Potential of ramucirumab in treating hepatocellular carcinoma patients with elevated baseline alpha-fetoprotein by Gilabert M, Raoul JL

“…Marine Gilabert,1,2 Jean-Luc Raoul3 1Department of Medical Oncology, Paoli-Calmettes Institute, 13232 Marseille Cedex 9, France; 2Centre de Recherche en Cancérologie de Marseille, Stress Cell Unit, Institut National de la Sante et de la Recherche Medicale 1068, Aix-Marseille University, Cedex 8, Marseille, France; 3Department of Medical Oncology, Institut de Cancérologie de l’Ouest René Gauducheau, 44805 Nantes, France Abstract: Hepatocellular carcinoma (HCC) represents ~90% of primary liver cancers and constitutes a major global health problem. …”
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Overcoming the therapeutic resistance of hepatomas by targeting the tumor microenvironment by Jiaxin Zhang, Huiqiong Han, Lei Wang, Wenjia Wang, Mei Yang, Yanru Qin

“…Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is the third leading cause of cancer-related mortality worldwide. …”
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Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma. by Motoyuki Otsuka, Akemi Takata, Takeshi Yoshikawa, Kentaro Kojima, Takahiro Kishikawa, Chikako Shibata, Mutsuhiro Takekawa, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike

“…These findings suggest the involvement of RACK1 in miRNA function and indicate that reduced miRNA function, due to decreased expression of RACK1, may have pathologically relevant roles in liver cancers.…”
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CANCER IN THE CASPIAN LITTORAL AND NORTH WEST AREA by B. A Salmasizadeh

“…The five more prevalent types of cancer found in that area in order of their incidence are esophageal, stomach, skin, lung and liver cancers. Except for cancer of esophagus which occurs with a very high variation in incidence in the area, the incidence of other 4 does not significantly differ in various parts of the region. …”
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Use of endophytic fungi in the Taxol anticancer drug production by Hebert Jair Barrales-Cureño, Raqueline de la Rosa Montoya

“…Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. …”
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A review on the importance of miRNA-135 in human diseases by Sepideh Kadkhoda, Solat Eslami, Solat Eslami, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard

“…Meanwhile, miR-135 has been shown to be up-regulated in bladder, oral, colorectal and liver cancers. Studies in breast, gastric, lung and pancreatic cancers as well as head and neck squamous cell carcinoma have reported dual roles for miR-135. …”
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The physics of radioembolization by Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong

“…Abstract Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles and have enabled the large-scale application in a palliative setting. …”
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Six Main Contributing Factors to High Levels of Mycotoxin Contamination in African Foods by Queenta Ngum Nji, Olubukola Oluranti Babalola, Theodora Ijeoma Ekwomadu, Nancy Nleya, Mulunda Mwanza

“…Africa is one of the regions with high mycotoxin contamination of foods and continues to record high incidences of liver cancers globally. The agricultural sector of most African countries depends largely on climate variables for crop production. …”
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In Silico Screening Anticancer of Six Triterpenoids toward miR-494 and TNF-α Targets by Vikra Ardiansyah Zaini, Purwantiningsih Sugita, Luthfan Irfana, Suminar Setiati Achmadi

“…Hepatocellular carcinoma (HCC) accounts for up to 90% of all primary liver cancers worldwide. Cinobufagin is recognized to inhibit miR-494 as the HCC target. …”
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A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers by Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Samadian

“…In lung, cervical and liver cancers, studies have reported contradictory results regarding the role of miR-1246. miR-1246 has been reported to regulate activity of RAF/MEK/ERK, GSK3β, Wnt/β-catenin, JAK/STAT, PI3K/AKT, THBS2/MMP and NOTCH2 pathways. …”
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The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling by Taniguchi, Cullen M., Winnay, Jonathon, Kondo, Tatsuya, Bronson, Roderick T., Guimaraes, Alexander R., Aleman, Jose O., Luo, Ji, Stephanopoulos, Gregory, Weissleder, Ralph, Cantley, Lewis C., Kahn, C. Ronald

“…Expression of Pik3r1, the gene encoding p85, is decreased in human prostate, lung, ovarian, bladder, and liver cancers, consistent with the possibility that p85 has tumor suppressor properties. …”
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Role and mechanism of arsenic in regulating angiogenesis. by Ling-Zhi Liu, Yue Jiang, Richard L Carpenter, Yi Jing, Stephen C Peiper, Bing-Hua Jiang

“…Arsenic is a wide spread carcinogen associated with several kinds of cancers including skin, lung, bladder, and liver cancers. Lung is one of the major targets of arsenic exposure. …”
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The Orexin receptors: Structural and anti-tumoral properties by Alain Couvineau, Pascal Nicole, Valérie Gratio, Thierry Voisin

“…Moreover, the identification of OX1R expression in digestive cancers encompassing colon, pancreas and liver cancers and its ability to trigger mitochondrial apoptosis in tumoral cells, indicate a new putative therapeutical action of orexins and paradoxically OXR antagonists. …”
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New KAT6 inhibitors induce senescence and arrest cancer growth by Fei Huang

“…This research showed promise in arresting tumour growth in pre-clinical models of blood and liver cancers as well as delaying or stopping relapse without damaging the cells' DNA or some harmful side-effects caused by chemotherapy and radiotherapy.…”
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Urinary glycan markers for disease. by Alonzi, D, Su, Y, Butters, T

“…HCC (hepatocellular carcinoma) accounts for 80-90% of all liver cancers. It occurs more often in men than women and occurs mostly in people 50-60 years old. …”

Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma by Georgios Charalampopoulos, Roberto Iezzi, Maria Tsitskari, Argyro Mazioti, Olympia Papakonstantinou, Alexis Kelekis, Nikolaos Kelekis, Dimitrios Filippiadis

“…Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. …”
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Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function by Julián Piñeiro Fernández, Kimberly A. Luddy, Cathal Harmon, Cliona O’Farrelly

“…This discordance suggests immune suppression by the environments of primary and secondary liver cancers. Classic tumor microenvironments (TME) are poorly perfused, leading to accumulation of tumor cell metabolites, diminished O₂, and decreased nutrient levels, all of which impact immune cell phenotype and function. …”
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In Vitro Antimelanoma Properties of <i>Verbena officinalis</i> Fractions by Rabia Nisar, Sanjay Adhikary, Saeed Ahmad, Mohammad Abrar Alam

“…Extracts of this plant are therapeutic agents for the potential treatment of different diseases, including colorectal and liver cancers, but have not been explored for their anti-melanoma potential so far. …”
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Biochemical Evaluation of Some Liver Enzymes in Type 2 Diabetes Mellitus Iraqi Patients by Ali Abdul Hussain Kasim, Mohammed M. Mohammed

“…Many studies had showed that; diabetes is associated with high risk of chronic liver disease, primary liver cancers and liver cirrhosis. However, most of these studies were performed in Western countries, and there is a lack of information from Iraq. …”
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Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach by Pradeep Kumar, Amit Kumar Singh, Kavindra Nath Tiwari, Sunil Kumar Mishra, Vishnu D. Rajput, Tatiana Minkina, Simona Cavalu, Ovidiu Pop

“…In the current context of the increased incidence of liver cancers, this approach could be a useful prognostic biomarker and HCC prevention target. …”
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