Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells by Laura Contreras, Alfonso Rodríguez-Gil, Jordi Muntané, Jesús de la Cruz

“…Genes functionally related to membrane trafficking, stress-responsible and unfolded protein responses, circadian clock and activation of apoptosis were predominantly upregulated, while genes involved in cell growth and cycle, DNA replication and repair, ribosome biogenesis, translation initiation and proteostasis were downregulated. …”
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Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains. by Fabia Tomie Tano, Gustavo Rolim Barbosa, Eloiza de Rezende, Rodolpho Ornitz Oliveira Souza, Sandra Marcia Muxel, Ariel Mariano Silber, Giuseppe Palmisano, Beatriz Simonsen Stolf

“…The proteins more abundant in LV79 promastigotes participate mainly in translation and amino acid and nucleotide metabolism, while the more abundant in PH8 are involved in carbohydrate metabolism, cytoskeleton composition and vesicle/membrane trafficking. Interestingly, although the virulence factor GP63 was more abundant in the less virulent LV79 strain, zymography suggests a higher protease activity in PH8. …”
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MiR-214-3p targets Ras-related protein 14 (RAB14) to inhibit cellular migration and invasion in esophageal Cancer cells by Pornima Phatak, Whitney M. Burrows, Timothy Michael Creed, Mariam Youssef, Goo Lee, James M. Donahue

“…In this study, we examined the interaction between miR-214-3p and RAB14, a membrane trafficking protein shown to exert oncogenic functions in other malignancies, in esophageal cancer cells. …”
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Aquaporin splice variation differentially modulates channel function during marine teleost egg hydration. by Alba Ferré, François Chauvigné, Cinta Zapater, Roderick Nigel Finn, Joan Cerdà

“…Recent studies have shown that the subdomains of two water channels (Aqp1ab1 and Aqp1ab2) encoded in a teleost-specific aquaporin-1 cluster (TSA1C) co-evolved with duplicated Ywhaz-like (14-3-3ζ-like) binding proteins to differentially control their membrane trafficking for maximal egg hydration. Here, we report that in species that encode the full TSA1C, in-frame intronic splice variants of Aqp1ab1 result in truncated proteins that cause dominant-negative inhibition of the canonical channel trafficking to the plasma membrane. …”
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Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease by Mariona Jové, Natàlia Mota-Martorell, Èlia Obis, Joaquim Sol, Meritxell Martín-Garí, Isidre Ferrer, Manuel Portero-Otin, Reinald Pamplona

“…Ether lipids determine the neural membrane structural and functional properties, membrane trafficking, cell signaling and antioxidant defense mechanisms. …”
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Ultrastructure and 3D reconstruction of a diplonemid protist (Diplonemea) and its novel membranous organelle by Daria Tashyreva, Jiří Týč, Aleš Horák, Julius Lukeš

“…We suggest that the colv is involved in food processing and membrane trafficking, and describe its close association with other components of the cellular digestive system. …”
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The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis by Nydia Tejeda-Munoz, Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit, Raul Ayala, Neil O'Brien, Edward M De Robertis

“…Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryonic development and cancer. …”
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A Genomic and Transcriptomic Overview of MATE, ABC, and MFS Transporters in <i>Citrus sinensis</i> Interaction with <i>Xanthomonas citri</i> subsp. <i>citri</i> by Maria H. M. Julião, Saura R. Silva, Jesus A. Ferro, Alessandro M. Varani

“…The multi-antimicrobial extrusion (MATE), ATP-binding cassette (ABC), and major facilitator superfamily (MFS) are the main plant transporters families, playing an essential role in the membrane-trafficking network and plant-defense mechanism. …”
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Low temperature and short-term high-CO2 treatment in postharvest storage of table grapes at two maturity stages: Effects on transcriptome profiling. by Raquel Rosales, Irene Romero, Carlos Fernandez-Caballero, M. Isabel Escribano, Carmen Merodio, M Teresa Sanchez-Ballesta

“…Thus, genes involved in gluconeogenesis, photosynthesis, mRNA translation and lipid transport were up-regulated in the case of early-harvested grapes, and genes related to protein folding stability and intracellular membrane trafficking in late-harvested grapes. The beneficial effect of high CO2 treatment maintaining table grape quality seems to be an active process requiring the induction of several transcription factors and kinases in early-harvested grapes, and the activation of processes associated to the maintenance of energy in late-harvested grapes.…”
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The Neuron Navigators: Structure, function, and evolutionary history by Regina M. Powers, Regina M. Powers, Robert F. Hevner, Robert F. Hevner, Shelley Halpain, Shelley Halpain

“…Overall, Navigators participate in the cytoskeletal response to extracellular cues via microtubules and actin filaments, in conjunction with membrane trafficking. We propose that uptake of fluid-phase cues and nutrients and/or downregulation of cell surface receptors could represent general mechanisms that explain Navigator functions. …”
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Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine by Wakako Fujita, Hitoshi Uchida, Masashi Kawanishi, Yusuke Kuroiwa, Manabu Abe, Kenji Sakimura

“…Receptor transporter protein 4 (RTP4), one of the receptor chaperone proteins, contributes to the maturation and membrane trafficking of opioid receptor heteromers consisting of mu (MOPr) and delta (DOPr) opioid receptors (MOPr-DOPr). …”
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Snap29 Is Dispensable for Self-Renewal Maintenance but Required for Proper Differentiation of Mouse Embryonic Stem Cells by Yumei Jia, Zhaoyuan Guo, Jiahao Zhu, Guanyu Qin, Wenwen Sun, Yu Yin, Haiying Wang, Renpeng Guo

“…Synaptosomal-associated protein 29 (Snap29) is implicated in numerous intracellular membrane trafficking pathways, including autophagy, which is involved in the maintenance of ESC pluripotency. …”
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Identification and Characterization Analysis of Transient Receptor Potential Mucolipin Protein of <i>Laodelphax striatellus</i> Fallén by Haitao Wang, Yan Dong, Baijie Wan, Yinghua Ji, Qiufang Xu

“…Transient receptor potential mucolipin (TRPML) protein in flies plays a pivotal role in Ca²⁺ ions release, resulting in membrane trafficking, autophagy and ion homeostasis. However, to date, the characterization of TRPML in agricultural pests remains unknown. …”
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Analyzing the cellular plasma membrane by fast and efficient correlative STED and platinum replica EM by Dmytro Puchkov, Paul Markus Müller, Martin Lehmann, Claudia Matthaeus

“…The combination of STED microscopy and platinum replica SEM or TEM provides the highest spatial resolution of plasma membrane proteins and their underlying membrane and is, therefore, a suitable method to study cellular events like endocytosis, membrane trafficking, or membrane tension adaptations.…”
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Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. by María J Tenorio, Breyan H Ross, Charlotte Luchsinger, Andrés Rivera-Dictter, Cecilia Arriagada, Diego Acuña, Marcelo Aguilar, Viviana Cavieres, Patricia V Burgos, Pamela Ehrenfeld, Gonzalo A Mardones

“…GOLPH3 has also been observed associated with vesicles and tubules arising from the Golgi, as well as other cellular compartments, and hence it has been implicated in several membrane trafficking events. Whether these and other features are typical to all different types of cells is unknown. …”
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Transcriptome analysis of chloride intracellular channel knockdown in Drosophila identifies oxidation-reduction function as possible mechanism of altered sensitivity to ethanol sed... by Rory M Weston, Rebecca E Schmitt, Mike Grotewiel, Michael F Miles

“…CLICs have been implicated in a wide variety biological processes including ion channel activity, apoptosis, membrane trafficking, and enzymatic oxidoreductase activity. …”
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Normal oil body formation in Marchantia polymorpha requires functional coat protein complex I proteins by Takehiko Kanazawa, Takehiko Kanazawa, Ryuichi Nishihama, Takashi Ueda, Takashi Ueda

“…A tightly regulated membrane trafficking system mediates the transportation and localization of these substances. …”
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RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway by Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, David, Harper, J. W.

“…These data reveal a novel function for TBK1 in mitophagy, which parallels that of LRRK2-mediated phosphorylation of the homologous site in distinct RABs to control membrane trafficking.…”
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RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread by Sanderlin, Allen G, Vondrak, Cassandra, Scricco, Arianna J., Scricco, Arianna J., Fedrigo, Indro, Ahyong, Vida, Lamason, Rebecca L.

“…Interestingly, eukaryotic cells can also directly exchange cellular components via intercellular communication pathways (e.g., trans-endocytosis) using cell–cell adhesion, membrane trafficking, and membrane remodeling proteins. Therefore, we hypothesized that L. monocytogenes would hijack these types of host proteins during spread. …”
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MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9 by Chai, Sunghee, Cambronne, Xiaolu A., Eichhorn, Stephen William, Goodman, Richard H.

“…This enzyme is known to palmitoylate H-Ras, a modification required for proper membrane trafficking. Treatment with bicuculline, a GABA[subscript A] receptor antagonist, decreased DHHC9 expression in somatostatin-positive interneurons and membrane localization of an H-Ras reporter in a manner that depended on miR-134. …”
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