Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology by Stanley M. Walls, Dale A. Chatfield, Karen Ocorr, Greg L. Harris, Rolf Bodmer

“…Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. …”
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Metabolomic Analysis of Human Astrocytes in Lipotoxic Condition: Potential Biomarker Identification by Machine Learning Modeling by Daniel Báez Castellanos, Cynthia A. Martín-Jiménez, Andrés Pinzón, George E. Barreto, Guillermo Federico Padilla-González, Andrés Aristizábal, Martha Zuluaga, Janneth González Santos

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FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis by Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M Lambooij, Hendrik JP van der Zande, Enchen Zhou, Maarten E Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R Boon, Yanan Wang, Patrick CN Rensen

“…FGF21 prevented hepatic lipotoxicity, accompanied by activation of thermogenic tissues and attenuation of adipose tissue inflammation, improvement of hyperglycemia and hypertriglyceridemia, and upregulation of hepatic programs involved in fatty acid oxidation and cholesterol removal. …”
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Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes by Yoon S. Oh, Gong D. Bae, Dong J. Baek, Eun-Young Park, Hee-Sook Jun, Hee-Sook Jun, Hee-Sook Jun

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Protopanaxadiol ameliorates palmitate-induced lipotoxicity and pancreatic β-cell dysfunction in INS-1 cells by Dahae Lee, Sungyoul Choi, Ki Sung Kang

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Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice by Anita M. van denHoek, Elsbet J. Pieterman, José W. van derHoorn, Marta Iruarrizaga‐Lejarreta, Cristina Alonso, Lars Verschuren, Tore Skjæret, Hans M.G. Princen, David A. Fraser

“…Although both rosiglitazone and icosabutate reduced hepatic inflammation, only icosabutate elicited antifibrotic effects in association with decreased hepatic concentrations of multiple lipotoxic lipid species and an oxidative stress marker. …”
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Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells by Yunxia Zhu, Xiaoyan Zhang, Li Zhang, Mingliang Zhang, Ling Li, Deng Luo, Yuan Zhong

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DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S] by Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg

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Hydroxycitric acid inhibits kidney stone through crystallization regulation and reduction of hyperoxalate-induced lipotoxicity by Yi-Han Zhang, Jun-Yi Xian, Shu-Jue Li, Chun-Yao Li, Bang-Xian Yu, Qing Liang, Ling-Hong Huang, Guo-Hua Zeng, Xin-Yuan Sun

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PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. by Gema Medina-Gomez, Sarah L Gray, Laxman Yetukuri, Kenju Shimomura, Sam Virtue, Mark Campbell, R Keira Curtis, Mercedes Jimenez-Linan, Margaret Blount, Giles S H Yeo, Miguel Lopez, Tuulikki Seppänen-Laakso, Frances M Ashcroft, Matej Oresic, Antonio Vidal-Puig

“…In summary, the PPARg2 isoform prevents lipotoxicity by (a) promoting adipose tissue expansion, (b) increasing the lipid-buffering capacity of peripheral organs, and (c) facilitating the adaptive proliferative response of beta-cells to insulin resistance.…”
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Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma by Kohei Yagi, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Keiichi Akahoshi, Hiroaki Ono, Minoru Tanabe, Shinji Tanaka

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Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence by Huizhen Zhang, Yongtao Wang, Lihuan Guan, Yixin Chen, Panpan Chen, Jiahong Sun, Frank J. Gonzalez, Min Huang, Huichang Bi

“…Cellular lipotoxicity was further confirmed by lipotoxicity assays. …”
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The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity[S] by Yongzhao Zhang, Kevin Larade, Zhi-gang Jiang, Susumu Ito, WenFang Wang, Hao Zhu, H. Franklin Bunn

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SKELETAL MUSCLE LIPOTOXICITY AND ITS RELATIONSHIP WITH INSULIN RESISTANCE. STUDIES IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME by María Eugenia Oliva, María del Rosario Ferreira, Victoria Aiassa, María Eugenia D’Alessandro

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Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity by Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren

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Evidence showing lipotoxicity worsens outcomes in covid-19 patients and insights about the underlying mechanisms by Rodrigo Cartin-Ceba, Biswajit Khatua, Bara El-Kurdi, Shubham Trivedi, Sergiy Kostenko, Zaid Imam, Ryan Smith, Christine Snozek, Sarah Navina, Vijeta Sharma, Bryce McFayden, Filip Ionescu, Eugene Stolow, Sylvia Keiser, Aziz Tejani, Allison Harrington, Phillip Acosta, Saatchi Kuwelker, Juan Echavarria, Girish B. Nair, Adam Bataineh, Vijay P. Singh

“…Summary: We compared three hospitalized patient cohorts and conducted mechanistic studies to determine if lipotoxicity worsens COVID-19. Cohort-1 (n = 30) compared COVID-19 patients dismissed home to those requiring intensive-care unit (ICU) transfer. …”
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Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity by Sheree D. Martin, Timothy Connor, Andrew Sanigorski, Kevin A. McEwen, Darren C. Henstridge, Brunda Nijagal, David De Souza, Dedreia L. Tull, Peter J. Meikle, Greg M. Kowalski, Clinton R. Bruce, Paul Gregorevic, Mark A. Febbraio, Fiona M. Collier, Ken R. Walder, Sean L. McGee

“…Abstract Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. …”
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Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells by Bergsten Peter, Sargsyan Ernest

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Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells by Hiteshi Dhami-Shah, Rama Vaidya, Manasi Talwadekar, Eisha Shaw, Shobha Udipi, Ullas Kolthur-Seetharam, Ashok D.B. Vaidya

“…Conclusion: Picroside II significantly attenuated FFAs-induced-lipotoxicity. The reduction in ROS, increased antioxidant enzymes, and improvement in mitochondrial function underlie the mechanisms of action of picroside II. …”
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Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis by Xin Zeng, Min Zhu, Xiaohong Liu, Xuanmin Chen, Yujia Yuan, Lan Li, Jingping Liu, Yanrong Lu, Jingqiu Cheng, Younan Chen

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