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Long-term storage limits PCR-based analyses of malaria parasites in archival dried blood spots.
Publicat 2012“…BACKGROUND: Blood samples collected in epidemiological and clinical investigations and then stored, often at room temperature, as blood spots dried on a filter paper have become one of the most popular source of material for further molecular analyses of malaria parasites. The dried blood spots are often archived so that they can be used for further retrospective investigations of parasite prevalence, or as new genetic markers come to the fore. …”
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Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections.
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OX40 stimulation enhances protective immune responses induced after vaccination with attenuated malaria parasites
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Complete avian malaria parasite genomes reveal features associated with lineage specific evolution in birds and mammals
Publicat 2018“…Avian malaria parasites are prevalent around the world, and infect a wide diversity of bird species. …”
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A malaria parasite cross reveals genetic determinants of Plasmodium falciparum growth in different culture media
Publicat 2022“…What genes determine in vitro growth and nutrient utilization in asexual blood-stage malaria parasites? Competition experiments between NF54, clone 3D7, a lab-adapted African parasite, and a recently isolated Asian parasite (NHP4026) reveal contrasting outcomes in different media: 3D7 outcompetes NHP4026 in media containing human serum, while NHP4026 outcompetes 3D7 in media containing AlbuMAX, a commercial lipid-rich bovine serum formulation. …”
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A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development
Publicat 2012“…Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C) in mitosis, and facilitate degradation of mitotic APC/C substrates. The malaria parasite, Plasmodium, is a haploid organism which, during its life-cycle undergoes two stages of mitosis; one associated with asexual multiplication and the other with male gametogenesis. …”
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Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.
Publicat 2005“…The folate pathway represents a powerful target for combating rapidly dividing systems such as cancer cells, bacteria and malaria parasites. Whereas folate metabolism in mammalian cells and bacteria has been studied extensively, it is understood less well in malaria parasites. …”
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Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin
Publicat 2017“…Motility of the apicomplexan malaria parasite Plasmodium falciparum is enabled by a multiprotein glideosome complex, whose core is the class XIV myosin motor, PfMyoA, and a divergent Plasmodium actin (PfAct1). …”
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Pooled sequencing and rare variant association tests for identifying the determinants of emerging drug resistance in malaria parasites.
Publicat 2014“…We explored the potential of pooled sequencing to swiftly and economically identify selective sweeps due to emerging artemisinin (ART) resistance in a South-East Asian malaria parasite population. ART resistance is defined by slow parasite clearance from the blood of ART-treated patients and mutations in the kelch gene (chr. 13) have been strongly implicated to play a role. …”
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Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites
Publicat 2019Journal article -
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Identification of malaria parasite-infected red blood cell surface aptamers by inertial microfluidic SELEX (I-SELEX)
Publicat 2015“…Plasmodium falciparum malaria parasites invade and remodel human red blood cells (RBCs) by trafficking parasite-synthesized proteins to the RBC surface. …”
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Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite
Publicat 2016“…During its asexual development within the red blood cell (RBC), Plasmodium falciparum (Pf), the most virulent human malaria parasite, exports proteins that modify the host RBC membrane. …”
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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
Publicat 2016“…The discovery of new druggable targets and pathways including those that are critical for multiple life cycle stages of the malaria parasite is a major goal for developing next-generation antimalarial drugs. …”
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Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections
Publicat 2021“…© 2015 Huang et al. Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. …”
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Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors
Publicat 2013“…This dataset represents an important contribution to our understanding of how HDAC inhibitors act on malaria parasites and identifies alpha tubulin II as a potential transcriptional marker of HDAC inhibition in malaria parasites that may be able to be exploited for future development of HDAC inhibitors as new antimalarial agents.…”
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