Trace Analysis of Multiple Tumor Exosomal PD‐L1 Based on SERS Immunoassay Platform by Chenyang Zhang, Kezhen Yi, Wuwen Zhang, Chaoning Huang, Shilian Dong, Fubing Wang, Xiangheng Xiao

“…Moreover, the platform has also been successfully used to distinguish common diseases, cancer, and healthy control (such as liver cancer, liver cirrhosis, and normal individuals). …”
Get full text

Fat and exposure to 4-nitroquinoline-1-oxide causes histologic and inflammatory changes in murine livers by Lenore D. Pitstick, Joanna Goral, Ryan A. Schmelter, Christine M. Fuja, Mae J. Ciancio, Matthew Pytynia, Alice Meyer, Jacalyn M. Green

“…Risk factors for liver cancer include tobacco use, alcohol consumption, obesity, and male sex. …”
Get full text

Economic evaluation of screening programs for hepatitis C virus infection: evidence from literature by Coretti S, Romano F, Orlando V, Codella P, Prete S, Di Brino E, Ruggeri M

“…Its main complications are cirrhosis and liver cancer. According to the World Health Organization (WHO), more than 185 million people worldwide are infected with hepatitis C virus and, of these, 350,000 die every year. …”
Get full text

A Novel Prognostic Model for Identifying the Risk of Hepatocellular Carcinoma Based on Angiogenesis Factors by Yuan Gao, Jia Liu, Dexi Zhao, Guanghao Diao

“…Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor prognosis. An optimized stratification of HCC patients to discriminate clinical benefit regarding different degrees of malignancy is urgently needed because of no effective and reliable prognostic biomarkers currently. …”
Get full text

Expressions of miR-96 and miR-103 in Hepatocellular Carcinoma and Their Correlation with Prognosis by XIAO Wei, LI Quan, ZHANG Hongchang, WEI Yangnian

“…Conclusion The high expression of miR-96 and miR-103 in liver cancer tissues are the independent influence factors of poor prognosis in primary hepatic carcinoma patients and could be used as the indexes of prognostic evaluation.…”
Get full text

Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity by Carolina M. Pusec, Vladimir Ilievski, Adam De Jesus, Zeenat Farooq, Joseph L. Zapater, Nadia Sweis, Hagar Ismail, Md Wasim Khan, Hossein Ardehali, Jose Cordoba-Chacon, Brian T. Layden

“…Its expression profile varies but has been identified to have low basal expression in normal liver but increases during states of stress including pregnancy, nonalcoholic fatty liver disease (NAFLD), and liver cancer. Here, we have developed a stable overexpression model of hepatic HKDC1 in mice to examine its effect on metabolic regulation. …”
Get full text

Identification of Hub Genes and Their Correlation With Immune Infiltration Cells in Hepatocellular Carcinoma Based on GEO and TCGA Databases by Rui Huang, Jinying Liu, Hui Li, Lierui Zheng, Haojun Jin, Yaqing Zhang, Wei Ma, Junhong Su, Min Wang, Kun Yang

“…Hepatocellular carcinoma (HCC) is a primary liver cancer with extremely high mortality in worldwide. …”
Get full text

Hepatectomy combined with apatinib and camrelizumab for CNLC stage IIIb hepatocellular carcinoma: a phase II trial protocol by Jie Zhang, Bang-De Xiang, Jian-Hong Zhong, Liang Ma, Jun Tao Huang, Wen Feng Gong, Le Qun Li

“…Introduction Current clinical guidelines recommend systematic antitumour therapy as the primary treatment option for patients with stage IIIb hepatocellular carcinoma (HCC) based on the China liver cancer (CNLC) staging criteria. Several different targeted therapeutics have been applied in combination with immunotherapeutic regimens to date in patients with advanced HCC. …”
Get full text

Chemical Constituents of <i>Euphorbia stracheyi</i> Boiss (Euphorbiaceae) by Hui Zhu, Xiangxiang Ren, Yanbo Huang, Tao Su, Lei Yang

“…The MTT method was used to determine the cytotoxic activity of five cancer cell lines (Leukemia HL-60, lung cancer A-549, liver cancer SMMC-7721, breast cancer MCF-7, and colon cancer SW480) on the isolated compounds. …”
Get full text

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. by Nilgun Gurbuz, Ahmed A Ashour, S Neslihan Alpay, Bulent Ozpolat

“…Recent studies have suggested that serotonin (5-HT) contributes to the tumor growth in a variety of cancers including prostate, colon, bladder and liver cancer. However, there is lack of evidence about the impact of 5-HT receptors on promoting pancreatic cancer. …”
Get full text

In-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal by Bishnu Prasad Pandey, Kapil Adhikari, Suman Prakash Pradhan, Hee Jeong Shin, Eun Kyeong Lee, Hye Jin Jung

“…Furthermore, the highest antiproliferative effect against cervical, liver, and colon cancer cell lines were observed in Melia azedarach as IC50 values of 10.50, 5.30, and 1.57 μg/mL respectively, while the strongest anti-metastatic potential on liver cancer cell line was found in Pleurospermum benthamii. …”
Get full text

Establishment of a Novel Mouse Hepatocellular Carcinoma Model for Dynamic Monitoring of Tumor Development by Bioluminescence Imaging by Xiangyi Cao, Xiangyi Cao, Yulong Zhang, Qianqian Zhou, Sujing Sun, Minwei He, Xiaohui Wang, Ping Ma, Xiaoang Yang, Liping Lv, Linsheng Zhan

“…In this way, a primary liver cancer model was established within six weeks. …”
Get full text

The impact of background liver disease on the long-term prognosis of very-early-stage HCC after ablation therapy. by Kenta Takaura, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Kouji Yamashita, Tomohiro Muto, Leona Osawa, Shuhei Sekiguchi, Yuka Hayakawa, Mayu Higuchi, Shun Kaneko, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Jun Itakura, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Namiki Izumi

“…<h4>Background and aim</h4>The long-term prognosis of hepatocellular carcinoma (HCC) treated at a very-early-stage (the Barcelona Clinical Liver Cancer (BCLC) classification stage 0) was unclear, especially in terms of background liver disease.…”
Get full text

Efficacy and safety of immune checkpoint inhibitors-combined antiangiogenic drugs in the treatment of hepatocellular carcinoma: A systematic review and meta analysis by Yu Zhong, Hong Huo, Shuqi Dai, Su Li

“…BackgroundHepatocellular carcinoma is a pathological type of liver cancer and accounts for the majority of primary liver cancers. …”
Get full text

Niosome as a Drug Delivery Carrier for Sorafenib: Preparation, Investigation of Physicochemical Properties, and In Vitro Effects on HepG2 Cell Line by Mohammad Amin Raeisi Estabragh, Behzad Behnam, Masoud Torkzadeh-Mahani, Abbas Pardakhty

“…Purpose: Sorafenib is known as one of the oral anti-cancer drugs used in liver cancer. However, its lipophilic nature can lead to side effects, variable pharmacokinetics, and poor absorption. …”
Get full text

Ramucirumab, A Second-Line Option For Patients With Hepatocellular Carcinoma: A Review Of The Evidence by De Luca E, Marino D, Di Maio M

“…Emmanuele De Luca,1,2,* Donatella Marino,1,2,* Massimo Di Maio1,2 1Department of Oncology, University of Turin, Torino, Italy; 2Division of Medical Oncology, Ordine Mauriziano Hospital, Torino, Italy*These authors contributed equally to this workCorrespondence: Massimo Di MaioDivision of Medical Oncology, Ordine Mauriziano Hospital, Via Magellano 1, Turin 10128, ItalyTel +39 011 5082032Fax +39 011 5085081Email massimo.dimaio@unito.itAbstract: Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and predominantly develops in patients with liver cirrhosis. …”
Get full text

Causal association of gut microbiota and esophageal cancer: a Mendelian randomization study by Xiangyu Gao, Zhiguo Wang, Bowen Liu, Yufeng Cheng

“…IntroductionDespite the growing body of evidence, the link between the gut microbiota and different types of tumors, such as colorectal, gastric, and liver cancer, is becoming more apparent. The gut microbiota can be used as a reference for evaluating various diseases, including cancer, and can also act as risk factors or preventive factors. …”
Get full text

Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular CarcinomaSummary by Qiqi Yang, Chuan Yan, Chunyue Yin, Zhiyuan Gong

“…Conclusions: In both zebrafish HCC models and human liver disease samples, a predominant serotonin synthesis and accumulation in males resulted in higher HSC density and activation as well as Tgfb1 expression, thus accelerating HCC carcinogenesis in males. Keywords: Liver Cancer, TGFB1, Kras, Zebrafish…”
Get full text

SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells by Lu Yuan MD, Xian Jian Wu MS, Wen Chuan Li MS, Chenyi Zhuo BS, ZuoMing Xu MS, Chuan Tan MS, RiHai Ma BS, JianChu Wang PhD, Jian Pu MS

“…Liver cancer is considered the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide. …”
Get full text

Sorafenib combined with transarterial chemoembolization versus transarterial chemoembolization alone for advanced-stage hepatocellular carcinoma: a propensity score matching study. by Hao Hu, Zhenhua Duan, Xiaoran Long, Yancu Hertzanu, Haibin Shi, Sheng Liu, Zhengqiang Yang

“…METHODS: We enrolled 321 patients and selected 280 with advanced HCC (Barcelona Clinic Liver Cancer stage C) who underwent TACE therapy between February 2009 and February 2013. …”
Get full text