Protein uptake by bacteria <subtitle>An endocytosis-like process in the planctomycete Gemmata obscuriglobus</subtitle> by John A. Fuerst, Evgeny Sagulenko

“…Endocytosis is a fundamental process of membrane-trafficking in eukaryotes, but has not been known to occur in bacteria or archaea. …”
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Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. by Zenner, H, Yoshimura, S, Barr, F, Crump, C

“…Rab GTPases are key cellular regulators of membrane trafficking events that, by their membrane association and binding of effector proteins, ensure the appropriate fusion of membranes. …”

Acidic Ca2+ stores and immune-cell function by Davis, LC, Morgan, AJ, Galione, A

“…Recent data suggest important roles of endo-lysosomal Ca²⁺&nbsp;channels, the Two-Pore Channels (TPCs) and the TRPML channels (mucolipins), in different aspects of immune-cell function, particularly impacting membrane trafficking, vesicle fusion/fission and secretion. …”

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation by Stewart, L, Gerner, L, Rettel, M, Stein, F, Burrows, J, Mills, IAN, Evergren, E

“…Based on our findings, we hypothesise that CAMKK2 sustains cell proliferation in large part through effects on organelle integrity and membrane trafficking.…”

The role of CaMKK2 in Golgi-associated vesicle trafficking by Kennedy, G, Gibson, O, O'Hare, DT, Mills, IG, Evergren, E

“…Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications in a cellular context and for disease.…”

Two mechanisms regulate directional cell growth in Arabidopsis lateral roots by Kirchhelle, C, Garcia-Gonzalez, D, Irani, N, Jérusalem, A, Moore, I

“…In young lateral roots of Arabidopsis thaliana, growth anisotropy also depends on RAB-A5c, a plant-specific small GTPase that specifies a membrane trafficking pathway to the geometric edges of cells. …”

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. by Hsu, C, Morohashi, Y, Yoshimura, S, Manrique-Hoyos, N, Jung, S, Lauterbach, M, Bakhti, M, Grønborg, M, Möbius, W, Rhee, J, Barr, F, Simons, M

“…Because Rab family guanosine triphosphatases (GTPases) together with their regulators are important membrane trafficking organizers, we investigated which Rab GTPase-activating proteins interfere with exosome release. …”

Intracellular membrane traffic at high resolution. by Weering, v, Brown, E, Sharp, T, Mantell, J, Cullen, P, Verkade, P

“…Furthermore, we provide a full protocol for immunolabeling on Lowicryl sections of high-pressure frozen cells as well as a detailed description of a simple CLEM method that can be applied to answer many membrane trafficking questions. We believe that these EM-based techniques are important tools to expand our understanding of the molecular details of endosomal sorting and intracellular membrane traffic in general.…”

Evolution of the endomembrane systems of trypanosomatids - conservation and specialisation by Venkatesh, D, Boehm, C, Barlow, L, Nankissoor, N, O'Reilly, A, Kelly, S, Dacks, J, Field, M

“…Parasite surfaces support multiple functions required for survival within their hosts, and maintenance and functionality of the surface depends on membrane trafficking. To understand the evolutionary history of trypanosomatid trafficking, where multiple lifestyles and mechanisms of host interactions are known, we examined protein families central to defining intracellular compartments and mediating transport, namely Rabs, SNAREs and RabGAPs, across all available Euglenozoa genomes. …”

Regulation of the endosomal SNX27-retromer by OTULIN by Stangl, A, Elliott, P, Pinto-Fernandez, A, Bonham, S, Harrison, L, Schaub, A, Kutzner, K, Keusekotten, K, Pfluger, P, El Oualid, F, Kessler, B, Komander, D, Krappmann, D

“…However, via association, OTULIN antagonizes SNX27-dependent cargo loading, binding of SNX27 to the VPS26A-retromer subunit and endosome-to-plasma membrane trafficking. Thus, we define an additional, non-catalytic function of OTULIN in the regulation of SNX27-retromer assembly and recycling to the cell surface.…”

Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking by Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li, Xiao-Long Zhang

“…Furthermore, EndoA2 interacted with the mechanically sensitive ion channel Piezo2 and promoted the membrane trafficking of Piezo2 in DRG neurons. Moreover, as an adaptor protein, EndoA2 also bound to kinesin family member 5B (KIF5B), which was involved in the EndoA2-mediated membrane trafficking process of Piezo2. …”
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Ezrin Regulates Ca²⁺ Ionophore-Induced Plasma Membrane Translocation of Aquaporin-5 by Shin-ichi Muroi, Yoichiro Isohama

“…In this study, we examined the effects of ezrin inhibition on membrane trafficking of AQP5. Ezrin inhibition selectively suppressed an ionomycin-induced increase in AQP5 translocation to the plasma membrane of mouse lung epithelial cells (MLE-12) without affecting the steady-state level of plasma membrane AQP5. …”
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SNARE Modulators and SNARE Mimetic Peptides by Mikhail Khvotchev, Mikhail Soloviev

“…The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins play a central role in most forms of intracellular membrane trafficking, a key process that allows for membrane and biocargo shuffling between multiple compartments within the cell and extracellular environment. …”
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To die or not to die? Lessons from lesion mimic mutants by Quentin eBruggeman, Cécile eRaynaud, Moussa eBenhamed, Moussa eBenhamed, Marianne eDelarue

“…Thanks to progress in molecular genetics, mutations causing the phenotype of a large number of LMM and their related suppressors were mapped, and the identification of the mutated genes shed light on major pathways in the onset of plant PCD such as (i) the involvements of chloroplasts and light energy, (ii) the roles of sphingolipids and fatty acids, (iii) a signal perception at the plasma membrane that requires efficient membrane trafficking, (iv) secondary messengers such as ion fluxes and ROS and (v) the control of gene expression as the last integrator of the signaling pathways.…”
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SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment. by Or Cabasso, Olga Pekar, Mia Horowitz

“…Endocytosis defines the entry of molecules or macromolecules through the plasma membrane as well as membrane trafficking in the cell. It depends on a large number of proteins that undergo protein-protein and protein-phospholipid interactions. …”
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Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties by Jun Udagawa, Kodai Hino

“…Those characteristic moieties give plasmalogen molecules unique biophysical and chemical properties that modulate membrane trafficking, lipid rafts, intramolecular PUFA moieties, and oxidative states. …”
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Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses by Brock Humphries, Zhishan Wang, Chengfeng Yang

“…They were originally thought to primarily affect cell migration and invasion; however, recent advances in our understanding of the biology and function of Rho GTPases have demonstrated their diverse roles within the cell, including membrane trafficking, gene transcription, migration, invasion, adhesion, survival and growth. …”
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Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila by Shichao Yu, Fangzhou Luo, Li Hua Jin

“…In this article, we selected three endosome markers, Rab5, Rab7, and Rab11, that play a key role in membrane trafficking and determined whether they participate in hematopoiesis. …”
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Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease by Kate L. Jordan, David J. Koss, Tiago F. Outeiro, Flaviano Giorgini

“…Rab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and membrane trafficking. Owing to their widespread functions in several steps of vesicle trafficking, Rabs have been implicated in the pathogenesis of several disorders, including cancer, diabetes, and multiple neurodegenerative diseases. …”
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Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi by Yujiro Higuchi

“…The industrially important filamentous fungus <i>Aspergillus oryzae</i>, known as the yellow <i>Koji</i> mold and also designated the Japanese National fungus, has been investigated for understanding the intracellular membrane trafficking machinery due to the great ability of valuable enzyme production. …”
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