Role of synaptotagmin-7 in glucagon-like peptide (GLP-1) secretion. by Kang, Yvonne Yu Han.

“…Synaptotagmins is a family of membrane trafficking proteins consisting of 15 different isoforms. …”
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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. by Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, D, Barr, F

“…A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human Rabs have no known GEF. …”

Homozygous mutations in TBC1D23 lead to a non-degenerative form of pontocerebellar hypoplasia by Marin-Valencia, I, Gerondopoulos, A, Zaki, MS, Ben-Omran, T, Almureikhi, M, Demir, E, Guemez-Gamboa, A, Gregor, A, Issa, MY, Appelhof, B, Roosing, S, Musaev, D, Rosti, B, Wirth, S, Stanley, V, Baas, F, Barr, FA, Gleeson, JG

“…TBC1D23 localized at the trans-Golgi and was regulated by the small GTPases Arl1 and Arl8, suggesting a role in trans-Golgi membrane trafficking. Altogether, this study provides a causative link between TBC1D23 mutations and PCH and suggests a less severe clinical course than other PCH subtypes.…”

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport by Hianara A Bustamante, Karina Cereceda, Alexis E González, Guillermo E Valenzuela, Yorka Cheuquemilla, Sergio Hernández, Eloisa Arias-Muñoz, Cristóbal Cerda-Troncoso, Susanne Bandau, Andrea Soza, Gudrun Kausel, Bredford Kerr, Gonzalo A Mardones, Jorge Cancino, Ronald T Hay, Alejandro Rojas-Fernandez, Patricia V Burgos

“…Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood. Here, we search for ubiquitin-related genes implicated in protein membrane trafficking performing a High-Content siRNA Screening including 1187 genes of the human “ubiquitinome” using amyloid precursor protein (APP) as a reporter. …”
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Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond by Mingli Li, Leisi Zhang, Chun-Wei Chen

“…By adding the lipid chain to proteins, it increases the hydrophobicity of proteins and modulates protein stability, interaction with effector proteins, subcellular localization, and membrane trafficking. Palmitoylation is catalyzed by a group of zinc finger DHHC-containing proteins (ZDHHCs), whereas depalmitoylation is catalyzed by a family of acyl-protein thioesterases. …”
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Protocol for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal organoids by Keiko Maeda, Katlynn Bugda Gwilt, Stefanie S. Schmieder, Nicholas C. Zachos, Wayne I. Lencer

“…The protocol facilitates quantification of membrane trafficking and can be used to probe endosomal compartments unique to polarized epithelia.For complete details on the use and execution of this protocol, please refer to Maeda K et al. (2022).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Lysosome Function and Dysfunction in Hereditary Spastic Paraplegias by Daisy Edmison, Luyu Wang, Swetha Gowrishankar

“…In this review, we highlight the different classes of HSPs that have been linked to lysosome defects: (1) a subset of complex HSPs where mutations in lysosomal genes are causally linked to the diseases, (2) other complex HSPs where mutation in genes encoding membrane trafficking adaptors lead to lysosomal defects, and (3) a subset of HSPs where mutations affect genes encoding proteins whose function is primarily linked to a different cellular component or organelle such as microtubule severing and Endoplasmic Reticulum-shaping, while also altering to lysosomes. …”
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Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function. by Matthew J Dominguez, Jon J McCord, R Bryan Sutton

“…Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level details of ferlin protein structure and function. …”
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Coordination of tissue cell polarity by auxin transport and signaling by Carla Verna, Sree Janani Ravichandran, Megan G Sawchuk, Nguyen Manh Linh, Enrico Scarpella

“…The prevailing hypothesis proposes that GNOM, a regulator of membrane trafficking, positions PIN-FORMED auxin transporters to the correct side of the plasma membrane; the resulting cell-to-cell, polar transport of auxin would coordinate tissue cell polarity and induce vein formation. …”
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A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking by Thomas Pohlmann, Sebastian Baumann, Carl Haag, Mario Albrecht, Michael Feldbrügge

“…An emerging theme in cellular logistics is the close connection between mRNA and membrane trafficking. A prominent example is the microtubule-dependent transport of mRNAs and associated ribosomes on endosomes. …”
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RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. by Wei Zou, Smita Yadav, Laura DeVault, Yuh Nung Jan, David R Sherwood

“…Using a candidate-based genetic screen in C. elegans, we have identified the small GTPase RAB-10 as a key regulator of membrane trafficking during dendrite morphogenesis. Loss of rab-10 severely reduced proximal dendritic arborization in the multi-dendritic PVD neuron. …”
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Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration by Alazne Arrazola Sastre, Miriam Luque Montoro, Hadriano M. Lacerda, Francisco Llavero, José L. Zugaza

“…Small guanosine triphosphatases (GTPases) of the Rab and Arf families are key regulators of vesicle formation and membrane trafficking. Membrane transport plays an important role in the central nervous system. …”
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Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome by Cho, Nam-Joon, Lee, Choongho, Pang, Phillip S., Pham, Edward A., Fram, Benjamin, Nguyen, Khanh, Xiong, Anming, Sklan, Ella H., Elazar, Menashe, Koytak, Elif S., Kersten, Caroline, Kanazawa, Kay K., Frank, Curtis W., Glenn, Jeffrey S.

“…PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle.…”
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RAB-A2a dependent membrane traffic in Arabidopsis thaliana by Woollard, A

“…</p> <p>In this project, I investigated a range of membrane trafficking pathways in <em>Arabidopsis thaliana</em>. …”

RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. by Nottingham, R, Pusapati, G, Ganley, I, Barr, F, Lambright, D, Pfeffer, SR

“…The substrates for most RabGAPs are unknown, and the potential for cross-talk between different membrane trafficking pathways remains uncharted territory. …”

Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster by Sechi, S, Frappaolo, A, Fraschini, R, Capalbo, L, Gottardo, M, Belloni, G, Glover, D, Wainman, A, Giansanti, M

“…We propose that Rab1, by associating with GOLPH3, controls membrane trafficking and contractile ring constriction during cytokinesis.…”

CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome by Enes Yağız Akdaş, Soeren Turan, Debarpan Guhathakurta, Arif Ekici, Seda Salar, D. Chichung Lie, Beate Winner, Anna Fejtova

“…C-terminal Binding Protein 1 (CTBP1) is a ubiquitously expressed transcriptional co-repressor and membrane trafficking regulator. A recurrent de novo c.991C>T mutation in CTBP1 leads to expression of p.R331W CTBP1 and causes hypotonia, ataxia, developmental delay, and tooth enamel defects syndrome (HADDTS), a rare early onset neurodevelopmental disorder. …”
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Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. by Abrar A Aljiboury, Eric Ingram, Nikhila Krishnan, Favour Ononiwu, Debadrita Pal, Julie Manikas, Christopher Taveras, Nicole A Hall, Jonah Da Silva, Judy Freshour, Heidi Hehnly

“…These studies demonstrate the need to acutely coordinate Rab8, Rab11, and Rab35-mediated membrane trafficking events to ensure appropriate timing in lumen and cilia formation during KV development.…”
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Impact of Environmental Stressors on Gene Expression in the Embryo of the Italian Wall Lizard by Rosaria Scudiero, Chiara Maria Motta, Palma Simoniello

“…Cadmium-responsive genes encode proteins involved in cellular protection, metabolism and proliferation, membrane trafficking, protein interactions, neuronal transmission and plasticity, immune response, and transcription regulatory factors. …”
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Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond by Nicole Wesch, Vladimir Kirkin, Vladimir V. Rogov

“…Besides autophagy, Atg8-proteins participate in many other pathways, among which membrane trafficking and neuronal signaling are the most known. …”
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