Showing 521 - 540 results of 8,722 for search '"medicinal chemistry"', query time: 0.27s Refine Results
  1. 521
    Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

    Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3... by Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, Zeinab Mahmoud

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  2. 522
    Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

    Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect by Tarek S. Ibrahim, Mohamed M. Hawwas, Azizah M. Malebari, Ehab S. Taher, Abdelsattar M. Omar, Thikryat Neamatallah, Zakaria K. Abdel-Samii, Martin K. Safo, Yaseen A. M. M. Elshaier

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  3. 523
    Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study

    Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study by Mohammad M. Al-Sanea, Tamer M. Nasr, Samir Bondock, Aya Y. Gawish, Nada M. Mohamed

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  4. 524
    Discovery and SAR analysis of phenylbenzo[d][1,3]dioxole-based proprotein convertase subtilisin/kexin type 9 inhibitors

    Discovery and SAR analysis of phenylbenzo[d][1,3]dioxole-based proprotein convertase subtilisin/kexin type 9 inhibitors by Fahui Li, Lihui Zhang, Jinhong Feng, Lei Zhang

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  5. 525
    Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development

    Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual sc... by Gülru Kayık, Nurcan Ş. Tüzün, Serdar Durdagi

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  6. 526
    Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine

    Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine by Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Sonia Del Prete, Clemente Capasso, Bogdan C. Simionescu, Claudiu T. Supuran

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  7. 527
    Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes

    Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes by Mehdi Bouchouit, Sofiane Bouacida, Bachir Zouchoune, Hocine Merazig, Silvia Bua, Zouhair Bouaziz, Marc Le Borgne, Claudiu T. Supuran, Abdelmalek Bouraiou

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  8. 528
    Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors

    Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors by Guangcheng Wang, Wenjing Liu, Meiyan Fan, Min He, Yongjun Li, Zhiyun Peng

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  9. 529
    Anticancer properties and mechanism of action of the fungal nucleoside clitocine and its derivatives

    Anticancer properties and mechanism of action of the fungal nucleoside clitocine and its derivatives by Christian Bailly

    Published 2024-04-01
    “…European Journal of Medicinal Chemistry Reports…”
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    Article
  10. 530
    Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups

    Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups by Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin, You-Zhi Tang

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  11. 531
    Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity

    Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity by Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran, Nada M. Mohamed

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  12. 532
    Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells

    Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells by Jaroslav Malina, Hana Kostrhunova, Hualong Song, Peter Scott, Viktor Brabec

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  13. 533
    A one-step procedure for immobilising the thermostable carbonic anhydrase (SspCA) on the surface membrane of Escherichia coli

    A one-step procedure for immobilising the thermostable carbonic anhydrase (SspCA) on the surface membrane of Escherichia coli by Sonia Del Prete, Rosa Perfetto, Mosè Rossi, Fatmah A. S. Alasmary, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran, Clemente Capasso

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  14. 534
    Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

    Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors by Adriano Mollica, Sveva Pelliccia, Valeria Famiglini, Azzurra Stefanucci, Giorgia Macedonio, Annalisa Chiavaroli, Giustino Orlando, Luigi Brunetti, Claudio Ferrante, Stefano Pieretti, Ettore Novellino, Sandor Benyhe, Ferenc Zador, Anna Erdei, Edina Szucs, Reza Samavati, Szabolcs Dvorácskó, Csaba Tomboly, Rino Ragno, Alexandros Patsilinakos, Romano Silvestri

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  15. 535
    Development and characterisation of SMURF2-targeting modifiers

    Development and characterisation of SMURF2-targeting modifiers by Dhanoop Manikoth Ayyathan, Gal Levy-Cohen, Moran Shubely, Sandy Boutros-Suleiman, Veronica Lepechkin-Zilbermintz, Michael Shokhen, Amnon Albeck, Arie Gruzman, Michael Blank

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  16. 536
    Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

    Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors by Özlen Güzel-Akdemir, Andrea Angeli, Kübra Demir, Claudiu T. Supuran, Atilla Akdemir

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  17. 537
    ALDEFLUOR activity, ALDH isoforms, and their clinical significance in cancers

    ALDEFLUOR activity, ALDH isoforms, and their clinical significance in cancers by Jiang-Jie Duan, Jiao Cai, Lei Gao, Shi-Cang Yu

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  18. 538
    Beta-lactamase database (BLDB) – structure and function

    Beta-lactamase database (BLDB) – structure and function by Thierry Naas, Saoussen Oueslati, Rémy A. Bonnin, Maria Laura Dabos, Agustin Zavala, Laurent Dortet, Pascal Retailleau, Bogdan I. Iorga

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  19. 539
    High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase

    High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase by Mazen Aseeri, José Luis Abad, Antonio Delgado, Gemma Fabriàs, Gemma Triola, Josefina Casas

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  20. 540
    Semisynthesis and anti-cancer properties of novel honokiol derivatives in human nasopharyngeal carcinoma CNE-2Z cells

    Semisynthesis and anti-cancer properties of novel honokiol derivatives in human nasopharyngeal carcinoma CNE-2Z cells by Bo-Han Li, Hui Ma, Jing Zhu, Jie Chen, Yi-Qun Dai, Xiao-Jing Zhang, Hong-Mei Li, Cheng-Zhu Wu

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article

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