Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with C... by Yaiza Tobajas, Marc Alemany-Fornés, Iris Samarra, Jordi Romero-Giménez, Jordi Cuñé-Castellana, Maria Tintoré, Antoni del Pino, Núria Canela, Josep M. del Bas, Nàdia Ortega-Olivé, Carlos de Lecea, Xavier Escoté

“…<b>Results</b>: Notably, the examined drugs—sertraline, pregabalin, paroxetine, alprazolam, and lorazepam—did not exhibit inhibitory effects on DAO activity or lead to reductions in DAO levels. …”
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Factors influencing delayed clearance of high dose methotrexate (HDMTX) in pediatric, adolescent, and young adult oncology patients by Ema Mosleh, Stacy Snyder, Ningying Wu, Daniel N. Willis, Rema Malone, Robert J. Hayashi

“…Increased TTC was associated with increasing age (RR 1.02, p&lt;0.0001), higher 24-hour MTX levels (RR 1.001, p=0.012) and 48-hour MTX levels (RR 1.02, p&lt;0.0001), RT (RR 1.004, p&lt;0.0001), use of IV lorazepam (RR 1.08, p=0.001) and IV metoclopramide (RR 1.08, p&lt;0.001) both on day 3. …”
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Características sociodemográficas, clínicas y perfil de riesgo anticolinérgico en una residencia sociosanitaria pública: estudio descriptivo by Elena Prado-Mel, Héctor Rodríguez Ramallo, Ángela María Villalba-Moreno, Emilio García Cabrera, Susana Sánchez-Fidalgo

“…Los principios activos con actividad anticolinérgica y/o sedante más frecuentemente prescritos fueron lorazepam, tramadol, tamsulosina y trazodona. El delirio y la ansiedad, junto con las infecciones de repetición del tracto urinario, fueron más prevalentes en el grupo de residentes que presentaban carga anticolinérgica (p<0,05).  …”
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Alcohol Withdrawal Severity Measures for Identifying Patients Requiring High-Intensity Care by Daniel C. To, MD, Tessa L. Steel, MD, MPH, Kyle A. Carey, MPH, Cara J. Joyce, PhD, Elizabeth M. Salisbury-Afshar, MD, MPH, Dana P. Edelson, MD, Anoop Mayampurath, PhD, Matthew M. Churpek, MD, MPH, PhD, Majid Afshar, MD, MSCR

“…The OR increased above 1.0 at a 24-hour lorazepam milligram equivalent dose cutoff of 15 mg. …”
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Utilization of psychotropic medicines in Romania during 1998–2018 by Irina Iaru, Camelia Bucsa, Andreea Farcas, Cristina Pop, Anamaria Cristina, Sebastian Armean, Irina Brumboiu, Oliviu Vostinaru, Cristina Mogosan

“…Diazepam lost popularity over time in detriment of the utilization of other anxiolytic benzodiazepines, such as alprazolam and lorazepam. ADs utilization markedly increased during the study period (the average annual growth rate was 13.66% starting 1999). …”
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Refining medical clearance protocol for patients with primary psychiatric complaints in the emergency department by Christopher Austin Casey, Jaime Guzman, Mckailey Salard, Natalie Wu, Ross Rieger, Payton Mangham, James Patterson

“…Most common intervention was intravenous (IV) fluids (n = 59; 45%) followed by admission to other service (n = 15; 8.4%), imaging (n = 10; 7.6%), antihypertensive medication (n = 3; 3.1%), cardiac workup (n = 3; 2.3%), antibiotics (n = 3; 2.3%), lorazepam for undocumented reasons (n = 2; 1.5%). Additional interventions completed once included immunizations, antiseizure medication, pain medication, and additional lab work. …”
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LAMOTRIGINE INDUCED LEUCOPENIA IN A PATIENT WITH TYPE 2 BIPOLAR DISEASE by S. VATANSEVER, N. USTA SAGLAM, E. BESTEPE

“…We started valproate 500 mg/d and on the 27th day of her stay, she was discharged with a euthymic mood, having no depressive symptoms or suicidal thoughts.Her last treatment was venlafaxine 225 mg, quetiapine XR 300 mg, quetiapine IR 100 mg, valproate 500 mg, lorazepam 1 mg daily. Methods It is a retrospective review. …”
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Exploring the intravenous narcotics and controlled drugs wastage and their financial impact: A descriptive single-center study by Azfar Athar Ishaqui, Abdullah Al Qahtani, Md. Ashraful Islam, Ibrahim Al Dossary, Muhammad Bilal Maqsood, Abdulaziz Al Dulaijan, Fahad Al Jowesim, Abdulaziz Salem Shafi Alshammari, Dhfer Mahdi AlShayban, Muhammad Taher Alsultan, Syed Azizullah Ghori, Salah-Ud-Din Khan, Faisal Yamin, Muhammad Shahid Iqbal

“…The controlled medications included Midazolam, Phenobarbital, Diazepam, Ketamine and Lorazepam. The annual consumption and wastage of the narcotic and controlled medications were documented using data report generated by narcotics and controlled medication in-charge pharmacist through the hospital’s online system. …”
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Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries by Anna Lukačišinová, Jindra Reissigová, Maja Ortner-Hadžiabdić, Jovana Brkic, Betul Okuyan, Daisy Volmer, Ivana Tadić, Pilar Modamio, Eduardo L. Mariño, Konstantine Tachkov, Rosa Liperotti, Graziano Onder, Harriet Finne-Soveri, Hein van Hout, Elizabeth P. Howard, Daniela Fialová

“…The most frequently prescribed BZDs were diazepam (27.9% of 426 BZD users), alprazolam (23.7%), bromazepam (22.8%) and lorazepam (16.7%). Independent factors associated with BZD use were female gender (OR 1.58, 95%CI 1.19–2.10), hyperpolypharmacy (OR 1.97, 95%CI 1.22–3.16), anxiety (OR 4.26, 95%CI 2.86–6.38), sleeping problems (OR 4.47, 95%CI 3.38–5.92), depression (OR 1.95, 95%CI 1.29–2.95), repetitive anxious complaints (OR 1.77, 95%CI 1.29–2.42), problems with syncope (OR 1.78, 95%CI 1.03–3.06), and loss of appetite (OR 0.60, 95%CI 0.38–0.94). …”
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High-Dose Benzodiazepines Positively Modulate GABA_A Receptors via a Flumazenil-Insensitive Mechanism by Na Wang, Jingjing Lian, Yanqing Cao, Alai Muheyati, Shanshan Yuan, Yujie Ma, Shuzhuo Zhang, Gang Yu, Ruibin Su

“…Midazolam, clonazepam, and lorazepam at 200 µM exhibited similar flumazenil-insensitive effects on the α₁β₂γ₂, α₂β₂γ₂ and α₅β₂γ₂ receptors, whereas the potentiation induced by 200 µM zolpidem or triazolam was abolished by flumazenil. …”
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GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment by Charles H. Williams, Leif R. Neitzel, Jessica Cornell, Samantha Rea, Ian Mills, Maya S. Silver, Jovanni D. Ahmad, Konstantin G. Birukov, Anna Birukova, Henry Brem, Betty Tyler, Eli E. Bar, Charles C. Hong

“…Notably GPR68, an acid sensing GPCR, is upregulated in radioresistant GBM. Usage of Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a variety of cancers. …”
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Comorbidities, symptoms and end-of-life medication use in hospitalised decedents before and during the COVID-19 pandemic: a retrospective regional cohort study in Ottawa, Canada by Shirley H Bush, Monisha Kabir, Peter Lawlor, James Downar, Brandi Vanderspank-Wright, Sarina Isenberg, Peter Tanuseputro, Akshai Iyengar, Claire Dyason, Julie Lapenskie, Colleen Webber, Henrique Parsons, Samantha Rose Adeli, Ella Besserer, Leila Cohen, Valérie Gratton, Rebekah Murphy, Grace Warmels, Adrianna Bruni, Chelsea Noel, Brandon Heidinger, Koby Anderson, Kyle Arsenault-Mehta, Krista Wooller, Daniel Bedard, Paula Enright, Isabelle Desjardins, Khadija Bhimji

“…COVID+ve group decedents used highest lorazepam and propofol doses.Conclusions COVID-19 decedents, particularly those in ICU, required higher EoL opioid and sedating medication doses than matched prepandemic or intrapandemic controls. …”
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Consciously Choosing Unconsciousness by Yuna Lee

“…For instance, benzodiazepines such as midazolam and lorazepam, commonly employed in palliative sedation, act as central nervous system depressants. …”
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Homeward by Julia K. Nguyen

“…The involuntary jerking had stopped and he only had some pain when turning. Methadone, lorazepam, and haloperidol were held. For the next nine days, we titrated the KFM. …”
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Dergilerden Özetler by Mete Korkut Gülmen, Mehmet Akif İnanıcı, Mehmet Şevki Sözen

“…Bu örneğin gaz kromotografisi-kütle spektrofotometri ile yapılan analizinde içinde lorazepam ve temazepam bulunduğu saptanmıştır. Bu bebekte ani solunum durması episodları üstüne belirtilen benzodiazepamların rolü bilinmemektedir. …”
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Dergilerden Özetler by Mete Korkut Gülmen, Mehmet Akif İnanıcı, Mehmet Şevki Sözen

“…Bu örneğin gaz kromotografisi-kütle spektrofotometri ile yapılan analizinde içinde lorazepam ve temazepam bulunduğu saptanmıştır. Bu bebekte ani solunum durması episodları üstüne belirtilen benzodiazepamların rolü bilinmemektedir. …”
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