Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity. by Mobegi, V, Duffy, C, Amambua-Ngwa, A, Loua, K, Laman, E, Nwakanma, D, MacInnis, B, Aspeling-Jones, H, Murray, L, Clark, T, Kwiatkowski, D, Conway, D

“…Highly recombining populations of the human malaria parasite Plasmodium falciparum throughout West Africa are closely related, as gene flow is relatively unrestricted in this endemic region, but markedly varying ecology and transmission intensity should cause distinct local selective pressures. …”

Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1. by Brown, A, Turner, L, Christoffersen, S, Andrews, K, Szestak, T, Zhao, Y, Larsen, S, Craig, A, Higgins, M

Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance. by Suwanarusk, R, Russell, B, Ong, A, Sriprawat, K, Chu, C, PyaePhyo, A, Malleret, B, Nosten, F, Renia, L

Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy. by Nzila, A, Ward, SA, Marsh, K, Sims, P, Hyde, J

“…We discuss how this information could lead to the identification of new targets in malaria parasites.…”

Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis by Mwanga, EP, Minja, EG, Mrimi, E, Jiménez, MG, Swai, JK, Abbasi, S, Ngowo, HS, Siria, DJ, Mapua, S, Stica, C, Maia, MF, Olotu, A, Sikulu-Lord, MT, Baldini, F, Ferguson, HM, Wynne, K, Selvaraj, P, Babayan, SA, Okumu, FO

“…<br> <strong>Conclusion</strong> These results demonstrate that mid-infrared spectroscopy coupled with supervised machine learning (MIR-ML) could be used to screen for malaria parasites in human DBS. The approach could have potential for rapid and high-throughput screening of Plasmodium in both non-clinical settings (e.g., field surveys) and clinical settings (diagnosis to aid case management). …”

The 3-phosphoinositide–dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites by Hitz, E, Wiedemar, N, Passecker, A, Graça, BAS, Scheurer, C, Wittlin, S, Brancucci, NMB, Vakonakis, I, Mäser, P, Voss, TS

Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. by Mehlotra, R, Mattera, G, Bockarie, M, Maguire, J, Baird, J, Sharma, Y, Alifrangis, M, Dorsey, G, Rosenthal, P, Fryauff, D, Kazura, J, Stoneking, M, Zimmerman, P

High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. by Anderson, T, Nair, S, Nkhoma, S, Williams, J, Imwong, M, Yi, P, Socheat, D, Das, D, Chotivanich, K, Day, N, White, N, Dondorp, A

“…In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. …”

Questioning the claimed superiority of malaria parasite ex vivo viability reduction over observed parasite clearance rate?  by White, NJ, Watson, JA

THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites. by Chang, H, Worby, C, Yeka, A, Nankabirwa, J, Kamya, M, Staedke, S, Dorsey, G, Murphy, M, Neafsey, D, Jeffreys, A, Hubbart, C, Rockett, K, Amato, R, Kwiatkowski, D, Buckee, C, Greenhouse, B

“…As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virulent human malaria parasite, effective tools for monitoring malaria epidemiology are urgent priorities. …”

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research by Mohring, F, Hart, M, Rawlinson, T, Henrici, R, Charleston, J, Diez Benavente, E, Patel, A, Hall, J, Almond, N, Campino, S, Clark, T, Sutherland, C, Baker, D, Draper, S, Moon, R

An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. by Dittrich, S, Mitchell, S, Blagborough, A, Wang, Q, Wang, P, Sims, P, Hyde, J

“…Folate metabolism in malaria parasites is a long-standing, clinical target for chemotherapy and prophylaxis. …”

Exploring the virulence gene interactome with <scp>CRISPR</scp> / <scp>dC</scp> as9 in the human malaria parasite by Bryant, Jessica M, Baumgarten, Sebastian, Dingli, Florent, Loew, Damarys, Sinha, Ameya, Claës, Aurélie, Preiser, Peter R, Dedon, Peter C, Scherf, Artur

“…This study establishes a tool for targeted chromatin purification of unaltered genomic loci and identifies novel chromatin-associated factors potentially involved in transcriptional control and/or chromatin organization of virulence genes in the human malaria parasite.…”
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Plasmodium cysteine repeat modular proteins 1-4: complex proteins with roles throughout the malaria parasite life cycle. by Thompson, J, Fernandez-Reyes, D, Sharling, L, Moore, S, Eling, WM, Kyes, SA, Newbold, C, Kafatos, F, Janse, C, Waters, A

Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum. by Li, J, Cox, L

“…Using the Vectorette technique, we have isolated a novel gene encoding an ORC1-like protein from the human malaria parasite Plasmodium falciparum. The gene has no introns and encodes a protein (PfORC1) of 1189 amino acid residues with a predicted molecular mass of 139 kDa. …”

Understanding the learned behavior of customized convolutional neural networks toward malaria parasite detection in thin blood smear images by Rajaraman, S, Silamut, K, Hossain, MA, Ersoy, I, Maude, RJ, Jaeger, S, Thoma, GR, Antani, SK

Bionomics of Anopheles latens in Kapit, Sarawak, Malaysian Borneo in relation to the transmission of zoonotic simian malaria parasite Plasmodium knowlesi by Tan, C.H., Vythilingam, I., Matusop, A., Chan, S.T., Singh, B.

“…Therefore, extensive studies were carried out in Peninsular Malaysia to determine the distribution, prevalence and species of malaria parasites in monkeys and apes and the natural vectors of monkey malaria parasites 4-7. …”
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A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells by Claessens, Antoine, Adams, Yvonne, Ghumra, Ashfaq, Lindergard, Gabriella, Andisi, Cheryl, Mok, Sachel, Turner, Louise, Arman, Mònica, Raza, Ahmed, Bozdech, Zbynek, Rowe, J. Alexandra, Buchan, Caitlin C., Bull, Peter C., Gupta, Archna P., Wang, Christian W.

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Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development by Yoshida, S, Shimada, Y, Kondoh, D, Kouzuma, Y, Ghosh, A, Jacobs-Lorena, M, Sinden, R

“…The midgut environment of anopheline mosquitoes plays an important role in the development of the malaria parasite. Using genetic manipulation of anopheline mosquitoes to change the environment in the mosquito midgut may inhibit development of the malaria parasite, thus blocking malaria transmission. …”

Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes. by Kriek, N, Tilley, L, Horrocks, P, Pinches, R, Elford, B, Ferguson, D, Lingelbach, K, Newbold, C

“…The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of antigenically diverse proteins is expressed on the surface of human erythrocytes infected with the malaria parasite P. falciparum, and mediates cytoadherence to the host vascular endothelium. …”