Showing 481 - 500 results of 8,722 for search '"medicinal chemistry"', query time: 0.30s Refine Results
  1. 481
    Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

    Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities by Claudiu T. Supuran

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  2. 482
    Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions

    Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions by Yuan Zhang, Xin Meng, Haikang Tang, Minghui Cheng, Fujun Yang, Wenqing Xu

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  3. 483
    Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies

    Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in s... by Mohamed H. Saad, Tarek F. El-Moselhy, Nabaweya S, El-Din, Ahmed B. M. Mehany, Amany Belal, Mohammed A. S. Abourehab, Haytham O. Tawfik, Mervat H. El-Hamamsy

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  4. 484
    Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer

    Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer by Zixin Xie, Donghua Cheng, Lu Luo, Guoliang Shen, Suwei Pan, Yaqian Pan, Bo Chen, Xuebao Wang, Zhiguo Liu, Yuan Zhang, Faqing Ye

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  5. 485
    Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

    Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation by Jonathan Elie, Omid Feizbakhsh, Nathalie Desban, Béatrice Josselin, Blandine Baratte, Amandine Bescond, Julien Duez, Xavier Fant, Stéphane Bach, Dominique Marie, Matthieu Place, Sami Ben Salah, Agnes Chartier, Sabine Berteina-Raboin, Apirat Chaikuad, Stefan Knapp, Fabrice Carles, Pascal Bonnet, Frédéric Buron, Sylvain Routier, Sandrine Ruchaud

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  6. 486
    Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity

    Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity by Dong-Jun Fu, Ting Wang

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  7. 487
    Correction to: Fischer et al., Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

    Correction to: Fischer et al., Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  8. 488
    Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

    Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme by Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Dabees, Ahmed E. Abdel Moneim, Ibrahim A. Abdel Wahab, Mohammad M. Abd-Alhaseeb, Mostafa M. M. El-Miligy

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  9. 489
    Designing a new biosensor “DNA ELISA” to detect Escherichia coli using genomic DNA and comparison of this method to PCR-ELISA

    Designing a new biosensor “DNA ELISA” to detect Escherichia coli using genomic DNA and comparison of this method to PCR-ELISA by Elaheh Hashemi, Mehdi Forouzandeh

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  10. 490
    Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

    Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies by Adel S. El-Azab, Abdullah Al-Dhfyan, Alaa A.-M. Abdel-Aziz, Laila A. Abou-Zeid, Hamad M. Alkahtani, Abdulrahman M. Al-Obaid, Manal A. Al-Gendy

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  11. 491
    Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols

    Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols by Alessandro Bonardi, Seppo Parkkila, Claudiu T. Supuran

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  12. 492
    The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids

    The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids by Andrea Angeli, Fatmah A. S. Alasmary, Sonia Del Prete, Sameh M. Osman, Zeid AlOthman, William A. Donald, Clemente Capasso, Claudiu T. Supuran

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  13. 493
    Evaluation of the paraoxonase-1 kinetic parameters of the lactonase activity by nonlinear fit of progress curves

    Evaluation of the paraoxonase-1 kinetic parameters of the lactonase activity by nonlinear fit of progress curves by Marko Goličnik, Aljoša Bavec

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  14. 494
    Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents

    Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agent... by Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher J. Fowler, Roberto Russo, Bruno Catalanotti, Valentina Onnis

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  15. 495
    Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R

    Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R by Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  16. 496
    Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

    Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy by Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  17. 497
    Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

    Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH by Mariantonia Logozzi, Davide Mizzoni, Clemente Capasso, Sonia Del Prete, Rossella Di Raimo, Mario Falchi, Daniela F. Angelini, Alessandro Sciarra, Martina Maggi, Claudiu T. Supuran, Stefano Fais

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  18. 498
    Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids

    Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids by Bilal Ahmad Khan, Syeda Shamila Hamdani, Muhammad Naeem Ahmed, Shahid Hameed, Muhammad Ashfaq, Ahmed M. Shawky, Mahmoud A. A. Ibrahim, Peter A. Sidhom

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  19. 499
    Novel tetrahydronaphthalen-1-yl-phenethyl ureas: synthesis and dual antibacterial-anticancer activities

    Novel tetrahydronaphthalen-1-yl-phenethyl ureas: synthesis and dual antibacterial-anticancer activities by Yusuf Akbaba, Fatma Necmiye Kacı, Mehmet Enes Arslan, Süleyman Göksü, Adil Mardinoğlu, Hasan Türkez

    Published 2024-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  20. 500
    Clinical implications of a mechanistic link connecting SARS-Cov-2, diabetes mellitus, Zinc in COVID-19 pathophysiology, and the prophylactics in the treatment of SARS-CoV-2

    Clinical implications of a mechanistic link connecting SARS-Cov-2, diabetes mellitus, Zinc in COVID-19 pathophysiology, and the prophylactics in the treatment of SARS-CoV-2 by Deeptimayee Rout, Atish Kumar Sahoo

    Published 2023-12-01
    “…European Journal of Medicinal Chemistry Reports…”
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