Oxidative stress and lipotoxicity by Amy K. Hauck, David A. Bernlohr

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Sexual dimorphism in inorganic mercury toxicokinetics and the attendant lipotoxic and non-lipotoxic dyslipidemia in the rat by A.D. Wusu, O.O. Ogunrinola, O.K. Afolabi, E.O. Abam, D.O. Babayemi, O.A. Dosumu, O.B. Onunkwor, E.A. Balogun, O.O. Odukoya, O. Ademuyiwa

“…Mixed sexual dimorphism characterised circulating-lipid- and organ-lipid lipotoxic and non-lipotoxic dyslipidemia. The highest dose of inorganic Hg, induced hypercholesterolemia in the males as opposed to hypocholesterolemia in the female. …”
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The role of lipotoxicity in smoke cardiomyopathy. by Priscila P Santos, Fernando Oliveira, Vanessa C M P Ferreira, Bertha F Polegato, Meliza G Roscani, Ana Angelica Fernandes, Pamela Modesto, Bruna P M Rafacho, Silmeia G Zanati, Annarita Di Lorenzo, Luiz S Matsubara, Sergio A R Paiva, Leonardo A M Zornoff, Marcos F Minicucci, Paula S Azevedo

“…These data suggest that impairment in fatty acid oxidation and the accumulation of cardiac lipids characterize lipotoxicity. CS group exhibited increased oxidative stress and decreased antioxidant defense. …”
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Fatty acid and lipotoxicity in obesity and diabetes

The Contribution of Lipotoxicity to Diabetic Kidney Disease by Jeffrey R. Schelling

“…Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. …”
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Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate by Justin Hou Ming Yung, Lucy Shu Nga Yeung, Aleksandar Ivovic, Yao Fang Tan, Emelien Mariella Jentz, Battsetseg Batchuluun, Himaben Gohil, Michael B. Wheeler, Jamie W. Joseph, Adria Giacca, Mortimer Mamelak

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Editorial: Lipotoxicity, mitotoxicity, and drug targets by Nina Krako Jakovljevic, Neoma T. Boardman, Marina Makrecka-Kuka

Subjects: “…lipotoxicity…”
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Enhanced oleate uptake and lipotoxicity associated with laurate by Yasuyuki Kitaura, Kana Inoue, Naoki Kato, Nahomi Matsushita, Yoshiharu Shimomura

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Lipotoxicity: what is the fate of fatty acids?1 by Jennifer G. Duncan

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Progress of research on role of lipotoxicity in pathogenesis of sarcopenia by JIANG Qi, YANG Liu, HE Jiaojiao, LI Weixin

Subjects: “…free fatty acids|lipotoxicity|sarcopenia|pathogenesis…”
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Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium by Tom Kretzschmar, Jasmine M. F. Wu, P. Christian Schulze

Subjects: “…lipotoxicity…”
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The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction by Mengyuan Ge, Mengyuan Ge, Flavia Fontanesi, Sandra Merscher, Sandra Merscher, Alessia Fornoni, Alessia Fornoni

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Lipotoxicity as the Leading Cause of Non-Alcoholic Steatohepatitis by Marija Branković, Igor Jovanović, Marija Dukić, Tijana Radonjić, Svetlana Oprić, Slobodan Klašnja, Marija Zdravković

“…The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing factor for chronic liver complications, such as cirrhosis and/or development of hepatocellular carcinoma (HCC). Liver lipotoxicity can influence the accumulation of reactive oxygen species (ROS), so oxidative stress is also crucial for the progression of NASH. …”
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GCKIII kinases in lipotoxicity: Roles in NAFLD and beyond by Margit Mahlapuu, Mara Caputo, Ying Xia, Emmelie Cansby

“…Conclusions: Several lines of evidence suggest that GCKIII proteins govern the susceptibility to hepatic lipotoxicity and that pharmacological inhibition of these kinases could mitigate NAFLD development and aggravation. …”
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Ceramide is a cardiotoxin in lipotoxic cardiomyopathy*s⃞ by Tae-Sik Park, Yunying Hu, Hye-Lim Noh, Konstantinos Drosatos, Kazue Okajima, Jonathan Buchanan, Joseph Tuinei, Shunichi Homma, Xian-Cheng Jiang, E. Dale Abel, Ira J. Goldberg

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Lipotoxicity as a Barrier for T Cell-Based Therapies by Romy Böttcher-Loschinski, Judit Rial Saborido, Martin Böttcher, Sascha Kahlfuss, Dimitrios Mougiakakos

Subjects: “…lipotoxicity…”
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Spaceflight Activates Lipotoxic Pathways in Mouse Liver. by Karen R Jonscher, Alba Alfonso-Garcia, Jeffrey L Suhalim, David J Orlicky, Eric O Potma, Virginia L Ferguson, Mary L Bouxsein, Ted A Bateman, Louis S Stodieck, Moshe Levi, Jacob E Friedman, Daila S Gridley, Michael J Pecaut

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The role of ER stress in lipid metabolism and lipotoxicity by Jaeseok Han, Randal J. Kaufman

“…In this review, we highlight recent findings that link ER stress and UPR signaling to the pathogenesis of peripheral organs due to lipotoxicity.…”
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Effects of High Glucose and Lipotoxicity on Diabetic Podocytes by Ran Nakamichi, Kaori Hayashi, Hiroshi Itoh

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Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity by Joaquín Pérez-Schindler, Elyzabeth Vargas-Fernández, Bettina Karrer-Cardel, Danilo Ritz, Alexander Schmidt, Christoph Handschin

“…Abstract Non-alcoholic fatty liver disease is a continuum of disorders among which non-alcoholic steatohepatitis (NASH) is particularly associated with a negative prognosis. Hepatocyte lipotoxicity is one of the main pathogenic factors of liver fibrosis and NASH. …”
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