Spectrum of Haematological malignancies managed at tertiary centre: A one-year retrospective review by Anjan Shrestha, Shovana Thapa, Usha Mnandhar, Gita Sayami, Pradeep K Shrestha, Yogendra P Singh

“…Hematological malignancies are a group of cancers that arise from a malignant transformation of cells of the bone marrow or lymphatic system. There are several classification systems for Hematological Malignancies. …”
Get full text

Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis by Eleuterio Lombardo, Pablo Mancheño-Corvo, Mercedes Lopez-Santalla, Mercedes Lopez-Santalla, Ramon Menta, Olga DelaRosa, Francisca Mulero, Borja del Rio, Cristina Ramirez, Dirk Büscher, Juan A. Bueren, Juan A. Bueren, Juan Lopez-Belmonte, Wilfried Dalemans, Marina I. Garin, Marina I. Garin

“…These results suggest that homing of MSCs to the lymphatic system plays an important role in the mechanism of action of MSCs in vivo. …”
Get full text

Thoracic lymphatic anomalies in patients with univentricular hearts: correlation of morphologic findings in isotropic T2-weighted MRI with the outcome after fontan palliation by Anja Hanser, Michael Hofbeck, Melanie Hofmeister, Petros Martirosian, Andreas Hornung, Michael Esser, Fritz Schick, Renate Kaulitz, Jörg Michel, Konstantin Nikolaou, Jürgen Schäfer, Christian Schlensak, Ludger Sieverding

“…Findings of the lymphatic system were correlated with clinical and laboratory parameters obtained at the annual routine check-up.ResultsEight patients (group 1) showed type 4 lymphatic abnormalities. …”
Get full text

Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyel... by Mary-Anne Migotto, Karine Mardon, Karine Mardon, Jacqueline Orian, Gisbert Weckbecker, Rainer Kneuer, Rajiv Bhalla, Rajiv Bhalla, David C. Reutens, David C. Reutens

“…From gamma counting studies, initial tracer uptake within the lymphatic system was found to be higher in the draining lymph nodes (inguinal or subiliac and sciatic) following s.c. vs. i.v. administration; within the CNS a significantly higher tracer uptake was observed at 24 h in the cerebellum, cerebrum, and thoracic spinal cord (p < 0.05 for all) following s.c. vs. i.v. administration.Conclusions: The preclinical data suggest that initial tracer uptake was significantly higher in the draining lymph nodes (subiliac and sciatic) and parts of CNS (the cerebellum and cerebrum) when administered s.c. compared with i.v in EAE mice.…”
Get full text

Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database by Zhao Li, Changying Guo, Xingfei Liu, Xingfei Liu, Zhengzhou Qiu, Zhengzhou Qiu, Ruilin Zhang, Ruilin Zhang

“…At the SOC level, blood and lymphatic system disorders (ROR, 6.70; 95% confidence interval [CI]: 5.47–8.22) were the only SOC that met all four algorithms. …”
Get full text

Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets by Maylin Wong-Guerra, Maylin Wong-Guerra, Maylin Wong-Guerra, Camila Calfio, Camila Calfio, Ricardo B. Maccioni, Ricardo B. Maccioni, Leonel E. Rojo, Leonel E. Rojo, Leonel E. Rojo

“…We specifically focus on the role of B and T cells, immuno-senescence, the brain lymphatic system (BLS), gut-brain axis alterations, and dysfunctional interactions between neurons, microglia and astrocytes. …”
Get full text

Histological study of seventeen organs from dugong (Dugong dugon) by Patcharaporn Kaewmong, Pathompong Jongjit, Araya Boonkasemsanti, Kongkiat Kittiwattanawong, Piyamat Kongtueng, Pitchaya Matchimakul, Wasan Tangphokhanon, Prapawadee Pirintr, Jaruwan Khonmee, Songphon Buddhasiri, Promporn Piboon, Sonthaya Umsumarng, Raktham Mektrirat, Korakot Nganvongpanit, Wanpitak Pongkan

“…Tissue sections were obtained from the urinary system (kidney), muscular system (striated skeletal muscle and smooth muscle), cardiovascular system (cardiac muscle (ventricle), coronary artery, and coronary vein), respiratory system (trachea and lung), gastrointestinal system (esophagus, stomach, small intestine, liver, and pancreas), reproductive system (testis), lymphatic system (spleen and thymus), and endocrine system (pancreas). …”
Get full text

Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies by Yongchao Wang, Jinjin Wang, Dandan Zhu, Yufei Wang, Guangchao Qing, Yuxuan Zhang, Xiaoxuan Liu, Xing-Jie Liang

“…In this review, we first recapitulate the fundamentals for the in vivo fate of NBCIs including physio-anatomical features of lymphatic system and strategies to modulate immune responses. …”
Get full text

Design, Synthesis and Biochemical Evaluation of Novel Ethanoanthracenes and Related Compounds to Target Burkitt’s Lymphoma by Andrew J. Byrne, Sandra A. Bright, James P. McKeown, John E. O’Brien, Brendan Twamley, Darren Fayne, D. Clive Williams, Mary J. Meegan

“…Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. …”
Get full text

Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases by Chuan Zhang, Chuan Zhang, Yujuan Zhang, Maolin Liang, Xiumin Shi, Xiumin Shi, Yan Jun, Longfei Fan, Kai Yang, Feng Wang, Wei Li, Ran Zhu

“…Herein, we design NaGdF4:Yb,Tm@NaLuF4 upconversion nanoparticles with PEG and anti-HER2 monoclonal antibody (trastuzumab, Herceptin) (NP-mAb), the delivery of NP-mAb through the lymphatic system allows for effective targeting and accumulation in lymphatic metastasis. …”
Get full text

Immunosuppressive effect of PLGA-FK506-NPs in treatment of acute cardiac rejection via topical subcutaneous injection by Cheng Deng, Qiaofeng Jin, Ya Wu, Huiling Li, Luyang Yi, Yihan Chen, Tang Gao, Wenyuan Wang, Jing Wang, Qing Lv, Yali Yang, Jia Xu, Wenpei Fu, Li Zhang, Mingxing Xie

“…Current administration route is not conducive enough to exert its efficacy in lymphatic system. Herein, we proposed that subcutaneous (SC) administration of FK506-loaded nanoparticles (PLGA-FK506-NPs) would be valuable for treating acute rejection after HT. …”
Get full text

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat by Eunson Jung, Daniel Gardner, Dongwon Choi, Eunkyung Park, Young Jin Seong, Sara Yang, Jorge Castorena-Gonzalez, Antoine Louveau, Zhao Zhou, Gene K. Lee, David P. Perrault, Sunju Lee, Maxwell Johnson, George Daghlian, Maria Lee, Yeo Jin Hong, Yukinari Kato, Jonathan Kipnis, Michael J. Davis, Alex K. Wong, Young-Kwon Hong

“…Abstract The lymphatic system plays a key role in tissue fluid homeostasis, immune cell trafficking, and fat absorption. …”
Get full text

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis by Mercedes Lopez-Santalla, Mercedes Lopez-Santalla, Pablo Mancheño-Corvo, Amelia Escolano, Ramon Menta, Olga DelaRosa, Jose Luis Abad, Dirk Büscher, Juan M. Redondo, Juan A. Bueren, Juan A. Bueren, Wilfried Dalemans, Eleuterio Lombardo, Marina I. Garin, Marina I. Garin

“…A small proportion of Luci-eASCs can migrate to other locations within the lymphatic system and to other tissues and organs, having a preferential migration toward the intestine in colitic mice. …”
Get full text

Genitourinary tuberculosis in the structure of autopsy morphological findings in deceased patients at the late stages of HIV infection by L. V. Puzyreva, A. V. Mordyk, S. A. Rudenko

“…The lesions of the lymphatic system during life were exposed in 17.4 ± 3.5% of patients. …”
Get full text

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes by Myriam Lamrayah, Capucine Phelip, Renaud Rovera, Céline Coiffier, Nora Lazhar, Francesca Bartolomei, Evelyne Colomb, Bernard Verrier, Claire Monge, Sophie Richard

“…Then, whole-body biodistribution studies using a fluorescent formulation highlighted that the presence of poloxamers influenced positively the dissemination profile by dragging nanoparticles through the lymphatic system until the draining and distant lymph nodes. …”
Get full text

Oligo-Fucoidan supplementation enhances the effect of Olaparib on preventing metastasis and recurrence of triple-negative breast cancer in mice by Li-Mei Chen, Pao-Pao Yang, Aushia Tanzih Al Haq, Pai-An Hwang, You-Chen Lai, Yueh-Shan Weng, Michelle Audrey Chen, Hsin-Ling Hsu

“…Importantly, olaparib supplemented with oral administration of Oligo-Fucoidan in mice inhibited postsurgical TNBC recurrence and metastasis with increased cytotoxic T cells in the lymphatic system and decreased regulatory T cells and M2 macrophages in tumors. …”
Get full text

French national diagnosis and care protocol (PNDS, protocole national de diagnostic et de soins): cystic lymphatic malformations by Nicolas Leboulanger, Annouk Bisdorff, Olivia Boccara, Anne Dompmartin, Laurent Guibaud, Christine Labreze, Jacques Lagier, Bénédicte Lebrun-Vignes, Denis Herbreteau, Aline Joly, Julie Malloizel-Delaunay, Arnaud Martel, Stéphane Munck, Frédérique Saint-Aubin, Annabel Maruani

“…Nearly 75% of them are located in the head and neck because of the highly dense lymphatic system in this region. Physical examination (showing painless masses with normal skin color and depressible consistency, or cutaneous/mucosal lymphangiectasia) and color Doppler ultrasonography, usually allow for diagnosis. …”
Get full text

Corpora Amylacea in the Human Brain Exhibit Neoepitopes of a Carbohydrate Nature by Marta Riba, Marta Riba, Marta Riba, Elisabet Augé, Elisabet Augé, Elisabet Augé, Iraida Tena, Jaume del Valle, Jaume del Valle, Jaume del Valle, Laura Molina-Porcel, Laura Molina-Porcel, Teresa Ximelis, Teresa Ximelis, Jordi Vilaplana, Jordi Vilaplana, Jordi Vilaplana, Carme Pelegrí, Carme Pelegrí, Carme Pelegrí

“…These structures, which act as waste containers, are released from the brain to the cerebrospinal fluid, reach the cervical lymph nodes via the meningeal lymphatic system and may be phagocytosed by macrophages. …”
Get full text

Soporte nutricional y tratamiento con octreótido del quilotórax Nutritional support and treatment of chylothorax with octreotide by M. Sirvent Ochando, P. López Villodre, M. J. Martínez Seguí

“…The use of lipid emulsions is no contraindicated since they do not reach the lymphatic system. With regards to EN, the formulations may be lipid-free or with low lipid content. …”
Get full text

RETRACTED: A Deep Insight Into CAR-T Cell Therapy in Non-Hodgkin Lymphoma: Application, Opportunities, and Future Directions by Faroogh Marofi, Faroogh Marofi, Heshu Sulaiman Rahman, Heshu Sulaiman Rahman, Muhammad Harun Achmad, Klunko Nataliya Sergeevna, Klunko Nataliya Sergeevna, Wanich Suksatan, Walid Kamal Abdelbasset, Walid Kamal Abdelbasset, Maria Vladimirovna Mikhailova, Navid Shomali, Mahboubeh Yazdanifar, Ali Hassanzadeh, Majid Ahmadi, Roza Motavalli, Yashwant Pathak, Yashwant Pathak, Sepideh Izadi, Mostafa Jarahian

“…Non-Hodgkin’s lymphoma (NHL) is a cancer that starts in the lymphatic system. In NHL, the important part of the immune system, a type of white blood cells called lymphocytes become cancerous. …”
Get full text