizhen Ye, Zhengyong Wen, Yunyun Lv, Xinhui Zhang, Junmin Xu, Shaosen Yang, Ruobo Gu, Xueqiang Lin, Qiong Shi

“…Many studies have focused on limb development-related genes, of which the T-box transcription factor 4 gene (<i>tbx4</i>) has been considered as one of the most essential factors in the regulation of the hindlimb development. …”
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Hopkins Syndrome with Mycoplasma Infection by J Gordon Millichap

“…A 3-year-old boy with acute flaccid paralysis of the right lower limb developing one week after treatment and recovery from an acute asthma attack is reported from the Department of Child Health, Milton Keynes General Hospital, UK.…”
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Femoral pseudoaneurysm as a complication of slipped capital femoral epiphysis treatment by Carlos Roberto Schwartsmann, João Pedro Farina Brunelli, Gabriel Severo da Silva, Silvio Coelho

“…This report presents a case of bilateral slipped capital femoral epiphysis treated with pinning, in which one of the limbs developed a very rare condition: the formation of a femoral pseudoaneurysm that ruptured.…”
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Disseminated varicella-zoster virus infection in an aplastic anemia- paroxysmal nocturnal hemoglobinuria syndrome patient: A case report by Jie Wang, Zheng Yang, Danhong Ren, Zhanli Shi, Kun Fang, Zhihui Li

“…During his hospitalization in our hospital, he developed fever, abdominal pain, and lower back pain, and his face, penis, trunk, and limbs developed itchy rash. Subsequently, the patient had to undergo cardiopulmonary resuscitation because of sudden cardiac arrest, and be transferred to ICU for treatment. …”
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Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. by Kelly M Gutpell, William T Hrinivich, Lisa M Hoffman

“…Our results indicated that eight week-old gastrocnemius muscles of both mdx/utrn+/- and dko hind limb developed fibrosis whereas age-matched mdx gastrocnemius muscle did not (p = 0.002). …”
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Bullous lesions following phototherapy in a newborn by Marina Moura Toscano, Flavia Fernandes Cintra, Ludmila Oliveira Resende, Paula Casteleti, Lucas Hirano Arruda Moraes, Maria Cecilia da Matta Rivitti-Machado, Marcello Menta Simonsen Nico, Juliana Zoboli Del Bigio, Werther Brunow de Carvalho

“…Fecal acholia and choluria associated with extensive bullous skin lesions in his trunk, abdomen, and upper and lower limbs developed during phototherapy. Several diagnostic hypotheses were presented, including neonatal porphyria, hemochromatosis, Alagille syndrome, and neonatal lupus. …”
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Clinical and microbiological features of host-bacterial interplay in chronic venous ulcers versus other types of chronic skin ulcers by Mara Mădălina Mihai, Mara Mădălina Mihai, Mircea Ioan Popa, Alina Maria Holban, Irina Gheorghe-Barbu, Liliana Gabriela Popa, Mariana-Carmen Chifiriuc, Călin Giurcăneanu, Coralia Bleotu, Coralia Bleotu, Corina Ioana Cucu, Veronica Lazăr

“…IntroductionChronic venous ulcers of the lower limbs develop in the context of advanced venous disease and have a significant impact on the patient’s quality of life, being associated with depression and worrisome suicide rates, as well as with an economic burden caused by increased medical care costs and high epidemiological risks of healthcare associated infections and emergence of strains resistant to multiple classes of antibiotics and/ or antiseptics. …”
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Acute Reversible Motor Predominant Polyradiculoneuropathy among Thai Prisoners after the Outbreak of H3N2 Influenza: A Case Series by Phichamon Khanittanuphong, Thanyalak Amornpojnimman, Sirichai Cheewatanakornkul, Watchara Viratyaporn, Ittipon Preechawettayakul, Chorfa Buntong, Pat Korathanakhun, Erin Kathleen O’Ferrall

“…Results: Among 262 H3N2 influenza patients, motor predominant polyradiculoneuropathy predominantly affecting the lower limbs developed in 10 patients. EMG revealed significantly decreased compound muscle action potentials with preserved distal latencies and conduction velocities in the peroneal nerves. …”
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Factors affecting the incidence of postmastectomy lymphedema in patients with locally advanced breast cancer by N.A. Kоzlovskaya, N.A. Artemova, S.A. Krasny

“…Among obese patients who had been operated according to the standard technique, the edema of the upper limb developed significantly more often (58.7±7.3%) when compared with the main group (36.4±7.3%, p=0.034). …”
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A novel Hoxd13 mutation causes synpolydactyly and promotes osteoclast differentiation by regulating pSmad5/p65/c-Fos/Rank axis by Lishan Zhang, Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin

“…The results showed that the homozygous mutation of Hoxd13 also caused SPD, but heterozygous mutation did not affect limbs development, which was different from that of SPD patients. …”
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