Synthesis of Novel Potent Biologically Active <i>N</i>-Benzylisatin-Aryl Hydrazones in Comparison with Lung Cancer Drug ‘Gefitinib’ by Huda S. Al-Salem, Hatem A. Abuelizz, Iman S. Issa, Amany Z. Mahmoud, Ali AlHoshani, Md Arifuzzaman, A. F. M. Motiur Rahman

“…Developing anticancer therapeutics with no/few side effects is a challenge for medicinal chemists. The absence of antibacterial activity of an anticancer drug removes its detrimental effect toward intestinal flora and therefore leads to reduced side effects. …”
Get full text

DetoxiProt: an integrated database for detoxification proteins by Yang Zhen, Yu Ying, Yao Lei, Li Guangui, Wang Lin, Hu Yiyao, Wei Haibin, Wang Li, Hammami Riadh, Razavi Roxanne, Zhong Yang, Liang Xufang

“…This database would be a valuable source for toxicologists, pharmacologists and medicinal chemists. DetoxiProt database is freely available at <url>http://lifecenter.sgst.cn/detoxiprot/</url>.…”

Computational Design of New Teixobactin Analogues as Inhibitors of Lipid II Flippase MurJ by Andreea Calianu, Radu Tamaian

“…Overall, the proposed computational drug design approach for novel antibiotics might be a useful asset for medicinal chemists and translational pharmacologists.…”
Get full text

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1 by Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong

“…These findings are helpful for the medicinal chemists to design and develop next generation tyrosine kinase inhibitors with improved safety, as well as to guide reasonable applications of icotinib and erlotinib in clinic, especially for avoiding their potential DDI risks via UGT1A1 inhibition.…”
Get full text

ArachnoServer: a database of protein toxins from spiders by Kaas Quentin, Raven Robert J, Cai Shuzhi, Miljenović Tomas, Wood David LA, Escoubas Pierre, Herzig Volker, Wilson David, King Glenn F

“…</p> <p>Conclusion</p> <p>ArachnoServer provides a single source of high-quality information about proteinaceous spider toxins that will be an invaluable resource for pharmacologists, neuroscientists, toxinologists, medicinal chemists, ion channel scientists, clinicians, and structural biologists. …”
Get full text

Dual Inhibition of AChE and BChE with the C-5 Substituted Derivative of Meldrum’s Acid: Synthesis, Structure Elucidation, and Molecular Docking Studies by Haroon Mehfooz, Aamer Saeed, Anamika Sharma, Fernando Albericio, Fayaz Ali Larik, Farukh Jabeen, Pervaiz Ali Channar, Ulrich Flörke

“…Alzheimer’s disease (AD) lies in the category of those diseases which are still posing challenges to medicinal chemists, and the search for super-effective drugs for the treatment of AD is a work in progress. …”
Get full text

Cyclic Benzimidazole Derivatives and Their Antitumor Activity by Karminski-Zamola, G., Hranjec, M.

“…Over the past years benzimidazole derivatives are one of the most extensively studied classes of heterocyclic compounds, and have received much attention from synthetic organic as well as medicinal chemists, because of their well known biological activities and their applications in several areas as materials in electronics, in electrochemistry as anticorrosive agents, as polymers or optical materials and fluorescent tags in DNA sequencing. …”
Get full text

Chemical, Antioxidant and Antibacterial Assessment of Clove (Syzygium aromaticum) Seed Extract and in-silico Pharmacokinetic Exploration of the Prominent Compounds by O. U. Igwe, M. U. Anyaogu, I. E. Otuokere

“…This may help pharmacologists and other medicinal chemists create and synthesize even more potent drug candidates. …”
Get full text

Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021) by Ashima Dhiman, Rupam Sharma, Rajesh K. Singh

“…The goal of this review article is to point the way for medicinal chemists to design and develop effective indole-based anticancer agents.…”
Get full text

An innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymes. by Mahreen Arooj, Sugunadevi Sakkiah, Guang ping Cao, Keun Woo Lee

“…Nevertheless, to design multitarget inhibitors is concurrently a great challenge for medicinal chemists. We have developed a novel computational approach by integrating the affinity predictions from structure-based virtual screening with dual ligand-based pharmacophore to discover potential dual inhibitors of human Thymidylate synthase (hTS) and human dihydrofolate reductase (hDHFR). …”
Get full text

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity by Valery M. Dembitsky, Ekaterina Ermolenko, Nick Savidov, Tatyana A. Gloriozova, Vladimir V. Poroikov

“…This review provides insights on further utilization of polycyclic endoperoxides by medicinal chemists, pharmacologists, and the pharmaceutical industry.…”
Get full text

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization by Ayman Abo Elmaaty, Mohammed I. A. Hamed, Muhammad I. Ismail, Eslam B. Elkaeed, Hamada S. Abulkhair, Muhammad Khattab, Ahmed A. Al-Karmalawy

“…NSAIDs may be used by medicinal chemists as lead compounds for the development of potent SARS-CoV-2 (M^pro) inhibitors. …”
Get full text

In-silico based discovery of potential Keap1 inhibitors using the strategies of pharmacophore screening, molecular docking, and MD simulation studies by Ekta Singh, Gurubasavaraja Swamy Purawarga Matada, Prasad Sanjay Dhiwar, Rajesh B. Patil, Rohit Pal

“…It opens new avenues for medicinal chemists to explore antioxidant-stimulating molecules targeting the Keap1-Nrf2 pathway.…”
Get full text

Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies by Ricardo Ribeiro, Eugénia Pinto, Carla Fernandes, Emília Sousa

“…Solid-phase Fmoc- and Boc-protection chemistry is the major synthetic strategy to obtain marine cyclic peptides with antimicrobial properties, and key examples are presented guiding microbiologist and medicinal chemists to the discovery of new antimicrobial drug candidates from marine sources.…”
Get full text

New directions towards the synthesis of bicyclo[1.1.1]pentane derivatives by Caputo, D

“…Bicyclo[1.1.1]pentanes have emerged as bioisosteres, used by medicinal chemists to replace 1,4-disubstituted arenes and improve the physicochemical properties of the drugs they synthesise. …”

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines by Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Mohd Yamin, Bohari, Leong, Sze Wei, Abdul Bahari, Mohd Nazri, Lim, Sock Jin, Mohd Faudzi, Siti Munirah, Jalil, Juriyati, Abas, Faridah, Mohd Fauzi, Norsyahida, Ismail, Nor Hadiani, Jantan, Ibrahim, Lam, Kok Wai

“…The syntheses and bioactivities of symmetrical curcumin and its analogues have been the subject of interest by many medicinal chemists and pharmacologists over the years. To improve our understanding, we have synthesized a series of unsymmetrical monocarbonyl curcumin analogues and evaluated their effects on prostaglandin E2 production in lipopolysaccharide-induced RAW264.7 and U937 cells. …”
Get full text

SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS by L.A. SAGHAEI

“…This metabolic behavior has led the medicinal chemists to design compounds such as N-hydroxyalkyl derivatives which do not undergo extensive metabolism. …”
Get full text

Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents by Nilesh Gajanan Bajad, Sudhir Kumar Singh, Sushil Kumar Singh, Tryambak Deo Singh, Meenakshi Singh

“…The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists. Exploration of indole derivatives in drug discovery has rapidly yielded a vast array of biologically active compounds with broad therapeutic potential. …”
Get full text

α-Glucosidase, α-Amylase and Antioxidant Evaluations of Isolated Bioactives from Wild Strawberry by Mohammed A. Huneif, Seham M. Alqahtani, Alqahtani Abdulwahab, Sultan A. Almedhesh, Mater H. Mahnashi, Muhammad Riaz, Najm Ur-Rahman, Muhammad Saeed Jan, Farhat Ullah, Muhammad Aasim, Abdul Sadiq

“…Diabetes mellitus is a metabolic disorder and is a global challenge to the current medicinal chemists and pharmacologists. This research has been designed to isolate and evaluate antidiabetic bioactives from <i>Fragaria indica</i>. …”
Get full text

Synthesis and Biological Evaluation of Some Newer 1H-Benzo[b][1,5]diazepin-2(3H)-one Derivatives as Potential Anticonvulsant Agents by Dinesh D Rishipathak, Dipak Patil, Hemant U Chikhale

“…In the hopes of discovering the latest and ultimate therapy, medicinal chemists will keep on to hunt for new antiepileptic compounds with high specificity and low CNS toxicity. …”
Get full text