Analysis of networks in the dorsolateral prefrontal cortex in chronic schizophrenia: Relevance of altered immune response by América Vera-Montecinos, Ricard Rodríguez-Mias, Èlia Vila, Judit Villén, Belén Ramos, Belén Ramos, Belén Ramos, Belén Ramos

“…Furthermore, our network analyses showed crosstalk between proteins involved in MHC class II antigen presentation, membrane trafficking, Golgi-to-ER retrograde transport, Nef-mediated CD8 downregulation and the immune system with only one module built by 13 proteins. …”
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Quantitative Phosphoproteomic Analysis Provides Insights into the Sodium Bicarbonate Responsiveness of <i>Glycine max</i> by Qiang Li, Minglong Li, Huiying Ma, Man Xue, Tong Chen, Xiaodong Ding, Shuzhen Zhang, Jialei Xiao

“…A protein kinase/phosphatase interactor analysis showed that the interacting proteins were mainly involved in/with transporters/membrane trafficking, transcriptional level regulation, protein level regulation, signaling/stress response, and miscellaneous functions. …”
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Molecular interplays of the Entamoeba histolytica endosomal sorting complexes required for transport during phagocytosis by Cecilia Bañuelos, Abigail Betanzos, Abigail Betanzos, Rosario Javier-Reyna, Ausencio Galindo, Esther Orozco

“…A proteomic approach performed here, using an anti-LBPA antibody, revealed that some proteins related to membrane trafficking, cellular transport, cytoskeleton dynamics, and transcriptional and translational functions are secreted and associated to LBPA. …”
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Exploring the Role of PI3P in Platelets: Insights from a Novel External PI3P Pool by Abdulrahman Mujalli, Julien Viaud, Sonia Severin, Marie-Pierre Gratacap, Gaëtan Chicanne, Karim Hnia, Bernard Payrastre, Anne-Dominique Terrisse

“…Phosphoinositides (PIs) play a crucial role in regulating intracellular signaling, actin cytoskeleton rearrangements, and membrane trafficking by binding to specific domains of effector proteins. …”
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Identification of GOLPH3 Partners in <i>Drosophila</i> Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders by Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D’Avino, Maria Grazia Giansanti

“…We recently showed that PI(4)P-GOLPH3 couples membrane trafficking with contractile ring assembly during cytokinesis in dividing <i>Drosophila</i> spermatocytes. …”
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Evidence from bioinformatics, expression and inhibition studies of phosphoinositide-3 kinase signalling in <it>Giardia intestinalis</it> by Crompton Mark R, Tarr Sarah J, van der Giezen Mark, Cox Siân SE, Tovar Jorge

“…Phosphoinositide-3 kinase (PI3K) signalling pathways have a central involvement in many vital eukaryotic processes, such as regulation of cell growth, intracellular membrane trafficking and cell motility. Here we present evidence for the existence of functional PI3K intracellular signalling pathways in <it>G. intestinalis</it>.…”
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Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets by Isabel García-Dorival, Miguel Ángel Cuesta-Geijo, Inmaculada Galindo, Ana del Puerto, Lucía Barrado-Gil, Jesús Urquiza, Covadonga Alonso

“…These ASFV fusion proteins shared interacting partners, suggesting potential common functions. Membrane trafficking and lipid metabolism were important categories, as we found significant interactions with several enzymes of the lipid metabolism. …”
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Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses by Maria Andres-Alonso, Maximilian Borgmeyer, Hadi Mirzapourdelavar, Jakob Lormann, Kim Klein, Michaela Schweizer, Sabine Hoffmeister-Ullerich, Anja M. Oelschlegel, Alexander Dityatev, Michael R. Kreutz

“…Accordingly, in mice lacking a component of trans-Golgi network-to-plasma membrane trafficking, we find fewer GSs and significantly reduced PSA-NCAM levels in distal dendrites of CA1 neurons that receive input from the temporoammonic pathway. …”
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Natural Antioxidant By-Product Mixture Counteracts the Effects of Aflatoxin B1 and Ochratoxin A Exposure of Piglets after Weaning: A Proteomic Survey on Liver Microsomal Fraction by Roua Gabriela Popescu, George Cătălin Marinescu, Andreea Luminița Rădulescu, Daniela Eliza Marin, Ionelia Țăranu, Anca Dinischiotu

“…Pathways enrichment revealed that fatty acid metabolism, steroid biosynthesis, regulation of actin cytoskeleton, regulation of gene expression by spliceosomes, membrane trafficking, peroxisome, thermogenesis, retinol, pyruvate, and amino acids metabolism pathways are also affected by the mycotoxins. …”
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PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms by Yevgeniya A Mironova, Guy M Lenk, Jing-Ping Lin, Seung Joon Lee, Jeffery L Twiss, Ilaria Vaccari, Alessandra Bolino, Leif A Havton, Sang H Min, Charles S Abrams, Peter Shrager, Miriam H Meisler, Roman J Giger

“…Collectively, our studies identify PI(3,5)P2 as a key regulator of myelin membrane trafficking and myelinogenesis.…”
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Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I by Tianyao Guo, Zhigui Duan, Jia Chen, Chunliang Xie, Ying Wang, Ping Chen, Xianchun Wang

“…Functional analysis indicated that Syt I may exert impacts by interacting with other proteins on multiple cellular processes, including vesicular membrane trafficking, synaptic transmission, metabolic regulation, catalysis, transmembrane transport and structure formation, etc. …”
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Microenvironmental hypoxia induces dynamic changes in lung cancer synthesis and secretion of extracellular vesicles by Tse, Shun Wilford, Tan, Chee Fan, Park, Jung Eun, Gnanasekaran, JebaMercy, Gupta, Nikhil, Low, Jee Keem, Yeoh, Kheng Wei, Chng, Wee Joo, Tay, Chor Yong, McCarthy, Neil E., Lim, Sai Kiang, Sze, Siu Kwan

“…In addition, functional clustering analyses revealed that tumour hypoxia was strongly associated with rapid synthesis and EV loading of lysosome-related hydrolases and membrane-trafficking proteins to enhance EVs secretion. Moreover, lung cancer-derived EVs were also enriched in signalling molecules capable of inducing epithelial-mesenchymal transition in recipient cancer cells to promote their migration and invasion. …”
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Cell biology and genetic regulation of secondary cells in the Drosophila accessory gland by Leiblich, A

“…In addition, as a consequence of this research, the <em>Drosophila</em> AG is emerging as an important model to study a number of conserved aspects of cell biology, particularly membrane trafficking, relevant to human diseases, including cancer.…”

Effect of Leptin of N-Methyl-N’-Nitro-N- nitrosoguanidine induced histological and genetic changes in stomach of male sprague-dawley rats / Faizatul Isyraqiah Ahmad Muhammad by Ahmad Muhammad, Faizatul Isyraqiah

“…Compared to control, 25% of LEPT-treated stomachs showed hyperplasia and dysplasia, and upregulated genes include Furin (protein maturation), Eef1a1 and Eif4g2 (translation factors), Tmed2 (vesicular trafficking), Rab7a (plasma membrane trafficking), Rfwd2 (protein degradation), Fth1 and Ftl1 (oxygen transport), Tspan8, Tspan1, Fxyd3, and Rack1 (cell migration), Pde4d (signal transduction), Nupr1 and Ybx1 (transcription factors), Ptma and Tmem134 (oncogenes), Srsf2 (mRNA maturation), and Reep5 (cell proliferation). …”
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Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis by Md Rezanur Rahman, Tania Islam, Ferdinando Nicoletti, Maria Cristina Petralia, Rosella Ciurleo, Francesco Fisicaro, Manuela Pennisi, Alessia Bramanti, Talip Yasir Demirtas, Esra Gov, Md Rafiqul Islam, Bashair M. Mussa, Mohammad Ali Moni, Paolo Fagone

“…Inflammatory-associated processes and membrane trafficking pathways as common biological processes were found to be in common between SCZ and T2DM. …”
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Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons by Weili Kong, Mauricio Montano, Michael J. Corley, Ekram Helmy, Hirofumi Kobayashi, Martin Kinisu, Rahul Suryawanshi, Xiaoyu Luo, Loic A. Royer, Nadia R. Roan, Melanie Ott, Lishomwa C. Ndhlovu, Warner C. Greene

“…Infection is further positively modulated by the two-pore segment channel 2 (TPC2) protein that regulates membrane trafficking and endocytosis. Astrocyte infection produces a pathological response closely resembling reactive astrogliosis characterized by elevated type I interferon (IFN) production, increased inflammation, and the decreased expression of transporters of water, ions, choline, and neurotransmitters. …”
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Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii by Kai He, Qiangqiang Wang, Xuwen Gao, Tao Tang, Huiyong Ding, Shaojun Long

“…Abstract Background The protozoan parasite Toxoplasma gondii encodes a dozen Rab proteins, which are parts of the small GTPase superfamily and regulate intracellular membrane trafficking. Our previous study showed that depletion of Rab1B caused severe defects regarding parasite growth and morphological structure, yet early defects of endocytic trafficking and vesicle sorting to the rhoptry in T. gondii are not expected to have a strong effect. …”
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RAB6B is a potential prognostic marker and correlated with the remolding of tumor immune microenvironment in hepatocellular carcinoma by Hao Peng, Erwei Zhu, Jitao Wang, Jitao Wang, Xuanlong Du, Chonggao Wang, Meng Yang, Yewei Zhang

“…The Ras-associated binding (Rab) proteins constitute the largest family of the Ras superfamily of small GTPases, which mainly mediate membrane trafficking processes. RAB6B is a member of Rab GTPases, and it has been found to be dysregulated in various tumors. …”
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Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development by Christian Bollmann, Susanne Schöning, Katharina Kotschnew, Julia Grosse, Nicole Heitzig, Gabriele Fischer von Mollard

“…Abstract Background Neurons are highly specialized cells with a complex morphology generated by various membrane trafficking steps. They contain Golgi outposts in dendrites, which are formed from somatic Golgi tubules. …”
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Essential role of the conserved oligomeric Golgi complex in Toxoplasma gondii by Clem Marsilia, Mrinalini Batra, Irina D. Pokrovskaya, Changqi Wang, Dale Chaput, Daria A. Naumova, Vladimir V. Lupashin, Elena S. Suvorova

“…Deprivation of the COG complex induces a pronounced effect on Golgi and ER membranes, which suggests that the T. gondii COG complex has a wider role in intracellular membrane trafficking. We demonstrated that besides its conservative role in retrograde intra-Golgi trafficking, the COG complex also interacted with anterograde and novel transport machinery. …”
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