Identification of decreased intrinsic capacity: Performance of diagnostic measures of the ICOPE Screening tool in community dwelling older people in the VIMCI study by Xavier Rojano i Luque, Sergi Blancafort-Alias, Susanna Prat Casanovas, Susanna Forné, Nuria Martín Vergara, Pilar Fabregat Povill, Maria Vila Royo, Rosa Serrano, Dolores Sanchez-Rodriguez, Montserrat Vílchez Saldaña, Iris Martínez, Mariola Domínguez López, Francesc Riba Porquet, Aimar Intxaurrondo González, Antoni Salvà Casanovas

“…Early identification of five domains of IC (cognition, locomotion, vitality, sensory (hearing and vision), and psychological) has been shown to be related with adverse outcomes and can guide actions towards primary prevention and healthy ageing. …”
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Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation by Herbert Izo Ninsiima, Ejike Daniel Eze, Kenneth Ssekatawa, Halima Nalugo, Caroline Asekenye, David Onanyang, Edson Ireeta Munanura, Moses Ariong, Kevin Matama, Gerald Zirintunda, Ngala Elvis Mbiydzenyuy, Fred Ssempijja, Adam Moyosore Afodun, Regan Mujinya, Ibe Michael Usman, Oscar Hilary Asiimwe, Julius Tibyangye, Keneth Iceland Kasozi

“…Paw edema was measured at a 2 h interval for 3 days, while the pain was assessed by measuring the locomotion activity using the voluntary wheel running and the anxiety-like behavior. …”
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EMPOWER-PD - A physical therapy intervention to empower the individuals with Parkinson’s disease: a study protocol for a feasibility randomized controlled trial by Helena de Oliveira Braga, Elaine Cristina Gregório, Rafaela Simon Myra, Ana Sofia Kauling de Souza, Talita Vitorina Kunh, Jessica Klug, Adriana Coutinho de Azevedo Guimarães, Alessandra Swarowsky

“…Both protocols consist of mobility and locomotion training, and aim at improving motor and non-motor symptoms through different approaches. …”
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Syntaxin 1B Mediates Berberine’s Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model by Yang-Min Zheng, Yang-Min Zheng, Bo Chen, Bo Chen, Jian-Dong Jiang, Jing-Pu Zhang, Jing-Pu Zhang

“…In addition, we found that berberine (BBR) reduced larvae hyperexcitatory locomotion and abnormal movement trajectory in a concentration-dependent manner, slowed down excessive photosensitive seizure-like swimming, and assisted in the recovery of the expression levels of STX1B. …”
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Multi-omics analysis of oral bacterial biofilm on titanium oxide nanostructure modified implant surface: In vivo sequencing-based pilot study in beagle dogs by Hanyu Sun, Yuki Chan, Xuan Li, Ruogu Xu, Zhengchuan Zhang, Xiucheng Hu, Fan Wu, Feilong Deng, Xiaolin Yu

“…Notably, the nanostructured surfaces in NT and NTN groups had limited impact on the diversity and community structure of oral microbiota according to the 16S rRNA sequencing results, and the nanostructures in NTN group could down-regulate the genes associated with localization and locomotion based on Gene Ontology (GO) terms enrichment analysis. …”
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Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa by Lan Lu, Yuting Zhao, Guojuan Yi, Mingxing Li, Li Liao, Chen Yang, Chihin Cho, Bin Zhang, Jie Zhu, Kun Zou, Qiang Cheng

“…In GO process, it was found that the core targets were significantly enriched in multiple biological processes involving locomotion, chemotaxis and motility mediated by flagellum/cilium, which was related to KEGG pathways such as bacterial chemotaxis, oxidative phosphorylation, ribosome, biofilm formation, cyanoamino acid metabolism and quorum sensing. …”
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Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats by Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng

“…The optimal time window of nafamostat was screened by evaluating hindlimb locomotion and electrophysiology. As nafamostat is a serine protease inhibitor known to target thrombin, we used argatroban (Arg), a thrombin-specific inhibitor, as a positive control in the time window experiments. …”
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Effects of Simulated Microgravity on the Physiology of Stenotrophomonas maltophilia and Multiomic Analysis by Xiaolei Su, Xiaolei Su, Yinghua Guo, Yinghua Guo, Tingzheng Fang, Tingzheng Fang, Xuege Jiang, Dapeng Wang, Dapeng Wang, Diangeng Li, Po Bai, Bin Zhang, Junfeng Wang, Changting Liu

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that the increased motility might be associated the upregulation of differentially expressed proteins (DEPs) involved in locomotion, localization, biological adhesion, and binding, in accordance with the upregulated DEGs in cell motility according to COG classification, including pilP, pilM, flgE, flgG, and ronN. …”
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Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 i... by Marsida Kallupi, Jenni Kononoff, Philippe A. Melas, Johanna S. Qvist, Giordano de Guglielmo, Eric R. Kandel, Olivier George

“…Results: Contrary to our expectations, DBS of the NAcc shell induced a slight increase in cocaine self-administration, and increased cocaine-induced locomotion after extended access of cocaine self-administration. …”
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Survival, Integration, and Axon Growth Support of Glia Transplanted into the Chronically Contused Spinal Cord by D. J. Barakat, S. M. Gaglani, S. R. Neravetla, A. R. Sanchez, C. M. Andrade, Y. Pressman, R. Puzis, M. S. Garg, M. B. Bunge, Damien Daniel Pearse

“…Moreover, SC grafted animals demonstrated modest, though significant, improvements in open field locomotion and exhibited less foot position errors (base of support and foot rotation). …”
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Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia by Iole Indovina, Iole Indovina, Allegra Conti, Francesco Lacquaniti, Francesco Lacquaniti, Jeffrey P. Staab, Luca Passamonti, Luca Passamonti, Nicola Toschi, Nicola Toschi

“…They also had lower connectivity metrics in two brain networks, one positioned to process incoming visual space-motion information, assess threat, and initiate/inhibit behavioral responses (visuospatial-emotional network) and one positioned to control and monitor locomotion (vestibular-navigational network). Introversion interacted with agoraphobic symptoms to lower the connectivity of the visuospatial-emotional network. …”
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Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient Zebrafish by Shengchi Shi, Shengchi Shi, Tingting Shu, Tingting Shu, Tingting Shu, Xi Li, Qiyong Lou, Xia Jin, Jiangyan He, Zhan Yin, Zhan Yin, Zhan Yin, Gang Zhai, Gang Zhai

“…The interrenal gland enlargement, increased pituitary proopiomelanocortin a (pomca) expression, decreased locomotion activity and response to light-stimulated stress were observed in cyp17a2-deficient fish. …”
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Injury characteristics and their association with clinical complications among emergency care patients in Tanzania by Armand Zimmerman, Loren K. Barcenas, Msafiri Pesambili, Francis Sakita, Simon Mallya, Joao Ricardo Nickenig Vissoci, Lawrence Park, Blandina T. Mmbaga, Janet Prvu Bettger, Catherine A. Staton

“…Mortality was 5.3%, median length of hospital stay was 6.1 days (IQR: 3.1, 15.0), self-care dependence was 54.2%, and locomotion dependence was 41.5%. Conclusions: Our study sample included primarily young men suffering road traffic crashes with delayed hospital presentations and prolonged hospital stays. …”
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Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs by Rhys D. Brady, Rhys D. Brady, Ker Rui Wong, Dale L. Robinson, Richelle Mychasiuk, Stuart J. McDonald, Stuart J. McDonald, Ryan A. D’Cunha, Glenn R. Yamakawa, Mujun Sun, John D. Wark, Peter Vee Sin Lee, Terence J. O’Brien, Terence J. O’Brien, Pablo M. Casillas-Espinosa, Pablo M. Casillas-Espinosa, Sandy R. Shultz, Sandy R. Shultz

“…Open-field testing to assess locomotion was conducted at 23-weeks post-SE. At 24-weeks post-SE, rats were euthanized and tibia were extracted to determine trabecular morphology by micro-computed tomography (µCT), while femurs were used to investigate mechanical properties via 3-point bending.Results: All post-SE rats had spontaneous seizures at 10- and 22-weeks post-SE, while none of the sham rats had seizures. µCT trabecular analysis of tibia revealed no differences in total volume, bone volume, bone volume fraction, trabecular number, or trabecular separation between post-SE or sham rats, although post-SE rats did have increased trabecular thickness. …”
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Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans by Haikel Dridi, Frances Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken, Alain Lacampagne, Andrew Marks

“…Age-dependent loss of body wall muscle function and impaired locomotion occur within 2 weeks in Caenorhabditis elegans (C. elegans); however, the underlying mechanism has not been fully elucidated. …”
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The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans by Luca Pannone, Valentina Muto, Francesca Nardecchia, Martina Di Rocco, Martina Di Rocco, Emilia Marchei, Federica Tosato, Stefania Petrini, Giada Onorato, Giada Onorato, Enrico Lanza, Enrico Lanza, Lucia Bertuccini, Filippo Manti, Viola Folli, Viola Folli, Serena Galosi, Elia Di Schiavi, Vincenzo Leuzzi, Marco Tartaglia, Simone Martinelli

“…Automated analysis of C. elegans locomotion indicates that chc-1 mutants move slower than their isogenic controls and display defective synaptic plasticity. …”
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Comprehensive molecular and morphological resolution of blubber stratification in a deep-diving, fasting-adapted seal by J. I. Khudyakov, K. N. Allen, D. E. Crocker, N. S. Trost, A. H. Roberts, L. Pirard, C. Debier, E. R. Piotrowski, J. P. Vázquez-Medina

“…Blubber is a modified subcutaneous adipose tissue in marine mammals that provides energy storage, thermoregulation, hydrodynamic locomotion, and buoyancy. Blubber displays vertical stratification by lipid content, fatty acid composition, and vascularization, leading to the assumption that deeper blubber layers are metabolically active, while superficial layers are mainly structural and thermoregulatory. …”
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Establishment and classification of dairy cow podal diseases at Itapecuru Mirim dairy basin, State of Mara tate Maranhão, Brazil Prevalência e classificação de afecções podais em f... by Porfírio Candanedo Guerra, Rudson Almeida Oliveira, Hamilton Pereira Santos, Hélder de Moraes Pereira, Pedro Paulo Machado, Whaubtyfran Cabral Teixeira

“…The animal with difficulty in the locomotion were contended for digit cleaning and subsequent evaluation, considering the affected podal area. …”
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Simultaneous Cervical and Lumbar Spinal Cord Stimulation Induces Facilitation of Both Spinal and Corticospinal Circuitry in Humans by Behdad Parhizi, Behdad Parhizi, Trevor S. Barss, Trevor S. Barss, Trevor S. Barss, Vivian K. Mushahwar, Vivian K. Mushahwar, Vivian K. Mushahwar

“…Coupling between cervical and lumbar spinal networks (cervico-lumbar coupling) is vital during human locomotion. Impaired cervico-lumbar coupling after neural injuries or diseases can be reengaged via simultaneous arm and leg cycling training. …”
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Intrinsic Capacity Declines with Elevated Homocysteine in Community-Dwelling Chinese Older Adults by Lin S, Wang F, Zheng J, Yuan Y, Huang F, Zhu P

“…IC involved five domains of cognition, locomotion, sensory, vitality, and psychology evaluated by the Mini-cog scale, 4-m walk test, self-reported visual and hearing conditions, MNA-SF scale, and GDS-4 scale, respectively. …”
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