Oral Drug Delivery via Intestinal Lymphatic Transport Utilizing Lipid-Based Lyotropic Liquid Crystals by Linh Dinh, Bingfang Yan

“…Our review focuses on recent approaches using oral LLC drug delivery strategies targeting the intestinal lymphatic system to enhance drug bioavailability.…”
Get full text

Ileal volvulus secondary to cystic lymphangioma: A rare case report with a literature review by Shoog F Alfadhel, Abdulmajeed A Alghamdi, Saif A Alzahrani

“…Lymphangioma is a benign malformation of the lymphatic system. It usually affects the neck, head, and rarely, the abdomen. …”
Get full text

Occult solitary submucosal jejunal metastasis from esophageal carcinoma by Maier Alfred, Porubsky Christian, Matzi Veronika, Gollowitsch Franz, Lindenmann Joerg, Smolle-Juettner Freyja

“…</p> <p>Conclusion</p> <p>Because of the extensic esophageal lymphatic system, an occult widespread dissemination of the tumor cells into the abdominal cavity is possible. …”
Get full text

Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection by Ester Maria Mota, Henrique Leonel Lenzi

“…Like other metastrongylides, A. costaricensis passes over the pulmonary circulation to migrate from the lymphatic system to the arterial circulation, where they circulate during some days before reaching their definitive habitat. …”
Get full text

Alterations of the MEK/ERK, BMP, and Wnt/β-catenin pathways detected in the blood of individuals with lymphatic malformations. by Taehan Kim, Elidia Tafoya, Malcolm P Chelliah, Ramrada Lekwuttikarn, Jiang Li, Kavita Y Sarin, Joyce Teng

“…Lymphatic malformation (LM) is a developmental anomaly of the lymphatic system that may lead to disfigurement, organ dysfunction and recurrent infection. …”
Get full text

Case report of generalized lymphatic dysplasia with PIEZO1 mutation and review of the literature by Wedad Alhazmi, Afnan Qurban, Essa Alrashidi

“…Background: The newborn malformation of primary lymphatic dysplasia (PLD), developed primarily due to PIEZO1 gene autosomal recessive mutation, is known to hinder with the lymphatic system action, causing chyle or lymph effusion into the peritoneal cavity or pleura. …”
Get full text

ICG Lymphography in a 4-week Postmortem Cadaver: Implications for a Supermicrosurgery Training Model by Elizabeth G. Zolper, BS, Jenna C. Bekeny, BA, Kenneth L. Fan, MD, Chieh-Han John Tzou, MD, PhD, David H. Song, MD, MBA

“…Our technique was confirmed with handheld SPY fluorescence imaging, which visualized a clearly defined, linear lymphatic system. By outlining a straightforward, reproducible method of lymphatic mapping in cadaveric specimens, our group aims to expand the frontiers of surgical models for SM.…”
Get full text

Cystic lymphangioma in a 44-year-old woman by Moncef Sellami, Abdelmonem Ghorbel

“…Cystic lymphangioma is a congenital malformation of the lymphatic system. This condition is usually observed among children and very rarely among adults. …”
Get full text

Neck mass and bilateral pleural effusions in a 53-year-old female by Sophia K. Papathanasiou, Ilias E. Dimeas, Sotirios I. Sinis, Zoe Daniil, Konstantinos I. Gourgoulianis

“…The most common cause is trauma, iatrogenic or non, owing to thoracic duct injury, which transports chyle from the lymphatic system into the bloodstream. The case we describe is of a 53-year-old female who was referred to our hospital with bilateral pleural effusions and a left supraclavicular mass. …”
Get full text

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. by Wigle, J, Harvey, N, Detmar, M, Lagutina, I, Grosveld, G, Gunn, MD, Jackson, D, Oliver, G

“…The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In Prox1(-)(/-) embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. …”

Regulation of lymphatic function and injury by nitrosative stress in obese mice by Sonia Rehal, Raghu P. Kataru, Geoffrey E. Hespe, Jung Eun Baik, Hyeung Ju Park, Catherine Ly, JinYeon Shin, Babak J. Mehrara

“…These findings suggest that manipulation of the lymphatic system may represent a novel means of treating metabolic abnormalities associated with obesity.…”
Get full text

Role of epithelial mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC): is tumor budding the missing link? by Eva eKaramitopoulou

“…The lethal nature of pancreatic cancer is attributed to its high metastatic potential to the lymphatic system and distant organs. Lack of effective therapeutic options contributes to the high mortality rates of PDAC. …”
Get full text

Lymphangiogenesis in gastric cancer: function and mechanism by Pengpeng Liu, Ping’an Ding, Chenyu Sun, Shuya Chen, Scott Lowe, Lingjiao Meng, Qun Zhao

“…There is increasing evidence that the lymphatic system may play a crucial role in regulating tumor immune response and limiting tumor metastasis, since tumor lymphangiogenesis is more prominent in tumor metastasis and diffusion. …”
Get full text

Classical Cases of Lymphangioma – As Multiple Vesicular Eruptions by Anju Devi, Anjali Narwal, Achla Bharti Yadav, Virender Singh, Ambika Gupta

“…Lymphangiomas are uncommon congenital hamartomas of the lymphatic system, usually diagnosed in infancy and early childhood. …”
Get full text

Inflow Occlusion Combined With Bleomycin Sclerotherapy for Management of Macro/Mixed Cystic Lymphatic Malformation in Children by Tao Han, Yi Ji, Jie Cui, Weimin Shen

“…Background: The link between cystic lymphatic malformation (cLM) and normal lymphatic system has become the focus of research. This study aimed to assess the outcomes of indocyanine green (ICG) lymphography-guided inflow occlusion combined with bleomycin sclerotherapy for the management of macro or mixed cLM in children.Methods: Between June 2018 and October 2020, inflow occlusion combined with bleomycin sclerotherapy was performed in 81 cLM patients (age range from 6 months to 8 years). …”
Get full text

Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease by Zhengyun Han, Xingmao Yang, Shuiqing Huang

“…Recent research has demonstrated the potential involvement of sleep deprivation in both the pathogenesis and progression of AD through glial cell activation, the glial lymphatic system, orexin system, circadian rhythm system, inflammation, and the gut microbiota. …”
Get full text

Perivascular Spaces, Glymphatic System and MR by Linya Yu, Xiaofei Hu, Haitao Li, Yilei Zhao

“…It is now believed that this system carries out the similar functions as the lymphatic system in other parts of the body and plays an important role in the removal of metabolic waste and the maintenance of homeostatic fluid circulation in the brain. …”
Get full text

Endotypes of Prematurity and Phenotypes of Bronchopulmonary Dysplasia: Toward Personalized Neonatology by Maria Pierro, Karen Van Mechelen, Elke van Westering-Kroon, Eduardo Villamor-Martínez, Eduardo Villamor

“…According to this view, the pathogenesis of BPD is multifactorial and heterogeneous with different patterns of antenatal stress (endotypes) that combine with varying postnatal insults and might distinctively damage the development of airways, lung parenchyma, interstitium, lymphatic system, and pulmonary vasculature. This results in different clinical phenotypes of BPD. …”
Get full text

Trans-urethral resection of bladder tumor (TURBT) and radiofrequency ablation of renal tumor: Rare etiologies of chyluria by Richard Assaker, MD, Georges El Hasbani, MD, Jose Vargas, MD, Kalind Parashar, MD, Ginu A Thomas, MD, Neda Yagan, MD

“…Chyluria is a rare entity which is caused by abnormal communication between the lymphatic system and the urinary tract, which allows the passage of chyle into the urine. …”
Get full text

Unusual presentation of diffuse large B-cell lymphoma involving the calcaneus: A case report by Ashley Mariano, Lawrence M. Fallat

“…Lymphoma involves malignancy of the lymphatic system which includes the spleen, thymus, bone marrow and lymph nodes. …”
Get full text