Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates by Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Céline Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard

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DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy by Rahul Kumar, Vincent Francis, Maria S. Ioannou, Adriana Aguila, Maleeha Khan, Emily Banks, Gopinath Kulasekaran, Peter S. McPherson

“…Summary: Cytokinesis relies on membrane trafficking pathways regulated by Rabs and guanine nucleotide exchange factors (GEFs). …”
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Phospholipase Family Enzymes in Lung Cancer: Looking for Novel Therapeutic Approaches by Sara Salucci, Beatrice Aramini, Anna Bartoletti-Stella, Ilaria Versari, Giovanni Martinelli, William Blalock, Franco Stella, Irene Faenza

“…Phosphatidylinositols are lipid molecules and key players in the inositol signaling pathway that have a pivotal role in cell cycle regulation, proliferation, differentiation, membrane trafficking, and gene expression. In this review, we discuss the current understanding of phosphoinositide-specific phospholipase enzymes and their emerging roles in LC.…”
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Loss of Class III Phosphoinositide 3-Kinase Vps34 Results in Cone Degeneration by Ammaji Rajala, Feng He, Robert E. Anderson, Theodore G. Wensel, Raju V. S. Rajala

“…The absence of Vps34 was previously found to disrupt autophagy and other membrane-trafficking pathways in some sensory neurons, but the roles of phosphatidylinositol 3-phosphate and Vps34 in cone photoreceptor cells have not previously been explored. …”
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Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains by Fabia Tomie Tano, Gustavo Rolim Barbosa, Eloiza de Rezende, Rodolpho Ornitz Oliveira Souza, Sandra Marcia Muxel, Ariel Mariano Silber, Giuseppe Palmisano, Beatriz Simonsen Stolf

“…The proteins more abundant in LV79 promastigotes participate mainly in translation and amino acid and nucleotide metabolism, while the more abundant in PH8 are involved in carbohydrate metabolism, cytoskeleton composition and vesicle/membrane trafficking. Interestingly, although the virulence factor GP63 was more abundant in the less virulent LV79 strain, zymography suggests a higher protease activity in PH8. …”
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A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells by Christopher Olson, Pengyang Zhang, Joy Ku, Renceh Flojo, Darin Boyes, Biao Lu

“…Furthermore, we investigated the impact of brefeldin A (BFA), an inhibitor of ER-to-Golgi membrane trafficking, on protein secretion. Interestingly, BFA inhibited protein secretion via the ER-Golgi pathway while stimulating exosome-mediated protein secretion under same experimental conditions. …”
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Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment by Dandan Zhu, Ke Song, Jinling Chen, Jianxin Wang, Xiaolei Sun, Hongyan Qian, Xijuan Gu, Lingbo Zhang, Yongwei Qin, Yinong Duan

“…Abstract Background Septin4 (SEPT4) exists widely in human tissues and is related to mechanical stability, actin dynamics, membrane trafficking, viral replication and apoptosis. Data from many studies have suggested that SEPT4 plays a significant role in liver fibrosis. …”
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Mitophagy and spermatogenesis: Role and mechanisms by Damilare Emmanuel Rotimi, Matthew Iyobhebhe, Elizabeth Temidayo Oluwayemi, Ikponmwosa Owen Evbuomwan, Rotdelmwa Maimako Asaleye, Oluwafemi Adeleke Ojo, Oluyomi Stephen Adeyemi

“…During spermatogenesis, mitophagy can influence cell homeostasis and participates in a variety of membrane trafficking activities. Crucially, it has been demonstrated that defective mitophagy can impede spermatogenesis. …”
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Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy by Takashi Nozawa, Hirotaka Toh, Junpei Iibushi, Kohei Kogai, Atsuko Minowa-Nozawa, Junko Satoh, Shinji Ito, Kazunori Murase, Ichiro Nakagawa

“…Abstract Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial infection in xenophagy is not known. …”
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Isoprene Emission Influences the Proteomic Profile of Arabidopsis Plants under Well-Watered and Drought-Stress Conditions by Ilaria Mancini, Guido Domingo, Marcella Bracale, Francesco Loreto, Susanna Pollastri

“…Unexpectedly, isoprene also alters membrane trafficking.…”
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Cleavage activates Dispatched for Sonic Hedgehog ligand release by Daniel P Stewart, Suresh Marada, William J Bodeen, Ashley Truong, Sadie Miki Sakurada, Tanushree Pandit, Shondra M Pruett-Miller, Stacey K Ogden

“…Cleavage site mutation alters Dispatched membrane trafficking and reduces ligand release, leading to compromised pathway activity in vivo. …”
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The Mysterious Ways of ErbB2/HER2 Trafficking by Vibeke Bertelsen, Espen Stang

“…In this review, we will discuss different molecular mechanisms suggested to be important for making ErbB2 resistant to down-regulation, and review how membrane trafficking is involved when down-regulation and/or relocalization of ErbB2 is induced.…”
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Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons by Emma T Watson, Michaela M Pauers, Michael J Seibert, Jason D Vevea, Edwin R Chapman

“…These experiments reveal a new-found membrane trafficking pathway, for SV proteins, in classically polarized mammalian neurons and provide a glimpse at the first steps of SV biogenesis.…”
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A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation by Alberto Azzalin, Francesca Brambilla, Eloisa Arbustini, Katia Basello, Attilio Speciani, Pierluigi Mauri, Paola Bezzi, Lorenzo Magrassi

“…Increased SHC3 levels are associated to increased glucose uptake mediated by changes in membrane trafficking of glucose transporters of the solute carrier 2A superfamily (GLUT/SLC2A). …”
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Ubiquitination-dependent control of sexual differentiation in fission yeast by Fabrizio Simonetti, Tito Candelli, Sebastien Leon, Domenico Libri, Mathieu Rougemaille

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Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins by Michael A. Cahill

“…Modern PGRMC proteins regulate multiple functions, including CYP450-mediated steroidogenesis, membrane trafficking, heme homeostasis, glycolysis/Warburg effect, fatty acid metabolism, mitochondrial regulation, and genomic CpG epigenetic regulation of gene expression. …”
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Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites by Xing Liang, Marcela Kokes, Richard D Fetter, Maria Danielle Sallee, Adrian W Moore, Jessica L Feldman, Kang Shen

“…A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. …”
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Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia by Guoli Zhou, Emily Winn, Duong Nguyen, Eric P. Kasten, Margaret G. Petroff, Hanne M. Hoffmann

“…Gene set variation analysis revealed an interplay between co-alterations of circadian clock genes and PE with altered hypoxia, cell migration/invasion, autophagy, and membrane trafficking pathways. Using human placental trophoblast HTR-8 cells, we show that CRY1/2 and NR1D1/2 regulate trophoblast migration. …”
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Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18. by Guo-Li Li, Ying-Qian Han, Bing-Qian Su, Hai-Shen Yu, Shuang Zhang, Guo-Yu Yang, Jiang Wang, Fang Liu, Sheng-Li Ming, Bei-Bei Chu

“…RAB GTPases (RABs) control intracellular membrane trafficking with high precision. In the present study, we carried out a short hairpin RNA (shRNA) screen focused on a library of 62 RABs during infection with porcine reproductive and respiratory syndrome virus 2 (PRRSV-2), a member of the family Arteriviridae. …”
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SAP97 and cortactin remodeling in arrhythmogenic Purkinje cells. by Wen Dun, Patrick Wright, Peter Danilo, Peter J Mohler, Penelope A Boyden

“…At the same time, cortactin/Kv1.5 colocalization is increased at the ID, suggesting an ongoing active process of membrane trafficking of the channel protein. Finally, the Kv1.5 current, measured as the RSD1379-sensitive current, at +40 mV did not differ between NZPCs (0.81±0.24 pA/pF, n = 14) and IZPCs (0.83±0.21 pA/pF, n = 13, NS). …”
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