Characterization of the expression pattern of the Caf1 regulator of gene expression in the malaria parasite Plasmodium falciparum by Manivannen, Veronica Lavanya

“…Project title: Characterization of the expression pattern of the Caf1 regulator of gene expression in the malaria parasite Plasmodium falciparum. Submitted by: Veronica Lavanya Manivannen Background: CCR4 and CCR4-associated factor 1 (Caf1) repress gene expression through mRNA deadenylation activity with CCR4, and are important in Plasmodium falciparum for correct, timely expression of mRNA during the intraerythrocytic cycle (IDC), and survival of the parasite in the human host. …”
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Principal Component Analysis Combined with Second Order Statistical Feature Method for Malaria Parasites Classification by Wahab, Iis Hamsir Ayub, Susanto, Adhi, Santosa, Paulus Insap, Tjokronegoro, Maesadji

“…The main challenge in detecting malaria parasites is how to identify the subset of relevant features. …”
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Polymorphism of a high molecular weight schizont antigen of the human malaria parasite Plasmodium falciparum. by McBride, J, Newbold, C, Anand, R

“…Intraspecies antigenic diversity in the blood stages of the human malaria parasite Plasmodium falciparum was investigated using a collection of murine monoclonal antibodies and clones of the parasite. …”

Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum by Manickam, Y, Chaturvedi, R, Babbar, P, Malhotra, N, Jain, V, Sharma, A

Survival probability of drug resistant mutants in malaria parasites (vol 264, pg 53, 1997) by Mackinnon, M

A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites. by Martinelli, A, Cheesman, S, Hunt, P, Culleton, R, Raza, A, Mackinnon, M, Carter, R

“…However, identification of specific antigens as candidates for vaccines against asexual blood stages of malaria parasites has been based on largely circumstantial evidence. …”

A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle. by Angrisano, F, Delves, M, Sturm, A, Mollard, V, McFadden, G, Sinden, R, Baum, J

“…Malaria parasite motility relies on an internal parasite actomyosin motor that, when linked to the host cell substrate, propels motile zoites forward. …”

Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent. by Taylor, A, Schaffner, S, Cerqueira, G, Nkhoma, S, Anderson, T, Sriprawat, K, Phyo, A, Nosten, F, Neafsey, D, Buckee, C

“…For sexually recombining haploid organisms such as the human malaria parasite P. falciparum, however, there have been no systematic assessments of the type of data and methods required to resolve fine scale connectivity. …”

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites by Amambua-Ngwa, A, Tetteh, K, Manske, M, Gomez-Escobar, N, Stewart, L, Deerhake, M, Cheeseman, I, Newbold, C, Holder, A, Knuepfer, E, Janha, O, Jallow, M, Campino, S, Macinnis, B, Kwiatkowski, D, Conway, D

“…To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-end short-read sequences of parasites in clinical isolates from an endemic Gambian population, which were mapped to the 3D7 strain reference genome to yield high-quality genome-wide coding sequence data for 65 isolates. …”

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite by Day, J, Passecker, A, Beck, H, Vakonakis, I

“…Plasmodium falciparum is the most lethal of human-infective malaria parasites. Hallmark of P. falciparum malaria is extensive remodelling of host erythrocytes by the parasite, which facilitates the development of virulence properties such as host cell adhesion to the endothelial lining of the microvasculature. …”

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response by Zhu, L, van der Pluijm, RW, Kucharski, M, Nayak, S, Tripathi, J, White, NJ, Day, NPJ, Faiz, A, Phyo, AP, Amaratunga, C, Lek, D, Ashley, EA, Nosten, F, Smithuis, F, Ginsburg, H, von Seidlein, L, Lin, K, Imwong, M, Chotivanich, K, Mayxay, M, Dhorda, M, Nguyen, HC, Nguyen, TNT, Miotto, O, Newton, PN, Jittamala, P, Tripura, R, Pukrittayakamee, S, Peto, TJ, Hien, TT, Dondorp, AM, Bozdech, Z

The genome of Plasmodium knowlesi, a zoonotic malaria parasite with host range from monkey to man. by Pain, A, Berry, A, Bohme, U, Mungall, K, Finn, R, Mistry, J, Jackson, A, Mourier, T, Pasini, E, Kocken, C, Rajandream, M, Turner, M, Newbold, C, Thomas, A, Barrell, B, Berriman, M

Is malaria parasite ex-vivo viability reduction really “superior” to observed parasite clearance rate? by White, NJ, Watson, JA

Inverse associations of human leukocyte antigen and malaria parasite types in two West African populations. by Young, K, Frodsham, A, Doumbo, O, Gupta, S, Dolo, A, Hu, J, Robson, K, Crisanti, A, Hill, A, Gilbert, S

“…In this case, both the key environmental contributor, i.e., the malaria parasite, and a major biological mechanism are well defined. …”

An atypical ortholog of 6-pyruvoyltetrahydropterin synthase provides the missing link in the folate biosynthesis of malaria parasites. by Dittrich, S, Mitchell, S, Blackborough, A, Wang, P, Sims, P, Hyde, J

A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle by Angrisano, F, Delves, M, Sturm, A, Mollard, V, McFadden, G, Sinden, R, Baum, J

“…Malaria parasite motility relies on an internal parasite actomyosin motor that, when linked to the host cell substrate, propels motile zoites forward. …”

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development by Malleret, B, Claser, C, Ong, A, Suwanarusk, R, Sriprawat, K, Howland, S, Russell, B, Nosten, F, Rénia, L

“…Microscopic examination of Giemsa-stained thin blood smears remains the gold standard method used to quantify and stage malaria parasites. However, this technique is tedious and requires trained microscopists. …”

Malaria parasite detection and cell counting for human and mouse using thin blood smear microscopy by Poostchi, M, Ersoy, I, McMenamin, K, Gordon, E, Palaniappan, N, Pierce, S, Maude, R, Bansal, A, Srinivasan, P, Miller, L, Palaniappan, K, Thoma, G, Jaeger, S

Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control by Lefevre, T, Ohm, J, Dabiré, KR, Cohuet, A, Choisy, M, Thomas, MB, Cator, L

“…Compared to the significant effort devoted to understanding the biology of malaria transmission from vertebrate hosts to mosquito vectors, the strategies that malaria parasites have evolved to maximize transmission from vectors to vertebrate hosts have been largely overlooked. …”

Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites. by Nair, S, Nash, D, Sudimack, D, Jaidee, A, Barends, M, Uhlemann, A, Krishna, S, Nosten, F, Anderson, T

“…We describe an example of such a "soft" selective sweep in the malaria parasite Plasmodium falciparum that involves adaptive genome rearrangements. …”