HUBUNGAN ANTARA EKSPRESI P53 DENGAN EKSPRESI VEGF-C PADA KARSINOMA DUKTAL INVASIF PAYUDARA by , CITRA DEWI RAHAYU SETIA WATI, , dr. Irianiwati Widodo, Sp. PA (K).

“…Metastasis in breast carcinoma via lymphatics system is initiated by lymphangiogenesis. P53 and Vascular Endothelial Growth Factor (VEGF)-C have important role in lymphangiogenesis, but their correlation is still unclear. …”

Links demystified: Periodontitis and cancer by Gowri Pendyala, Saurabh Joshi, Shantanu Chaudhari, Dhananjay Gandhage

“…Cancer is marked by the uncontrolled growth of cells, tissue invasion and metastasis to various organs via the circulatory and lymphatic systems. Recent data have expanded the concept that inflammation is a critical component of tumor progression. …”
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Molecular epidemiology of porcine Cytomegalovirus (PCMV) in Sichuan Province, China: 2010-2012. by Xiao Liu, Shan Liao, Ling Zhu, Ling Zhu, Zhiwen Xu, Yuancheng Zhou

“…Porcine cytomegalovirus (PCMV) is an immunosuppressive virus that mainly inhibits the immune function of the macrophage and T-cell lymphatic systems, and has caused huge economic losses to the porcine breeding industry. …”
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Computer tomography of uro-lymphatic fistulas associated with renal colic by Pavel B. Gelezhe, Kristina M. Goryacheva

“…Uro-lymphatic fistulas are a rare condition caused by the formation of a connection between the urinary and lymphatic systems, which is caused by, as a rule, lymphatic vessel obstruction due to parasitic infestation. …”
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Heterogeneity of neutrophils in cancer: one size does not fit all by Song Chen, Qingyu Zhang, Lisha Lu, Chunhui Xu, Jiajia Li, Jiali Zha, Fengxia Ma, Hongbo R. Luo, Alan Y. Hsu

“…Neutrophil involvement pertains to tumor cells’ ability to construct a suitable tumor microenvironment (TME) that accelerates their own growth and malignancy, by facilitating their interaction with surrounding cells through the circulatory and lymphatic systems, thereby influencing tumor development and progression. …”
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Lymphatic blood filling in CLEC-2-deficient mouse models by Elizabeth J Haining, Kate L Lowe, Surasak Wichaiyo, Raghu P Kataru, Zoltan Nagy, Dean Pj Kavanagh, Sian Lax, Ying Di, Bernhard Nieswandt, Benoît Ho-Tin-Noé, Babak J Mehrara, Yotis A Senis, Julie Rayes, Steve P Watson

“…We report that CLEC-2 expression on platelets is not required to maintain a barrier between the blood and lymphatic systems in unchallenged mice, post-development. …”
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Continuous positive airway pressure increases CSF flow and glymphatic transport by Burhan Ozturk, Sunil Koundal, Ehab Al Bizri, Xinan Chen, Zachary Gursky, Feng Dai, Andrew Lim, Paul Heerdt, Jonathan Kipnis, Allen Tannenbaum, Hedok Lee, Helene Benveniste

“…Respiration can positively influence cerebrospinal fluid (CSF) flow in the brain, yet its effects on central nervous system (CNS) fluid homeostasis, including waste clearance function via glymphatic and meningeal lymphatic systems, remain unclear. Here, we investigated the effect of supporting respiratory function via continuous positive airway pressure (CPAP) on glymphatic-lymphatic function in spontaneously breathing anesthetized rodents. …”
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Role of miRNAs in Melanoma Metastasis by Anna Gajos-Michniewicz, Malgorzata Czyz

“…While miRNAs can act locally in the cell where they are synthesized, they can also influence the phenotype of neighboring melanoma cells or execute their function in the direct tumour microenvironment by modulating ECM (extracellular matrix) and the activity of fibroblasts, endothelial cells, and immune cells. miRNAs are involved in all stages of melanoma metastasis, including intravasation into the lumina of vessels, survival during circulation in cardiovascular or lymphatic systems, extravasation, and formation of the pre-metastatic niche in distant organs. miRNAs contribute to metabolic alterations that provide a selective advantage during melanoma progression. …”
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Differential Clearance of Aβ Species from the Brain by Brain Lymphatic Endothelial Cells in Zebrafish by Yun-Mi Jeong, Jae-Geun Lee, Hyun-Ju Cho, Wang Sik Lee, Jinyoung Jeong, Jeong-Soo Lee

“…The failure of amyloid beta (Aβ) clearance is a major cause of Alzheimer’s disease, and the brain lymphatic systems play a crucial role in clearing toxic proteins. …”
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TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals. by Yasuhiro Yoshimatsu, Shiori Kimuro, Joris Pauty, Kazuki Takagaki, Sanae Nomiyama, Akihiko Inagawa, Kentaro Maeda, Katarzyna A Podyma-Inoue, Kentaro Kajiya, Yukiko T Matsunaga, Tetsuro Watabe

“…Lymphatic systems play important roles in the maintenance of fluid homeostasis and undergo anatomical and physiological changes during inflammation and aging. …”
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Tumor Microenvironment by Borros Arneth

“…<i>Background and Objectives:</i> The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. …”
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A Review of Recent Advances in Computer-Aided Detection Methods Using Hyperspectral Imaging Engineering to Detect Skin Cancer by Hung-Yi Huang, Yu-Ping Hsiao, Riya Karmakar, Arvind Mukundan, Pramod Chaudhary, Shang-Chin Hsieh, Hsiang-Chen Wang

“…Notably, MM possesses a greater capacity for invasiveness, enabling infiltration into adjacent tissues and dissemination via both the circulatory and lymphatic systems. Risk factors associated with skin cancer encompass ultraviolet (UV) radiation exposure, fair skin complexion, a history of sunburn incidents, genetic predisposition, immunosuppressive conditions, and exposure to environmental carcinogens. …”
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Identifying and Treating Ascending Cholangitis. A case report and review of literature. by Phillip Linholm, Patrick E. Young, Walter Reed

“…With biliary stasis and increases in intraductal pressure, bacteria migrate into the venous and lymphatic systems with subsequent bacteremia. The rate of gallstone development is 3-4 % annually in those >60 years old with up to a 15% overall prevalence in the US. …”
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Many Voices in a Choir: Tumor-Induced Neurogenesis and Neuronal Driven Alternative Splicing Sound Like Suspects in Tumor Growth and Dissemination by Zodwa Dlamini, Kgomotso Mathabe, Llewellyn Padayachy, Rahaba Marima, George Evangelou, Konstantinos N. Syrigos, Arianna Bianchi, Georgios Lolas, Rodney Hull

“…While the contribution of blood and lymphatic systems to the development and progression of cancer is well known and is targeted with anticancer drugs, the contribution of the nervous system is less well studied and understood. …”
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Blood–brain barrier and laser technology for drug brain delivery by Oxana V. Semyachkina-Glushkovskaya, Arkady S. Abdurashitov, Elena I. Saranceva, Eketerina G. Borisova, Alexander A. Shirokov, Nikita V. Navolokin

“…Here, we show the first successful experimental results in this field discussing the adventures and disadvantages of PDT-related BBB disruption as well as alternatives to overcome these limitations and possible mechanisms with new pathways for brain clearance via glymphatic and lymphatic systems.…”
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Urogenital involvement in the Klippel-Trenaunay-Weber syndrome: treatment options and results by Fabio C. Vicentini, Francisco T. Denes, Cristiano M. Gomes, Alexandre Danilovic, Frederico A. Silva, Miguel Srougi

“…OBJECTIVE: Klippel-Trenaunay-Weber syndrome (KTWS) is a congenital condition characterized by vascular malformations of the capillary, venous and lymphatic systems associated to soft tissue and bone hypertrophy in the affected areas. …”
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The Impact of PM10 and Other Airborne Particulate Matter on the Cardiopulmonary and Respiratory Systems of Sports Personnel under Atmospheric Exposure by Xinheng Huang

“…According to the definition of the World Health Organization, it is called thoracic-enterable particulate matter because it can enter the body through the respiratory tract and be deposited into the lungs or absorbed into the blood and lymphatic systems. The toxic substances in it can enter the bloodstream directly and cause serious harm to human health. …”
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Emerging nano-strategies against tumour microenvironment (TME): a review by Debojyoti Mandal, Kriti Kushwaha, Jeena Gupta

“…Carcinogenesis relies on the tumour microenvironment because it contains tumour cells that communicate with neighbouring cells via the circulatory and lymphatic systems. During all stages of carcinogenesis, non-malignant cells in the tumour microenvironment promote unchecked cell proliferation. …”
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Blood microvasculature and lymphatic densities in endometrial polyps and adjacent and distant endometrium by Njume Peter Nijkang, Lyndal Anderson, Robert Markham, Ian Stewart Fraser, Frank Manconi

“…The light microscopy literature provides very little information regarding their microvasculature and lymphatic systems; however, a plethora of ultrasound data demonstrating single central arteries in most medium- or large-sized endometrial polyps are well documented. …”
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Reprogramming of sentinel lymph node microenvironment during tumor metastasis by Yen-Liang Li, Wen-Chun Hung

“…The two main routes for cancer cell dissemination are the blood and lymphatic systems. The underlying mechanism of hematogenous metastasis has been well characterized in the past few decades. …”
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