Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway by Jeonghyeon Moon, Keun-Hyung Cho, JooYeon Jhun, JeongWon Choi, Hyun-Sik Na, Jeong Su Lee, Seung Yoon Lee, Jun-Ki Min, Anan Shetty, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho

“…Joint injury, being overweight, differences in leg length, high levels of joint stress, abnormal joint or limb development, and inherited factors have been implicated in the etiology of OA. …”
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Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution by Fang Ye, Guodong Zhang, Weigao E., Haide Chen, Chengxuan Yu, Lei Yang, Yuting Fu, Jiaqi Li, Sulei Fu, Zhongyi Sun, Lijiang Fei, Qile Guo, Jingjing Wang, Yanyu Xiao, Xinru Wang, Peijing Zhang, Lifeng Ma, Dapeng Ge, Suhong Xu, Juan Caballero-Pérez, Alfredo Cruz-Ramírez, Yincong Zhou, Ming Chen, Ji-Feng Fei, Xiaoping Han, Guoji Guo

“…Here the authors report a scRNA-seq method to profile neotenic, metamorphic and limb development stages, highlighting unique perturbation patterns of cell type-related gene expression throughout metamorphosis.…”
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Genome Sequencing of the Japanese Eel (<i>Anguilla japonica</i>) for Comparative Genomic Studies on <i>tbx4</i> and a <i>tbx4</i> Gene Cluster in Teleost Fishes by Weiwei Chen, Chao Bian, Xinxin You, Jia Li, Lizhen Ye, Zhengyong Wen, Yunyun Lv, Xinhui Zhang, Junmin Xu, Shaosen Yang, Ruobo Gu, Xueqiang Lin, Qiong Shi

“…Many studies have focused on limb development-related genes, of which the T-box transcription factor 4 gene (<i>tbx4</i>) has been considered as one of the most essential factors in the regulation of the hindlimb development. …”
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Hopkins Syndrome with Mycoplasma Infection by J Gordon Millichap

“…A 3-year-old boy with acute flaccid paralysis of the right lower limb developing one week after treatment and recovery from an acute asthma attack is reported from the Department of Child Health, Milton Keynes General Hospital, UK.…”
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Femoral pseudoaneurysm as a complication of slipped capital femoral epiphysis treatment by Carlos Roberto Schwartsmann, João Pedro Farina Brunelli, Gabriel Severo da Silva, Silvio Coelho

“…This report presents a case of bilateral slipped capital femoral epiphysis treated with pinning, in which one of the limbs developed a very rare condition: the formation of a femoral pseudoaneurysm that ruptured.…”
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Bilateral Persistent Sciatic Arteries Complicated with Acute Left Lower Limb Ischemia by Hsuan-Yin Wu, Yu-Jen Yang, Chao-Han Lai, Jun-Neng Roan, Chwan-Yau Luo, Chung-Dann Kan

“…In the early embryonic stage, the sciatic artery is the major blood supply for the lower limb bulb and is later replaced by the iliofemoral artery as the limb develops. Its failure to regress, sometimes associated with femoral arterial hypoplasia, and therefore becoming the dominant inflow to the lower extremity is called PSA. …”
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Stress cardiomyopathy associated with area postrema syndrome as a presentation of neuromyelitis optica: case report by Sungsik An, Hyeo-il Ma, Jooyeon Song, Hong-Mi Choi, Young Eun Kim

“…Myoclonus on the limbs developed afterward. Taken with suspicion of area postrema syndrome (APS), the brain MRI showed a demyelinating lesion in the medulla oblongata. …”
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Disseminated varicella-zoster virus infection in an aplastic anemia- paroxysmal nocturnal hemoglobinuria syndrome patient: A case report by Jie Wang, Zheng Yang, Danhong Ren, Zhanli Shi, Kun Fang, Zhihui Li

“…During his hospitalization in our hospital, he developed fever, abdominal pain, and lower back pain, and his face, penis, trunk, and limbs developed itchy rash. Subsequently, the patient had to undergo cardiopulmonary resuscitation because of sudden cardiac arrest, and be transferred to ICU for treatment. …”
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Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. by Kelly M Gutpell, William T Hrinivich, Lisa M Hoffman

“…Our results indicated that eight week-old gastrocnemius muscles of both mdx/utrn+/- and dko hind limb developed fibrosis whereas age-matched mdx gastrocnemius muscle did not (p = 0.002). …”
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Bullous lesions following phototherapy in a newborn by Marina Moura Toscano, Flavia Fernandes Cintra, Ludmila Oliveira Resende, Paula Casteleti, Lucas Hirano Arruda Moraes, Maria Cecilia da Matta Rivitti-Machado, Marcello Menta Simonsen Nico, Juliana Zoboli Del Bigio, Werther Brunow de Carvalho

“…Fecal acholia and choluria associated with extensive bullous skin lesions in his trunk, abdomen, and upper and lower limbs developed during phototherapy. Several diagnostic hypotheses were presented, including neonatal porphyria, hemochromatosis, Alagille syndrome, and neonatal lupus. …”
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Clinical and microbiological features of host-bacterial interplay in chronic venous ulcers versus other types of chronic skin ulcers by Mara Mădălina Mihai, Mara Mădălina Mihai, Mircea Ioan Popa, Alina Maria Holban, Irina Gheorghe-Barbu, Liliana Gabriela Popa, Mariana-Carmen Chifiriuc, Călin Giurcăneanu, Coralia Bleotu, Coralia Bleotu, Corina Ioana Cucu, Veronica Lazăr

“…IntroductionChronic venous ulcers of the lower limbs develop in the context of advanced venous disease and have a significant impact on the patient’s quality of life, being associated with depression and worrisome suicide rates, as well as with an economic burden caused by increased medical care costs and high epidemiological risks of healthcare associated infections and emergence of strains resistant to multiple classes of antibiotics and/ or antiseptics. …”
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Acute Reversible Motor Predominant Polyradiculoneuropathy among Thai Prisoners after the Outbreak of H3N2 Influenza: A Case Series by Phichamon Khanittanuphong, Thanyalak Amornpojnimman, Sirichai Cheewatanakornkul, Watchara Viratyaporn, Ittipon Preechawettayakul, Chorfa Buntong, Pat Korathanakhun, Erin Kathleen O’Ferrall

“…Results: Among 262 H3N2 influenza patients, motor predominant polyradiculoneuropathy predominantly affecting the lower limbs developed in 10 patients. EMG revealed significantly decreased compound muscle action potentials with preserved distal latencies and conduction velocities in the peroneal nerves. …”
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Factors affecting the incidence of postmastectomy lymphedema in patients with locally advanced breast cancer by N.A. Kоzlovskaya, N.A. Artemova, S.A. Krasny

“…Among obese patients who had been operated according to the standard technique, the edema of the upper limb developed significantly more often (58.7±7.3%) when compared with the main group (36.4±7.3%, p=0.034). …”
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A novel Hoxd13 mutation causes synpolydactyly and promotes osteoclast differentiation by regulating pSmad5/p65/c-Fos/Rank axis by Lishan Zhang, Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin

“…The results showed that the homozygous mutation of Hoxd13 also caused SPD, but heterozygous mutation did not affect limbs development, which was different from that of SPD patients. …”
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Twenty-four-hour ambulatory electrocardiography characterization of heart rhythm in Vipera berus-envenomed dogs by Anna Rave Vestberg, Anna Tidholm, Ingrid Ljungvall

“…All four dogs bitten on a limb developed pathologic arrhythmias. Otherwise, no significant differences in clinical, hematological or biochemical variables were seen between dogs with pathologic arrhythmias and those without. …”
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Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: A prospective observational study... by Gorgni Silvia, Mordenti Patrizia, Muroni Monica, Biasini Claudia, Cremona Gabriele, Lazzaro Antonio, Cordani Maria, Bertè Raffaella, Cappucciati Lorella, Di Nunzio Camilla, Vallisa Daniele, Civardi Giuseppe, Cavanna Luigi, Zaffignani Elena, Ambroggi Massimo, Bidin Livia, Palladino Maria, Rodinò Carmelina, Tibaldi Laura

“…Symptomatic deep-vein thrombosis of the upper limbs developed in 48 patients (2.42%). Catheter-related infections occurred in 197 (9.96%) of the catheters inserted. …”
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Absence of P2Y2 Receptor Does Not Prevent Bone Destruction in a Murine Model of Muscle Paralysis-Induced Bone Loss by Ankita Agrawal, Maria Ellegaard, Kristian Agmund Haanes, Ning Wang, Alison Gartland, Ming Ding, Helle Praetorius, Niklas Rye Jørgensen, Niklas Rye Jørgensen

“…Female mice injected with botulinum toxin (BTX) in the hind limb developed muscle paralysis and femoral DXA analysis showed reduction in bone mineral density (&lt;10%), bone mineral content (&lt;16%) and bone area (&lt;6%) in wildtype (WT) compared to KO littermates (with &lt;13%, &lt;21%, &lt;9% respectively). …”
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