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201
Protocol for determination of phosphatidylinositol 3-phosphate levels and localization in Candida glabrata by confocal microscopy
Published 2024-03-01“…Summary: Phosphatidylinositol 3-phosphate (PI3P) levels govern membrane trafficking in Candida glabrata. Here, we present a confocal imaging-based protocol for PI3P localization analysis using the GFP-FYVE (found in Fab1, YOTB, Vac1, and EEA1) fusion protein. …”
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202
Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants
Published 2019-03-01“…Of all the phosphoinositides in eukaryotic cells, phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] constitutes the smallest fraction, yet it is a crucial lipid in animal and yeast membrane trafficking systems. Here, we review the recent findings on the physiological functions of PtdIns(3,5)P2 and its enzyme—formation of aploid and binucleate cells (FAB1)—along with the regulatory proteins of FAB1 and the downstream effector proteins of PtdIns(3,5)P2 in Arabidopsis.…”
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203
The Molecular Interplay between Human Coronaviruses and Autophagy
Published 2021-08-01“…Most human coronaviruses interact with the proteins and/or double-membrane vesicles of autophagy, the membrane trafficking pathway that degrades and recycles the intracellular protein aggregates, organelles, and pathogens, including viruses. …”
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204
Regulation of the Hippo signaling pathway by deubiquitinating enzymes in cancer
Published 2019-12-01“…Changes in ubiquitin chain topology results in the stabilization of proteins, membrane trafficking, and the alteration of cellular localization. …”
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205
Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1
Published 2022-11-01“…In this review, we summarize recent advances toward the functions and molecular mechanisms of Munc18‐1 and Munc13‐1 in guiding neuronal SNARE complex assembly, and discuss the functional similarities and differences between Munc18‐1 and Munc13‐1 in neurons and their homologs in other intracellular membrane trafficking systems.…”
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206
HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis
Published 2023-10-01“…Abstract Vesicular transport driven by membrane trafficking systems conserved in eukaryotes is critical to cellular functionality and homeostasis. …”
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207
snz/SNX25 at the crossroad of endocytosis and lipid handling in autophagy
Published 2022-12-01“…Hence, understanding how membrane trafficking is coupled to autophagy induction and how cells rewire trafficking upon high autophagic needs is instrumental to our understanding of autophagy. …”
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208
The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development
Published 2022-12-01“…Phosphoinositides (PIs), a group of signaling phospholipids, play a crucial role in development and tissue homeostasis by regulating membrane trafficking, cytoskeleton reorganization, and organelle identity. …”
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209
Role of GARP Vesicle Tethering Complex in Golgi Physiology
Published 2023-03-01“…The Golgi associated retrograde protein complex (GARP) is an evolutionarily conserved component of Golgi membrane trafficking machinery that belongs to the Complexes Associated with Tethering Containing Helical Rods (CATCHR) family. …”
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210
Crystal structure of the GABA(A)-receptor-associated protein, GABARAP.
Published 2002“…The GABA(A)-receptor-associated protein (GABARAP) is a member of a growing family of intracellular membrane trafficking and/or fusion proteins and has been implicated in plasma membrane targeting and/or recycling of GABA(A) receptors. …”
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211
Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation.
Published 2010-05-01“…The differentiation of an extracellular matrix (ECM) at the apical side of epithelial cells implies massive polarised secretion and membrane trafficking. An epithelial cell is hence engaged in coordinating secretion and cell polarity for a correct and efficient ECM formation.We are studying the molecular mechanisms that Drosophila tracheal and epidermal cells deploy to form their specific apical ECM during differentiation. …”
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212
Axon-glia interaction and membrane traffic in myelin formation
Published 2014-01-01“…Furthermore, we discuss myelin membrane trafficking with particular focus on endocytic recycling and the control of PLP (proteolipid protein) transport by SNARE proteins. …”
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213
Emerging roles for microtubules in angiosperm pollen tube growth highlight new research cues
Published 2015-02-01“…Recent data on membrane trafficking suggests a role of microtubules in fine delivery and repositioning of vesicles to sustain pollen tube growth. …”
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214
Golgi Metal Ion Homeostasis in Human Health and Diseases
Published 2022-01-01“…Main functions of the Golgi, including membrane trafficking, protein glycosylation, and sorting, require a well-maintained stable microenvironment in the sub-compartments of the Golgi, along with metal ion homeostasis. …”
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215
Physiological and Pathological Roles of the Cytohesin Family in Neurons
Published 2022-05-01“…The cytohesin proteins, consisting of four closely related members (cytohesins-1, -2, -3, and -4), are a subfamily of the Sec7 domain-containing guanine nucleotide exchange factors for ADP ribosylation factors (Arfs), which are critical regulators of membrane trafficking and actin cytoskeleton remodeling. Recent advances in molecular biological techniques and the development of a specific pharmacological inhibitor for cytohesins, SecinH3, have revealed the functional involvement of the cytohesin–Arf pathway in diverse neuronal functions from the formation of axons and dendrites, axonal pathfinding, and synaptic vesicle recycling, to pathophysiological processes including chronic pain and neurotoxicity induced by proteins related to neurodegenerative disorders, such as amyotrophic lateral sclerosis and Alzheimer’s disease. …”
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216
Golgi-Targeting Anticancer Natural Products
Published 2023-03-01“…Moreover, it provides a signaling hub that facilitates not only membrane trafficking processes but also cellular response pathways to various types of stresses. …”
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217
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer
Published 2014-02-01“…They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flotillins are frequently overexpressed in various types of human cancers. …”
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218
Advances in Autophagy Regulatory Mechanisms
Published 2016-05-01“…This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes engulf cytoplasmic cargo to form vesicles that transport their content to the lysosome for degradation. …”
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219
Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation.
Published 2008-11-01“…Lipid rafts are membrane microdomains that function as platforms for signal transduction and membrane trafficking. Tyrosine kinase interacting protein (Tip) of T lymphotropic Herpesvirus saimiri (HVS) is targeted to lipid rafts in T cells and downregulates TCR and CD4 surface expression. …”
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220
Studying the nucleated mammalian cell membrane by single molecule approaches.
Published 2014-01-01“…Based on these observations, we proposed a Protein Layer-Lipid-Protein Island (PLLPI) model, to provide a better understanding of cell membrane structure, membrane trafficking and viral fusion mechanisms.…”
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