Showing 621 - 640 results of 8,722 for search '"medicinal chemistry"', query time: 0.85s Refine Results
  1. 621
    Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents

    Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents by Wandong Liu, Caiyun Hou, Jiaming Li, Xiaodong Ma, Yanchun Zhang, Mengqi Hu, Yuanzheng Huang

    Published 2020-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  2. 622
    Identifying requirements for RSK2 specific inhibitors

    Identifying requirements for RSK2 specific inhibitors by Eric B. Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A. O’Doherty, Deborah A. Lannigan

    Published 2021-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  3. 623
    Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase

    Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase by Francesco Balestri, Mario Cappiello, Roberta Moschini, Umberto Mura, Antonella Del-Corso

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  4. 624
    Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors

    Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors by Lianbao Ye, Tao Zhao, Wenjun Du, Anhu Li, Wei Gao, Jingrong Li, Ling Wang, Weiqiang Chen

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  5. 625
    Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates

    Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates by Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran

    Published 2018-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  6. 626
    Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives

    Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives by Wei-Yun Guo, Liu-Zeng Chen, Bang-Nian Shen, Xin-Hua Liu, Guang-Ping Tai, Qing-Shan Li, Li Gao, Ban-Feng Ruan

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  7. 627
    Design, synthesis, characterization, antimicrobial activity, cytotoxicity, molecular docking, and in-silico ADMET analysis of the novel cefuroxime derivatives

    Design, synthesis, characterization, antimicrobial activity, cytotoxicity, molecular docking, and in-silico ADMET analysis of the novel cefuroxime derivatives by Ananta Kumar Das, Prosenjit Paul, Mahian Parveg Pranto, Md. Jahid Hassan, Koushik Saha, Md. Emdad Hossain

    Published 2024-04-01
    “…European Journal of Medicinal Chemistry Reports…”
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    Article
  8. 628
    Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation

    Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation by Chunqiong Li, Quanjun Yang, Li Zhang

    Published 2024-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  9. 629
    Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR

    Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR by Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  10. 630
    Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

    Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines by Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna

    Published 2023-12-01
    “…European Journal of Medicinal Chemistry Reports…”
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    Article
  11. 631
    Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)

    Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK) by Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  12. 632
    Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation

    Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation by Pengming Pan, Dengbo Ji, Zhongjun Li, Xiangbao Meng

    Published 2024-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  13. 633
    Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

    Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bi... by Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid

    Published 2019-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  14. 634
    Curcumin analogues exert potent inhibition on human and rat gonadal 3β-hydroxysteroid dehydrogenases as potential therapeutic agents: structure-activity relationship and in silico docking

    Curcumin analogues exert potent inhibition on human and rat gonadal 3β-hydroxysteroid dehydrogenases as potential therapeutic agents: structure-activity relationship and in silico... by Xinyi Qiao, Lei Ye, Jialin Lu, Chengshuang Pan, Qianjin Fei, Yang Zhu, Huitao Li, Han Lin, Ren-shan Ge, Yiyan Wang

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  15. 635
    Improved in vitro potency of Clofazimine derivatives against Neisseria species

    Improved in vitro potency of Clofazimine derivatives against Neisseria species by Masahide Yano, Jessica M. Lawson-Rulli, Reilly M. Coates, Jennifer Heldring, Marvin J. Miller, Rui Liu

    Published 2024-08-01
    “…European Journal of Medicinal Chemistry Reports…”
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    Article
  16. 636
    Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells

    Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells by Jia Liu, Xingwang Zhu, Liu Yu, Minghuan Mao

    Published 2022-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  17. 637
    Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties

    Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties by Tuba Tekeli, Suleyman Akocak, Andrea Petreni, Nebih Lolak, Servet Çete, Claudiu T. Supuran

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  18. 638
    Anti-cancer activity and cellular uptake of 7,3′,4′- and 7,8,4′-trihydroxyisoflavone in HepG2 cells under hypoxic conditions

    Anti-cancer activity and cellular uptake of 7,3′,4′- and 7,8,4′-trihydroxyisoflavone in HepG2 cells under hypoxic conditions by Wen-Sheng Tzeng, Wei-Lin Teng, Pao-Hsien Huang, Feng-Lin Yen, Yow-Ling Shiue

    Published 2024-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  19. 639
    Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein–protein docking, peptide docking and molecular dynamics simulations

    Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein–protein docking, peptide docking and molecular dyna... by Shaher Bano Mirza, Ramin Ekhteiari Salmas, M. Qaiser Fatmi, Serdar Durdagi

    Published 2017-01-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article
  20. 640
    Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents

    Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents by Ahmed F. Khalil, Tarek F. El-Moselhy, Eman A. El-Bastawissy, Rasha Abdelhady, Nancy S. Younis, Mervat H. El-Hamamsy

    Published 2023-12-01
    “…Journal of Enzyme Inhibition and Medicinal Chemistry…”
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    Article

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