Emergence of Intrahepatic Cholangiocarcinoma: How High-Throughput Technologies Expedite the Solutions for a Rare Cancer Type by Meng-Shin Shiao, Khajeelak Chiablaem, Varodom Charoensawan, Varodom Charoensawan, Varodom Charoensawan, Nuttapong Ngamphaiboon, Natini Jinawath, Natini Jinawath

“…Intrahepatic cholangiocarcinoma (ICC) is the cancer of the intrahepatic bile ducts, and together with hepatocellular carcinoma (HCC), constitute the majority of primary liver cancers. ICC is a rare disorder as its overall incidence is < 1/100,000 in the United States and Europe. …”
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Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions by Hasan AM, Cavalu S, Kira AY, Hamad RS, Abdel-Reheim MA, Elmorsy EA, El-kott AF, Morsy K, AlSheri AS, Negm S, Saber S

“…Finally, the review discusses in detail the recent therapeutic and diagnostic applications of NDDs that have been conducted in oral, esophageal, gastric, colon, and liver cancers, aiming to offer valuable insights into the current and future state of utilizing NDDs for the local treatment of GI cancers. …”
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Genotoxic and Anti-Genotoxic Assessments of Fermented <i>Houttuynia cordata</i> Thunb. Leaf Ethanolic Extract and Its Anti-Cancer Effect in a Dual-Organ Carcinogenesis Model of Col... by Chonikarn Singai, Pornsiri Pitchakarn, Sirinya Taya, Rawiwan Wongpoomchai, Ariyaphong Wongnoppavich

“…In conclusion, FHCL exhibits significant preventive properties against colon and liver cancers in this dual-organ carcinogenesis model. …”
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Radon and cancers other than lung cancer in underground miners: a collaborative analysis of 11 studies. by Darby, S, Whitley, E, Howe, G, Hutchings, S, Kusiak, R, Lubin, J, Morrison, H, Tirmarche, M, Tomásek, L, Radford, E

“…CONCLUSIONS: The increases in mortality from stomach and liver cancers and leukemia are unlikely to have been caused by radon, since they are unrelated to cumulative exposure. …”

The Phenoxyphenol Compound diTFPP Mediates Exogenous C₂-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcino... by Wen-Tsan Chang, Yung-Ding Bow, Yen-Chun Chen, Chia-Yang Li, Jeff Yi-Fu Chen, Yi-Ching Chu, Yen-Ni Teng, Ruei-Nian Li, Chien-Chih Chiu

“…Hepatocellular carcinoma (HCC) is a severe disease that accounts for 80% of liver cancers. Chemotherapy is the primary therapeutic strategy for patients who cannot be treated with surgery or who have late-stage HCC. …”
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AluScan sequencing and its application to cancer genomics by Ganbolor Sukhbaatar, Si Chen, Wai‐Kin Mat, Hong Xue

“…Result and Conclusion The utility of the AluScan method was illustrated by its usage in delineating the central role of interstitial loss‐of‐heterozygosity (LOH) mutations in cancers, the widespread occurence of forward‐reverse mutation cycles between different stages of cancer development, prognosis of liver cancers based on their relative abundances in LOHs and somatic copy‐number‐variations (CNVs), and prediction of the susceptibility of a genome to cancers based on reccurent germline CNVs. …”
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Disruption of Growth Hormone Receptor Signaling Abrogates Hepatocellular Carcinoma Development by Haque A, Sahu V, Lombardo JL, Xiao L, George B, Wolff RA, Morris JS, Rashid A, Kopchick JJ, Kaseb AO, Amin HM

“…Abedul Haque,1 Vishal Sahu,1 Jamie Lynne Lombardo,2 Lianchun Xiao,3 Bhawana George,1 Robert A Wolff,4 Jeffrey S Morris,3 Asif Rashid,2 John J Kopchick,5,6 Ahmed O Kaseb,4 Hesham M Amin1,7 1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 3Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 4Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 5Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; 6Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; 7MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USACorrespondence: Hesham M Amin, Department of Hematopathology, Unit 072, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA, Tel +1 713 794-1769, Fax +1 713 792-7273, Email hamin@mdanderson.org Ahmed O Kaseb, Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA, Tel +1 713 792-2828, Fax +1 713 745-1163, Email akaseb@mdanderson.orgIntroduction: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancers. It is an aggressive neoplasm with dismal outcome because most of the patients present with an advanced-stage disease, which precludes curative surgical options. …”
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Antitumor Potential of Withanolide Glycosides from Ashwagandha (<i>Withania somnifera</i>) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilica... by Dahae Lee, Jae Sik Yu, Ji Won Ha, Seoung Rak Lee, Bum Soo Lee, Jin-Chul Kim, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim

“…Overall, these results indicate that WAD (<b>3</b>) induced HepG2 apoptosis and inhibited HUVEC tube formation, suggesting its potential application in treating liver cancers.…”
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Cancer incidence and mortality in China, 2022 by Bingfeng Han, Rongshou Zheng, Hongmei Zeng, Shaoming Wang, Kexin Sun, Ru Chen, Li Li, Wenqiang Wei, Jie He

“…Sustained implementation of prevention and control measures has resulted in significant reductions in the incidence and mortality rates of certain historically high incidence cancers, such as esophageal, stomach and liver cancers. Adherence to the guidelines of the Healthy China Action Plan and the Cancer Prevention and Control Action Plan, along with continued efforts in comprehensive risk factor control, cancer screening, early diagnosis and treatment, and standardization of diagnostic and therapeutic protocols, are key strategies to effectively mitigate the increasing cancer burden by 2030.…”
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In Silico Analysis and Functional Characterization of Antimicrobial and Insecticidal Vicilin from Moth Bean (<i>Vigna aconitifolia</i> (Jacq.) Marechal) Seeds by Muhammad Ateeq, Muhammad Muzammal Adeel, Ayesha Kanwal, Muhammad Tahir ul Qamar, Ahsan Saeed, Binish Khaliq, Qamar Saeed, Muhammad Nauman Atiq, Muhammad Bilal, Metab Alharbi, Abdulrahman Alshammari, Ahmed Akrem

“…Furthermore, by using MMT assay, the cytotoxicity effect of <i>Vac</i>V on the growth of HepG2 liver cancerous cells was tested. <i>Vac</i>V showed cytotoxicity against the HepG-2 line and the acquired value was 180 µg after 48 h. …”
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Surveillance of Symptom Burden Using the Patient-Reported Outcome Version of the Common Terminology Criteria for Adverse Events in Patients With Various Types of Cancers During Che... by Danbee Kang, Sooyeon Kim, Hyunsoo Kim, Mangyeong Lee, Sun-Young Kong, Yoon Jung Chang, Sung Hoon Sim, Yeon-Joo Kim, Juhee Cho

“…Patients with breast, gastric, and liver cancers were more likely to have the hand-foot syndrome. …”
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Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma by Li CJ, Tsai HW, Chen YL, Wang CI, Lin YH, Chu PM, Chi HC, Huang YC, Chen CY

“…Chao-Jen Li,1,&ast; Hung-Wen Tsai,2,&ast; Yi-Li Chen,3 Chun-I Wang,4 Yang-Hsiang Lin,5 Pei-Ming Chu,6,7 Hsiang-Cheng Chi,8,9 Yi-Ching Huang,3 Cheng-Yi Chen3 1Department of General & Gastroenterological Surgery, An Nan Hospital, China Medical University, Tainan, Taiwan; 2Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; 5Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 6Department of Anatomy, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 7Department of Medical Education, Chung Shan Medical University Hospital, Taichung, Taiwan; 8Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan; 9Chinese Medicine Research Center, China Medical University, Taichung, Taiwan&ast;These authors contributed equally to this workCorrespondence: Cheng-Yi Chen, Tel/Fax +886-6-2353535&num;5329, Email cychen@gs.ncku.edu.twIntroduction: Hepatocellular carcinoma (HCC) accounts for 80% of all liver cancers and is the 2nd leading cause of cancer-related death in Taiwan. …”
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Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance by Scott RA, Cross TJS, Clarke C, Khan SA, Ryder SD, Franklin J, Aravinthan AD

“…Even in a universal healthcare system such as NHS, which is free at the point of care, delivery of HCC surveillance has not improved over the last decade and remains variable.Keywords: hepatocellular carcinoma, primary surveillance, ultrasound scan, cirrhosis, liver cancer…”
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