Showing 581 - 600 results of 8,722 for search '"medicinal chemistry"', query time: 0.77s Refine Results
  1. 581
    Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis

    Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis by Jiří Dostál, Jiří Brynda, Lucie Vaňková, Syeda Rehana Zia, Iva Pichová, Olga Heidingsfeld, Martin Lepšík

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  2. 582
    Correction to: Synthesis, antitumor screening and cell cycle analysis of novel benzothieno[3,2-b]pyran derivatives

    Correction to: Synthesis, antitumor screening and cell cycle analysis of novel benzothieno[3,2-b]pyran derivatives

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  3. 583
    Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity

    Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity by Simonetta Caira, Antonio Iannelli, Rosaria Sciarrillo, Gianluca Picariello, Giovanni Renzone, Andrea Scaloni, Pietro Addeo

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  4. 584
    Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

    Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators by Andrea Angeli, Niccolò Chiaramonte, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  5. 585
    Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry

    Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry by Jamal A.H. Kowah, Ruobing Gao, Fu Li, Chenxi Guang, Meiyan Jiang, Xiaolin Wu, Lisheng Wang, Xu Liu

    Published 2023-04-01
    “…European Journal of Medicinal Chemistry Reports…”
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  6. 586
    Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor

    Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor by Yaling Zhang, Li Chen, Xiabing Li, Li Gao, Yunxia Hao, Baolin Li, Yaping Yan

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  7. 587
    New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives

    New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives by Olga Ciupak, Mateusz Daśko, Karol Biernacki, Janusz Rachon, Maciej Masłyk, Konrad Kubiński, Aleksandra Martyna, Sebastian Demkowicz

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  8. 588
    Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates

    Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates by Alessio Nocentini, Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A.S. Alasmary, Zeid AlOthman, Clemente Capasso, Fabrizio Carta, Paola Gratteri, Claudiu T. Supuran

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  9. 589
    Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors

    Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors by Samar El-Kalyoubi, Samiha A. El-Sebaey, A. M. Rashad, Hanan A. AL-Ghulikah, Mostafa M. Ghorab, Sherin M. Elfeky

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  10. 590
    Structure–activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors

    Structure–activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors by Xiao-hui Gao, Lin-bo Liu, Hao-ran Liu, Jing-jing Tang, Lu Kang, Hongnian Wu, Peiwu Cui, Jianye Yan

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  11. 591
    Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers

    Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic in... by Naglaa M. Ahmed, Mosaad S. Mohamed, Samir M. Awad, Neama A. Abd El-tawab, Mohamed S. Gaballah, Ahmed M. Said

    Published 2024-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  12. 592
    Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

    Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with... by Asmaa A. Mandour, Ibrahim F. Nassar, Mohammed T. Abdel Aal, Mahmoud A. E. Shahin, Wael A. El-Sayed, Maghawry Hegazy, Amr Mohamed Yehia, Ahmed Ismail, Mohamed Hagras, Eslam B. Elkaeed, Hanan M. Refaat, Nasser S. M. Ismail

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  13. 593
    Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers

    Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers by Mostafa M. Ghorab, Maged S. Abdel-Kader, Ali S. Alqahtani, Aiten M. Soliman

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  14. 594
    Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

    Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone by Fernanda A. H. Batista, Sérgio L. Ramos, Giusy Tassone, Andrei Leitão, Carlos A. Montanari, Maurizio Botta, Mattia Mori, Júlio C. Borges

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  15. 595
    Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

    Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation by Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao, Shengzheng Wang

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  16. 596
    Functionality study of chalcone-hydroxypyridinone hybrids as tyrosinase inhibitors and influence on anti-tyrosinase activity

    Functionality study of chalcone-hydroxypyridinone hybrids as tyrosinase inhibitors and influence on anti-tyrosinase activity by L. Ravithej Singh, Yu-Lin Chen, Yuan-Yuan Xie, Wei Xia, Xing-Wen Gong, Robert C. Hider, Tao Zhou

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  17. 597
    Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-кB activation

    Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-кB activation by Wei Cong, Yue Sun, Yi-Fan Sun, Wei-Bin Yan, Yu-Long Zhang, Zhong-Fei Gao, Chun-Hua Wang, Gui-Ge Hou, Jia-Jing Zhang

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  18. 598
    Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds

    Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds by Samar Said Fatahala, Shahenda Mahgub, Heba Taha, Rania Helmy Abd-El Hameed

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  19. 599
    Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues

    Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues by Dong Hwan Kim, Jaehyeon Kim, Hakmin Lee, Dongyun Lee, So Myoung Im, Ye Eun Kim, Miryeong Yoo, Yong-Pil Cheon, Jason C. Bartz, Young-Jin Son, Eun-Kyoung Choi, Yong-Sun Kim, Jae-Ho Jeon, Hyo Shin Kim, Sungeun Lee, Chongsuk Ryou, Tae-gyu Nam

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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  20. 600
    1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

    1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery by Claire Raingeval, Olivier Cala, Béatrice Brion, Marc Le Borgne, Roderick Eliot Hubbard, Isabelle Krimm

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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